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Tokushima UniversityGraduate School of Technology, Industrial and Social SciencesDivision of Bioscience and BioindustryBioengineeringBiomolecular Functions and Technology
Tokushima UniversityFaculty of Bioscience and BioindustryDepartment of Bioscience and BioindustryApplied Life Science
Tokushima UniversityFaculty of Bioscience and BioindustryDepartment of Bioscience and BioindustryFood Science
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Research Activity

His Web Page

Field of Study

Biochemistry, Cell Physiology, Molecular Cell Biology, Developmental Biology

Subject of Study

Studies on Water Channel, Aquaporin, Studies on Processing Protease, Studies on Oral Tissue Development (Aquaporin, Water Channel, processing protease, proprotein convertase, Oral Tissue, development)

Book / Paper

Book:

1. Tetsuya Akamatsu, Chenjuan Yao and Kazuo Hosoi :
Methods for animal tissue culture and techniques to prevent cell death, growth defect, and cell mutation,
Technical Information Institute Co., Ltd., Apr. 2014.
2. Kazuo Hosoi, Tetsuya Akamatsu and others :
Special Oral Biology - Salivary Glands,
Gakken Shoin, Tokyo, Feb. 2006.
3. Kazuo Hosoi, Tomihiko Higuti, Masanori Kashimata, Rieko Arakaki, Naokatu Arakaki, Jun Tada, Keiko Tsumura, Tetsuya Akamatsu, Kyouko Takeda, Akemichi Ueno, Midori Suenaga, Yoshinobu Baba and others :
Experimental Manual for Molecular Cell Biology, 2nd Edition,
Nankodo, Tokyo, Apr. 2004.
4. Hideaki Nagamune, Kazuaki Muramatsu, Masakatsu Higashine, Tetsuya Akamatsu, Yasuhiro Tamai, Yasuo Yonetomi, Akihiko Tsuji, Keisuke Izumi, Takemasa Sakaguchi, Tetsuya Yoshida and Yoshiko Matsuda :
Cyclic AMP-inducible procalcitonin processing in thyroidal parafollicular cells is regulated by the Kexin family protease, PC1.,
IOS Press, Amsterdam, Mar. 1997.

Academic Paper (Judged Full Paper):

1. Hiroshi Yoshimura, Sugai Tokio, Kato Nobuo, Tominaga Takashi, Tominaga Yoko, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
Interplay between non-NMDA and NMDA receptor activation during oscillatory wave propagation: Analyses of caffeine-induced oscillations in the visual cortex of rats,
Neural Networks, Vol.79, 141-149, 2016.
(DOI: 10.1016/j.neunet.2016.03.012,   PubMed: 27136667)
2. Hiroshi Yoshimura, 川邊 真道, 須貝 外喜夫, 加藤 伸郎, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
Influences of oral impairment on neural oscilltion and wave propagation in the neocortex of rats,
Neuroscience Research Suppl, Vol.Suppl, 2015.
3. Gang Chen, Chenjuan Yao, Takahiro Hasegawa, Tetsuya Akamatsu, Hiroshi Yoshimura and Kazuo Hosoi :
Effects of isoproterenol on aquaporin 5 levels in the parotid gland of mice in vivo.,
American Journal of Physiology, Endocrinology and Metabolism, Vol.306, No.1, E100-E108, 2014.
(DOI: 10.1152/ajpendo.00317.2013,   PubMed: 24192288,   Elsevier: Scopus)
4. Hiroshi Yoshimura, Tokio Sugai, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Nobuo Kato :
Age-dependent emergence of caffeine-assisted voltage oscillations in the endopiriform nucleus of rats.,
Neuroscience Research, Vol.76, No.1-2, 16-21, 2013.
(DOI: 10.1016/j.neures.2013.02.010,   PubMed: 23517711,   Elsevier: Scopus)
5. Nunuk Purwanti, Mileva Ratko Karabasil, Shinsuke Matsuo, Gang Chen, Javkhlan Purevjav, Ahmad Azlina, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
Induction of Sca-1 via activation of STAT3 system in the duct cells of the mouse submandibular gland by ligation of the main excretory duct,
American Journal of Physiology, Gastrointestinal and Liver Physiology, Vol.301, No.5, G814-G824, 2011.
(DOI: 10.1152/ajpgi.00408.2010,   PubMed: 21868636)
6. Purevjav Javkhlan, Yuka Hiroshima, Ahmad Azlina, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu, Jun-ichi Kido, Toshihiko Nagata and Kazuo Hosoi :
Lipopolysaccharide-mediated induction of calprotectin in the submandibular and parotid glands of mice,
Inflammation, Vol.34, No.6, 668-680, 2011.
(DOI: 10.1007/s10753-010-9277-1,   PubMed: 21125321)
7. Takahiro Hasegawa, Ahmad Azlina, Javkhlan Purevjav, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
Novel phosphorylation of aquaporin-5 at its threonine 259 through cAMP signaling,
American Journal of Physiology, Cell Physiology, Vol.301, No.3, C667-C678, 2011.
(DOI: 10.1152/ajpcell.00058.2011,   PubMed: 21633078)
8. Nunuk Purwanti, Daisuke Tsuji, Ahmad Azlina, Mileva Ratko Karabasil, Purevjav Javkhlan, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu, Kouji Itou and Kazuo Hosoi :
Induction of Sca-1 in the duct cells of the mouse submandibular gland by obstruction of the main excretory duct,
Journal of Oral Pathology & Medicine, Vol.40, No.8, 651-658, 2011.
(DOI: 10.1111/j.1600-0714.2011.01011.x,   PubMed: 21884259)
9. Mileva Ratko Karabasil, Takahiro Hasegawa, Ahmad Azlina, Nunuk Purwanti, Chenjuan Yao, Tetsuya Akamatsu, Shigemasa Tomioka and Kazuo Hosoi :
Effects of naturally occurring G103D point mutation of AQP5 on its water permeability, trafficking, and cellular localization in the submandibular gland of rats,
Biology of the Cell, Vol.103, No.2, 69-86, 2011.
(DOI: 10.1042/BC20100086,   PubMed: 21138418)
10. Ahmad Azlina, Purevjav Javkhlan, Yuka Hiroshima, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
Roles of lysosomal proteolytic systems in AQP5 degradation in the submandibular gland of rats following chorda tympani parasympathetic denervation,
American Journal of Physiology, Gastrointestinal and Liver Physiology, Vol.299, No.5, G1106-G1117, 2010.
(DOI: 10.1152/ajpgi.00194.2010,   PubMed: 20689061)
11. Chenjuan Yao, Nunuk Purwanti, Mileva Ratko Karabasil, Ahmad Azlina, Javkhlan Purevjav, Takahiro Hasegawa, Tetsuya Akamatsu, Toru Hosoi, Koichiro Ozawa and Kazuo Hosoi :
Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-κB and p-c-Jun/c-Fos,
The American Journal of Pathology, Vol.177, No.2, 724-734, 2010.
(DOI: 10.2353/ajpath.2010.090282,   PubMed: 20522648)
12. Mileva Ratko Karabasil, Takahiro Hasegawa, Ahmad Azlina, Nunuk Purwanti, Javkhlan Purevjav, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
Trafficking of GFP-AQP5 chimeric proteins conferred with unphosphorylated amino acids at their PKA-target motif (152SRRTS) in MDCK-II cells,
The Journal of Medical Investigation : JMI, Vol.56, No.1, 2, 55-63, 2009.
(Tokushima University Institutional Repository: 111308,   DOI: 10.2152/jmi.56.55,   PubMed: 19262015)
13. Tetsuya Akamatsu, Ahmad Azlina, Nunuk Purwanti, Mileva Ratko Karabasil, Takahiro Hasegawa, Chenjuan Yao and Kazuo Hosoi :
Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland,
Developmental Biology, Vol.325, No.2, 434-443, 2009.
(DOI: 10.1016/j.ydbio.2008.10.015,   PubMed: 19013448)
14. Xuefei Li, Ahmad Azlina, Mileva Ratko Karabasil, Nunuk Purwanti, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic agonist,
American Journal of Physiology, Gastrointestinal and Liver Physiology, Vol.295, No.1, G112-G123, 2008.
(DOI: 10.1152/ajpgi.00359.2007,   PubMed: 18450949)
15. Tetsuya Akamatsu, Nunuk Purwanti, Mileva Ratko Karabasil, Xuefei Li, Chenjuan Yao, Norio Kanamori and Kazuo Hosoi :
Temporospatially regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during development of the rat submandibular gland,
Developmental Dynamics, Vol.236, No.1, 314-320, 2007.
(DOI: 10.1002/dvdy.21008,   PubMed: 17083113)
16. Kwartarini Murdiastuti, Nunuk Purwanti, Mileva Ratko Karabasil, Xuefei Li, Chenjuan Yao, Tetsuya Akamatsu, Norio Kanamori and Kazuo Hosoi :
A naturally occurring point mutation in the rat aquaporin 5 gene, influencing its protein production by and secretion of water from salivary glands,
American Journal of Physiology, Gastrointestinal and Liver Physiology, Vol.291, No.6, GI1081-GI1088, 2006.
(DOI: 10.1152/ajpgi.00449.2005,   PubMed: 16901987)
17. Chisato Kosugi, Xuefei Li, Chenjuan Yao, Tetsuya Akamatsu, Norio Kanamori and Kazuo Hosoi :
Protein kinase A-regulated membrane trafficking of a green fluorescent protein-aquaporin 5 chimera in MDCK cells,
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.1763, No.4, 337-344, 2006.
(DOI: 10.1016/j.bbamcr.2006.02.005,   PubMed: 16603260)
18. Chenjuan Yao, Mileva Ratko Karabasil, Nunuk Purwanti, Xuefei Li, Tetsuya Akamatsu, Norio Kanamori and Kazuo Hosoi :
Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1b in the submandibular gland of mice,
The Journal of Biological Chemistry, Vol.281, No.12, 7968-7976, 2006.
(DOI: 10.1074/jbc.M507705200,   PubMed: 16423834)
19. Keiko Tsumura, Xuefei Li, Kwartarini Murdiastuti, Most Nahid Parvin, Tetsuya Akamatsu, Chenjuan Yao, Norio Kanamori, Kiyotoshi Inenaga, Hiroshi Yamashita and Kazuo Hosoi :
Downregulation of AQP2 expression in the kidney of polydipsic STR/N mice,
American Journal of Physiology, Renal Physiology, Vol.290, No.2, F478-F485, 2006.
(DOI: 10.1152/ajprenal.00029.2005,   PubMed: 16144968,   Elsevier: Scopus)
20. Chenjuan Yao, Xuefei Li, Murdiastuti Kwartarini, Chisato Kosugi, Tetsuya Akamatsu, Norio Kanamori and Kazuo Hosoi :
Lipopolysaccharide-induced elevation and secretion of Interleukin-1b in the submandibular gland of male mice,
Immunology, Vol.116, No.2, 213-222, 2005.
(DOI: 10.1111/j.1365-2567.2005.02212.x,   PubMed: 16162270)
21. Most Nahid Parvin, Shingo Kurabuchi, Kwartarini Murdiastuti, Chenjuan Yao, Chisato Kosugi, Tetsuya Akamatsu, Norio Kanamori and Kazuo Hosoi :
Subcellular redistribution of AQP5 by vasoactive intestinal polypeptide (VIP) in the Brunner's gland of the rat duodenum,
American Journal of Physiology, Gastrointestinal and Liver Physiology, Vol.288, No.6, G1283-G1291, 2005.
(DOI: 10.1152/ajpgi.00030.2004,   PubMed: 15650134)
22. Tetsuya Akamatsu, Most Nahid Parvin, Kwartarini Murdiastuti, Chisato Kosugi, Chenjuan Yao, Osamu Miki, Norio Kanamori and Kazuo Hosoi :
Expression and localization of aquaporins, members of the water channel family, during development of the rat submandibular gland.,
Pflügers Archiv : European Journal of Physiology, Vol.446, No.6, 641-651, 2003.
(DOI: 10.1007/s00424-003-1109-9,   PubMed: 12838423)
23. Kwartarini Murdiastuti, Osamu Miki, Chenjuan Yao, Most Nahid Parvin, Chisato Kosugi, Tetsuya Akamatsu, Norio Kanamori and Kazuo Hosoi :
Divergent expression and localization of aquaporin 5, an exocrine-type water channel, in the submandibular gland of Sprague-Dawley rats.,
Pflügers Archiv : European Journal of Physiology, Vol.445, No.3, 405-412, 2002.
(DOI: 10.1007/s00424-002-0940-8)
24. Kwartarini Murdiastuti, Osamu Miki, Chenjuan Yao, Nahid Most. Parvin, Tetsuya Akamatsu, Tetsuya Akamatsu, Norio Kanamori, Norio Kanamori and Keiko Tsumura :
Divergent expression and localization of aquaporin 5, an exocrine-type water channel, in the submandibular gland of Sprague-Dawley rats.,
Pflügers Archiv : European Journal of Physiology, Vol.445, No.3, 405-412, 2002.
25. Most Nahid Parvin, Keiko Tsumura, Tetsuya Akamatsu, Norio Kanamori and Kazuo Hosoi :
Expression and localization of AOP5 in the stomach and duodenum of the rat.,
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.1542, No.1-3, 116-124, 2002.
(DOI: 10.1016/S0167-4889(01)00172-0,   PubMed: 11853885)
26. Norio Kanamori, Tetsuya Akamatsu, Chisato Kosugi, Most Nahid Parvin and Kazuo Hosoi :
Methylene blue as a vascular filling dye.,
ITE Leters on Batteries, New Technologies & Medicine (with News), Vol.3, No.1, 75-77, 2002.
27. Wei Wei, Most Nahid Parvin, Keiko Tsumura, Tetsuya Akamatsu, Jun Tada, Norio Kanamori and Kazuo Hosoi :
Induction of C-reactive protein, serum amyloid P component, and kininogens in the submandibular and lacrimal glands of rats with experimentally induced inflammation.,
Life Sciences, Vol.69, No.3, 359-368, 2001.
28. Most Nahid Parvin, Kwartarini Murdiastuti, Tetsuya Akamatsu, Norio Kanamori, Norihiko Maeda and Kazuo Hosoi :
Expression and locarization of AQP4 in the crypt epithelial cells of the rat duodenum.,
Biomedical Research (India), Vol.12, No.2, 77-82, 2001.
29. Norio Kanamori, Tetsuya Akamatsu, Jun Tada, Keiko Tsumura, Most Nahid Parvin, Kwartarini Murdiastui, Wei Wei and Kazuo Hosoi :
Search for the dye that stains the vascular system.,
ITE Leters on Batteries, New Technologies & Medicine (with News), Vol.2, No.1, 116-119, 2001.
30. Tetsuya Akamatsu, Yoshiko Matsuda, Keiko Tsumura, Jun Tada, Most Nahid Parvin, Wei Wei, Norio Kanamori and Kazuo Hosoi :
Highly regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during dentinogenesis.,
Biochemical and Biophysical Research Communications, Vol.272, No.2, 410-415, 2000.
(DOI: 10.1006/bbrc.2000.2752,   PubMed: 10833428,   Elsevier: Scopus)
31. Kazuo Hosoi, Sachiko Matsuura, Keiko Tsumura, Wei Wei, Most Nahid Parvin, Jun Tada, Tetsuya Akamatsu, Norio Kanamori and Kazuo Suzuki :
Expression of kininogens in the connective tissue-type mast cells of the rats.,
Immunology, Vol.101, No.4, 531-540, 2000.
(DOI: 10.1046/j.1365-2567.2000.00132.x,   PubMed: 11122457,   Elsevier: Scopus)
32. Jun Tada, Takamasa Sawa, Naoki Yamanaka, Masayuki Shono, Tetsuya Akamatsu, Keiko Tsumura, Most Nahid Parvin, Norio Kanamori and Kazuo Hosoi :
Involvement of vesicle-cytoskeleton interaction in AQP5 trafficking in AQP5-gene-transfected HSG cells.,
Biochemical and Biophysical Research Communications, Vol.266, No.2, 443-447, 1999.
33. Tetsuya Akamatsu, Yoshiko Matsuda, Keiko Tsumura, Jun Tada, Most Nahid Parvin, Norio Kanamori and Kazuo Hosoi :
Subtilisin-like proprotein convertase PACE4 (SPC4) is a candidate processing enzyme of bone morphogenetic proteins during tooth formation,
Developmental Dynamics, Vol.216, No.4/5, 481-488, 1999.
34. Akihiko Tsuji, Chiemi Hine, Yasuhiro Tamai, Kayoko Yonemoto, Kazushige Mori, Shigeru Yoshida, Miwa Bando, Eri Sakai, Kenji Mori, Tetsuya Akamatsu and Yoshiko Matsuda :
Genomic organization and alternative splicing of human PACE4 (SPC4), Kexin-like processing endoprotease.,
The Journal of Biochemistry, Vol.122, No.2, 438-452, 1997.
35. Tetsuya Akamatsu, Shigeo Daikoku, Hideaki Nagamune, Shigeru Yoshida, Kenji Mori, Akihiko Tsuji and Yoshiko Matsuda :
Developmental expression of a novel Kexin family protease, PACE4E, in the rat olfactory system.,
Histochemistry and Cell Biology, Vol.108, No.2, 95-103, 1997.
36. Kenji Mori, Sachiko Kii, Akihiko Tsuji, Masami Nagahama, Akiyoshi Imamaki, Keiko Hayashi, Tetsuya Akamatsu, Hideaki Nagamune and Yoshiko Matsuda :
A Novel Human PACE4 Isoform, PACE4E Is an Active Processing Protease Containing a Hydrophobic Cluster at the Carboxy Terminus,
The Journal of Biochemistry, Vol.121, No.5, 941-948, 1997.
37. Hideaki Nagamune, Kazuaki Muramatsu, Tetsuya Akamatsu, Yasuhiro Tamai, Keisuke Izumi, Akihiko Tsuji and Yoshiko Matsuda :
Distribution of the kexin family proteases in pancreatic islets., --- PACE4C is specifically expressed in B cells of pancreatic islets ---,
Endocrinology, Vol.136, No.1, 357-360, 1995.
38. Akihiko Tsuji, Tetsuya Akamatsu, Hideaki Nagamune and Yoshiko Matsuda :
Identification of targeting proteinase for rat α1-macroglobulin in vivo., --- Mast-cell tryptase is a major component of the α1-macroglobulin-proteinase complex endocytosed into rat liver lysosomes. ---,
The Biochemical Journal, Vol.298, No.1, 79-85, 1994.

Academic Paper (Unrefereed Paper):

1. Chenjuan Yao, Tetsuya Akamatsu, Takahiro Hasegawa and Hiroshi Yoshimura :
The Defense System of Oral Cavity: Lipopolysaccharide Induced Inflammatory Response in the Mice Salivary Gland,
BIT's 1st Annual World Congress of Oral & Dental Medicine Conference Abstract Book, 107, 2014.
2. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Salivary Gland Development, Differentiation, and Regeneration - Role of Subtilisin-like Proprotein Convertase PACE4/SPC4,
BIT's 1st Annual World Congress of Oral & Dental Medicine Conference Abstract Book, 59, 2014.
3. Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Hiroshi Yoshimura :
Enhanced ubiquitylation and downregulation of aquaporin-5 by ubiquitin ligases,
Journal of Oral Biosciences, Vol.Suppl., 204, 2014.
4. Chenjuan Yao, Tetsuya Akamatsu, Takahiro Hasegawa and Hiroshi Yoshimura :
Expression of water channel AQP5 in regeneration model of salivary gland,
Journal of Oral Biosciences, Vol.Suppl., 204, 2014.
5. Minegishi Makoto, Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Induced expression of subtilisin-like proprotein convertase in regeneration model of salivary gland,
Journal of Oral Biosciences, Vol.Suppl., 138, 2014.

Review, Commentary:

1. Kazuo Hosoi, Chenjuan Yao, Takahiro Hasegawa, Hiroshi Yoshimura and Tetsuya Akamatsu :
Dynamics of Salivary Gland AQP5 under Normal and Pathologic Conditions,
International Journal of Molecular Sciences, Vol.21, No.4, 1182, Feb. 2020.
(Tokushima University Institutional Repository: 114575,   DOI: 10.3390/ijms21041182,   Elsevier: Scopus)
2. Tetsuya Akamatsu :
Structure and Function of the Salivary Gland,
Journal of Oral Health and Biosciences, Vol.28, No.2, 77-86, Feb. 2016.
(Tokushima University Institutional Repository: 109872,   CiNii: 120005823527)
3. Tetsuya Akamatsu :
Physiological role of a subtilisin-like proprotein convertase, PACE4, in submandibular gland development,
Journal of Oral Biosciences, Vol.52, No.2, 81-93, May 2010.
(DOI: 10.2330/joralbiosci.52.81,   CiNii: 10027105459)
4. Most Parvin Nahid, Jun Tada, Tetsuya Akamatsu and Kazuo Hosoi :
Structure, function, and transcriptional regulation of aquaporins, proteins of the water channel family,
Dentistry in Japan, Vol.37, 26-31, Mar. 2001.
5. Yoshiko Matsuda, Akihiko Tsuji, Hideaki Nagamune, Tetsuya Akamatsu, Chiemi Hine, Kazuaki Muramatsu, Kenji Mori, Yasuhiro Tamai and Kayoko Yonemoto :
Novel members of mammalian Kexin family proteases, PACE4C, PACE4D, PC7A and PC7B.,
Advances in Experimental Medicine and Biology, Vol.389, 63-71, Sep. 1996.

Proceeding of International Conference:

1. Chenjuan Yao, Tetsuya Akamatsu, Takahiro Hasegawa and Hiroshi Yoshimura :
Induced expression of a subtilisin-like proprotein convertase PACE4 in the regeneration model of rat submandibular gland.,
The 4th International Symposium on Salivary Glands in Honor of Niels Stensen, Okazaki (Japan), Nov. 2016.
2. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Sexual difference in the regeneration model of the rat submandibular gland.,
The 4th International Symposium on Salivary Glands in Honor of Niels Stensen, Okazaki (Japan), Nov. 2016.
3. Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Hiroshi Yoshimura :
Post-translational modifications of water channel aquaporin-5 in salivary gland cells, Oral Neuroscience 2016,
Oral Neuroscience 2016, Osaka, Oct. 2016.
4. Hiroshi Yoshimura, Tetsuya Akamatsu, Chenjuan Yao and Takahiro Hasegawa :
Synaptic plasticity in the brain -Roles of NMDA receptor- (Invited lecture at Nantong University),
Sep. 2016.
5. Chenjuan Yao, Tetsuya Akamatsu, Takahiro Hasegawa and Hiroshi Yoshimura :
The Defense System of Oral Cavity: Lipopolysaccharide Induced Inflammatory Response in the Mice Salivary Gland,
Haikou, China, Nov. 2014.
6. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Salivary Gland Development, Differentiation, and Regeneration - Role of Subtilisin-like Proprotein Convertase PACE4/SPC4,
Haikou, China, Nov. 2014.
7. Mileva Ratko Karabasil, Kwartarini Murdiastuti, Nunuk Purwanti, Azlina Ahmad, Javkhlan Purevjav, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
Effects of natural point mutation of rat aquaporin 5 expressed in vitro on its capacity of water permeability and membrane trafficking,
The Journal of Medical Investigation : JMI, Vol.56, No.Suppl, 398-400, Tokushima, Dec. 2009.
(Tokushima University Institutional Repository: 111488,   DOI: 10.2152/jmi.56.398,   PubMed: 20224238)
8. Purevjav Javkhlan, Yuka Hiroshima, Azlina Ahmad, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu, Jun-ichi Kido, Toshihiko Nagata and Kazuo Hosoi :
Induction of calprotectin mRNAs by lipopolysaccharide in the salivary gland of mice,
The Journal of Medical Investigation : JMI, Vol.56, No.Suppl, 287-289, Tokushima, Dec. 2009.
(Tokushima University Institutional Repository: 111354,   DOI: 10.2152/jmi.56.287,   PubMed: 20224205)
9. Azlina Ahmad, Xuefei Li, Purevjav Javkhlan, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
Down-regulation of submandibular gland AQP5 following parasympathetic denervation in rats,
The Journal of Medical Investigation : JMI, Vol.56, No.Suppl, 273-276, Tokushima, Dec. 2009.
(Tokushima University Institutional Repository: 111348,   DOI: 10.2152/jmi.56.273,   PubMed: 20224200)
10. Nunuk Purwanti, Azlina Ahmad, Mileva Ratko Karabasil, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
Involvement of the IL-6/STAT3/Sca-1 system in proliferation of duct cells following duct ligation in the submandibular gland of mice,
The Journal of Medical Investigation : JMI, Vol.56, No.Suppl, 253-254, Tokushima, Dec. 2009.
(Tokushima University Institutional Repository: 111340,   DOI: 10.2152/jmi.56.253,   PubMed: 20224192)
11. Tetsuya Akamatsu, Azlina Ahmad, Purevjav Javkhlan, Takahiro Hasegawa, Chenjuan Yao and Kazuo Hosoi :
Salivary Gland Development: Its mediation by a subtilisin-like proprotein convertase, PACE4,
The Journal of Medical Investigation : JMI, Vol.56, No.Suppl, 241-246, Tokushima, Dec. 2009.
(Tokushima University Institutional Repository: 111337,   DOI: 10.2152/jmi.56.241,   PubMed: 20224189)
12. Kazuo Hosoi, Shingo Kurabuchi, Yamato Kikkawa, Jun Tada, Tetsuya Akamatsu, Naoki Yamanaka, Takuya Matsumoto, Norio Kanamori and Keiko Tsumura :
Salivary gland tissue kallikrein family and processing of growth factor precursors and proenzymes.,
European Journal of Morphology, Vol.36, No.suppl, 82-85, Cagliari, Italy, Aug. 1998.
13. Hideaki Nagamune, Kazuaki Muramatsu, Masakatsu Higashine, Tetsuya Akamatsu, Yasuhiro Tamai, Yasuo Yonetomi, Akihiko Tsuji, Keisuke Izumi, Takemasa Sakaguchi, Tetsuya Yoshida and Yoshiko Matsuda :
Cyclic AMP-inducible procalcitonin processing in thyroidal parafollicular cells is regulated by the Kexin family protease, PC1.,
International Symposium on Medical Aspects of Protease Inhibitors; In "Medical Aspects of Proteases and Protease Inhibitors": Biomedical and Health Research, Vol.15, 22-33, Amsterdam, May 1997.

Proceeding of Domestic Conference:

1. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Involvment of subtilisin-like proprotein convertase PACE4 in regeneration of salivary gland,
第55回歯科基礎医学会(2013年9月19日-21日),
2. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Involvment of subtilisin-like proprotein convertase PACE4 in regeneration of salivary gland,
第55回歯科基礎医学会[2013年9月19日(金)-21日(日)],
3. Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
唾液腺細胞におけるアクアポリン5の翻訳後修飾,
第53回歯科基礎医学会学術大会(2011年9月30日-10月2日)サテライトシンポジウムSS11,
4. Maeda Saori, Hiroshi Yoshimura, Miyaji Yuji, Hiroyuki Kanayama, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
Increase in theta-band EEG activities under tasting chocolate with unmatched odor stimulation,
第41回日本神経科学大会, Jul. 2018.
5. 前田 さおり, Hiroshi Yoshimura, 宮地 ゆうじ, 金山 宏幸, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
Theta band brain activity during checking the unmatched olfactory-taste information,
第95回日本生理学大会, Mar. 2018.
6. 前田 さおり, 宮地 裕司, 金山 宏幸, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Hiroshi Yoshimura :
甘味とニオイのミスマッチが甘味認知に与える影響,
第69回日本生理学会中国・四国地方会, Oct. 2017.
7. Mio Hata, Tetsuya Akamatsu, Chenjuan Yao, 前田 さおり, 宮地 裕司, 金山 宏幸, Takahiro Hasegawa and Hiroshi Yoshimura :
唾液腺再生モデルにおける雌雄差の影響,
第69回日本生理学会中国・四国地方会, Oct. 2017.
8. 前田 さおり, Hiroshi Yoshimura, 宮地 ゆうじ, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
Influences of Match/Mismatch of taste and odor on taste perception: An electroencephalogram frequency analysis study,
日本味と匂学会第51回大会, Sep. 2017.
9. Hiroshi Yoshimura, 須貝 外喜夫, 加藤 伸郎, 冨永 貴志, 冨永 洋子, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
カフェイン投与により誘発される視覚野オシレーション におけるnon-NMDA受容体とNMDA受容体の相互交錯的関与,
第40回日本神経科学大会, Jul. 2017.
10. Maeda Saori, Miyachi Yuki, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Hiroshi Yoshimura :
Influences of olfactory stimulation on taste perception: An electroencephalogram frequency analysis study,
The 94th Annual Meeting of the Physiological Science of Japan, Mar. 2017.
11. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Sexual difference in regeneration of salivary gland,
第58回歯科基礎医学会学術大会, Aug. 2016.
12. Shimatani Tatsuya, Minegishi Makoto, Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Induction of a subtilisin-like proprotein convertase PACE4 in regeneration model of salivary gland Part II,
第58回歯科基礎医学会学術大会, Aug. 2016.
13. Hiroshi Yoshimura, 川邊 真道, 須貝 外喜夫, 加藤 伸郎, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
Influences of oral impairment on neural oscilltion and wave propagation in the neocortex of rats,
第38回日本神経科学大会, Jul. 2015.
14. Tetsuya Akamatsu :
Structure and Function of the Salivary Gland,
Jun. 2015.
15. Chenjuan Yao, Tetsuya Akamatsu, Takahiro Hasegawa and Hiroshi Yoshimura :
Expression of water channel AQP5 in regeneration model of salivary gland,
第56回歯科基礎医学会, Sep. 2014.
16. Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Hiroshi Yoshimura :
Enhanced ubiquitylation and downregulation of aquaporin-5 by ubiquitin ligases,
第56回歯科基礎医学会, Sep. 2014.
17. Minegishi Makoto, Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Induced expression of subtilisin-like proprotein convertase in regeneration model of salivary gland,
第56回歯科基礎医学会(福岡国際会議場/福岡県), Sep. 2014.
18. Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Hiroshi Yoshimura :
ヒト唾液腺HSG細胞における構成的なAQP5の取り込み,
第55回歯科基礎医学会[2013年9月19日(金)-21日(日)], Sep. 2013.
19. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Involvment of subtilisin-like proprotein convertase PACE4 in regeneration of salivary gland,
Journal of Oral Biosciences, Vol.55, No.Suppl., 199, Sep. 2013.
20. Hiroshi Yoshimura, 須貝 外喜夫, Chenjuan Yao, Tetsuya Akamatsu, Takahiro Hasegawa and 加藤 伸郎 :
ラット大脳皮質におけるnon-NMDA受容体活動に依存する20Hzオシレーション,
第36回日本神経科学大会[2013年6月20日(木)-23日(日)], Jun. 2013.
21. Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Hiroshi Yoshimura :
ヒト唾液腺HSG細胞における構成的なAQP5の取り込み,
Journal of Oral Biosciences, Vol.55, No.Suppl., 199, 2013.
22. Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
唾液腺細胞におけるアクアポリン5の翻訳後修飾,
Journal of Oral Biosciences, Vol.53, No.Supplement, 104, Sep. 2011.
23. Purevjav Javkhlan, Yuka Hiroshima, Ahmad Azlina, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu, Toshihiko Nagata and Kazuo Hosoi :
Calprotectin expression in the mouse salivary gland: Induction by lipopolysaccharide,
第52回歯科基礎医学会(2010年9月20-22日), Sep. 2010.
24. Yuka Hiroshima, Purevjav Javkhlan, Ahmad Azlina, Takahiro Hasegawa, Tetsuya Akamatsu and Kazuo Hosoi :
Porphyromonas gingivalis由来LPSはヒト好中球からのレジスチンの遊離を促進する,
第52回歯科基礎医学会(2010年9月20-22日), Sep. 2010.
25. Takahiro Hasegawa, Ahmad Azlina, Purevjav Javkhlan, Yuka Hiroshima, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
唾液腺細胞におけるアクアポリン5リン酸化のシグナル伝達機構,
第52回歯科基礎医学会(2010年9月20-22日), Sep. 2010.
26. Purevjav Javkhlan, Yuka Hiroshima, Ahmad Azlina, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu, Toshihiko Nagata and Kazuo Hosoi :
Calprotectin expression in the mouse salivary gland: Induction by lipopolysaccharide,
Journal of Oral Biosciences, Vol.52, No.supplement, 94, Sep. 2010.
27. Yuka Hiroshima, Javkhlan Purevjav, Ahmad Azlina, Takahiro Hasegawa, Tetsuya Akamatsu and Kazuo Hosoi :
Porphyromonas gingivalis由来LPSはヒト好中球からのレジスチンの遊離を促進する,
Journal of Oral Biosciences, Vol.52, No.supplement, 148, Sep. 2010.
28. Takahiro Hasegawa, Ahmad Azlina, Javkhlan Purevjav, Yuka Hiroshima, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
唾液腺細胞におけるアクアポリン5リン酸化のシグナル伝達機構,
Journal of Oral Biosciences, Vol.52, No.supplement, 164, Sep. 2010.
29. プルワンティ ヌヌク, Daisuke Tsuji, アズリナ アハマド, カラバシル ミレーバ, Chenjuan Yao, Takahiro Hasegawa, Tetsuya Akamatsu, Kouji Itou and Kazuo Hosoi :
Transient increase in IL-6 by duct ligation leading to continuous elevation of Sca-1, a stem cells marker, in the mouse submandibular gland,
第49回歯科基礎医学会学術大会, Aug. 2007.
30. プルワンティ ヌヌク, Daisuke Tsuji, カラバシル ミレーバ, Xuefei Li, Chenjuan Yao, Tetsuya Akamatsu, Norio Kanamori, Kouji Itou and Kazuo Hosoi :
Effect of duct ligation on the expression of cellular markers of duct/acini and side population dynamics of the mouse submandibular gland,
第48回歯科基礎医学会学術大会, Sep. 2006.

Et cetera, Workshop:

1. Chenjuan Yao, Takahiro Hasegawa, Tetsuya Akamatsu and Hiroshi Yoshimura :
マウス耳下腺における水チャネルAQP5のイソプロテレノールによるdouwn-regulationの機構,
Journal of Oral Biosciences, Vol.54, No.Suppl., 153,
2. Shimatani Tatsuya, Minegishi Makoto, Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Induction of a subtilisin-like proprotein convertase PACE4 in regeneration model of salivary gland Part II,
Journal of Oral Biosciences, Vol.Suppl., 415, Aug. 2016.
3. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Sexual difference in regeneration of salivary gland,
Journal of Oral Biosciences, Vol.Suppl., 451, Aug. 2016.
4. Tetsuya Akamatsu :
基礎系教育講演,
Journal of Oral Health and Biosciences, Vol.28, No.2, 97, Feb. 2016.
5. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
唾液腺再生への subtilisin-like proprotein convertase PACE4の関与,
自然科学研究機構生理学研究所研究会「唾液腺形態形成研究会~機能解析から器官再生へ~」, Aug. 2014.
6. Chenjuan Yao, Takahiro Hasegawa, Tetsuya Akamatsu and Hiroshi Yoshimura :
マウス耳下腺における水チャネルAQP5のイソプロテレノールによるdouwn-regulationの機構,第54回歯科基礎医学会(郡山)2012年9月14-16日,
Sep. 2012.
7. Hiroshi Yoshimura, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
細胞内cAMP上昇が大脳皮質味覚野から口腔体性感覚野への信号伝播速度に与える影響,第54回歯科基礎医学会(郡山)2012年9月14-16日,
Sep. 2012.
8. Chenjuan Yao, Takahiro Hasegawa, Tetsuya Akamatsu and Hiroshi Yoshimura :
マウス耳下腺における水チャネルAQP5のイソプロテレノールによるdouwn-regulationの機構,
Journal of Oral Biosciences, Vol.54, No.Suppl., 153, Sep. 2012.
9. Hiroshi Yoshimura, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
細胞内cAMP上昇が大脳皮質味覚野から口腔体性感覚野への信号伝播速度に与える影響,
Journal of Oral Biosciences, Vol.54, No.Suppl., 131, Sep. 2012.

Report:

1. Kazuo Hosoi, Norio Kanamori, Tetsuya Akamatsu and Chenjuan Yao :
Molecular mechanism of expression and regulation of water channel, esp. aquaporins in the exocrine gland,
, Report of research project, grant in-aid for scientific research (B), Tokushima, Mar. 2009.
2. Kazuo Hosoi, Norio Kanamori, Tetsuya Akamatsu and Chisato Kosugi :
Induction of inflammation cytokine and defense system of oral cavity: a trial in regeneration medicine,
Report of research project, Grant-in-Aid for Exploratory Research, Tokushima, Mar. 2006, Tokushima, Mar. 2006.
3. Kazuo Hosoi, Nobuyoshi Nakajo, Tatsuji Haneji and Tetsuya Akamatsu :
Inflammation by mast cell kininogen and its suppression Development of a new drug,
, Report of research project, grant in-aid for scientific research (B)(2), Tokushima, Mar. 2004.
4. Kazuo Hosoi, Norio Kanamori, Tetsuya Akamatsu, Jun Tada and Keiko Tsumura :
: Expression and regulation of a water channel, aquaporin, in the exocrine gland,
Report of research project, grant in-aid for scientific research (C)(2), Tokushima, Mar. 2003.
5. Kazuo Hosoi, Norio Kanamori, Sachiko Matsuura, Tetsuya Akamatsu and Takamasa Sawa :
Molecular mechanism of expression and regulation of water channel proteins aquaporins in the salivary gland cells,
Report of research project, grant in-aid for scientific research (C)(2), Tokushima, Mar. 2001.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Development of low invasive long-term imaging technique for studying salivary gland Ca2+ response and functional regeneration (Project/Area Number: 16K11484 )
  • Elucidation of Molecular Mechanism of the Salivary Gland Regeneration ~ Toward the application to the Regenerative Medicine for Xerostomia ~ (Project/Area Number: 26462814 )
  • Elucidation of the molecular mechanism on the differentiation/maturation and functional expression of salivary acinar cell toward conquest of xerostomia. (Project/Area Number: 23592737 )
  • 病態時における外分泌腺型水チャネル、AQP5の発現と機能調節の分子機構 (Project/Area Number: 23592736 )
  • 唾液腺腺房細胞の分化誘導、及び機能発現の分子メカニズムの解明 (Project/Area Number: 18791369 )
  • Moecular meohanism of expression and regulation of the water channe1, aquapor in 5 in the exocrine gland (Project/Area Number: 18390493 )
  • 水チャネル,アクアポリンの唾液腺発生過程における発現・局在及び機能制御機構の解明 (Project/Area Number: 16791126 )
  • 唾液腺における炎症性サイトカインの誘導と口腔の防御システム:再生医療への試み (Project/Area Number: 16659513 )
  • Characterization of β cell-specific gene obtained by large cDNA sequencing. (Project/Area Number: 15590943 )
  • Molecular mechanisms of expression and regulation of water channel proteins aquaporins in the exocrine gland cells (Project/Area Number: 13671940 )
  • Inflammation by mast cell kininogen and its suppression -Development of a new drug (Project/Area Number: 13557154 )
  • 歯・唾液腺発生過程でのプロセシング酵素PACE4の発現制御機構及び生理機能の解明 (Project/Area Number: 12771107 )
  • Molecular mechanisms of expression and regulation of function of water channel proteins aquaporins in the salivary gland cells (Project/Area Number: 11671844 )
  • 口腔組織(歯,舌,唾液腺)発生におけるサチライシン様プロ蛋白質変換酵素の役割 (Project/Area Number: 10771013 )
  • A new physiologic function of tissue kallikrein family enzymes and processing of growth factor precursors (Project/Area Number: 08672129 )
  • Search by Researcher Number (80294700)