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Tokushima UniversityGraduate School of Biomedical Sciences医学域先端基礎栄養学教育研究プロジェクト
Tokushima UniversityGraduate School of Biomedical Sciences医学域Medical NutritionMedical NutritionDepartment of Nutrition and Metabolism
Tokushima UniversityGraduate School of Medical NutritionMedical Nutrition
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Academic Paper (Judged Full Paper):

1. Kazuhiro Nomura, Shinichi Kinoshita, Nao Mizusaki, Yoko Senga, Tsutomu Sasaki, Tadahiro Kitamura, Hiroshi Sakaue, Aki Emi, Tetsuya Hosooka, Masahiro Matsuo, Hitoshi Okamura, Taku Amo, M Alexander Wolf, Naomi Kamimura, Shigeo Ohta, Tomoo Itoh, Yoshitake Hayashi, Hiroshi Kiyonari, Anna Krook, R Juleen Zierath, Masato Kasuga and Wataru Ogawa :
Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism.,
Molecular Metabolism, Vol.86, 101968, 2024.
(DOI: 10.1016/j.molmet.2024.101968,   PubMed: 38885788,   Elsevier: Scopus)
2. Kazuhiro Nomura, Satoshi Inagaki, Naokazu Muramae, Hiroaki Takahashi, Kozue Abe, Kenji Kato, Yoshiaki Kido and Tomokazu Matsuda :
Association of short-term changes in HbA1c with body composition and the importance of muscle maintenance in patients with Type 2 diabetes.,
Journal of Diabetes and its Complications, Vol.38, No.6, 108746, 2024.
(DOI: 10.1016/j.jdiacomp.2024.108746,   PubMed: 38749296)
3. Hiromi Matsuo, Ryota Matsui, Koshi Kumagai, Satoshi Ida, Yoko Saino, Aya Fujihara, Kumi Takagi, Yukiko Itami, Misuzu Ishii, Naoki Moriya, Yuna Izumi-Mishima, Kazuhiro Nomura, M Yasuo Tsutsumi, Souya Nunobe, Rie Tsutsumi and Hiroshi Sakaue :
Impact of Olfactory Change on Postoperative Body Weight Loss in Patients with Gastric Cancer after Gastrectomy.,
Nutrients, Vol.16, No.6, 851, 2024.
(Tokushima University Institutional Repository: 119382,   DOI: 10.3390/nu16060851,   PubMed: 38542761)
4. Yu Hirata, Kazuhiro Nomura, Daisuke Kato, Yoshihisa Tachibana, Takahiro Niikura, Kana Uchiyama, Tetsuya Hosooka, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Yuji Hara, Takahiro Adachi, Koji Shibasaki, Hiroaki Wake and Wataru Ogawa :
A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy.,
The Journal of Clinical Investigation, Vol.132, No.10, 1-13, 2022.
(DOI: 10.1172/JCI154611,   PubMed: 35290243)
5. Naoki Kuramoto, Kazuhiro Nomura, Daisuke Kohno, Tadahiro Kitamura, Gerard Karsenty, Tetsuya Hosooka and Wataru Ogawa :
Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load.,
Scientific Reports, Vol.11, No.1, 3447, 2021.
(DOI: 10.1038/s41598-021-83098-z,   PubMed: 33568757)
6. Nao Mizusaki, Kazuhiro Nomura, Tetsuya Hosooka, Masashi Shiomi, Kazuo Ogawa, Tetsuto Tsunoda, Yoshikazu Tamori and Wataru Ogawa :
The Novel Lipid-Lowering Drug D-47 Ameliorates Hepatic Steatosis and Promotes Brown/Beige-Like Change of White Adipose Tissue in db/db Mice.,
The Kobe Journal of Medical Sciences, Vol.65, No.1, E36-E43, 2019.
(PubMed: 31341155)
7. Yu Hirata, Kazuhiro Nomura, Yoko Senga, Yuko Okada, Kenta Kobayashi, Shiki Okamoto, Yasuhiko Minokoshi, Michihiro Imamura, Shin'ichi Takeda, Tetsuya Hosooka and Wataru Ogawa :
Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis.,
JCI Insight, Vol.4, No.4, e124952, 2019.
(DOI: 10.1172/jci.insight.124952,   PubMed: 30830866)
8. Kenji Sugawara, Kazuhiro Nomura, Yuko Okada, Aki Sugano, Masaaki Matsumoto, Toru Takarada, Atsuko Takeuchi, Hiroyuki Awano, Yushi Hirota, Hisahide Nishio, Yutaka Takaoka and Wataru Ogawa :
In silico and in vitro analyses of the pathological relevance of the R258H mutation of hepatocyte nuclear factor 4α identified in maturity-onset diabetes of the young type 1.,
Journal of Diabetes Investigation, Vol.10, No.3, 680-684, 2018.
(DOI: 10.1111/jdi.12960,   PubMed: 30325586)
9. Kaku Matsugi, Tetsuya Hosooka, Kazuhiro Nomura and Wataru Ogawa :
Thrombospondin 1 Suppresses Insulin Signaling in C2C12 Myotubes.,
The Kobe Journal of Medical Sciences, Vol.62, No.1, E13-8, 2016.
(PubMed: 27492207)
10. Yukiko Kawasaki-Ogita, Yoshiyuki Hamamoto, Sachiko Honjo, Hiroki Ikeda, Yoshiharu Wada, Kazuhiro Nomura, Yorihiro Iwasaki, Ryuji Nohara and Hiroyuki Koshiyama :
The limited usefulness of the treadmill test or a risk-guided approach in screening for asymptomatic coronary heart disease in Japanese patients with type 2 diabetes.,
Internal Medicine, Vol.51, No.24, 3337-3342, 2012.
(DOI: 10.2169/internalmedicine.51.7878,   PubMed: 23257517)
11. Kazuhiro Nomura, Hiroki Ikeda, Kanako Mori, Yoshiyuki Hamamoto, Sachiko Honjo, Yukiko Kawasaki, Yoshiharu Wada and Hiroyuki Koshiyama :
Less variation of R-R interval of electrocardiogram in nonobese type 2 diabetes with nocturnal intermittent hypoxia.,
Endocrine Journal, Vol.60, No.2, 225-230, 2012.
(DOI: 10.1507/endocrj.ej11-0327,   PubMed: 23018979)
12. Yoshiyuki Hamamoto, Sachiko Honjo, Yukiko Kawasaki, Hiroki Ikeda, Kanako Mori, Kanta Fujimoto, Hisato Tatsuoka, Yorihiro Iwasaki, Kazuhiro Nomura, Yoshiharu Wada and Hiroki Koshiyama :
Relationship between telmisartan dose and glycaemic control in Japanese patients with type 2 diabetes mellitus and hypertension: a retrospective study.,
Clinical Drug Investigation, Vol.32, No.9, 577-582, 2012.
(DOI: 10.1007/BF03261912,   PubMed: 22812514)
13. Tomohisa Aoyama, Hiroki Ikeda, Yoshiyuki Hamamoto, Sachiko Honjo, Kazuhiro Nomura, Yoshiharu Wada, Jun Fujikawa, Yasuaki Hayashino, Shunichi Fukuhara and Hiroyuki Koshiyama :
Clinical heterogeneity of adult Japanese diabetes depending on titers of glutamic acid decarboxylase autoantibodies.,
Journal of Diabetes Investigation, Vol.3, No.3, 266-270, 2012.
(DOI: 10.1111/j.2040-1124.2011.00190.x,   PubMed: 24843575)
14. Shuying Li, Wataru Ogawa, Aki Emi, Kumiko Hayashi, Yoko Senga, Kazuhiro Nomura, Kenta Hara, Demin Yu and Masato Kasuga :
Role of S6K1 in regulation of SREBP1c expression in the liver.,
Biochemical and Biophysical Research Communications, Vol.412, No.2, 197-202, 2011.
(DOI: 10.1016/j.bbrc.2011.07.038,   PubMed: 21806970)
15. Kazuhiro Nomura, Yoshiyuki Hamamoto, Shiho Takahara, Osamu Kikuchi, Sachiko Honjo, Hiroki Ikeda, Yoshiharu Wada, Koichro Nabe, Ryosuke Okumra and Hiroyuki Koshiyama :
Relationship between carotid intima-media thickness and silent cerebral infarction in Japanese subjects with type 2 diabetes.,
Diabetes Care, Vol.33, No.1, 168-170, 2009.
(DOI: 10.2337/dc09-0453,   PubMed: 19808915)
16. Tetsuya Kimura, Hiroki Ikeda, Jun Fujikawa, Kazuhiro Nomura, Tomohisa Aoyama, Yoshiharu Wada, Koichiro Nabe, Yoshiyuki Hamamoto, Sachiko Honjo and Hiroyuki Koshiyama :
Usefulness of serum cystatin C in Japanese patients with type 2 diabetes mellitus and nephropathy.,
Diabetes Research and Clinical Practice, Vol.83, No.2, e58-61, 2008.
(DOI: 10.1016/j.diabres.2008.11.032,   PubMed: 19118914)
17. Yasuyuki Arai, Koichiro Nabe, Hiroki Ikeda, Sachiko Honjo, Yoshiharu Wada, Yoshiyuki Hamamoto, Kazuhiro Nomura, Tomokazu Aoki, Toshiaki Sano and Hiroyuki Koshiyama :
A case of lymphocytic panhypophysitis (LPH) during pregnancy.,
Endocrine, Vol.32, No.1, 117-121, 2007.
(DOI: 10.1007/s12020-007-9001-6,   PubMed: 17992609)
18. Kazuhiro Nomura, Hoshimi Kanemura, Takaya Satoh and Tohru Kataoka :
Identification of a novel domain of Ras and Rap1 that directs their differential subcellular localizations.,
The Journal of Biological Chemistry, Vol.279, No.21, 22664-22673, 2004.
(DOI: 10.1074/jbc.M314169200,   PubMed: 15031297)
19. Hirotaka Imai, Tomoko Koumura, Ryo Nakajima, Kazuhiro Nomura and Yasuhito Nakagawa :
Protection from inactivation of the adenine nucleotide translocator during hypoglycaemia-induced apoptosis by mitochondrial phospholipid hydroperoxide glutathione peroxidase.,
The Biochemical journal, Vol.371, No.Pt 3, 799-809, 2003.
(DOI: 10.1042/BJ20021342,   PubMed: 12534348)
20. Kazuhiro Nomura, H Imai, T Koumura, T Kobayashi and Y Nakagawa :
Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis.,
The Biochemical journal, Vol.351, No.Pt 1, 183-193, 2000.
(DOI: 10.1042/0264-6021:3510183,   PubMed: 10998361)
21. Kazuhiro Nomura, H Imai, T Koumura, M Arai and Y Nakagawa :
Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway.,
The Journal of biological chemistry, Vol.274, No.41, 29294-29302, 1999.
(DOI: 10.1074/jbc.274.41.29294,   PubMed: 10506188)
22. M Arita, Kazuhiro Nomura, H Arai and K Inoue :
alpha-tocopherol transfer protein stimulates the secretion of alpha-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.94, No.23, 12437-12441, 1997.
(DOI: 10.1073/pnas.94.23.12437,   PubMed: 9356467)

Academic Paper (Unrefereed Paper):

1. 宮部 由利, 奈部 浩一郎, 〓田 ひろみ, 中尾 哲史, Kazuhiro Nomura, 青山 倫久, 木村 哲也, 池田 弘毅, 本庶 祥子 and 越山 裕行 :
後腹膜腫瘍を合併し,診断に苦慮したクッシング病の1例,
日本内分泌学会雑誌, Vol.84, 76-79, 2008.
(CiNii: 1572543025585395840)
2. 福田 旭伸, 本庶 祥子, 青山 倫久, 木村 哲也, Kazuhiro Nomura, 奈部 浩一郎, 池田 弘毅, 和田 良春 and 越山 裕行 :
成人期に診断された Prader-Willi syndrome の一例,
日本内分泌学会雑誌, Vol.84, 105-106, 2008.
(CiNii: 1571698600655152768)
3. 佐久間 洋二朗, 奈部 浩一郎, 本庶 祥子, 池田 弘毅, 青山 倫久, 木村 哲也, Kazuhiro Nomura, 浜本 芳之, 和田 良春 and 越山 裕行 :
A case record of a patient with diabetes mellitus and MEN1,
糖尿病診療マスター, Vol.6, No.3, 309-313, 2008.
(DOI: 10.11477/mf.1415100818,   CiNii: 1390565159930841472)

Academic Letter:

1. Tetsuya Hosooka, Kazuhiro Nomura and Wataru Ogawa :
Vascular endothelial growth factor-B as a therapeutic target to prevent ectopic fat deposition.,
Journal of Diabetes Investigation, Vol.4, No.6, 525-527, 2013.
(DOI: 10.1111/jdi.12099,   PubMed: 24843704)
2. Wataru Ogawa and Kazuhiro Nomura :
Does adiponectin mimic exercise?,
Journal of Diabetes Investigation, Vol.1, No.6, 239-241, 2010.
(DOI: 10.1111/j.2040-1124.2010.00057.x,   PubMed: 24843438)

Review, Commentary:

1. Kazuhiro Nomura and 小川 渉 :
骨格筋の分子生物学,
日本臨床 = Japanese journal of clinical medicine, Vol.80, No.4, 681-686, Apr. 2022.
(CiNii: 1523106606091371136)
2. Kazuhiro Nomura, 平田 悠 and 小川 渉 :
糖尿病とサルコペニア,
医学のあゆみ, Vol.276, No.5, 405-409, Jan. 2021.
(CiNii: 1523669556008449664)
3. K Nabe, S Honjo, H Ikeda, Y Wada, Kazuhiro Nomura, Y Hamamoto, T Koh, Y Tatsuoka and H Koshiyama :
Diabetes insipidus and cognitive function.,
Medical Hypotheses, Vol.69, No.4, 764-766, Apr. 2007.
(DOI: 10.1016/j.mehy.2007.01.081,   PubMed: 17467188)
4. M Noda, Kazuhiro Nomura, Y Asou, H Nemoto, M Ishijima, M Takamoto, M Usui and K Kashimada :
[Bone metabolism and angiogenesis].,
Clinical calcium, Vol.11, No.4, 404-410, Apr. 2001.
(PubMed: 15775533)
5. Kazuhiro Nomura, H Imai, T Koumura and Y Nakagawa :
Involvement of mitochondrial phospholipid hydroperoxide glutathione peroxidase as an antiapoptotic factor.,
Biological signals and receptors, Vol.10, No.1-2, 81-92, 2001.
(DOI: 10.1159/000046877,   PubMed: 11223642)

Proceeding of International Conference:

1. K Uchiyama, Y Hirata, Kazuhiro Nomura, H Wijaya, M Taniguchi, S Kitaoka, T Furuyashiki and W Ogawa :
Mental stress induces muscle atrophy through brain inflammation and the C/EBPβδ pathway in skeletal muscle,
The 50th European Muscle Conference, Sep. 2023.
2. K Hozumi, K Sugawara, Y Hirata, Kazuhiro Nomura and W Ogawa :
Effects of Imeglimin on Mitochondrial Function, AMPK Activation, and Gene Expression in Hepatocytes and Myocytes,
The 50th European Muscle Conference, Sep. 2023.
3. T Inoue, Y Hirata, Kazuhiro Nomura and W Ogawa :
Role of myofiber Piezo1 in skeletal muscle hypertrophy induced by mechanical load,
The 50th European Muscle Conference, Sep. 2023.
4. Y Hirata, Kazuhiro Nomura and W Ogawa :
A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy,
The 50th European Muscle Conference, Sep. 2023.

Proceeding of Domestic Conference:

1. Kazuhiro Nomura and 小川 渉 :
運動療法に抵抗性を示す痩せにくい肥満,
第67回日本糖尿病学会年次学術集会シンポジウム, May 2024.
2. Sonoko Yasui-Yamada, Miyu Kubo, Yuna Izumi, Kazuhiro Nomura, Seiichiro Kamimura, Hideya Kashihara, Yu Saitou, Yoshiaki Kitamura, Mitsuo Shimada, Yasuhiro Hamada and Hiroshi Sakaue :
簡便に得られるデータから作成した四肢骨格筋量を予測する回帰式の妥当性検証,
第27回 日本病態栄養学会年次学術集会, Jan. 2024.
3. 橋本 脩平, 鈴木 佳子, 小笠 有加, 筑後 桃子, 橋本 一郎, 岩本 晃一, 美馬 俊介, 大藤 純, Kazuhiro Nomura and Hiroshi Sakaue :
自家培養表皮(ジェイス)移植を受けた広範囲熱傷患者の栄養管理 シングル・ケース・スタディ,
第27回 日本病態栄養学会年次学術集会, Jan. 2024.
4. Yuna Izumi, FUJIMOTO Saori, 谷口 萌々花, 大村 皐月, Sonoko Yasui-Yamada, 志内 哲也, 岡松 優子, 米代 武司, Kazuhiro Nomura, 堤 理恵 and Hiroshi Sakaue :
骨格筋-BAT間アミノ酸代謝連関に対する制御機構の解明,
第44回日本肥満学会学術集会, Nov. 2023.
5. 大村 皐月, Yuna Izumi, Kazuhiro Nomura, Sonoko Yasui-Yamada, 志内 哲也, 岡松 優子, 米代 武司, 堤 理恵 and Hiroshi Sakaue :
臓器間アミノ酸代謝連関の調節因子としての骨格筋由来IL-6発現メカニズムの解明,
第56回栄養・食糧学会中国四国支部大会, Oct. 2023.
6. 村上 遥音, Yuna Izumi, 鈴木 由紀, Sonoko Yasui-Yamada, Kazuhiro Nomura, 堤 理恵 and Hiroshi Sakaue :
廃用性筋萎縮の骨格筋代謝動態に対するMCT配合ケトン食の影響,
第56回栄養・食糧学会中国四国支部大会, Oct. 2023.
7. 筑後 桃子, 堤 理恵, 山田 静恵, 小笠 有加, 橋本 脩平, 藤本 紗織, 鈴木 佳子, Kazuhiro Nomura and Hiroshi Sakaue :
当院における早期栄養介入の現状と今後の課題,
第15回日本臨床栄養代謝学会中国四国支部学術集会, Sep. 2023.
8. Yuna Izumi, FUJIMOTO Saori, 谷口 萌々花, 大村 皐月, 志内 哲也, 岡松 優子, 米代 武司, 黒田 雅士, Kazuhiro Nomura, 堤 理恵 and Hiroshi Sakaue :
骨格筋による新たな体温維持機構の発見とその制御分子の同定,
第9回日本筋学会学術集会, Aug. 2023.
9. 平田 悠, Kazuhiro Nomura and 小川 渉 :
不動化における筋量制御のメカニズム,
第96回日本内分泌学会学術総会, Jun. 2023.
10. 内山 奏, 平田 悠, Kazuhiro Nomura, Wijaya Hendy, 谷口 将之, 北岡 志保, 古屋敷 智之 and 小川 渉 :
脳内炎症は骨格筋のC/EBP経路を介してストレス性筋萎縮を促進する,
第66回日本糖尿病学会年次学術総会, May 2023.
11. 内山 奏, 平田 悠, Kazuhiro Nomura, Wijaya Hendy, 谷口 将之, 北岡 志保, 古屋敷 智之 and 小川 渉 :
脳内炎症は骨格筋のC/EBP経路を介してストレス性筋萎縮を促進する,
第58回日本臨床分子医学会学術総会, Apr. 2023.
12. Kazuhiro Nomura and 小川 渉 :
運動による骨格筋リモデリングの活性化と加齢による破綻メカニズム,
第65回日本糖尿病学会年次学術集会シンポジウム, May 2022.
13. Kazuhiro Nomura, Krook Anna, Zierath Juleen and 小川 渉 :
肥満と老化による骨格筋機能の低下メカニズム,
40回日本肥満学会シンポジウム, Nov. 2019.
14. Kazuhiro Nomura, 細岡 哲也, 佐々木 努, 北村 忠弘, Hiroshi Sakaue, 春日 雅人 and 小川 渉 :
肥満における骨格筋アドレナリン抵抗性の関与とPGC-1α新規アイソフォームの役割,
Folia endocrinologica Japonica, Vol.92, No.1, 247, Apr. 2016.
15. Kazuhiro Nomura, 細岡 哲也, 佐々木 努, 北村 忠弘, Hiroshi Sakaue, 春日 雅人 and 小川 渉 :
肥満における骨格筋アドレナリン抵抗性の関与とPGC-1α新規アイソフォームの役割,
Folia endocrinologica Japonica, Vol.92, No.1, 247, Apr. 2016.
16. Kazuhiro Nomura, 水崎 奈央, 細岡 哲也, 佐々木 努, 北村 忠弘, Hiroshi Sakaue, 春日 雅人 and 小川 渉 :
骨格筋のアドレナリン抵抗性はPGC-1α新規アイソフォームの誘導不全により肥満を惹起する,
日本臨床分子医学会学術総会, Apr. 2014.
17. Kazuhiro Nomura, 水崎 奈央, 細岡 哲也, 佐々木 努, 北村 忠弘, Hiroshi Sakaue, 春日 雅人 and 小川 渉 :
骨格筋のアドレナリン抵抗性はPGC1α新規アイソフォームの誘導不全により肥満を惹起する,
Journal of the The Japan Diabetes Society, Vol.57, No.Suppl.1, S-423, 2014.