Tokushima University / Educator and Researcher Directory --- Sakai, Tohru

Personal Web Page

https://researchmap.jp/read0184057 (researchmap)

Field of Study

○	Public Health Nutrition, Nutritional Immunology

Subject of Study

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Book / Paper

Book:

1.	Tohru Sakai, 郡俊之, Mariko Nakamoto and Akiko Nakamoto : 公衆栄養学第7版, Kodansha, Tokyo, Jan. 2023.
2.	Tohru Sakai : 改訂感染と生体防御, Tokyo, Sep. 2018.
3.	Tohru Sakai : 公衆栄養学2018年版, Ishiyaku Publishers,Inc., Tokyo, Feb. 2018.
4.	Tohru Sakai : 公衆栄養学第5版, 株式会社講談社サイエンティフィク, Tokyo, Feb. 2015.
5.	Tohru Sakai : 公衆栄養学第5版, 株式会社中外医学社, Tokyo, Feb. 2015.
6.	Tohru Sakai : 免疫疾患(食物アレルギーなど), 株式会社中外医学社, Tokyo, Aug. 2014.
7.	Tohru Sakai : 公衆栄養学概論，がんを防ぐ食生活, Yokyo, Feb. 2014.
8.	Tohru Sakai, 郡俊之 and 山本茂 : 公衆栄養学第4版栄養科学シリーズNEXT, 講談社サイエンティフィック, Tokyo, Mar. 2013.
9.	Tohru Sakai : 改訂給食経営管理論, 建ぱく社, Mar. 2011.

Academic Paper (Judged Full Paper):

1.	TANAKA Yuko, YAMAMOTO Mako, Haruka Ohhashi, Akiko Nakamoto, Mariko Nakamoto and Tohru Sakai : The Soy Isoflavone Genistein Enhances IFN-γ-Induced PD-L1 Expression in B16F1 Melanoma Cells in Vitro, BPB Reports, Vol.7, No.1, 21-25, 2024.
2.	Mako Yamamoto, Yuko Tanaka, Risako Takeda, Akiko Nakamoto, Mariko Nakamoto, Hideo Yagita and Tohru Sakai : Soy isoflavone genistein attenuates the efficacy of immune checkpoint therapy in C57BL/6 mice inoculated with B16F1 melanoma and a high PD-L1 expression level reflects tumor resistance., Journal of Clinical Biochemistry and Nutrition, Vol.74, No.1, 57-62, 2023. (Summary) cells and the concentrations of interferon-γ and tumor necrosis factor-α in tumor tissue were not different among the experimental groups. A significant difference was also not found in microbe composition. Interestingly, a high expression level of PD-ligand (L)1 closely reflected the outcome of therapy by genistein or anti-PD-1 antibody. The study showed that a combination of genistein treatment does not improve the effect of immune blockade therapy. It also showed that a high PD-L1 expression level in tumors is a good prediction maker for the outcome of tumor therapy. (Link to Publication Site) ● Publication site (DOI): 10.3164/jcbn.23-76 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38292119 ● Search Scopus @ Elsevier (PMID): 38292119 ● Search Scopus @ Elsevier (DOI): 10.3164/jcbn.23-76 (DOI: 10.3164/jcbn.23-76, PubMed: 38292119)
3.	Akiko Nakamoto, Yuwa Hirabayashi, Chieri Anzaki, Mariko Nakamoto, Emi Shuto, Yoshitaka Nii and Tohru Sakai : Effects of polymethoxyflavonoids on T helper 17 cell differentiation in vitro and in vivo., The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 166-170, 2023. (Tokushima University Institutional Repository) ● Metadata: 118348 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.70.166 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164715 ● Search Scopus @ Elsevier (PMID): 37164715 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.166 (Tokushima University Institutional Repository: 118348, DOI: 10.2152/jmi.70.166, PubMed: 37164715)
4.	Akiko Nakamoto, Miho Goto, Hina Hasegawa, Chieri Anzaki, Mariko Nakamoto, Emi Shuto and Tohru Sakai : Essential Oil of Citrus sudachi Suppresses T Cell Activation Both In Vitro and In Vivo., Journal of Nutritional Science and Vitaminology, Vol.68, No.6, 513-520, 2022. (Link to Publication Site) ● Publication site (DOI): 10.3177/jnsv.68.513 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36596549 ● Search Scopus @ Elsevier (PMID): 36596549 ● Search Scopus @ Elsevier (DOI): 10.3177/jnsv.68.513 (DOI: 10.3177/jnsv.68.513, PubMed: 36596549)
5.	Mariko Nakamoto, Miku Kanmura, Mai Yoshida, Yukiko Tanaka, Satomi Ono, Yuki Iwasaki, Akiko Nakamoto and Tohru Sakai : Validity of dietary diversity assessed using short-form questionnaire among older Japanese community dwellers., The Journal of Medical Investigation : JMI, Vol.69, No.1.2, 31-37, 2022. (Summary) The validity of dietary variety score (DVS) using a short-form questionnaire has not been investigated using dietary diversity based on a quantitative distribution of consumed foods in older Japanese. We examined the association between DVS and objective dietary diversity using a Quantitative Index for Dietary Diversity (QUANTIDD) based on the quantitative distribution of foods consumed by older Japanese community dwellers. The subjects were 65 older Japanese community dwellers aged 60?79 years. We used two kinds of scores for assessment of dietary diversity. At first, dietary diversity was determined using DVS calculated from answers to a questionnaire about frequencies of intake of 10 food groups. Second, dietary intake was assessed using a 3-day dietary record with photographs, and dietary diversity was determined using QUANTIDD. The relationships between DVS and QUANTIDD were assessed using partial correlation coefficients controlling for confounders. The correlation coefficient between DVS and QUANTIDD was moderate (r=0.212-0.458). After controlling for confounders, those correlation coefficient between DVS and QUANTIDD remained moderate. The findings suggest that there was a moderate relationship between DVS and QUANTIDD, and DVS using a short-form questionnaire may be useful for assessing dietary diversity in older Japanese community dwellers. J. Med. Invest. 69 : 31-37, February, 2022. (Keyword) Aged / Diet / Eating / Food / Humans / Japan / Surveys and Questionnaires (Tokushima University Institutional Repository) ● Metadata: 117008 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.69.31 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35466143 ● Search Scopus @ Elsevier (PMID): 35466143 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.69.31 (Tokushima University Institutional Repository: 117008, DOI: 10.2152/jmi.69.31, PubMed: 35466143)
6.	Mariko Nakamoto, Miku Kanmura, Mai Yoshida, Kana Yamada, Akiko Nakamoto and Tohru Sakai : Dietary diversity and food choice motives during the COVID-19 pandemic among older Japanese: An Internet Panel Survey., Asia Pacific Journal of Clinical Nutrition, Vol.31, No.3, 433-440, 2022. (Summary) The findings suggest that the COVID-19 pandemic was associated with an increase in some food choice motives and a decrease in the frequency of eating out among elderly female Japanese. (Keyword) Aged / COVID-19 / Diet / Feeding Behavior / Female / Humans / Internet / Japan / Male / Pandemics / Retrospective Studies / Surveys and Questionnaires (Link to Publication Site) ● Publication site (DOI): 10.6133/apjcn.202209_31(3).0011 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36173215 ● Search Scopus @ Elsevier (PMID): 36173215 ● Search Scopus @ Elsevier (DOI): 10.6133/apjcn.202209_31(3).0011 (DOI: 10.6133/apjcn.202209_31(3).0011, PubMed: 36173215)
7.	Akiko Nakamoto, Hirabayashi Yuwa, Anzaki Chieri, Mariko Nakamoto, Emi Shuto and Tohru Sakai : Nobiletin suppresses the development of experimental autoimmune encephalomyelitis mediated by modulation of T helper 17 cell differentiation, Journal of Clinical Biochemistry and Nutrition, Vol.69, No.2, 145-150, 2021. (Summary) Multiple sclerosis is an organ-specific autoimmune disease that targets the myelin antigen in the central nervous system. Nobiletin is a dietary polymethoxylated flavonoid found in citrus fruits. In this study, we investigated how nobiletin affects the disease state and immune responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis mice. Nobiletin was administered orally from 14 days before immunization until the end of the experiment, and clinical scores were determined. The production levels of interleukin-17A and interferon-γ were measured in a culture supernatant of splenocytes stimulated with myelin oligodendrocyte glycoprotein. In addition, flow cytometric analysis was performed to examine the effect of nobiletin on T cell differentiation . Admin-istration of nobiletin significantly decreased the clinical score and interleukin-17A production in splenocytes. Furthermore, analysis showed that nobiletin significantly suppressed Th17 cell differentiation and interleukin-17A production in a dose-dependent manner. The results suggest that nobiletin attenuates experimental autoimmune encephalomyelitis severity through modulation of Th17 cell differentiation. (Tokushima University Institutional Repository) ● Metadata: 116141 (Link to Publication Site) ● Publication site (DOI): 10.3164/JCBN.20-178 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34616106 ● Summary page in Scopus @ Elsevier: 2-s2.0-85114706108 (Tokushima University Institutional Repository: 116141, DOI: 10.3164/JCBN.20-178, PubMed: 34616106, Elsevier: Scopus)
8.	Mariko Nakamoto, Rei Otsuka, Chikako Tange, Yukiko Nishita, Makiko Tomida, Tomoko Imai, Tohru Sakai, Fujiko Ando and Hiroshi Shimokata : Intake of isoflavones reduces the risk of all-cause mortality in middle-aged Japanese., European Journal of Clinical Nutrition, 2021. (Summary) The findings suggest that a higher intake of isoflavones might decrease the risk of all-cause mortality, especially in middle-aged Japanese. (Link to Publication Site) ● Publication site (DOI): 10.1038/s41430-021-00890-w (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33712722 ● Search Scopus @ Elsevier (PMID): 33712722 ● Search Scopus @ Elsevier (DOI): 10.1038/s41430-021-00890-w (DOI: 10.1038/s41430-021-00890-w, PubMed: 33712722)
9.	Akiko Nakamoto, Risako Takeda, Yuwa Hirabayashi, Mariko Nakamoto, Emi Shuto and Tohru Sakai : Citrus Polymethoxyflavonoids, Nobiletin, Heptamethoxyflavone and Natsudaidain, Suppress T Cell Activation In Vitro and In Vivo, BPB Reports, Vol.3, No.4, 138-141, 2020. (Link to Publication Site) ● Publication site (DOI): 10.1248/bpbreports.3.4_138 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1248/bpbreports.3.4_138 (DOI: 10.1248/bpbreports.3.4_138)
10.	Hitomi Sakai, Tohru Sakai, Badr Ali Hoida, Kaori Kanemaru and Kumio Yokoigawa : Analysis of cereal extracts as conditioning solutes to suppress the initial attachment of Escherichia coli to abiotic surfaces, European Food Research and Technology, 2020. (Keyword) Cereals / Escherichia coli / Attachment / Abiotic materials (Tokushima University Institutional Repository) ● Metadata: 114680 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00217-020-03444-9 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85081030075 (Tokushima University Institutional Repository: 114680, DOI: 10.1007/s00217-020-03444-9, Elsevier: Scopus)
11.	Mariko Nakamoto, Yuna Yun, Mariko Omine, Sarasa Mori, Emi Shuto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : Dietary diversity and characteristics of lifestyle and awareness of health in Japanese workers:a cross-sectional study., The Journal of Medical Investigation : JMI, Vol.67, No.3.4, 255-264, 2020. (Summary) The aim of this study was to clarify the characteristics of lifestyle and health awareness according to dietary diversity in a Japanese worksite population. The participants were 1,312 men and women aged 20 to 63 years who were living in Tokushima Prefecture, Japan during the period 2012-2013. We obtained anthropometric data and information on lifestyle characteristics using a self-administered questionnaire. Dietary intake was assessed using a food frequency questionnaire, and dietary diversity was determined using the Quantitative Index for Dietary Diversity (QUANTIDD). The characteristics of lifestyle and health awareness according to quartiles of the QUANTIDD score were assessed using the chi-square test and a general linear model. The higher the QUANTIDD score was, the larger were the proportions of participants who knew the appropriate amount of dietary intake and participants who referred to nutritional component information when choosing and/or buying food. Among participants with higher QUANTIDD scores, the proportion of participants who considered their current diet was good was high in women, whereas the proportion of participants who wanted to improve their diet in the future was high in men. Those results indicate that higher dietary diversity was related to better characteristics of lifestyle and awareness of health. J. Med. Invest. 67 : 255-264, August, 2020. (Tokushima University Institutional Repository) ● Metadata: 115420 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.67.255 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33148898 ● Search Scopus @ Elsevier (PMID): 33148898 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.255 (Tokushima University Institutional Repository: 115420, DOI: 10.2152/jmi.67.255, PubMed: 33148898)
12.	Mami Mitani, Yuki Minatogawa, Akiko Nakamoto, Mariko Nakamoto, Emi Shuto, Yoshitaka Nii and Tohru Sakai : Sudachitin, polymethoxyflavone from Citrus sudachi, enhances antigen-specific cellular and humoral immune responses in BALB/c mice., Journal of Clinical Biochemistry and Nutrition, Vol.64, No.2, 158-163, 2019. (Link to Publication Site) ● Publication site (DOI): 10.3164/jcbn.18-70 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30936628 ● Summary page in Scopus @ Elsevier: 2-s2.0-85064387091 (DOI: 10.3164/jcbn.18-70, PubMed: 30936628, Elsevier: Scopus)
13.	Mariko Nakamoto, Mariko Omine, Yuna Yun, Emi Shuto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : Associations of dietary diversity with allergic diseases in Japanese workers: a cross-sectional study., Asia Pacific Journal of Clinical Nutrition, Vol.28, No.4, 857-869, 2019. (Summary) The aim of this study was to determine the associations of dietary diversity with prevalences of allergic diseases. The participants were 1,317 men and women aged 20 to 63 years who were living in Tokushima Prefecture, Japan during the period 2012-2013. We obtained anthropometric data and information on lifestyle characteristics and current medical histories of allergic diseases using a self-administered questionnaire. Dietary intake was assessed using a food frequency questionnaire, and dietary diversity was determined using the Quantitative Index for Dietary Diversity (QUANTIDD). The ORs and 95% CIs for each of the allergic diseases with a 1 standard deviation (SD) increase in the QUANTIDD score were estimated, controlling for age, family history of allergic diseases, education, smoking, drinking, physical activity, energy intake and BMI. Higher dietary diversity showed significant inverse dose-response relationships with allergic diseases and allergic rhinitis in women. Multivariate-adjusted ORs (95% CI) for allergic diseases and allergic rhinitis with 1 SD increase in the QUANTIDD score were 0.77 (95% CI: 0.60-0.98, p=0.037) and 0.69 (95% CI: 0.53-0.90, p=0.007), respectively, in women. There were no significant associations between dietary diversity and allergic diseases in men. The results indicate that there is an inverse association between higher dietary diversity and allergic rhinitis in Japanese female workers. (Keyword) Adult / Asthma / Cross-Sectional Studies / Dermatitis, Atopic / Diet / Female / Food / Humans / Japan / Male / Middle Aged / Rhinitis, Allergic / Risk Factors / Young Adult (Link to Publication Site) ● Publication site (DOI): 10.6133/apjcn.201912_28(4).0023 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31826384 ● Summary page in Scopus @ Elsevier: 2-s2.0-85076486533 (DOI: 10.6133/apjcn.201912_28(4).0023, PubMed: 31826384, Elsevier: Scopus)
14.	Mariko Nakamoto, Yukiko Tanaka, Satomi Ono, Akiko Nakamoto, Emi Shuto and Tohru Sakai : Associations of marital and parental status and family members living together with health-related behaviors in Japanese young workers : a cross-sectional study., The Journal of Medical Investigation : JMI, Vol.66, No.1-2, 141-147, 2019. (Summary) The aim of this study was to clarify the associations of family members living together with healthrelated behaviors in Japanese young workers. The participants were 300 men and women aged 20-39 years in 2015 who had a job. A web-based self-administered questionnaire on status of partnering and parenting, number of family members living together, dietary habits, drinking habit, smoking habit, self-rated health, employment status, working time and commuting time was conducted through Internet. Multiple logistic regression analysis and general linear models were used to assess the association of family members living together with healthrelated behaviors. The multivariate-adjusted odds ratio (95% confidence interval, p-value) for current drinking in unmarried participants living with their parents compared to unmarried participants living alone was 0.35 (0.13-0.93, p=0.036). The adjusted means of frequency of breakfast skipping and frequency of eating out showed a trend for inverse associations with the presence of a partner and children. However, those associations disappeared after adjustment for age of youngest child. The findings suggest that the presence of parents might affect drinking behavior and that age of youngest child living together might affect the frequency of breakfast skipping in young Japanese workers. J. Med. Invest. 66 : 141-147, February, 2019. (Keyword) epidemiology / nutrition (Tokushima University Institutional Repository) ● Metadata: 113409 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.66.141 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31064927 ● Search Scopus @ Elsevier (PMID): 31064927 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.141 (Tokushima University Institutional Repository: 113409, DOI: 10.2152/jmi.66.141, PubMed: 31064927)
15.	Akiko Nakamoto, Mami Mitani, Kana Urayama, Akari Maki, Mariko Nakamoto, Emi Shuto, Yoshitaka Nii and Tohru Sakai : Nobiletin Enhances Induction of Antigen-Specific Immune Responses in BALB/c Mice Immunized with Ovalbumin., Journal of Nutritional Science and Vitaminology, Vol.65, No.3, 278-282, 2019. (Link to Publication Site) ● Publication site (DOI): 10.3177/jnsv.65.278 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31257269 ● Search Scopus @ Elsevier (PMID): 31257269 ● Search Scopus @ Elsevier (DOI): 10.3177/jnsv.65.278 (DOI: 10.3177/jnsv.65.278, PubMed: 31257269)
16.	Mariko Nakamoto, Rei Otsuka, Yukiko Nishita, Chikako Tange, Makiko Tomida, Yuki Kato, Tomoko Imai, Tohru Sakai, Fujiko Ando and Hiroshi Shimokata : Soy food and isoflavone intake reduces the risk of cognitive impairment in elderly Japanese women., European Journal of Clinical Nutrition, Vol.27, No.6, 1458-1462, 2018. (Summary) Data were derived from the National Institute for Longevity Sciences-Longitudinal Study of Aging. Subjects comprised 403 men and 373 women aged 60-81 years at baseline who participated in the follow-up study at least once. Bean, soy product and soy isoflavone intake was assessed using a 3-day dietary record at baseline. Cognitive function was assessed by the Mini-Mental State Examination (MMSE). MMSE scores of 23 were used to define cognitive impairment. The relationship between bean, soy product and soy isoflavone intake and cognitive impairment was assessed using a generalized estimating equation. Multivariate-adjusted odds ratios (95% confidence intervals) for cognitive impairment with a 1 s.d. increase in total bean, total soybean and total soy isoflavone intakes were 0.48 (0.28-0.81; p = 0.006), 0.51 (0.32-0.83; p = 0.007), and 0.55 (0.32-0.93; p = 0.026), respectively, in women. Total soybean and soy isoflavone intake might decrease the risk of cognitive impairment in elderly Japanese women. (Keyword) nutrition / epidemiology / dementia (Link to Publication Site) ● Publication site (DOI): 10.1038/s41430-017-0061-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29348624 ● Summary page in Scopus @ Elsevier: 2-s2.0-85040678215 (DOI: 10.1038/s41430-017-0061-2, PubMed: 29348624, Elsevier: Scopus)
17.	Mariko Nakamoto, Emi Shuto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : Soy product and isoflavone intake associations with allergic diseases in Japanese workers: rhinitis, dermatitis and asthma., Asia Pacific Journal of Clinical Nutrition, Vol.27, No.6, 1277-1285, 2018. (Summary) The aim of this study was to determine the associations of intake of soy products and isoflavones with allergic diseases. We conducted a cross-sectional study in 1437 participants (aged 20-64 years) who were living in Tokushima Prefecture, Japan during the period 2010- 2011. We obtained anthropometric data and information on life style characteristics including dietary intake and current medical histories of allergic diseases using a structural self-administered questionnaire. Multiple logistic regression models were used to assess the associations of soy products and isoflavones with allergic diseases after controlling for age, family history of allergic diseases, smoking, drinking, physical activity, energy intake, BMI and dietary factors. Intake of soy products showed significant inverse dose-response relationships with allergic rhinitis. The third quartile for soy products had an adjusted OR of 0.56 (95% CI: 0.35-0.91) compared to the reference group (first quartile), though intake of soy products showed no dose-response relationship with atopic dermatitis. Intake of soy isoflavones showed a significant inverse dose-response relationship with atopic dermatitis, though the association between intake of soy isoflavones and atopic dermatitis was U-shaped after adjustments for potential confounders. On the other hand, the associations between intake of soy isoflavones and other allergic diseases were not significant. The results indicate that higher intake of soy products is associated with reduced risk of allergic rhinitis in Japanese workers. Furthermore, moderate intake amounts of soy products and soy isoflavones are associated with inverse risk of atopic dermatitis. (Keyword) epidemiology / nutrition (Link to Publication Site) ● Publication site (DOI): 10.6133/apjcn.201811_27(6).0015 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30485927 ● Search Scopus @ Elsevier (PMID): 30485927 ● Search Scopus @ Elsevier (DOI): 10.6133/apjcn.201811_27(6).0015 (DOI: 10.6133/apjcn.201811_27(6).0015, PubMed: 30485927)
18.	Xiaolin Yang, Mariko Nakamoto, Emi Shuto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Ayako Tamura, Hirokazu Uemura, Kokichi Arisawa, Makoto Funaki and Tohru Sakai : Associations between intake of dietary fermented soy food and concentrations of inflammatory markers: a cross-sectional study in Japanese workers, The Journal of Medical Investigation : JMI, Vol.65, No.1-2, 74-80, 2018. (Summary) Epidemiological investigations have shown that consumption of soybeans or soy foods reduces the risk of the development of cardiovascular disease, cancer and osteoporosis. The aim of this study was to determine the associations between different soy foods and inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, and IL-18, in Japanese workers. The cross-sectional study included 1,426 Japanese workers (1,053 men and 373 women) aged 20 to 64 years. Intake of 12 soy foods was estimated by a validated food frequency questionnaire. Associations of total soy foods, fermented soy food, non-fermented soy food, soy isoflavone with hs-CRP, IL-6, and IL-18 levels were examined by general linear model regression analysis. We found that total fermented soy food intake was inversely associated with multivariable-adjusted geometric concentration of IL-6 in men (Q1:1.03 pg/mL, Q5:0.94 pg /mL;P for trend = 0.031). Furthermore, it was shown that IL-6 concentrations were inversely associated with miso intake (β = -0.068;p = 0.034) and soy sauce intake in men (β = -0.074;p = 0.018). This study suggests that intake of total fermented soy food, miso and soy sauce be associated with IL-6 concentrations in Japanese men. J. Med. Invest. 65:74-80, February, 2018. (Tokushima University Institutional Repository) ● Metadata: 111414 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.65.74 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29593198 ● CiNii @ National Institute of Informatics (CRID): 1390282679224674560 ● Summary page in Scopus @ Elsevier: 2-s2.0-85044467994 (Tokushima University Institutional Repository: 111414, DOI: 10.2152/jmi.65.74, PubMed: 29593198, CiNii: 1390282679224674560, Elsevier: Scopus)
19.	Tohru Sakai, Miyuki Ohhata, Misaki Fujii, Sayaka Oda, Yasuna Kusaka, Miki Matsumoto, Akiko Nakamoto, Tomoyo Taki, Mariko Nakamoto and Emi Shuto : Brazilian Green Propolis Promotes Weight Loss and Reduces Fat Accumulation in C57BL/6 Mice Fed A High-Fat Diet, Biological & Pharmaceutical Bulletin, Vol.40, No.4, 391-395, 2017. (Summary) Propolis is a bee product with various biological properties. C57BL/6 mice were fed a high-fat diet and treated with propolis for 14 weeks. Body weight in mice treated with 2% propolis was less than that in control mice from 3 weeks after the start of treatment until 14 weeks except for the 7th week. Mice treated with propolis showed significantly lower epididymal fat weight and subcutaneous fat weight. Infiltration of epididymal fat by macrophages and T cells was reduced in the propolis group. Supplementation of propolis increased feces weight and fat content in feces, suggesting that mechanisms of weight reduction by propolis partly include a laxative effect and inhibition of fat absorption. (Keyword) propolis / weight / fat absorption (Link to Publication Site) ● Publication site (DOI): 10.1248/bpb.b16-00577 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28381793 ● Summary page in Scopus @ Elsevier: 2-s2.0-85016978833 (DOI: 10.1248/bpb.b16-00577, PubMed: 28381793, Elsevier: Scopus)
20.	Hitomi Kobayashi, Mami Mitani, Yuka Minatogawa, Satoko Hayashi, Mariko Nakamoto, Emi Shuto, Yoshitaka Nii and Tohru Sakai : Extracts of citrus Sudachi peel attenuate body weight gain in C57BL/6 mice fed a high-fat diet, The Journal of Medical Investigation : JMI, Vol.64, No.1.2, 20-23, 2017. (Summary) Citrus Sudachi is the special local product of Tokushima Prefecture, and over 98% of Sudachi consumed in Japan every year is produced in Tokushima Prefecture. In this study, we evaluated the function of sudachi peel extract (SPE) using an animal model of obesity. C57BL/6 mice were fed a high-fat diet containing 1% SPE powder. Treatment with SPE significantly decreased body weight compared to that of mice fed a high-fat diet. A significant difference in body weight was observed between the control and SPE groups from 7 weeks after the start of the experiment, the significant difference continued until the end of the 14-week experiment. Reduction of blood glucose levels following insulin administration in SPE-treated mice was grater than that in control mice. Determination of mRNA expression in adipose tissue showed that the expression level of TNF-α in the SPE group was significantly decreased compared to that on the control group. These results suggest that SPE potentially has the ability to attenuate body weight gain. J. Med. Invest. 64: 20-23, February, 2017. (Keyword) Citrus sudachi / high-fat diet / inflammation / weight (Tokushima University Institutional Repository) ● Metadata: 111075 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.64.20 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28373623 ● Search Scopus @ Elsevier (PMID): 28373623 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.64.20 (Tokushima University Institutional Repository: 111075, DOI: 10.2152/jmi.64.20, PubMed: 28373623)
21.	Rie Tsutsumi, Masakazu Goda, Chisa Fujimoto, Kyoko Kanno, Misaki Nobe, Yoshiaki Kitamura, Koji Abe, Misako Kawai, Hideki Matsumoto, Tohru Sakai and Noriaki Takeda : Effects of chemotherapy on gene expression of lingual taste receptors in patients with head and neck cancer., The Laryngoscope, Vol.126, No.3, E103-E109, 2015. (Summary) We aimed to test the hypothesis that chemotherapy changes the gene expression of taste receptors in the tongue to induce dysgeusia in patients with head and neck cancer. Prospective observation study. We enrolled 21 patients who received chemoradiotherapy and five patients who underwent radiotherapy for head and neck cancer. The messenger RNA (mRNA) levels of the taste receptor subunits T1R1, T1R2, T1R3, and T2R5 were measured in lingual mucosa scrapings obtained with a small spatula. The perception thresholds of umami, sweet, and bitter tastes were assessed by the whole mouth gustatory test. In four patients with severe stomatitis induced by chemoradiotherapy, the mRNA levels of T1R1, T1R2, T1R3, and T2R5 in the lingual mucosa were significantly decreased. However, in 17 patients with mild/moderate stomatitis, the mRNA levels of T1R3 were significantly and transiently decreased, whereas those of T1R1 and T1R2 remained unchanged and those of T2R5 mRNA were significantly and transiently increased after chemotherapy. There was a significant negative correlation between the perception thresholds of umami or sweet tastes and lingual mRNA levels of T1R3 in patients with mild/moderate stomatitis after chemotherapy. Although the perception threshold of bitter taste remained unchanged, lingual mRNA levels of T2R5 were significantly increased in patients who complained of phantogeusia after chemotherapy. Chemotherapy specifically changed the gene expression of T1R3 and T2R5 in head and neck cancer patients with mild/moderate stomatitis, resulting in both dysgeusia of umami and sweet tastes as well as phantogeusia. 4. Laryngoscope, 126:E103-E109, 2016. (Keyword) Adult / Aged / Aged, 80 and over / analysis of variance / Antineoplastic Agents / Chemoradiotherapy / Cohort Studies / Dysgeusia / Female / gene expression / Head and Neck Neoplasms / Humans / Japan / Male / Middle Aged / Prognosis / Prospective Studies / RNA, Messenger / Receptors, G-Protein-Coupled / Risk Assessment / Severity of Illness Index / Taste Buds / Tongue (Link to Publication Site) ● Publication site (DOI): 10.1002/lary.25679 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26422579 ● Search Scopus @ Elsevier (PMID): 26422579 ● Search Scopus @ Elsevier (DOI): 10.1002/lary.25679 (DOI: 10.1002/lary.25679, PubMed: 26422579)
22.	Tohru Sakai, Tomoyo Taki, Akiko Nakamoto, Shiho Tazaki, Mai Arakawa, Mariko Nakamoto, Rie Tsutsumi and Emi Shuto : Dietary ribonucleic Acid suppresses inflammation of adipose tissue and improves glucose intolerance that is mediated by immune cells in C57BL/6 mice fed a high-fat diet., Journal of Nutritional Science and Vitaminology, Vol.61, No.1, 73-78, 2015. (Summary) Recent evidence suggests that immune cells play an important role in differentiation of inflammatory macrophages in adipose tissue, which contributes to systemic chronic inflammation. Dietary ribonucleic acid (RNA) has been shown to modulate immune function. We hypothesized that RNA affects immune cell function in adipose tissue and then improves inflammatory response in adipose tissue. C57/BL6 mice and recombination activating gene-1 (RAG-1) knockout mice on a C57BL/6 mice background were fed a high-fat diet containing 1% RNA for 12 wk. An oral glucose tolerance test was performed. Supplementation of dietary RNA in C57BL/6 mice fed a high-fat diet resulted in a smaller area under the curve (AUC) after oral glucose administration than that for control mice. The mRNA expression levels of inflammation-related cytokines in adipose tissue and serum interleukin-6 levels were reduced by dietary RNA supplementation. Interestingly, reduction of the AUC value by RNA supplementation was abolished in T and B cell-deficient RAG-1 knockout mice. These results indicate that RNA improves inflammation in adipose tissue and reduces the AUC value following oral glucose administration in a T and B cell-dependent manner. (Link to Publication Site) ● Publication site (DOI): 10.3177/jnsv.61.73 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25994141 ● Summary page in Scopus @ Elsevier: 2-s2.0-84929733065 (DOI: 10.3177/jnsv.61.73, PubMed: 25994141, Elsevier: Scopus)
23.	Akiko Nakamoto, Emi Shuto, Rie Tsutsumi, Mariko Nakamoto, Yoshitaka Nii and Tohru Sakai : Vitamin A Deficiency Impairs Induction of Oral Tolerance in Mice., Journal of Nutritional Science and Vitaminology, Vol.61, No.2, 147-153, 2015. (Summary) Oral tolerance is a phenomenon of induction of systemic unresponsiveness to antigens ingested by the oral route and loss of immune response. Studies have shown the importance of vitamin A in oral tolerance in vitro but not in an in vivo experimental model. Therefore, we carried out experiments to determine how vitamin A deficiency affects tolerance induction and the ability of mesenteric lymph node (MLN) CD11c(+) cells to induce regulatory T cells (Tregs). Immunological tolerance was induced by oral ovalbumin (OVA) administration in vitamin A-sufficient mice. OVA-specific antibody and cytokine production were significantly reduced. On the other hand, in vitamin A-deficient mice, both OVA-specific antibody and cytokine production were not suppressed by oral OVA administration. Regarding induction of Tregs, the conversion rate of Foxp3(+) cells from naïve CD4(+) cell by CD11c(+) cells was decreased in vitamin A-deficient mice. Our study indicates that vitamin A deficiency causes the breakdown of oral tolerance in vivo. (Link to Publication Site) ● Publication site (DOI): 10.3177/jnsv.61.147 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26052145 ● Summary page in Scopus @ Elsevier: 2-s2.0-84930703907 (DOI: 10.3177/jnsv.61.147, PubMed: 26052145, Elsevier: Scopus)
24.	Rie Tsutsumi, Tomomi Yoshida, Yoshitaka Nii, Naoki Okahisa, Shinya Iwata, Masao Tsukayama, Rei Hashimoto, Yasuko Taniguchi, Hiroshi Sakaue, Toshio Hosaka, Emi Shuto and Tohru Sakai : Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle., Nutrition & Metabolism, Vol.11, 32, 2014. (Summary) Obesity is a major risk factor for insulin resistance, type 2 diabetes, and stroke. Flavonoids are effective antioxidants that protect against these chronic diseases. In this study, we evaluated the effects of sudachitin, a polymethoxylated flavonoid found in the skin of the Citrus sudachi fruit, on glucose, lipid, and energy metabolism in mice with high-fat diet-induced obesity and db/db diabetic mice. In our current study, we show that sudachitin improves metabolism and stimulates mitochondrial biogenesis, thereby increasing energy expenditure and reducing weight gain. C57BL/6 J mice fed a high-fat diet (40% fat) and db/db mice fed a normal diet were treated orally with 5 mg/kg sudachitin or vehicle for 12 weeks. Following treatment, oxygen expenditure was assessed using indirect calorimetry, while glucose tolerance, insulin sensitivity, and indices of dyslipidemia were assessed by serum biochemistry. Quantitative polymerase chain reaction was used to determine the effect of sudachitin on the transcription of key metabolism-regulating genes in the skeletal muscle, liver, and white and brown adipose tissues. Primary myocytes were also prepared to examine the signaling mechanisms targeted by sudachitin in vitro. Sudachitin improved dyslipidemia, as evidenced by reduction in triglyceride and free fatty acid levels, and improved glucose tolerance and insulin resistance. It also enhanced energy expenditure and fatty acid β-oxidation by increasing mitochondrial biogenesis and function. The in vitro assay results suggest that sudachitin increased Sirt1 and PGC-1α expression in the skeletal muscle. Sudachitin may improve dyslipidemia and metabolic syndrome by improving energy metabolism. Furthermore, it also induces mitochondrial biogenesis to protect against metabolic disorders. (Link to Publication Site) ● Publication site (DOI): 10.1186/1743-7075-11-32 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25114710 ● Search Scopus @ Elsevier (PMID): 25114710 ● Search Scopus @ Elsevier (DOI): 10.1186/1743-7075-11-32 (DOI: 10.1186/1743-7075-11-32, PubMed: 25114710)
25.	Tohru Sakai, Mariko Nakamoto, Akiko Nakamoto, Emi Shuto, 小林ゆき子, 土居幸雄 and 木戸康弘 : Academic Degrees and Teacher Competency Requirements in Dietitian and National Registered Dietitian Training Facilities, The Japanese Journal of Nutrition and Dietetics, Vol.72, No.5, 262-271, 2014. (Summary) Objective: To obtain personnel information of teaching staff in universities, colleges, and vocational schools with dietitian and/or registered dietitian programs, including number of teaching staff with a dietitian or registered dietitian license and the distribution of academic degrees. Competencies (e.g., education, research administration) required of staff for teaching the curriculum were also evaluated.Methods: A mail survey was conducted in February and March 2013 inquiring on number of teaching staff, number of teaching staff with a dietitian license or who were registered dietitians, and age and position of staff. In addition, staff competencies were evaluated for their importance in dietitian and registered dietitian training facilities.Results: The response rate was 66.1% (78 schools) and 68.5% (102 schools) for dietitian and registered dietitian training facilities, respectively. Most teachers were aged 30~49 in both dietitian and registered dietitian training facilities. In registered dietitian training facilities, 40% of teachers over age 30 had their Ph.D., and 39.5%, 75.9%, and 66.5% aged 20~29, 30~49, and 50~65 had a master's and/or doctoral degree, respectively. In dietitian training facilities, about 20% of teachers over age 30 had a Ph.D., and 28.4%, 47.4%, and 44.0% aged 20~29, 30~49, and 50~65 had a master's and/or doctoral degree, respectively. "Education" was considered the most important competency.Conclusion: We obtained basic information concerning age and education characteristics of teachers in dietitian and national registered dietitian training schools. Education was identified by facility directors as the most important competency. (Keyword) dietitian and national registered dietitian training facilities / teacher / degree / competency (Link to Publication Site) ● Publication site (DOI): 10.5264/eiyogakuzashi.72.262 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001206547275776 ● Search Scopus @ Elsevier (DOI): 10.5264/eiyogakuzashi.72.262 (DOI: 10.5264/eiyogakuzashi.72.262, CiNii: 1390001206547275776)
26.	Toshio Hosaka, Sayaka Sasaga, Yukiko Yamasaka, Yoshitaka Nii, Kazuhiro Edazawa, Rie Tsutsumi, Emi Shuto, Naoki Okahisa, Shinya Iwata, Hiroyuki Tomotake and Tohru Sakai : Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fatty liver in KK-A(y) mice., The Journal of Medical Investigation : JMI, Vol.61, No.3-4, 345-352, 2014. (Summary) Buckwheat powder or protein has been shown to decrease the total serum cholesterol level in non-diabetic mice or rats. However, the lipid-lowering effect of buckwheat bran extract (BBE) in diabetic mice has not been fully elucidated. KK-A(y) mice that received six-week treatment with BBE showed decreased body weight and liver weight compared to those of control (vehicle) mice. However, there was no significant difference in food intake. BBE treatments prevented liver triglyceride accumulation and decreased the serum level of triglycerides. In addition, mRNA expression levels lipogenic enzyme genes, fatty acid synthase, acetyl-coenzyme a oxidase and stearyl-coenzyme a desaturase 1, but not those of -oxidized enzyme genes, were decreased in BBE-treated mice. Level of transcription factors ChREBP and SREBP1c, transcripts of lipogenic genes, were also decreased in BBE-treated mice. These results suggest that chronic treatment with BBE derivatives could have beneficial effects on hypertriglycemia in patients with type 2 diabetes mellitus. (Tokushima University Institutional Repository) ● Metadata: 109583 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.61.345 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25264053 ● Summary page in Scopus @ Elsevier: 2-s2.0-84907513565 (Tokushima University Institutional Repository: 109583, DOI: 10.2152/jmi.61.345, PubMed: 25264053, Elsevier: Scopus)
27.	Mariko Nakamoto, Kokichi Arisawa, Hirokazu Uemura, Sakurako Katsuura-Kamano, Hidenobu Takami, Fusakazu Sawachika, Miwa Yamaguchi, Tomoya Juta, Tohru Sakai, Eisaku Toda, Kei Mori, Manabu Hasegawa, Masaharu Tanto, Masayuki Shima, Yoshio Sumiyoshi, Kenji Morinaga, Kazunori Kodama, Takaichiro Suzuki, Masaki Nagai and Hiroshi Satoh : Association between blood levels of PCDDs/PCDFs/dioxin-like PCBs and history of allergic and other diseases in the Japanese population., International Archives of Occupational and Environmental Health, Vol.86, No.8, 849-859, 2013. (Summary) Previous studies reported that exposure to dioxins was associated with an increased risk of various diseases in general populations. The aim of this study was to examine the association between levels of dioxins in blood and allergic and other diseases. We conducted a cross-sectional study on 1,063 men and 1,201 women (aged 15-76 years), who were living throughout Japan and not occupationally exposed to dioxins, during 2002-2010. In fasting blood samples, polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) were analyzed by isotope dilution high-resolution gas chromatography/mass spectrometry. We obtained information on life style and self-reported history of diseases using a questionnaire. Blood pressure, blood levels of hemoglobin A1c, and serum lipids were also measured. Multiple logistic regression models were used to analyze the association between dioxin levels in blood and various diseases. Toxic equivalents of PCDDs/PCDFs and total dioxins showed significant inverse dose-response relationships with atopic dermatitis, after adjustments for potential confounders. The highest quartile for total dioxins had an adjusted odds ratio of 0.26 (95 % confidence interval 0.08-0.70) compared to the reference group (first quartile). The odds ratios for hypertension, diabetes mellitus, hyperlipidemia, gout in men, and gynecologic diseases in women significantly increased with increasing toxic equivalents of PCDDs/PCDFs, DL-PCBs, and total dioxins in blood. The present findings suggest that background exposure to dioxins was associated with reduced risk of atopic dermatitis. The results also support the idea that low-level exposure to dioxins is associated with an increased risk of diabetes, hypertension, and hyperlipidemia. (Keyword) Adolescent / Adult / Aged / Benzofurans / Cross-Sectional Studies / Dermatitis, Atopic / Diabetes Mellitus / Environmental Exposure / Female / Humans / Hyperlipidemias / Hypertension / Japan / Life Style / Male / Middle Aged / Polychlorinated Biphenyls / Questionnaires / Tetrachlorodibenzodioxin / Young Adult (Link to Publication Site) ● Publication site (DOI): 10.1007/s00420-012-0819-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23014754 ● Search Scopus @ Elsevier (PMID): 23014754 ● Search Scopus @ Elsevier (DOI): 10.1007/s00420-012-0819-8 (DOI: 10.1007/s00420-012-0819-8, PubMed: 23014754)
28.	Takako Ichihara, Ayako Tamura, Takako Minagawa, Yumi Kuwamura, Chisato Kosugi, 安藝菜奈子, Toshio Hosaka, Emi Shuto, Tohru Sakai and Makoto Funaki : Epidemiology : Relationship between Physical Activity and Metabolic Syndrome in Male Workers, Journal of the The Japan Diabetes Society, Vol.56, No.9, 637-645, 2013. (Keyword) メタボリックシンドローム / 身体活動 / 勤労男性 / 横断調査 (Link to Publication Site) ● Publication site (DOI): 10.11213/tonyobyo.56.637 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679885162752 ● Summary page in Scopus @ Elsevier: 2-s2.0-84886613919 (DOI: 10.11213/tonyobyo.56.637, CiNii: 1390282679885162752, Elsevier: Scopus)
29.	中本真理子, Tohru Sakai, Emi Shuto, 安藝菜奈子, Chisato Kosugi, Akiko Hata, Kaori Shinoda, Yumi Kuwamura, Takako Minagawa, Takako Ichihara, Ayako Tamura and Makoto Funaki : Period between Dinner and Bedtime Is Related to Hypertension, Journal of Japanese Society of Nutrition and Food Science, Vol.66, No.4, 185-193, 2013. (Summary) The aim of this study was to examine the association between the period between dinner and bedtime, and various adult lifestyle-related diseases in the workplace. We analyzed 470 men and 252 women aged 20-65 years who had been enrolled in baseline surveys conducted for the Tokushima Diabetes Cohort Study in a workplace setting in Tokushima prefecture. Multiple logistic regression models were used for analyzing the association of the time between dinner and bedtime and the prevalence rates of adult lifestyle-related diseases. The period between dinner and bedtime tended to show an inverse dose-response relationship with hypertension (p for trend = 0.04) after adjustment for age, sex and other potential confounders. The group with the longest period between dinner and bedtime had an adjusted odds ratio of 0.38 (95% confidence interval 0.17-0.82) compared to the reference group (first quartile group) . Additionally, the period between dinner and bedtime showed an inverse dose-response relationship with hypertension for subjects who ate dinner after 21:00 (p for trend = 0.02) . These results indicate that the period between dinner and bedtime is inversely associated with the prevalence of hypertension. (Keyword) hypertension / lifestyle / cross-sectional study / work site population (Link to Publication Site) ● Publication site (DOI): 10.4327/jsnfs.66.185 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282681268995200 ● Search Scopus @ Elsevier (DOI): 10.4327/jsnfs.66.185 (DOI: 10.4327/jsnfs.66.185, CiNii: 1390282681268995200)
30.	Tohru Sakai, Tomoyo Taki, Akiko Nakamoto, Emi Shuto, Rie Tsutsumi, Takayuki Toshimitsu, Seiya Makino and Shuuji Ikegami : Lactobacillus plantarum OLL2712 regulates glucose metabolism in C57BL/6 mice fed a high-fat diet., Journal of Nutritional Science and Vitaminology, Vol.59, No.2, 144-147, 2013. (Summary) The aim of the present study was to determine the effect of oral administration of Lactobacillus plantarum OLL2712 (L. plantarum OLL2712) on glucose and lipid metabolism in mice with high-fat diet-induced obesity. Mice that had been administered 10(9) cfu heat-killed L. plantarum OLL2712 for 12 wk showed significant reduction of blood glucose levels in response to insulin. Furthermore, mRNA expression of interleukin-1β in adipose tissue and serum levels of nonesterified fatty acids in mice administered L. plantarum OLL2712 were significantly lower than those in control mice. These results indicate that L. plantarum OLL2712 regulates glucose metabolism. (Keyword) Adipose Tissue / Animals / Blood Glucose / cholesterol / Diet, High-Fat / Fatty Acids, Nonesterified / insulin / Interleukin-1beta / Lactobacillus plantarum / Lipid Metabolism / Male / Mice / Mice, Inbred C57BL / obesity / Probiotics / RNA, Messenger / Triglycerides (Link to Publication Site) ● Publication site (DOI): 10.3177/jnsv.59.144 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23727645 ● CiNii @ National Institute of Informatics (CRID): 1390282681301114368 ● Summary page in Scopus @ Elsevier: 2-s2.0-84878434562 (DOI: 10.3177/jnsv.59.144, PubMed: 23727645, CiNii: 1390282681301114368, Elsevier: Scopus)
31.	Mariko Nakamoto, Emi Shuto, Toshio Hosaka and Tohru Sakai : Dietary deoxynucleic acid induces type 2 T-helper immune response through toll-like receptor 9 in mice., European Journal of Nutrition, Vol.50, No.6, 421-426, 2011. (Summary) It has been shown that dietary nucleotides modulate immune response. Due to their unique properties in immune responses, nucleotides are used as immunonutrition in the field of clinical nutrition. In this study, we examined the effect of dietary deoxynucleic acid (DNA) on antigen (Ag)-specific immune response in ovalbumin (OVA)-immunized BALB/c mice and determined the mechanism using toll-like receptor 9 (TLR9) knock-out (KO) mice. BALB/c or TLR9 KO mice were fed control and 1% DNA diets and immunized with OVA. Spleen cells from OVA-immunized mice were stimulated with OVA in vitro, and the contents of IFN-γ and IL-4 in supernatants were measured by an ex vivo system. CD11c(+) dendritic cells were purified, and ability of cytokine induction to CD4(+) cells was examined. The level of OVA-specific IL-4 production in the DNA group was significantly higher than that in the control group. In contrast, the level of OVA-specific IFN-γ production in the DNA group was lower than that in the control group. The DNA diet decreased Ag-specific IL-4 production and enhanced Ag-specific IFN-γ production in TLR9 KO mice. CD11c(+) DCs from mice fed the DNA diet had a greater ability than CD11c(+) DCs from mice fed the control diet to induce the production of IL-4 from DO11.10 CD4(+) T cells. Dietary DNA increases Ag-specific IL-4 production and decreases IFN-γ production through a TLR9-dependent pathway. CD11c(+) dendritic cells are target cells in dietary DNA-induced immune regulation. (Keyword) Animals / Antigens, CD11c / Antigens, CD4 / Cell Differentiation / Cells, Cultured / DNA / Dendritic Cells / Diet / Female / Immunomodulation / Interferon-gamma / Interleukin-4 / Mice / Mice, Inbred BALB C / Mice, Knockout / Ovalbumin / Specific Pathogen-Free Organisms / Spleen / Th2 Cells / Toll-Like Receptor 9 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00394-010-0153-4 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21132311 ● Search Scopus @ Elsevier (PMID): 21132311 ● Search Scopus @ Elsevier (DOI): 10.1007/s00394-010-0153-4 (DOI: 10.1007/s00394-010-0153-4, PubMed: 21132311)
32.	Asuka Shiota, Yutaka Taketani, Yoichi Maekawa, Koji Yasutomo, Masataka Sata, Tohru Sakai, R. Mizuno, M. Isshiki, Hironori Yamamoto and Eiji Takeda : High phosphate diet reduces atherosclerosis formation in apolipoprotein E-deficient mice., Journal of Clinical Biochemistry and Nutrition, Vol.49, No.2, 109-114, 2011. (Summary) Although higher serum phosphate level is a risk factor for cardiovascular diseases in general population as well as chronic kidney disease patients, it has not been clarified whether higher phosphate can affect atherosclerotic plaque formation. In this study, we investigated the effect of prolonged-intake of different concentrations of phosphate on atherosclerosis formation using apolipoprotein E-deficient mice. Apolipoprotein E-deficient mice were fed with high fat diet including 0.6%, 1.2% or 1.8% phosphate. After 20-week treatment, atherosclerotic plaque formation in aorta in 1.8% phosphate diet group was unexpectedly less than that in the other groups. To elucidate mechanisms of suppression of plaque formation by high phosphate diet, we hypothesized that high phosphate diet may modify a profile of monocytes/macrophages suppressing plaque formation. We confirmed that elevated peripheral monocytes (CD11b+, F4/80+ cell numbers) in apolipoprotein E-deficient mice were decreased by feeding with 1.8% P diet. In addition, ex vivo study indicated that high dose of phosphate induced macrophage apoptosis. These observations suggest that excess phosphate intake decreased atherosclerosis formation, at least in part, by changing the profile of peripheral monocytes or inducing apoptosis of macrophages in apolipoprotein E-deficient mice. (Link to Publication Site) ● Publication site (DOI): 10.3164/jcbn.10-150 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21980226 ● Search Scopus @ Elsevier (PMID): 21980226 ● Search Scopus @ Elsevier (DOI): 10.3164/jcbn.10-150 (DOI: 10.3164/jcbn.10-150, PubMed: 21980226)
33.	Tohru Sakai, Yuko Hirota, Mariko Nakamoto, Emi Shuto, Toshio Hosaka, Seiya Makino and Shuji Ikegami : Suppression of oral tolerance by Lactococcus lactis in mice., Bioscience, Biotechnology, and Biochemistry, Vol.75, No.3, 599-601, 2011. (Summary) Although oral ovabumin (OVA) administration suppressed the antibody (Ab) response in OVA-immunized mice, Lactococcus lactis increased OVA-specific IgG2a in these mice. L. lactis increased the casein-specific IgG level in NC/Nga mice fed on a casein diet. The percentage of CD4(+)CD25(+) cells was increased in DO11.10 mice orally given OVA, but this increase of CD4(+)CD25(+) cells were suppressed in L. lactis-fed DO11.10 mice. (Keyword) Administration, Oral / Animals / CD4-Positive T-Lymphocytes / Caseins / Cytokines / Enzyme-Linked Immunosorbent Assay / Female / Immune Tolerance / Immunity, Mucosal / Immunization / Immunoglobulins / Lactococcus lactis / Mice / Mice, Transgenic / Ovalbumin / Probiotics (Link to Publication Site) ● Publication site (DOI): 10.1271/bbb.100714 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21389605 ● CiNii @ National Institute of Informatics (CRID): 1390001206480013312 ● Search Scopus @ Elsevier (PMID): 21389605 ● Search Scopus @ Elsevier (DOI): 10.1271/bbb.100714 (DOI: 10.1271/bbb.100714, PubMed: 21389605, CiNii: 1390001206480013312)
34.	Tohru Sakai, Sakina Furoku, Mariko Nakamoto, Emi Shuto, Toshio Hosaka, Yasuhiko Nishioka and Saburo Sone : Soy isoflavone equol perpetuates dextran sulfate sodium-induced acute colitis in mice., Bioscience, Biotechnology, and Biochemistry, Vol.75, No.3, 593-595, 2011. (Summary) The effects of the soy isoflavones, genistein, daidzein and equol, on experimental colitis were examined. Equol severely perpetrated dextran sulfate sodium (DSS)-induced colitis as evaluated by the weight loss. Production of the anti-inflammatory cytokine, IL-10, from T cells was decreased in the equol-treated mice. The results show that the soy isoflavone, equol, played an important role in the inflammatory response in the gastrointestinal tract. (Keyword) Animals / Body Weight / Colitis / Dextran Sulfate / Disease Models, Animal / Equol / Female / Genistein / Interleukin-10 / Isoflavones / Mice / Mice, Inbred BALB C / T lymphocytes (Link to Publication Site) ● Publication site (DOI): 10.1271/bbb.100710 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21389602 ● Search Scopus @ Elsevier (PMID): 21389602 ● Search Scopus @ Elsevier (DOI): 10.1271/bbb.100710 (DOI: 10.1271/bbb.100710, PubMed: 21389602)
35.	Yohko Hirata, Toshio Hosaka, Takeo Iwata, Le Thi Kim Chung, Bayasgalan Jambaldorj, Kiyoshi Teshigawara, Nagakatsu Harada, Hiroshi Sakaue, Tohru Sakai, Katsuhiko Yoshimoto and Yutaka Nakaya : Vimentin binds IRAP and is involved in GLUT4 vesicle trafficking., Biochemical and Biophysical Research Communications, Vol.405, No.1, 96-101, 2011. (Summary) Insulin-responsive aminopeptidase (IRAP) and GLUT4 are two major cargo proteins of GLUT4 storage vesicles (GSVs) that are translocated from a postendosomal storage compartment to the plasma membrane (PM) in response to insulin. The cytoplasmic region of IRAP is reportedly involved in retention of GSVs. In this study, vimentin was identified using the cytoplasmic domain of IRAP as bait. The validity of this interaction was confirmed by pull-down assays and immunoprecipitation in 3T3-L1 adipocytes. In addition, it was shown that GLUT4 translocation to the PM by insulin was decreased in vimentin-depleted adipocytes, presumably due to dispersing GSVs away from the cytoskeleton. These findings suggest that the IRAP binding protein, vimentin, plays an important role in retention of GSVs. (Keyword) 3T3-L1 Cells / Animals / Cystinyl Aminopeptidase / Cytoplasmic Vesicles / Gene Knockdown Techniques / Glucose Transporter Type 4 / Mice / Protein Transport / Vimentin (Tokushima University Institutional Repository) ● Metadata: 113298 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bbrc.2010.12.134 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21216232 ● Search Scopus @ Elsevier (PMID): 21216232 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2010.12.134 (Tokushima University Institutional Repository: 113298, DOI: 10.1016/j.bbrc.2010.12.134, PubMed: 21216232)
36.	Toshio Hosaka, Yoshitaka Nii, Hiroyuki Tomotake, Takahiro Ito, Aya Tamanaha, Yukiko Yamasaka, Sayaka Sasaga, Kazuhiro Edazawa, Rie Tsutsumi, Emi Shuto, Naoki Okahisa, Shinya Iwata and Tohru Sakai : Extracts of common buckwheat bran prevent sucrose digestion., Journal of Nutritional Science and Vitaminology, Vol.57, No.6, 441-445, 2011. (Summary) Buckwheat has been shown to have various health benefits such as reduction of hypertension and improvement of hypercholesterolemia; however, its effect on diabetes has not been fully elucidated. In this study, buckwheat bran extracts (BBE) inhibited sucrase activity in vitro more effectively than buckwheat. Balb/c mice pretreated with BBE showed dose-dependent reductions of blood glucose, greater than those observed with control mice, within 60 min following oral sucrose administration. Blood glucose levels in mice pretreated with buckwheat extracts were also significantly lower compared to those in control mice within 30 min following oral administration of sucrose. However, rutin, one of the abundant polyphenols of BBE, did not lower blood glucose level. Our data indicate that components of BBE other than rutin have inhibitory activity against sucrase in vivo. These results suggest that BBE could have beneficial effects on diabetes. (Keyword) Administration, Oral / Animals / Blood Glucose / diabetes mellitus / Dietary Sucrose / digestion / Dose-Response Relationship, Drug / Fagopyrum / Male / Mice / Mice, Inbred BALB C / Phytotherapy / Plant Extracts / Rutin / Seeds / Sucrose (Link to Publication Site) ● Publication site (DOI): 10.3177/jnsv.57.441 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22472288 ● Search Scopus @ Elsevier (PMID): 22472288 ● Search Scopus @ Elsevier (DOI): 10.3177/jnsv.57.441 (DOI: 10.3177/jnsv.57.441, PubMed: 22472288)
37.	Mariko Nakamoto, Tohru Sakai, Emi Shuto, Toshio Hosaka, Nanako Kataoka, Chisato Kosugi, Akiko Hata, Kaori Shinoda, Yumi Kuwamura, Takako Minagawa, Takako Ichihara, Ayako Tamura and Makoto Funaki : Does food intake and life style relate to the prevalence of allergic disease?, Journal of rehabilitation and health science, Vol.8, 15-21, 2010. (Keyword) allergy / 栄養調査 / 豆類 / vitamin A / lifestyle-related disease (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390573242531347328 (CiNii: 1390573242531347328)
38.	Kiyoshi Teshigawara, Toshio Hosaka, Miwa Yamaguchi, Eri Terada, Yuka Kisyuku, Keiko Fukunaga, Yohko Hirata, Bayasgalan Jambaldorj, Nagakatsu Harada, Tohru Sakai and Yutaka Nakaya : Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice., The Journal of Medical Investigation : JMI, Vol.57, No.3-4, 224-231, 2010. (Summary) Hyperbaric air (HBA) is used to improve healing of wounds including diabetic ulcer. The aim of this study was to clarify the effects of HBA exposure on lipid and glucose metabolism in db/db mice. HBA did not influence the weight of db/db mice. Serum levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly decreased after 6 weeks of treatment with HBA. The mRNA expressions of CPT-1, PPAR and PGC-1 genes, which are related to lipid metabolism, were significantly up-regulated in the muscle and liver. Increases in TNF and MCP1 mRNA, which impaired lipid metabolism, were also attenuated by HBA treatment. These results suggest that exposure of HBA could have beneficial effects on lipid metabolism in patients with type 2 diabetes mellitus. (Keyword) Animals / Base Sequence / Blood Glucose / Carnitine O-Palmitoyltransferase / Chemokine CCL2 / DNA Primers / Diabetes Mellitus, Type 2 / Fatty Acids, Nonesterified / Humans / Hyperbaric Oxygenation / Hyperlipidemias / insulin / Lipid Metabolism / Male / Mice / Mice, Mutant Strains / PPAR alpha / RNA, Messenger / Trans-Activators / Triglycerides / Tumor Necrosis Factor-alpha (Tokushima University Institutional Repository) ● Metadata: 79137 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.57.224 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20847521 ● Search Scopus @ Elsevier (PMID): 20847521 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.57.224 (Tokushima University Institutional Repository: 79137, DOI: 10.2152/jmi.57.224, PubMed: 20847521)
39.	Tohru Sakai, Mariko Nakamoto, Emi Shuto and Toshio Hosaka : Nutrition and immunity, Shikoku Acta Medica, Vol.66, No.1, 19-26, 2010. (Summary) It is known that nutritional state crucially affects immune function. In recent years, the contributionof the diet to the optimal working of the immune system has become wildly appreciatedand the influence of different dietary components on specific aspects of immune function has beenextensively studied. Soy isoflavone genistein suppresses antigen-specific immune response inBALB/c mice and suppresses development of atopic-like dermatitis in NC/Nga mice. In other soyisoflavone equol enhances antigen-specific IgE production via IL-13-mediated pathway. Further,equol exacerbates colitis of dextran sulfate sodium-treated mice. Therefore, immune stimulatoryeffects are strikingly different among soy isoflavones. In this reviews, in addition of the isoflavone,we overview the effects of dietary nucleic acid and protein-deficiency on antigen-specific immuneresponses. Furthermore, we present hot topics researches in the field of obesity and T cellfunction. (Keyword) soy isoflavone / genistein / equol / obesity / T cell (Tokushima University Institutional Repository) ● Metadata: 110309 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050001337465096832 (Tokushima University Institutional Repository: 110309, CiNii: 1050001337465096832)
40.	Tohru Sakai, Sakina Furoku, Mariko Nakamoto, Emi Shuto, Toshio Hosaka, Yasuhiko Nishioka and Saburo Sone : The Soy isoflavone equol enhances antigen-specific IgE production in ovalbumin-immunized BALB/c mice., Journal of Nutritional Science and Vitaminology, Vol.56, No.1, 72-76, 2010. (Summary) Although an immunomodulatory role of the soy isoflavone genistein has been demonstrated, the effects of other soy isoflavones on induction of antigen (Ag)-specific immune responses are not known. In this study, we therefore investigated the effects of daidzein and equol on ovalbumin (OVA)-specific T cell and B cell responses in BALB/c mice. Mice that had been treated with 20 mg/kg equol showed a significantly higher level of OVA-specific IgE than control mice. Levels of interferon (IFN)-gamma and interleukin (IL)-4 production were not different between the control and equol groups. However, IL-13 production level in mice administered 20 mg/kg equol was significantly higher than that in control mice. Strong induction of OVA-specific IgE production by equol was also observed in ovariectomized BALB/c mice, suggesting that the immunomodulatory effect of equol is not affected by endogenous estrogen. (Link to Publication Site) ● Publication site (DOI): 10.3177/jnsv.56.72 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20354350 ● Search Scopus @ Elsevier (PMID): 20354350 ● Search Scopus @ Elsevier (DOI): 10.3177/jnsv.56.72 (DOI: 10.3177/jnsv.56.72, PubMed: 20354350)
41.	Le Thi Kim Chung, Toshio Hosaka, Nagakatsu Harada, Bayasgalan Jambaldorj, Keiko Fukunaga, Yuka Nishiwaki, Kiyoshi Teshigawara, Tohru Sakai, Yutaka Nakaya and Makoto Funaki : Myosin IIA participates in docking of Glut4 storage vesicles with the plasma membrane in 3T3-L1 adipocytes., Biochemical and Biophysical Research Communications, Vol.391, No.1, 995-999, 2009. (Summary) In adipocytes and myocytes, insulin stimulation translocates glucose transporter 4 (Glut4) storage vesicles (GSVs) from their intracellular storage sites to the plasma membrane (PM) where they dock with the PM. Then, Glut4 is inserted into the PM and initiates glucose uptake into these cells. Previous studies using chemical inhibitors demonstrated that myosin II participates in fusion of GSVs and the PM and increase in the intrinsic activity of Glut4. In this study, the effect of myosin IIA on GSV trafficking was examined by knocking down myosin IIA expression. Myosin IIA knockdown decreased both glucose uptake and exposures of myc-tagged Glut4 to the cell surface in insulin-stimulated cells, but did not affect insulin signal transduction. Interestingly, myosin IIA knockdown failed to decrease insulin-dependent trafficking of Glut4 to the PM. Moreover, in myosin IIA knockdown cells, insulin-stimulated binding of GSV SNARE protein, vesicle-associated membrane protein 2 (VAMP2) to PM SNARE protein, syntaxin 4 was inhibited. These data suggest that myosin IIA plays a role in insulin-stimulated docking of GSVs to the PM in 3T3-L1 adipocytes through SNARE complex formation. (Keyword) 3T3-L1 Cells / Adipocytes / Animals / Cell Membrane / Cytoplasmic Vesicles / Gene Knockdown Techniques / Glucose / Glucose Transporter Type 4 / Insulin / Mice / Nonmuscle Myosin Type IIA / Protein Transport / SNARE Proteins / signal transduction / Vesicle-Associated Membrane Protein 2 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bbrc.2009.12.004 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19968963 ● Search Scopus @ Elsevier (PMID): 19968963 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2009.12.004 (DOI: 10.1016/j.bbrc.2009.12.004, PubMed: 19968963)
42.	Chung Thi Kim Le, Toshio Hosaka, Yoshida Masaki, Nagakatsu Harada, Hiroshi Sakaue, Tohru Sakai and Yutaka Nakaya : Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression., Biochemical and Biophysical Research Communications, Vol.390, No.3, 613-618, 2009. (Summary) Exendin-4 (Ex-4) is a glucagon-like peptide-1 receptor (GLP-1R) agonist that has been used as a drug injected subcutaneously for treatment of type 2 diabetes. Many studies have revealed molecular targets of Ex-4, but its influence on adipokines has not been determined. Our study showed that Ex-4 induced secretion of adiponectin into the culture medium of 3T3-L1 adipocytes. This effect of Ex-4 is due to increased adiponectin mRNA level through the GLP-1R. Both forskolin and 3-isobutyl-1-methylxanthine (IBMX), which may finally elevate cyclic adenosine monophosphate (cAMP) concentration, prevented the induction of adiponectin expression by Ex-4. Moreover, H89, a protein kinase A inhibitor, blocked the effect of Ex-4 on adiponectin. On the other hand, Ex-4 decreased the mRNA levels of inflammatory adipokines. The results indicate that Ex-4 directly promotes adiponectin secretion via the protein kinase A pathway in 3T3-L1 adipocytes and may ameliorate insulin resistance. (Keyword) 1-Methyl-3-isobutylxanthine / 3T3-L1 Cells / Adipocytes / Adipokines / Adiponectin / Animals / Cyclic AMP-Dependent Protein Kinases / Forskolin / Glucagon-Like Peptide 1 / Inflammation / insulin resistance / Isoquinolines / Mice / Peptides / Phosphodiesterase Inhibitors / Protein Kinase Inhibitors / RNA, Messenger / Receptors, Glucagon / Sulfonamides / Venoms (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bbrc.2009.10.015 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19850014 ● Search Scopus @ Elsevier (PMID): 19850014 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2009.10.015 (DOI: 10.1016/j.bbrc.2009.10.015, PubMed: 19850014)
43.	Emi Shuto, Yutaka Taketani, Tohru Sakai and Eiji Takeda : Hyperphosphatemia and cardiovascular disease, Shikoku Acta Medica, Vol.64, No.3,4, 114-116, 2008. (Summary) Hyperphosphatemia has been known as a risk factor for cardiovascular disease particularly inchronic kidney disease patients. Hyperphosphatemia can be involved in the calcification of vascularsmooth muscle cells, resulting in M¨onkeberg medial calcific sclerosis which is a type of arteriosclerosis.However, it has not been clarified whether hyperphosphatemia can deteriorate endothelialfunction and can be a risk factor of atherosclerosis. Our recent study demonstrated that hyperphosphatemiaincreased oxidative stress and decreased nitric oxide production in endothelial cells.In addition, hyperphosphatemia attenuated endothelium-dependent vasodilation reaction. Theseobservations suggest that hyperphosphatemia may cause endothelial dysfunction, and be an importantfactor for progression of atherosclerosis as well as vascular calcification. Positive associationbetween hyperphosphatemia and cardiovascular disease may be explained by the dual harmfuleffects of phosphorus on the vessels. (Keyword) hyperphosphatemia / cardiovascular disease / endothelial cell / oxidative stress / vascular calcification (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050564287418501888 (CiNii: 1050564287418501888)
44.	Tohru Sakai and Mari Kogiso : Soy isoflavones and immunity., The Journal of Medical Investigation : JMI, Vol.55, No.3-4, 167-173, 2008. (Summary) The amount of soy products consumed in Japan is much greater than that in Western countries. Recent evidence indicates that soy isoflavones play a beneficial role in obesity, cancer, osteoporosis, and cardiovascular disease. The soybean isoflavone genistein is present at high levels in soy products. Genistein is structurally similar to 17beta-estradiol (E2), and genistein has been suggested to be act as E2 or an antagonist against E2. Genistein suppresses antigen-specific immune response in vivo and lymphocyte proliferation response in vitro. However, genistein enhances the cytotoxic response mediated by NK and cytotoxic T cells and the cytokine production from T cells. Thus, the effect of genistein on immunity is immune cell-dependent. Due to its unique effect on immune function, genistein has been used for the treatment of the diseases in animal models and it has been found that genistein inhibits allergic inflammatory responses. In this review, we summarize current studies related to the effect of isoflavone genistein on the immune system. (Keyword) Animals / Antibody Formation / Cell Differentiation / Genistein / Humans / Immunity / Immunity, Cellular / Isoflavones / Neoplasms, Experimental / Phytoestrogens / Soybeans / T-Lymphocytes (Tokushima University Institutional Repository) ● Metadata: 110856 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.55.167 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18797128 ● Search Scopus @ Elsevier (PMID): 18797128 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.55.167 (Tokushima University Institutional Repository: 110856, DOI: 10.2152/jmi.55.167, PubMed: 18797128)
45.	Ono Kaori, Kazuaki Mawatari, Nagakatsu Harada, Akira Takahashi, Tohru Sakai, Ogoshi Shohei and Yutaka Nakaya : Nucleoside and nucleotide mixture OG-VI rescues cytotoxicity induced by chemotherapeutic agents in intestinal-like epithelial cell., The Journal of Medical Investigation : JMI, Vol.54, No.3,4, 235-242, 2007. (Summary) Immune cells and cells undergoing rapid turn-over can obtain exogenous nucleotides via salvage synthesis. We evaluated whether or not the balanced nucleoside and nucleotide mixture OG-VI, could rescue intestinal epithelial-like Caco-2 cells from the cytotoxic effects of several chemotherapeutic agents, in the presence and absence of glutamine (Gln). Cells were exposed to 5-fluorouracil (5FU), methotrexate (MTX) or 6-mercaptopurine (6MP), after which proliferation and cell cycle analyses were performed. Following exposure to the chemotherapeutic agents, we observed that cells treated with OG-VI proliferated well, whereas those without the supplement did not proliferate. Furthermore, following treatment with either 5FU or MTX, we observed that the number of cells in the G0/G1 phase decreased and those in the S phases increased. However, these cell cycle alterations were prevented by the addition of OG-VI. With the exception of 6MP-treated cells, we did not observe any effects on proliferation or cell cycle regulation that could be ascribed to the presence of Gln. Thus, we have demonstrated that OG-VI rescues cells from the cytotoxic effects of several chemotherapeutic agents. (Keyword) 6-Mercaptopurine / Antineoplastic Agents / Caco-2 Cells / Cell Cycle / Cell Proliferation / Cell Survival / Epithelial Cells / Fluorouracil / Humans / Intestines / Methotrexate / Nucleosides / Nucleotides (Tokushima University Institutional Repository) ● Metadata: 111518 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.54.235 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17878671 ● Search Scopus @ Elsevier (PMID): 17878671 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.54.235 (Tokushima University Institutional Repository: 111518, DOI: 10.2152/jmi.54.235, PubMed: 17878671)
46.	Hiroyuki Kose, Tohru Sakai, Shin-ichi Tsukumo, Kaichun Wei, Takahisa Yamada, Koji Yasutomo and Kozo Matsumoto : Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase κ gene in LEC rats, Genomics, Vol.89, No.6, 673-677, 2007. (Summary) The Long-Evans Cinnamon (LEC) rat has a spontaneous mutation, T helper immunodeficiency (thid), which causes a markedly reduced CD4(+) thymocyte population. Here we positionally clone the locus and identify a deletion in the gene encoding a receptor-like protein tyrosine phosphatase kappa (Ptprk) that led to complete loss of the transcript. The rat Ptprk gene exhibits 98% identity with the human and mouse counterparts and is expressed most abundantly in the CD4(-)CD8(-) double-negative stage. The downregulation of Ptprk in mouse immature thymocytes by RNA interference mimicked the thid phenotype. These results indicate that thid maps to the Ptprk locus and that functional Ptprk is crucial for lineage commitment or progression of CD4(+) T cells. We also found that Ptprk appears to function in parallel with or downstream of Th-POK/cKrox (also known as ZBTB7B), a master regulator of T cell lineage decision. (Keyword) T cell differentiation / Protein phosphatase / LEC rat / Thymus / Th-POK/cKrox (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ygeno.2007.03.001 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17434290 ● Search Scopus @ Elsevier (PMID): 17434290 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ygeno.2007.03.001 (DOI: 10.1016/j.ygeno.2007.03.001, PubMed: 17434290)

Academic Paper (Unrefereed Paper):

1.	Shuhai Chen, Masaaki Nishi, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto, Akiko Nakamoto, Tohru Sakai and Mitsuo Shimada : Polymethoxylated flavone sudachitin is a safe anticancer adjuvant that targets glycolysis in cancer-associated fibroblasts., Oncology Letters, Vol.24, No.1, 236, 2022. (Summary) Sudachitin is a polymethoxylated flavone found in the peel of , a unique specialty citrus fruit in Tokushima Prefecture, Japan. Previous reports have demonstrated that sudachitin has anti-inflammatory and metabolic regulatory activities. However, to the best of our knowledge, no studies have explored whether sudachitin can act as an antitumor therapeutic agent by regulating metabolic functions in the tumor microenvironment. In the present study, cell proliferation and cytotoxicity assays were used to determine whether sudachitin inhibited the growth of liver cancer and pancreatic carcinoma, cholangiocarcinoma and colorectal cancer cells and to compare its toxicity against normal fibroblasts and induced cancer-associated fibroblasts (CAFs). Using lactate assays and reverse transcription-quantitative PCR, the effects of sudachitin on glycolysis in CAFs were investigated. The effects of CAFs on malignant tumor cells were evaluated using cell proliferation, wound healing and invasion assays. As result, sudachitin inhibited various types of tumor cells with different half-maximal inhibitory concentrations. Treatment with 50 µM sudachitin for 48 h suppressed tumor and CAFs proliferation but was not cytotoxic against normal fibroblasts. This dose also inhibited glycolysis in CAFs and, thus, diminished their pro-tumorigenic activities. Overall, the present study revealed that sudachitin has promise as a safe and widely available natural antitumor adjuvant. (Tokushima University Institutional Repository) ● Metadata: 118072 (Link to Publication Site) ● Publication site (DOI): 10.3892/ol.2022.13356 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35720469 ● Search Scopus @ Elsevier (PMID): 35720469 ● Search Scopus @ Elsevier (DOI): 10.3892/ol.2022.13356 (Tokushima University Institutional Repository: 118072, DOI: 10.3892/ol.2022.13356, PubMed: 35720469)

Review, Commentary:

1.	Tsukasa Takaoka, Aki Endo, Kazunori Matsuda, 上田千鶴, 猿倉薫子, Rie Tsutsumi, Hiroshi Sakaue, Tohru Sakai, Shigeru Yamamoto and Noriaki Takeda : A Novel Method of Assessment of the Zinc Nutrition Status and Zinc Deficiency-Induced Taste Impairment, Practica Oto-Rhino-Laryngologica. Suppl., No.158, 133-137, Feb. 2022. (Link to Publication Site) ● Publication site (DOI): 10.5631/jibirinsuppl.158.133 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390573560394202496 ● Search Scopus @ Elsevier (DOI): 10.5631/jibirinsuppl.158.133 (DOI: 10.5631/jibirinsuppl.158.133, CiNii: 1390573560394202496)
2.	Tohru Sakai, Akiko Nakamoto and 新居佳孝 : 徳島県特産のスダチ -果皮成分の機能性についてー, New Food Industry, Vol.60, No.9, 19-24, 2018.
3.	Tohru Sakai, Emi Shuto and Rie Tsutsumi : Soy-Derived Compounds and Immune Response, Soy: Nutrition, consumption and Health, 147-159, 2013. (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-84892079014 (Elsevier: Scopus)

Proceeding of International Conference:

1.	Akiko Hata, Koji Yonemoto, Nanako Aki, Tohru Sakai, Emi Shuto, Takayuki Nakao, Masashi Miyoshi and Makoto Funaki : Identifying a Dietary Pattern Associated with Metabolic Syndrome by Reduced Rank Regression in Japanese Male Workers, Diabetes, Vol.65, No.Suppl.1, A604-A605, Jun. 2016.
2.	Takako Ichihara, Ayako Tamura, Yumi Kuwamura, Takako Minagawa, Nanako Kataoka, Chisato Kosugi, Hata Akiko, Emi Shuto, Tohru Sakai and Makoto Funaki : The Effects of physical Activity on Metabolic Symdrome, --- From the 2009 Cross-Sectional Syudy on Working Men in Tokushima ---, 9th International Diabetes Federation Westeran Pacific Region Congress,4th Scientific Meeting of the Asian Association Study of Diabetes, Vol.3, No.Supplement 1, 269, Kyoto, Nov. 2012.
3.	Emi Shuto, Yutaka Taketani, W Kusunise, T Tanaka, D Horie, Kikuko Amou, Hironori Yamamoto, Tohru Sakai and Eiji Takeda : Excessive dietary phosphorus acutely impairs endothelial function in healthy men, The American Society of Nephrology 42nd ANNUAL MEETING & Scientific Exposition, San Diego, Oct. 2009.

Proceeding of Domestic Conference:

1.	Mariko Nakamoto, Tsuzuri Nagashima, Yukiko Tanaka, Satomi Ono, Yuki Iwasaki, Akiko Nakamoto, 張姝, kaoriori Kinoshita, Kanae Furuya, Tomoko Imai, Rei Otsuka and Tohru Sakai : 地域在住高齢者における日本食品成分表に基づく主要な13食品群の摂取頻度を用いた食事バランススコアの検討, 第34回日本疫学会学術総会, Jan. 2024. (Keyword) 地域在住高齢者 / 日本食品成分表 / 食事バランススコア
2.	Akiko Nakamoto, Moyu Takeuchi, Mariko Nakamoto and Tohru Sakai : 給食施設における使用済み布巾の殺菌方法とその効果に関する検討, 第18回日本給食経営管理学会学術総会, Nov. 2023.
3.	Mariko Nakamoto, Akiko Nakamoto, Yuka Hasegawa and Tohru Sakai : 環境負荷に基づく食事の寄与食品群特性に関する検証, 第18回日本給食経営管理学会学術総会, Nov. 2023. (Keyword) 環境負荷 / 食事
4.	Koki Torami, Mariko Nakamoto, THUY THI BUI, Akiko Nakamoto and Tohru Sakai : 若年者の空腹状態による食選択行動に及ぼす潜在的要因の影響, 第8回日本栄養改善学会四国支部学術総会, May 2023.
5.	Ayumi Tohjoh, Mariko Nakamoto, Kana Yamada, Koki Torami, Akiko Nakamoto, Akiko Hata, 安藝菜奈子, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : 徳島県勤労者における食事摂取の多様性と炎症性マーカーとの横断的検討, 第8回日本栄養改善学会四国支部学術総会, May 2023.
6.	Akiko Nakamoto, Maki Hattori, Mariko Nakamoto and Tohru Sakai : 抗炎症機構に対するポリメトキシフラボノイドの作用, 第77回日本栄養・食糧学会大会, 295, May 2023.
7.	Mariko Nakamoto, Ayumi Tohjoh, Kana Yamada, Koki Torami, Akiko Nakamoto, Akiko Hata, 安藝菜奈子, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : 徳島県勤労者における食事摂取の多様性と炎症マーカーとの関連, Journal of Japanese Society of Nutrition and Food Science, 74, May 2023.
8.	Mariko Nakamoto, Yui Shimizu, Akiko Nakamoto and Tohru Sakai : 管理栄養士養成課程の学生立案献立における食事多様性の高い献立の特徴, 第17回日本給食経営管理学会学術総会, Nov. 2022.
9.	Hitomi Sakai, Tohru Sakai and Kumio Yokoigawa : 身の回りの素材に対する小麦粉由来アラビノキシランの大腸菌付着抑制効果について, 第43回日本食品微生物学会, Sep. 2022.
10.	山本真子, Akiko Nakamoto, Mariko Nakamoto, 八木田秀雄 and Tohru Sakai : 大豆イソフラボンのガン免疫チェックポイント療法への応用, The Japanese Journal of Nutrition and Dietetics, Vol.80, No.5, 200, Sep. 2022.
11.	Akiko Nakamoto, 守田栞捺, Mariko Nakamoto and Tohru Sakai : ノビレチンのサイトカイン産生調節作用を介した抗肥満効果, The Japanese Journal of Nutrition and Dietetics, Vol.80, No.5, 195, Sep. 2022.
12.	Mariko Nakamoto, Akiko Nakamoto and Tohru Sakai : 管理栄養士養成課程の学生に対する給食経営管理実習が管理栄養士のコンピテンシーへ及ぼす影響, The Japanese Journal of Nutrition and Dietetics, Vol.80, No.5, 186, Sep. 2022. (Keyword) 給食経営管理 / 給食 / 教育効果 / コンピテンシー / 管理栄養士
13.	Kana Yamada, Mariko Nakamoto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : 徳島県勤労者のイソフラボン摂取量とメタボリックシンドローム構成因子との関連, The Japanese Journal of Nutrition and Dietetics, Vol.80, No.5, 207, Sep. 2022. (Keyword) epidemiology / 公衆栄養 / 栄養疫学
14.	Akiko Nakamoto, HIRABAYASHI Yuwa, Mariko Nakamoto and Tohru Sakai : 17型ヘルパーT細胞に対するポリメトキシフラボノイドの作用-In vitroおよびin vivo系での検討-, 第20回四国免疫フォーラム, Jun. 2022.
15.	Kana Yamada, Mariko Nakamoto, Akiko Nakamoto, Akiko Hata, 安藝菜奈子, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : 徳島県勤労者の大豆イソフラボン摂取量とメタボリックシンドロームとの関連, 第264回徳島医学会学術集会, 32, Feb. 2022.
16.	Kana Yamada, Mariko Nakamoto, Akiko Nakamoto, Akiko Hata, 安藝菜奈子, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : 徳島県勤労者のイソフラボン摂取量とメタボリックシンドロームとの関連, 第6回日本糖尿病・生活習慣病ヒューマンデータ学会年次学術集会, Dec. 2021.
17.	TAKEI Rie, Emi Shuto, Akiko Nakamoto, Mariko Nakamoto and Tohru Sakai : 大豆イソフラボンの癌間細胞に及ぼす影響, 第54回日本栄養・食糧学会中国四国支部大会・第7回日本栄養改善学会四国支部学術総会合同大会, Oct. 2021.
18.	Kana Yamada, Mariko Nakamoto, Miku Kammura, Mai Yoshida, Rino Uenosono, Akiko Nakamoto and Tohru Sakai : 新型コロナウイルス感染拡⼤による高齢者の食選択動機及び食生活への影響, 第54回日本栄養・食糧学会中四国支部大会・第7回日本栄養改善学会四国支部学術合同総会, Oct. 2021.
19.	近藤あかり, Tohru Sakai, Junji Terao and Rie Mukai : 血管内皮細胞における過酸化水素誘導性カベオリン-1リン酸化に対するケルセチンの抑制効果, 第54回日本栄養・食糧学会中国・四国支部大会第7回日本栄養改善学会四国支部学術総会合同大会(オンライン開催), Oct. 2021.
20.	Akiko Nakamoto, Mariko Nakamoto and Tohru Sakai : スダチ果皮由来精油成分が免疫細胞に及ぼす作用と抗原特異的免疫応答への影響, 第68回日本栄養改善学会学術総会, Vol.79, No.5, 107, Oct. 2021.
21.	Mariko Nakamoto, Miku Kanmura, Mai Yoshida, Rino Uenosono, Kana Yamada, Akiko Nakamoto and Tohru Sakai : 新型コロナウイルス感染拡大に伴う初回緊急事態宣言前後での高齢者の食選択動機及び食品摂取多様性の変化, 第68回日本栄養改善学会学術総会, Vol.79, No.5, 187, Oct. 2021. (Keyword) epidemiology / 食選択動機 / 食生活 / 高齢者
22.	HIRABAYASHI Yuwa, Akiko Nakamoto, ANZAKI Chieri, Mariko Nakamoto, Emi Shuto and Tohru Sakai : T細胞分化に与えるポリメトキシフラボノイドの影響, 第75回日本栄養・食糧学会大会, 27, Jul. 2021.
23.	HIRABAYASHI Yuwa, Akiko Nakamoto, ANZAKI Chieri, Mariko Nakamoto, Emi Shuto and Tohru Sakai : 実験的自己免疫性脳脊髄炎(EAE)マウスに対するノビレチンの作用, 第53回日本栄養・食糧学会中国・四国支部大会, 13, Oct. 2020.
24.	Mariko Nakamoto, Satomi Ono, Yukiko Tanaka, Akiko Nakamoto, Emi Shuto and Tohru Sakai : 徳島県の子育て世代におけるワークライフバランスと食行動の関係, 第67回日本栄養改善学会学術総会, Vol.78, No.5, Sep. 2020.
25.	Akiko Nakamoto, ANZAKI Chieri, HIRABAYASHI Yuwa, Mariko Nakamoto, Emi Shuto and Tohru Sakai : マクロファージに対するポリメトキシフラボンの作用-敗血症モデルマウスを用いた検討-, 第67回日本栄養改善学会学術総会, Vol.78, No.5, 67, Sep. 2020.
26.	Akiko Nakamoto, HIRABAYASHI Yuwa, ANZAKI Chieri, Mariko Nakamoto, Emi Shuto and Tohru Sakai : ノビレチンによる実験的自己免疫性脳脊髄炎(EAE)におけるT細胞機能への影響, 第74回日本栄養・食糧学会大会, 205, Apr. 2020.
27.	Mariko Nakamoto, Mariko Ohmine, Yuna Yun, Emi Shuto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : Associations of dietary diversity with allergic diseases in Japanese workers: a cross-sectional study, Journal of Shikoku Public Health Society, Vol.65, No.1, 32, Feb. 2020. (Keyword) epidemiology / nutrition / allergy / Japan
28.	Akiko Nakamoto, Kana Urayama, Chieri Anzaki, Yuwa Hirabayashi, Mariko Nakamoto, Emi Shuto and Tohru Sakai : ポリメトキシフラボンの免疫細胞に対する機能評価 -マクロファージおよび肥満細胞での解析-, 第66回日本栄養改善学会学術総会, Sep. 2019.
29.	Kana Urayama, Akiko Nakamoto, Chieri Anzaki, Yuwa Hirabayashi, Mariko Nakamoto, Emi Shuto and Tohru Sakai : 免疫細胞に対するスダチ果皮フラボノイドの作用に関する研究-肥満細胞およびマクロファージにおける検討-, 第259回徳島医学会学術集会, Aug. 2019.
30.	Akiko Nakamoto, Emi Shuto, Mariko Nakamoto and Tohru Sakai : スダチ果皮に含まれるスダチチンのin vitroにおける機能評価 -マクロファージおよび肥満細胞での解析-, 第73回日本栄養・食糧学会大会, May 2019.
31.	Emi Shuto, Mariko Nakamoto, Akiko Nakamoto and Tohru Sakai : エクオールの前駆脂肪細胞3T3-L1に対する作用, 第73回日本栄養・食糧学会大会, May 2019.
32.	Kana Urayama, Akiko Nakamoto, Chieri Anzaki, Yuwa Hirabayashi, Mariko Nakamoto, Emi Shuto and Tohru Sakai : スダチ果皮フラボノイドの免疫細胞に対する作用に関する研究―肥満細胞およびマクロファージに対する作用―, 第6回日本栄養改善学会四国支部学術総会, Apr. 2019.
33.	Hitomi Sakai, Kaori Kanemaru, Tohru Sakai and Kumio Yokoigawa : 調理器具素材への大腸菌の付着を抑制する小麦粉の成分の同定, 第39回日本食品微生物学会総会, Sep. 2018.
34.	Emi Shuto, Mariko Nakamoto, Akiko Nakamoto and Tohru Sakai : 食餌誘導性肥満マウスにおけるエクオールの作用, 第65回日本栄養改善学会学術総会, Sep. 2018.
35.	Akiko Nakamoto, Mariko Nakamoto, Emi Shuto and Tohru Sakai : スダチチンおよびデメトキシスダチチンによる免疫調節作用, 第65回日本栄養改善学会学術総会, Sep. 2018.
36.	Akiko Nakamoto, Mariko Nakamoto, Emi Shuto and Tohru Sakai : デメトキシスダチチンの免疫調節作用, 第5回日本栄養改善学会四国支部学術総会, Jun. 2018.
37.	Emi Shuto, Mayuka Kunimatsu, Akiko Nakamoto, Mariko Nakamoto and Tohru Sakai : 食餌誘導性肥満マウスにおけるエクオールの作用, 第72回日本栄養・食糧学会大会, May 2018.
38.	Akiko Nakamoto, Mariko Nakamoto, Emi Shuto and Tohru Sakai : デメトキシスダチチンによる免疫調節作用, 第72回日本栄養・食糧学会大会, May 2018.
39.	Hitomi Sakai, Tohru Sakai and Kumio Yokoigawa : 調理器具素材への大腸菌の付着を抑制する小麦粉の成分について, 第38回日本食品微生物学会学術総会, Oct. 2017.
40.	Hitoshi Shiyouno, Masakazu Goda, Koji Abe, Rie Tsutsumi, Tohru Sakai and Noriaki Takeda : 頭頸部癌患者に対する化学療法が舌の味覚受容体遺伝子発現に与える影響, 第42回日本外科系連合学会学術集会, Jun. 2017.
41.	Hitomi Sakai, Tohru Sakai and Kumio Yokoigawa : 調理器具素材への大腸菌の付着に及ぼす穀類の影響, 第37回日本食品微生物学会学術総会講演要旨集, 111, Sep. 2016.
42.	楊暁琳, Mariko Nakamoto, Tohru Sakai, Emi Shuto, 篠原尚子, Akiko Hata, Takako Minagawa, Takako Ichihara, Ayako Tamura, Yumi Kuwamura and Makoto Funaki : 徳島県男性勤労者の大豆発酵食品摂取は血清IL-6濃度を低下させる, 第63回日本栄養改善学会学術総会, Sep. 2016.
43.	篠原尚子, Mariko Nakamoto, Tohru Sakai, Emi Shuto, 楊暁琳, Akiko Hata, Takako Minagawa, Takako Ichihara, Ayako Tamura, Yumi Kuwamura and Makoto Funaki : 徳島県男性勤労者における珈琲，緑茶およびその他のお茶摂取と高尿酸血症との関連, 第63回日本栄養改善学会学術総会, Sep. 2016.
44.	Mariko Nakamoto, 楊暁琳, 篠原尚子 and Tohru Sakai : 徳島県勤労者の婚姻・子供の有無と欠食行動との関係, 第63回日本栄養改善学会学術総会, Sep. 2016.
45.	Takako Ichihara, Akiko Hata, Toshimi Onishi, Mariko Nakamoto, Emi Shuto, Tohru Sakai, Ayako Tamura, Takako Minagawa, Yukari Hisaka and Makoto Funaki : Association between daily life activities and blood pressure increaseThree-year longitudinal study in Japanese male employees living in suburban cities, The 6th Joint Symposium between Kagawa University and Chiang Mai University, Aug. 2016.
46.	篠原尚子, Mariko Nakamoto, Tohru Sakai, Emi Shuto, 楊暁琳, Akiko Hata, 安藝菜奈子, 四釜洋介, 板東由記子, Yukari Hisaka, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Takako Ichihara and Makoto Funaki : 徳島県男性勤労者におけるリスク保有状況別の嗜好飲料摂取と高尿酸血症の関連の検討, 第253回徳島医学会, Jul. 2016.
47.	Hitomi Sakai, Tohru Sakai and Kumio Yokoigawa : 大腸菌の非生物素材への付着に対する穀類の影響, 日本農芸化学会中四国支部第45回講演会要旨集, 23, Jun. 2016.
48.	三谷麻美, Mariko Nakamoto, Emi Shuto and Tohru Sakai : スダチチンの免疫調節作用-卵白アルブミン免疫マウスモデルでの検討-, 第70回日本栄養・食糧学会大会, May 2016.
49.	楊曉琳, Mariko Nakamoto, Tohru Sakai, Emi Shuto, 篠原尚子, Akiko Hata, 安藝菜奈子, Chisato Kosugi, Yosuke Shikama, Yukiko Bandou, Takako Minagawa, Takako Ichihara, Ayako Tamura, Yumi Kuwamura and Makoto Funaki : 徳島県勤労者を対象とした大豆摂取と炎症マーカーとの関連について, 第70回日本栄養食糧学会, May 2016.
50.	篠原尚子, Mariko Nakamoto, Tohru Sakai, Emi Shuto, 楊暁琳, Akiko Hata, 安藝菜奈子, Yosuke Shikama, Yukiko Bandou, Takako Minagawa, Takako Ichihara, Ayako Tamura, Yumi Kuwamura and Makoto Funaki : 徳島県勤労者における珈琲摂取と高尿酸血症との関連, 第70回日本栄養・食糧学会, May 2016.
51.	Mariko Nakamoto, Tohru Sakai, Emi Shuto, 安藝菜奈子, Akiko Hata, Yumi Kuwamura, Takako Minagawa, Takako Ichihara, Ayako Tamura and Makoto Funaki : 徳島県勤労者のイソフラボン摂取量とアレルギー疾患との関係, 第70回日本栄養・食糧学会, May 2016.
52.	國松真由香, Emi Shuto, 三谷麻美, Mariko Nakamoto and Tohru Sakai : 食餌誘導性肥満マウスにおけるエクオールの効果, 第70回日本栄養・食糧学会大会, May 2016.
53.	Akiko Hata, Koji Yonemoto, Nanako Aki, Tohru Sakai, Emi Shuto, Takayuki Nakao, Masashi Miyoshi and Makoto Funaki : 徳島県におけるメタボリックシンドロームと関連する食事パターンの検討, Journal of the The Japan Diabetes Society, Vol.59, No.Suppl.1, May 2016.
54.	篠原尚子, Mariko Nakamoto, Tohru Sakai, Emi Shuto, 楊暁琳, Akiko Hata, 安藝菜奈子, Yosuke Shikama, Yukiko Bandou, Takako Minagawa, Takako Ichihara, Ayako Tamura, Yumi Kuwamura and Makoto Funaki : 第3回日本栄養改善学会(四国支部会), 第3回日本栄養改善学会(四国支部会), Apr. 2016.
55.	Xiaolin Yang, Mariko Nakamoto, Tohru Sakai and 鈴木公 : 中国雲南省昆明市における幼児体型の違いに基づく生活習慣・食習慣に関する実態調査, 第14回日本栄養改善学会近畿支部学術総会, Dec. 2015. (Keyword) 幼児 / 肥満 / 食習慣
56.	Tohru Sakai, Mariko Nakamoto and Emi Shuto : スダチ果皮による血糖上昇抑制作用の検討, 第62回日本栄養改善学会学術総会, Sep. 2015.
57.	Emi Shuto, Mami Mitani, Mariko Nakamoto and Tohru Sakai : 食餌誘導性肥満マウスにおけるエクオールの効果, 第62回日本栄養改善学会学術総会, Sep. 2015.
58.	Mami Mitani, Mariko Nakamoto, Emi Shuto and Tohru Sakai : In vivo におけるスダチチンの免疫調節作用 -ALZET pumpを用いた検討-, 第62回日本栄養改善学会学術総会, Sep. 2015.
59.	Mariko Nakamoto, Emi Shuto, Mami Mitani and Tohru Sakai : 豆乳摂取は若年者の心身ストレスを改善するか, 第62回日本栄養改善学会学術総会, Sep. 2015.
60.	Mayuka Sakaguchi, Akiko Hata, Yosuke Shikama, Nanako Aki, Tohru Sakai, Emi Shuto, Rie Tsutsumi, Takayuki Nakao, Masashi Miyoshi, Makoto Funaki and Koji Yonemoto : Reduced Rank Regressionにより抽出された食事パターンの一般化可能性に関する検討∼メタボリックシンドローム発症追跡データを用いて∼, Journal of the The Japan Diabetes Society, Vol.58, No.Suppl.1, May 2015.
61.	Masakazu Goda, Yoshiaki Kitamura, 高橋美香, 島谷美映, Rie Tsutsumi, Tohru Sakai and Noriaki Takeda : 頭頸部癌化学療法が舌の味覚受容体遺伝子発現に及ぼす影響, 日本耳鼻咽喉科学会第39回四国四県地方部会連合学会, Dec. 2013.
62.	Akiko Nakamoto, Emi Shuto and Tohru Sakai : ビタミンA欠乏は経口免疫寛容を破綻させる, 第60回日本栄養改善学会学術総会, Sep. 2013.
63.	Miku Kioka, Emi Shuto and Tohru Sakai : 実験的自己免疫性脳脊髄炎マウスにおける大豆イソフラボンの効果, 第60回日本栄養改善学会学術総会, Sep. 2013.
64.	Tohru Sakai, 中本真理子, 中本晶子, 小林ゆき子, 土居幸雄 and 木戸康博 : 管理栄養士・栄養士養成施設における栄養士・管理栄養士の就業状態等の調査研究, 第60回日本栄養改善学会学術総会, Sep. 2013.
65.	Masakazu Goda, Rie Tsutsumi, Chisa Fujimoto, Tohru Sakai and Noriaki Takeda : 頭頸部癌化学療法が舌の味覚受容体遺伝子発現に及ぼす影響, 第26回日本口腔・咽頭科学会, Sep. 2013.
66.	中本真理子, Tohru Sakai, Emi Shuto, 安藝菜奈子, Chisato Kosugi, Akiko Hata, Kaori Shinoda, Yumi Kuwamura, Takako Minagawa, Takako Ichihara, Ayako Tamura and Makoto Funaki : 徳島県勤労者の血清脂肪酸濃度とインスリン抵抗性との関係に関する疫学研究, 第67回日本栄養・食糧学会大会, May 2013.
67.	Akiko Hata, Yukiko Bandou, Yosuke Shikama, 安藝菜奈子, Chisato Kosugi, 西村美穂, 阿部房代, 佐藤美子, 中奥真理子, 片山りか, 赤松康代, Tohru Sakai, Emi Shuto, Rie Tsutsumi, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, 中尾隆之, 三好雅士, Hiroki Moriguchi, Yuu Tamaki, Toshio Matsumoto and Makoto Funaki : 徳島県におけるadiponectinや高感度CRPとメタボリックシンドロームとの関連, Journal of the The Japan Diabetes Society, Vol.Vol.56, No.Suppl.1, S.208, May 2013.
68.	秦明子, Yukiko Bandou, Yosuke Shikama, 安藝菜奈子, Chisato Kosugi, 西村美穂, 阿部房代, 佐藤美子, 中奥真理子, 片山りか, 赤松康代, 丹下幸子, Tohru Sakai, Emi Shuto, Rie Tsutsumi, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Yumi Kuwamura, Takayuki Nakao, Masashi Miyoshi, Hiroki Moriguchi, Yuu Tamaki, Toshio Matsumoto and Makoto Funaki : 徳島県におけるadiponectinや高感度CRPとメタボリックシンドロームとの関連, Journal of the The Japan Diabetes Society, Vol.56, Apr. 2013.
69.	Rie Tsutsumi, Tohru Sakai, Masakazu Goda, Yoshiaki Kitamura, Koji Abe, Noriaki Takeda, Chisa Fujimoto, 河合美佐 and 松本英希 : 頭頸部癌の放射線・化学療法中における味覚異常と味覚受容体について, 日本耳鼻咽喉科学会徳島県地方部会第70回学術講演会, Mar. 2013.
70.	Tohru Sakai : 核酸は免疫調節機能により糖脂質代謝を制御するか?, 第8回日本食品免疫学会, Oct. 2012.
71.	中本真理子, Emi Shuto and Tohru Sakai : 徳島県勤労者の食事パターンとアレルギー既往との関連, 第59回日本栄養改善学会, Sep. 2012.
72.	中本真理子, Tohru Sakai, Emi Shuto, Nanako Kataoka, Chisato Kosugi, 秦明子, Kaori Shinoda, Yumi Kuwamura, Takako Minagawa, Takako Ichihara, Ayako Tamura and Makoto Funaki : 徳島県勤労者の夕食終了から就寝時間までの間隔と生活習慣病有病状況との関係に関する疫学研究, 第66回日本栄養食糧学会大会, May 2012.
73.	吉田知美, 笹賀早也香, 三好まどか, Rie Tsutsumi, Emi Shuto, Toshio Hosaka, 新居佳孝, 津嘉山正夫, 岡久修己, 岩田深也 and Tohru Sakai : スダチ抽出物であるスダチチンの肥満および糖尿病予防作用, 第66回日本栄養食糧学会大会, May 2012.
74.	中本真理子, Tohru Sakai, Emi Shuto, Nanako Kataoka, Chisato Kosugi, Akiko Hata, Kaori Shinoda, Yumi Kuwamura, Takako Minagawa, Takako Ichihara, Ayako Tamura and Makoto Funaki : 徳島県勤労者の夕食終了から就寝時間までの間隔と生活習慣病有病状況との関係に関する疫学研究, 第66回日本栄養・食糧学会大会, May 2012.
75.	Yukiko Bandou, Yosuke Shikama, 西村美穂, Chisato Kosugi, 安芸菜奈子, Akiko Hata, 赤松康代, 片山りか, 阿部房代, Tohru Sakai, Emi Shuto, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Hiroki Moriguchi, Tomiaki Morikawa, Yuu Tamaki and Makoto Funaki : 徳島県におけるadiponectinの糖代謝異常予測因子としての検討, Journal of the The Japan Diabetes Society, Vol.Vol.55, No.Suppl.1, S.359, May 2012.
76.	Chisato Kosugi, 安藝菜奈子, Yukiko Bandou, Yosuke Shikama, 西村美穂, 片山りか, 丹下幸子, 阿部房代, 赤松康代, Akiko Hata, 木宿由佳, Kaori Shinoda, Tohru Sakai, Emi Shuto, Rie Tsutsumi, Toshio Hosaka, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Tomiaki Morikawa, Yuu Tamaki and Makoto Funaki : 初期糖代謝異常を発見する指標としてのIL-18測定有用性の検討, Journal of the The Japan Diabetes Society, Vol.Vol.55, No.Suppl.1, S.290, May 2012.
77.	Tohru Sakai and Emi Shuto : 食餌性核酸による糖および脂質代謝調節機構, 第58回日本栄養改善学会学術総会, Sep. 2011.
78.	中本真理子, Emi Shuto and Tohru Sakai : 徳島県勤労者のイソフラボン摂取とアレルギー既往との関係に関する疫学研究, 第58回日本栄養改善学会学術総会, Sep. 2011.
79.	Emi Shuto and Tohru Sakai : 食餌誘導性肥満マウスにおける大豆イソフラボンの効果, 第58回日本栄養改善学会学術総会, Sep. 2011.
80.	中本真理子, Tohru Sakai, Emi Shuto, Toshio Hosaka, Nanako Kataoka, Chisato Kosugi, 秦明子, Kaori Shinoda, Yumi Kuwamura, Takako Minagawa, Takako Ichihara, Ayako Tamura and Makoto Funaki : 徳島県勤労者の豆類摂取量とアレルギー既往との関係に関する疫学研究, 第65回日本栄養食糧学会大会, May 2011.
81.	Tohru Sakai, 荒川真衣, 田崎志保, Emi Shuto, 中本真理子 and Toshio Hosaka : 核酸およびリボ核酸はインスリン抵抗性および脂質代謝を改善する, 第65回日本栄養食糧学会大会, May 2011.
82.	Emi Shuto, 荒川真衣, 田崎志保, 中本真理子, Rie Tsutsumi, Toshio Hosaka and Tohru Sakai : 食餌誘導性肥満マウスにおける大豆イソフラボンの炎症反応への影響, 第65回日本栄養食糧学会大会, May 2011.
83.	中本真理子, Tohru Sakai, Emi Shuto, Toshio Hosaka, Nanako Kataoka, Chisato Kosugi, Akiko Hata, Kaori Shinoda, Yumi Kuwamura, Takako Minagawa, Takako Ichihara, Ayako Tamura and Makoto Funaki : 徳島県勤労者の豆類摂取量とアレルギー既往との関係に関する疫学研究, 第65回日本栄養・食糧学会大会, May 2011.
84.	Yosuke Shikama, Chisato Kosugi, Nanako Kataoka, Yukiko Bandou, Akiko Hata, Kaori Shinoda, 木村純子, 赤松康代, 片山りか, 庄野真代, 簾馨, 藤森洋子, Tohru Sakai, Emi Shuto, Toshio Hosaka, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Hiroki Moriguchi, Tomiaki Morikawa, Yuu Tamaki and Makoto Funaki : 非肥満者に見られる糖・脂質代謝異常，高血圧に脂肪組織の機能異常が関与する可能性の検討, Journal of the The Japan Diabetes Society, Vol.Vol.54, No.Suppl.1, May 2011.
85.	Yukiko Bandou, Chisato Kosugi, Nanako Kataoka, Yosuke Shikama, Akiko Hata, 赤松康代, 片山りか, 庄野真代, 簾馨, Kaori Shinoda, Tohru Sakai, Emi Shuto, Toshio Hosaka, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Hiroki Moriguchi, Tomiaki Morikawa, Yuu Tamaki and Makoto Funaki : 徳島県におけるadiponectinおよびHOMA-IRと糖・脂質早期代謝異常との相関性についての考察, Journal of the The Japan Diabetes Society, Vol.Vol.54, No.Suppl.1, May 2011.
86.	Yukiko Bandou, Chisato Kosugi, Nanako Kataoka, Yosuke Shikama, 秦明子, 木村純子, 赤松康代, 片山りか, 庄野真代, 簾馨, Kaori Shinoda, Tohru Sakai, Emi Shuto, Toshio Hosaka, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Hiroki Moriguchi, Tomiaki Morikawa, Yuu Tamaki and Makoto Funaki : 徳島県におけるadiponectinおよびHOMA-IRと糖・脂質早期代謝異常との相関性についての考察, Journal of the The Japan Diabetes Society, Vol.54, No.Suppl.1, S-248, 2011.
87.	Yosuke Shikama, Chisato Kosugi, Nanako Kataoka, Yukiko Bandou, 秦明子, Kaori Shinoda, 木村純子, 赤松康代, 片山りか, 庄野真代, 簾馨, 藤森洋子, Tohru Sakai, Emi Shuto, Toshio Hosaka, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Hiroki Moriguchi, Tomiaki Morikawa, Yuu Tamaki and Makoto Funaki : 非肥満者に見られる糖・脂質代謝異常，高血圧に脂肪組織の機能異常が関与する可能性の検討, Journal of the The Japan Diabetes Society, Vol.54, No.Suppl.1, S-355, 2011.
88.	Tohru Sakai, Mariko Nakamoto and Emi Shuto : 徳島県勤労者における練り製品摂取量と食品群別摂取量・生活習慣との関連について, 第57回日本栄養改善学会集会, Sep. 2010.
89.	Tohru Sakai, Mariko Nakamoto and Emi Shuto : 徳島県勤労者における練り製品摂取量と食品群別摂取量・生活習慣との関連について, 第57回日本栄養改善学会集会, Sep. 2010.
90.	Tohru Sakai, Mariko Nakamoto, Emi Shuto and Toshio Hosaka : 核酸による2型ヘルパーT細胞分化制御のメカニズム, 核酸・核タンパク質機能性研究会, Aug. 2010.
91.	Tohru Sakai : 大豆イソフラボンの免疫制御機構, 第6回食品免疫学会学術総会, Jun. 2010.
92.	Emi Shuto, Yutaka Taketani, 大屋美穂, 小河真理子, 中西美咲, Kikuko Amou, Toshio Hosaka, Hironori Yamamoto, Tohru Sakai and Eiji Takeda : ヒトにおける食事性高リン負荷による血管内皮機能への影響, 第64回日本栄養・食糧学会大会,徳島,平成22年5月21日~23日, May 2010.
93.	Tohru Sakai, 府録咲奈, Mariko Nakamoto, Emi Shuto and Toshio Hosaka : 大豆イソフラボンの大腸炎病態制御に関する研究, 第64回日本栄養食糧学会大会, May 2010.
94.	Chisato Kosugi, Nanako Kataoka, Kaori Shinoda, Akiko Hata, 木村純子, 赤松康代, 片山りか, 藤森洋子, Tohru Sakai, Emi Shuto, Toshio Hosaka, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Yutaka Nakaya, Bayasgalan Jambaldorj, Hiroki Moriguchi, Tomiaki Morikawa, Yuu Tamaki, 福原俊一, 竹上美沙 and Makoto Funaki : 初期糖代謝異常状態の慢性炎症管理におけるIL-18の有用性についての検討, Journal of the The Japan Diabetes Society, Vol.Vol.53, No.Suppl.1, S.299, May 2010.
95.	Nanako Kataoka, Kaori Shinoda, Chisato Kosugi, Akiko Hata, 木村純子, 赤松康代, 片山りか, 藤森洋子, Tohru Sakai, Emi Shuto, Toshio Hosaka, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Yutaka Nakaya, Bayasgalan Jambaldorj, Hiroki Moriguchi, Tomiaki Morikawa, Yuu Tamaki, 福原俊一, 竹上美沙 and Makoto Funaki : 徳島県における糖代謝異常発生過程でのインスリン抵抗性の関与, Journal of the The Japan Diabetes Society, Vol.Vol.53, No.Suppl.1, S.298, May 2010.
96.	Akiko Hata, Chisato Kosugi, Nanako Kataoka, Kaori Shinoda, 木村純子, 赤松康代, 片山りか, 藤森洋子, Tohru Sakai, Emi Shuto, Toshio Hosaka, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Yutaka Nakaya, Bayasgalan Jambaldorj, Hiroki Moriguchi, Tomiaki Morikawa, Yuu Tamaki, 福原俊一, 竹上美沙 and Makoto Funaki : インスリン抵抗性を伴う高リスク糖尿病発症者となる危険因子の探索, Journal of the The Japan Diabetes Society, Vol.Vol.53, No.Suppl 1, S207, May 2010.
97.	秦明子, Chisato Kosugi, Nanako Kataoka, Kaori Shinoda, 木村純子, 赤松康代, 片山りか, 藤森洋子, Tohru Sakai, Emi Shuto, Toshio Hosaka, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Yutaka Nakaya, Jambaldorj Baysaglan, Hiroki Moriguchi, Tomiaki Morikawa, Yuu Tamaki, 福原俊一 and Makoto Funaki : インスリン抵抗性を伴う高リスク糖尿病発症者となる危険因子の探索, Journal of the The Japan Diabetes Society, Vol.53, No.Suppl.1, S-207, May 2010.
98.	Nanako Kataoka, Kaori Shinoda, Chisato Kosugi, 秦明子, 木村純子, 赤松康代, 片山りか, 藤森洋子, Tohru Sakai, Emi Shuto, Toshio Hosaka, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Yutaka Nakaya, Jambaldorj Baysaglan, Hiroki Moriguchi, Tomiaki Morikawa, Yuu Tamaki, 福原俊一, 竹上美沙 and Makoto Funaki : 徳島県における糖代謝異常発生過程でのインスリン抵抗性の関与, Journal of the The Japan Diabetes Society, Vol.53, No.Suppl.1, S-298, May 2010.
99.	Chisato Kosugi, Nanako Kataoka, Kaori Shinoda, 秦明子, 木村純子, 赤松康代, 片山りか, 藤森洋子, Tohru Sakai, Emi Shuto, Toshio Hosaka, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Yutaka Nakaya, Jambaldorj Baysaglan, Hiroki Moriguchi, Tomiaki Morikawa, Yuu Tamaki, 福原俊一, 竹上美沙 and Makoto Funaki : 初期糖代謝異常状態の慢性炎症管理におけるIL-18の有用性についての検討, Journal of the The Japan Diabetes Society, Vol.53, No.Suppl.1, S-299, May 2010.
100.	Emi Shuto, Yutaka Taketani, Kikuko Amou, Toshio Hosaka, Hironori Yamamoto, Tohru Sakai and Eiji Takeda : 食事性のリン過剰摂取は血管内皮機能を障害する, 第13回日本病態栄養学会年次学術集会, Jan. 2010.
101.	Emi Shuto, Yutaka Taketani, Hironori Yamamoto, Tohru Sakai and Eiji Takeda : ヒトにおける食事性高リン負荷による血管内皮機能障害, 第63回日本栄養・食糧学会大会, May 2009.
102.	Emi Shuto, Yutaka Taketani, Hironori Yamamoto, Hisami Okumura, Tohru Sakai and Eiji Takeda : 食後高リン血症は血管内皮機能障害を惹起し心血管疾患のリスクとなる, 第55回栄養改善学会学術総会, Sep. 2008.

Report:

1.	Mariko Nakamoto, Sarasa Mori, Emi Shuto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : Soy and Isoflavone Intake and Lifestyle and Health Awareness in Japanese Workers, SOY PROTEIN RESEARCH, Japan, Vol.24, 154-161, Jul. 2022.
2.	Mariko Nakamoto, Sarasa Mori, Akimitsu Ohkohji, Emi Shuto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : 大豆製品・大豆含有成分摂取と推定腎機能との関係を探る臨床疫学研究, Soy protein research, Vol.23, 182-191, 2020.
3.	Tohru Sakai and Mariko Nakamoto : Prospective study of the favorable effects of higher dietary miso intake on component of metabolic syndrome in Japanese work site population, Report of central miso research institute, No.38, 68-76, Mar. 2017.
4.	Mariko Nakamoto and Tohru Sakai : The association between dietary consumption and cognitive function according to Equol productivity in Japanese elderly; a cross-sectional study, Soy Protein Research, Japan, Vol.20, 165-172, 2017. (Keyword) dementia / epidemiology / nutrition
5.	Mariko Nakamoto and Tohru Sakai : Soy milk intake improves stress status in university students, SOY PROTEIN RESEARCH, Japan, Vol.36, No.18, 182-187, Jun. 2016. (Keyword) soy milk / stress / university student / cross-over trial

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Basic study determining effects of polumethoxyflavonoids on immune functions. (Project/Area Number: 22K11701 )
Function of dietary polymethoxylated flavonoid on metabolism and immune function. (Project/Area Number: 19K11768 )
Elucidation of the inhibitory effect of soy isoflavones on cancer stem cells and a new approach towards cancer treatment (Project/Area Number: 17K00857 )
Intake of soy foods regulates the development of metabolic syndrom (Project/Area Number: 25350126 )
Effect of soy isoflavones on allergic diseases in cross-sectional study (Project/Area Number: 22500760 )
Basic study that examining immune regulatory effect of soy isoflavones. (Project/Area Number: 19500685 )
Impact of zinc nutrient status on acquirement of antibody and prevalence of infectious disease among Vietnamese infants (Project/Area Number: 18406027 )
調節性T細胞を標的とした細胞内寄生性原虫のエスケープ機構の解明 (Project/Area Number: 15790214 )
Evaluation of the conversation type of nutrition education for the improvement of the individual health (Project/Area Number: 15590548 )
食品抗原に対する免疫寛容誘導の環境ホルモンによる修飾機構に関する研究 (Project/Area Number: 14657017 )
メラノーマに対するフュージョン及びコンビネーションDNAワクチン療法の新規開発 (Project/Area Number: 13218090 )
メラノーマに対するフュージョン及びコンビネーションDNAワクチン療法の新規開発 (Project/Area Number: 12217101 )
マラリアの病原性に関与する熱ショック蛋白質90の遺伝子解析 (Project/Area Number: 11877046 )
遺伝子銃を用いたマラリアMSP-1遺伝子によるDNAワクチン及びワクチン抗原同定 (Project/Area Number: 11770131 )
マラリア原虫の病原性(エスケープ)に係わる分子シャペロンHSP90の機能 (Project/Area Number: 11153219 )
マラリア原虫の病原性に係わる熱ショック蛋白質の機能 (Project/Area Number: 11147219 )
Clarification of evasion mechanisms of protozoa on the basis of expression pattern of heat shock proteins in parasites and hosts. (Project/Area Number: 10470067 )
分子シャペロンHSP90のマラリア原虫の病原性における機能の解析 (Project/Area Number: 10172222 )
Th分化を調節する抗原提示細胞内酵素・カテプシンB (Project/Area Number: 10167214 )
マラリア原虫の病原性に係わる熱ショック蛋白質の機能 (Project/Area Number: 10166216 )
遺伝子鏡を用いたマラリア感染に対するDNAワクチネーションの基礎的研究 (Project/Area Number: 09877055 )
分子シャペロンHSP65による原虫感染宿主細胞のアポトーシスの抑制と感染防御 (Project/Area Number: 09276221 )
マラリア原虫感染における原虫および宿主の熱ショック蛋白質の機能 (Project/Area Number: 09270218 )
システインプロテアーゼによるリーシュマニア感染T細胞機能的分化の新しい制御理論 (Project/Area Number: 08877052 )
マラリア原虫の病原性に係わる分子としての熱ショック蛋白質の機能 (Project/Area Number: 08281210 )
Role of HSP65 in host protection against intracellular protozoan infection. (Project/Area Number: 06454200 )
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Professor : Sakai, Tohru

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)