徳島大学 / 教育研究者総覧 --- 中本晶子

個人のホームページ

https://researchmap.jp/a-nakamoto (researchmap)

専門分野

○	ライフサイエンス (Life sciences) [栄養学、健康科学 (Nutrition and health science)]
○	ライフサイエンス (Life sciences) [免疫学 (Immunology)]

研究テーマ

著書・論文

著書:

1.	酒井徹, 郡俊之, 中本真理子, 中本晶子 : 公衆栄養学第7版, 株式会社講談社, 東京, 2023年1月.
2.	中本晶子 : 感染防御と栄養, 株式会社薬事日報社, 2022年7月.
3.	中本晶子 : 栄養科学シリーズNEXT 公衆栄養学第6版, 株式会社講談社サイエンティフィク, 2022年1月.
4.	中本晶子 : 管理栄養士養成のための栄養学教育モデル・コア・カリキュラム準拠第10巻「公衆栄養学」 2022年版, 医歯薬出版株式会社, 2022年.
5.	中本晶子 : 管理栄養士養成のための栄養学教育モデル・コア・カリキュラム準拠第10巻公衆栄養学 2021年度版公衆栄養活動の実践のための理論と展開, 医歯薬出版株式会社, 2021年3月.
6.	中本晶子 : 栄養科学シリーズNEXT 公衆栄養学第6版, 株式会社講談社サイエンティフィク, 2019年2月.
7.	中本晶子 : 管理栄養士講座改訂感染と生体防御, 株式会社建帛社, 東京, 2018年9月.

学術論文(審査論文):

1.	Akiko Nakamoto, Yuwa Hirabayashi, Chieri Anzaki, Mariko Nakamoto, Emi Shuto, Yoshitaka Nii and Tohru Sakai : Effects of polymethoxyflavonoids on T helper 17 cell differentiation in vitro and in vivo., The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 166-170, 2023. (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.70.166 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164715 ● Search Scopus @ Elsevier (PMID): 37164715 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.166 (DOI: 10.2152/jmi.70.166, PubMed: 37164715)
2.	Akiko Nakamoto, Miho Goto, Hina Hasegawa, Chieri Anzaki, Mariko Nakamoto, Emi Shuto and Tohru Sakai : Essential Oil of Citrus sudachi Suppresses T Cell Activation Both In Vitro and In Vivo., Journal of Nutritional Science and Vitaminology, Vol.68, No.6, 513-520, 2022. (出版サイトへのリンク) ● Publication site (DOI): 10.3177/jnsv.68.513 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36596549 ● Search Scopus @ Elsevier (PMID): 36596549 ● Search Scopus @ Elsevier (DOI): 10.3177/jnsv.68.513 (DOI: 10.3177/jnsv.68.513, PubMed: 36596549)
3.	Mariko Nakamoto, Miku Kanmura, Mai Yoshida, Yukiko Tanaka, Satomi Ono, Yuki Iwasaki, Akiko Nakamoto and Tohru Sakai : Validity of dietary diversity assessed using short-form questionnaire among older Japanese community dwellers., The Journal of Medical Investigation : JMI, Vol.69, No.1.2, 31-37, 2022. (要約) The validity of dietary variety score (DVS) using a short-form questionnaire has not been investigated using dietary diversity based on a quantitative distribution of consumed foods in older Japanese. We examined the association between DVS and objective dietary diversity using a Quantitative Index for Dietary Diversity (QUANTIDD) based on the quantitative distribution of foods consumed by older Japanese community dwellers. The subjects were 65 older Japanese community dwellers aged 60?79 years. We used two kinds of scores for assessment of dietary diversity. At first, dietary diversity was determined using DVS calculated from answers to a questionnaire about frequencies of intake of 10 food groups. Second, dietary intake was assessed using a 3-day dietary record with photographs, and dietary diversity was determined using QUANTIDD. The relationships between DVS and QUANTIDD were assessed using partial correlation coefficients controlling for confounders. The correlation coefficient between DVS and QUANTIDD was moderate (r=0.212-0.458). After controlling for confounders, those correlation coefficient between DVS and QUANTIDD remained moderate. The findings suggest that there was a moderate relationship between DVS and QUANTIDD, and DVS using a short-form questionnaire may be useful for assessing dietary diversity in older Japanese community dwellers. J. Med. Invest. 69 : 31-37, February, 2022. (キーワード) Aged / Diet / Eating / Food / Humans / Japan / Surveys and Questionnaires (徳島大学機関リポジトリ) ● Metadata: 117008 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.69.31 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35466143 ● Search Scopus @ Elsevier (PMID): 35466143 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.69.31 (徳島大学機関リポジトリ: 117008, DOI: 10.2152/jmi.69.31, PubMed: 35466143)
4.	Mariko Nakamoto, Miku Kanmura, Mai Yoshida, Kana Yamada, Akiko Nakamoto and Tohru Sakai : Dietary diversity and food choice motives during the COVID-19 pandemic among older Japanese: An Internet Panel Survey., Asia Pacific Journal of Clinical Nutrition, Vol.31, No.3, 433-440, 2022. (要約) The findings suggest that the COVID-19 pandemic was associated with an increase in some food choice motives and a decrease in the frequency of eating out among elderly female Japanese. (キーワード) Aged / COVID-19 / Diet / Feeding Behavior / Female / Humans / Internet / Japan / Male / Pandemics / Retrospective Studies / Surveys and Questionnaires (出版サイトへのリンク) ● Publication site (DOI): 10.6133/apjcn.202209_31(3).0011 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36173215 ● Search Scopus @ Elsevier (PMID): 36173215 ● Search Scopus @ Elsevier (DOI): 10.6133/apjcn.202209_31(3).0011 (DOI: 10.6133/apjcn.202209_31(3).0011, PubMed: 36173215)
5.	Akiko Nakamoto, Hirabayashi Yuwa, Anzaki Chieri, Mariko Nakamoto, Emi Shuto and Tohru Sakai : Nobiletin suppresses the development of experimental autoimmune encephalomyelitis mediated by modulation of T helper 17 cell differentiation, Journal of Clinical Biochemistry and Nutrition, Vol.69, No.2, 145-150, 2021. (要約) Multiple sclerosis is an organ-specific autoimmune disease that targets the myelin antigen in the central nervous system. Nobiletin is a dietary polymethoxylated flavonoid found in citrus fruits. In this study, we investigated how nobiletin affects the disease state and immune responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis mice. Nobiletin was administered orally from 14 days before immunization until the end of the experiment, and clinical scores were determined. The production levels of interleukin-17A and interferon-γ were measured in a culture supernatant of splenocytes stimulated with myelin oligodendrocyte glycoprotein. In addition, flow cytometric analysis was performed to examine the effect of nobiletin on T cell differentiation . Admin-istration of nobiletin significantly decreased the clinical score and interleukin-17A production in splenocytes. Furthermore, analysis showed that nobiletin significantly suppressed Th17 cell differentiation and interleukin-17A production in a dose-dependent manner. The results suggest that nobiletin attenuates experimental autoimmune encephalomyelitis severity through modulation of Th17 cell differentiation. (徳島大学機関リポジトリ) ● Metadata: 116141 (出版サイトへのリンク) ● Publication site (DOI): 10.3164/JCBN.20-178 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34616106 ● Summary page in Scopus @ Elsevier: 2-s2.0-85114706108 (徳島大学機関リポジトリ: 116141, DOI: 10.3164/JCBN.20-178, PubMed: 34616106, Elsevier: Scopus)
6.	Akiko Nakamoto, Risako Takeda, Yuwa Hirabayashi, Mariko Nakamoto, Emi Shuto and Tohru Sakai : Citrus Polymethoxyflavonoids, Nobiletin, Heptamethoxyflavone and Natsudaidain, Suppress T Cell Activation In Vitro and In Vivo, BPB Reports, Vol.3, No.4, 138-141, 2020. (出版サイトへのリンク) ● Publication site (DOI): 10.1248/bpbreports.3.4_138 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1248/bpbreports.3.4_138 (DOI: 10.1248/bpbreports.3.4_138)
7.	Mariko Nakamoto, Yuna Yun, Mariko Omine, Sarasa Mori, Emi Shuto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : Dietary diversity and characteristics of lifestyle and awareness of health in Japanese workers:a cross-sectional study., The Journal of Medical Investigation : JMI, Vol.67, No.3.4, 255-264, 2020. (要約) The aim of this study was to clarify the characteristics of lifestyle and health awareness according to dietary diversity in a Japanese worksite population. The participants were 1,312 men and women aged 20 to 63 years who were living in Tokushima Prefecture, Japan during the period 2012-2013. We obtained anthropometric data and information on lifestyle characteristics using a self-administered questionnaire. Dietary intake was assessed using a food frequency questionnaire, and dietary diversity was determined using the Quantitative Index for Dietary Diversity (QUANTIDD). The characteristics of lifestyle and health awareness according to quartiles of the QUANTIDD score were assessed using the chi-square test and a general linear model. The higher the QUANTIDD score was, the larger were the proportions of participants who knew the appropriate amount of dietary intake and participants who referred to nutritional component information when choosing and / or buying food. Among participants with higher QUANTIDD scores, the proportion of participants who considered their current diet was good was high in women, whereas the proportion of participants who wanted to improve their diet in the future was high in men. Those results indicate that higher dietary diversity was related to better characteristics of lifestyle and awareness of health. J. Med. Invest. 67 : 255-264, August, 2020. (徳島大学機関リポジトリ) ● Metadata: 115420 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.67.255 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33148898 ● Search Scopus @ Elsevier (PMID): 33148898 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.255 (徳島大学機関リポジトリ: 115420, DOI: 10.2152/jmi.67.255, PubMed: 33148898)
8.	Mami Mitani, Yuki Minatogawa, Akiko Nakamoto, Mariko Nakamoto, Emi Shuto, Yoshitaka Nii and Tohru Sakai : Sudachitin, polymethoxyflavone from Citrus sudachi, enhances antigen-specific cellular and humoral immune responses in BALB/c mice., Journal of Clinical Biochemistry and Nutrition, Vol.64, No.2, 158-163, 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.3164/jcbn.18-70 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30936628 ● Summary page in Scopus @ Elsevier: 2-s2.0-85064387091 (DOI: 10.3164/jcbn.18-70, PubMed: 30936628, Elsevier: Scopus)
9.	Mariko Nakamoto, Omine Mariko, Yun Yuna, Emi Shuto, Akiko Nakamoto, Akiko Hata, Aki Nanako, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : Associations of dietary diversity with allergic diseases in Japanese workers: a cross-sectional study., Asia Pacific Journal of Clinical Nutrition, Vol.28, No.4, 857-869, 2019. (要約) The aim of this study was to determine the associations of dietary diversity with prevalences of allergic diseases. The participants were 1,317 men and women aged 20 to 63 years who were living in Tokushima Prefecture, Japan during the period 2012-2013. We obtained anthropometric data and information on lifestyle characteristics and current medical histories of allergic diseases using a self-administered questionnaire. Dietary intake was assessed using a food frequency questionnaire, and dietary diversity was determined using the Quantitative Index for Dietary Diversity (QUANTIDD). The ORs and 95% CIs for each of the allergic diseases with a 1 standard deviation (SD) increase in the QUANTIDD score were estimated, controlling for age, family history of allergic diseases, education, smoking, drinking, physical activity, energy intake and BMI. Higher dietary diversity showed significant inverse dose-response relationships with allergic diseases and allergic rhinitis in women. Multivariate-adjusted ORs (95% CI) for allergic diseases and allergic rhinitis with 1 SD increase in the QUANTIDD score were 0.77 (95% CI: 0.60-0.98, p=0.037) and 0.69 (95% CI: 0.53-0.90, p=0.007), respectively, in women. There were no significant associations between dietary diversity and allergic diseases in men. The results indicate that there is an inverse association between higher dietary diversity and allergic rhinitis in Japanese female workers. (キーワード) Adult / Asthma / Cross-Sectional Studies / Dermatitis, Atopic / Diet / Female / Food / Humans / Japan / Male / Middle Aged / Rhinitis, Allergic / Risk Factors / Young Adult (出版サイトへのリンク) ● Publication site (DOI): 10.6133/apjcn.201912_28(4).0023 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31826384 ● Summary page in Scopus @ Elsevier: 2-s2.0-85076486533 (DOI: 10.6133/apjcn.201912_28(4).0023, PubMed: 31826384, Elsevier: Scopus)
10.	Mariko Nakamoto, Yukiko Tanaka, Satomi Ono, Akiko Nakamoto, Emi Shuto and Tohru Sakai : Associations of marital and parental status and family members living together with health-related behaviors in Japanese young workers : a cross-sectional study., The Journal of Medical Investigation : JMI, Vol.66, No.1-2, 141-147, 2019. (要約) The aim of this study was to clarify the associations of family members living together with healthrelated behaviors in Japanese young workers. The participants were 300 men and women aged 20-39 years in 2015 who had a job. A web-based self-administered questionnaire on status of partnering and parenting, number of family members living together, dietary habits, drinking habit, smoking habit, self-rated health, employment status, working time and commuting time was conducted through Internet. Multiple logistic regression analysis and general linear models were used to assess the association of family members living together with healthrelated behaviors. The multivariate-adjusted odds ratio (95% confidence interval, p-value) for current drinking in unmarried participants living with their parents compared to unmarried participants living alone was 0.35 (0.13-0.93, p=0.036). The adjusted means of frequency of breakfast skipping and frequency of eating out showed a trend for inverse associations with the presence of a partner and children. However, those associations disappeared after adjustment for age of youngest child. The findings suggest that the presence of parents might affect drinking behavior and that age of youngest child living together might affect the frequency of breakfast skipping in young Japanese workers. J. Med. Invest. 66 : 141-147, February, 2019. (キーワード) 疫学 (epidemiology) / 栄養 (nutrition) (徳島大学機関リポジトリ) ● Metadata: 113409 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.66.141 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31064927 ● Search Scopus @ Elsevier (PMID): 31064927 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.141 (徳島大学機関リポジトリ: 113409, DOI: 10.2152/jmi.66.141, PubMed: 31064927)
11.	Akiko Nakamoto, Mami Mitani, Kana Urayama, Akari Maki, Mariko Nakamoto, Emi Shuto, Yoshitaka Nii and Tohru Sakai : Nobiletin Enhances Induction of Antigen-Specific Immune Responses in BALB/c Mice Immunized with Ovalbumin., Journal of Nutritional Science and Vitaminology, Vol.65, No.3, 278-282, 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.3177/jnsv.65.278 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31257269 ● Search Scopus @ Elsevier (PMID): 31257269 ● Search Scopus @ Elsevier (DOI): 10.3177/jnsv.65.278 (DOI: 10.3177/jnsv.65.278, PubMed: 31257269)
12.	Mariko Nakamoto, Emi Shuto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : Soy product and isoflavone intake associations with allergic diseases in Japanese workers: rhinitis, dermatitis and asthma., Asia Pacific Journal of Clinical Nutrition, Vol.27, No.6, 1277-1285, 2018. (要約) The aim of this study was to determine the associations of intake of soy products and isoflavones with allergic diseases. We conducted a cross-sectional study in 1437 participants (aged 20-64 years) who were living in Tokushima Prefecture, Japan during the period 2010- 2011. We obtained anthropometric data and information on life style characteristics including dietary intake and current medical histories of allergic diseases using a structural self-administered questionnaire. Multiple logistic regression models were used to assess the associations of soy products and isoflavones with allergic diseases after controlling for age, family history of allergic diseases, smoking, drinking, physical activity, energy intake, BMI and dietary factors. Intake of soy products showed significant inverse dose-response relationships with allergic rhinitis. The third quartile for soy products had an adjusted OR of 0.56 (95% CI: 0.35-0.91) compared to the reference group (first quartile), though intake of soy products showed no dose-response relationship with atopic dermatitis. Intake of soy isoflavones showed a significant inverse dose-response relationship with atopic dermatitis, though the association between intake of soy isoflavones and atopic dermatitis was U-shaped after adjustments for potential confounders. On the other hand, the associations between intake of soy isoflavones and other allergic diseases were not significant. The results indicate that higher intake of soy products is associated with reduced risk of allergic rhinitis in Japanese workers. Furthermore, moderate intake amounts of soy products and soy isoflavones are associated with inverse risk of atopic dermatitis. (キーワード) 疫学 (epidemiology) / 栄養 (nutrition) (出版サイトへのリンク) ● Publication site (DOI): 10.6133/apjcn.201811_27(6).0015 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30485927 ● Search Scopus @ Elsevier (PMID): 30485927 ● Search Scopus @ Elsevier (DOI): 10.6133/apjcn.201811_27(6).0015 (DOI: 10.6133/apjcn.201811_27(6).0015, PubMed: 30485927)
13.	Tohru Sakai, Miyuki Ohhata, Misaki Fujii, Sayaka Oda, Yasuna Kusaka, Miki Matsumoto, Akiko Nakamoto, Tomoyo Taki, Mariko Nakamoto and Emi Shuto : Brazilian Green Propolis Promotes Weight Loss and Reduces Fat Accumulation in C57BL/6 Mice Fed A High-Fat Diet, Biological & Pharmaceutical Bulletin, Vol.40, No.4, 391-395, 2017. (要約) Propolis is a bee product with various biological properties. C57BL/6 mice were fed a high-fat diet and treated with propolis for 14 weeks. Body weight in mice treated with 2% propolis was less than that in control mice from 3 weeks after the start of treatment until 14 weeks except for the 7th week. Mice treated with propolis showed significantly lower epididymal fat weight and subcutaneous fat weight. Infiltration of epididymal fat by macrophages and T cells was reduced in the propolis group. Supplementation of propolis increased feces weight and fat content in feces, suggesting that mechanisms of weight reduction by propolis partly include a laxative effect and inhibition of fat absorption. (キーワード) propolis / weight / fat absorption (出版サイトへのリンク) ● Publication site (DOI): 10.1248/bpb.b16-00577 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28381793 ● Summary page in Scopus @ Elsevier: 2-s2.0-85016978833 (DOI: 10.1248/bpb.b16-00577, PubMed: 28381793, Elsevier: Scopus)
14.	Tohru Sakai, Tomoyo Taki, Akiko Nakamoto, Shiho Tazaki, Mai Arakawa, Mariko Nakamoto, Rie Tsutsumi and Emi Shuto : Dietary ribonucleic Acid suppresses inflammation of adipose tissue and improves glucose intolerance that is mediated by immune cells in C57BL/6 mice fed a high-fat diet., Journal of Nutritional Science and Vitaminology, Vol.61, No.1, 73-78, 2015. (要約) Recent evidence suggests that immune cells play an important role in differentiation of inflammatory macrophages in adipose tissue, which contributes to systemic chronic inflammation. Dietary ribonucleic acid (RNA) has been shown to modulate immune function. We hypothesized that RNA affects immune cell function in adipose tissue and then improves inflammatory response in adipose tissue. C57/BL6 mice and recombination activating gene-1 (RAG-1) knockout mice on a C57BL/6 mice background were fed a high-fat diet containing 1% RNA for 12 wk. An oral glucose tolerance test was performed. Supplementation of dietary RNA in C57BL/6 mice fed a high-fat diet resulted in a smaller area under the curve (AUC) after oral glucose administration than that for control mice. The mRNA expression levels of inflammation-related cytokines in adipose tissue and serum interleukin-6 levels were reduced by dietary RNA supplementation. Interestingly, reduction of the AUC value by RNA supplementation was abolished in T and B cell-deficient RAG-1 knockout mice. These results indicate that RNA improves inflammation in adipose tissue and reduces the AUC value following oral glucose administration in a T and B cell-dependent manner. (出版サイトへのリンク) ● Publication site (DOI): 10.3177/jnsv.61.73 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25994141 ● Summary page in Scopus @ Elsevier: 2-s2.0-84929733065 (DOI: 10.3177/jnsv.61.73, PubMed: 25994141, Elsevier: Scopus)
15.	Akiko Nakamoto, Emi Shuto, Rie Tsutsumi, Mariko Nakamoto, Yoshitaka Nii and Tohru Sakai : Vitamin A Deficiency Impairs Induction of Oral Tolerance in Mice., Journal of Nutritional Science and Vitaminology, Vol.61, No.2, 147-153, 2015. (要約) Oral tolerance is a phenomenon of induction of systemic unresponsiveness to antigens ingested by the oral route and loss of immune response. Studies have shown the importance of vitamin A in oral tolerance in vitro but not in an in vivo experimental model. Therefore, we carried out experiments to determine how vitamin A deficiency affects tolerance induction and the ability of mesenteric lymph node (MLN) CD11c(+) cells to induce regulatory T cells (Tregs). Immunological tolerance was induced by oral ovalbumin (OVA) administration in vitamin A-sufficient mice. OVA-specific antibody and cytokine production were significantly reduced. On the other hand, in vitamin A-deficient mice, both OVA-specific antibody and cytokine production were not suppressed by oral OVA administration. Regarding induction of Tregs, the conversion rate of Foxp3(+) cells from naïve CD4(+) cell by CD11c(+) cells was decreased in vitamin A-deficient mice. Our study indicates that vitamin A deficiency causes the breakdown of oral tolerance in vivo. (出版サイトへのリンク) ● Publication site (DOI): 10.3177/jnsv.61.147 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26052145 ● Summary page in Scopus @ Elsevier: 2-s2.0-84930703907 (DOI: 10.3177/jnsv.61.147, PubMed: 26052145, Elsevier: Scopus)
16.	酒井徹, 中本真理子, 中本晶子, 首藤恵泉, 小林ゆき子, 土居幸雄, 木戸康弘 : 管理栄養士・栄養士養成施設における教員の学位取得状況および教員に求められる知識や技能等に関する調査, 栄養学雑誌, Vol.72, No.5, 262-271, 2014年. (要約) 【目的】管理栄養士および栄養士養成施設において管理栄養士・栄養士免許を有する教員の数，教員の学位取得状況，各養成施設において教員に求められる知識や技能等を明らかにする．【方法】教員の学位取得状況，教員に求められる知識や技能および担当科目等の基礎情報に関する質問用紙を作成し，2013年2∼3月に全国の管理栄養士および栄養士養成施設に郵送した．【結果】回答が得られた施設は，管理栄養士養成施設78校(回答率66.1%)，栄養士養成施設102校であった(回答率68.5%)．教員の年齢区分では管理栄養士および栄養士養成施設共に30∼49歳が最も高かった．管理栄養士養成施設で管理栄養士免許を有する教員で博士の学位を有する者の割合は年齢層が上昇するごとに増え30歳以上では約4割程度であった．管理栄養士養成施設において管理栄養士免許保有教員のうち修士または博士の学位を有するものは，20∼29歳42.5%，30∼49歳75.7%，50∼65歳66.5%であった．栄養士養成施設において管理栄養士免許を有する教員で博士の学位を有するものの割合は30歳以上で約2割程度であった．栄養士養成校において管理栄養士免許保有教員のうち修士および博士の学位を有するものは，20∼29歳28.4%，30∼49歳47.4%，50∼65歳42.0%であった．養成施設が教員に求める知識や技能に関しては，「教育」が最も高く，エフォートに対する割合としては50∼59%と回答する施設が最も多かった．【結論】管理栄養士および栄養士養成施設における管理栄養士または栄養士免許を有する教員の年齢構成，学位取得状況等の基本情報が得られた．また養成施設が教員に対して求める知識や技能として最も高いのは「教育」であった． (キーワード) 管理栄養士・栄養士養成施設 / 教員 / 学位 / 知識・技能 (出版サイトへのリンク) ● Publication site (DOI): 10.5264/eiyogakuzashi.72.262 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001206547275776 ● Search Scopus @ Elsevier (DOI): 10.5264/eiyogakuzashi.72.262 (DOI: 10.5264/eiyogakuzashi.72.262, CiNii: 1390001206547275776)

学術論文(紀要・その他):

1.	Shuhai Chen, Masaaki Nishi, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto, Akiko Nakamoto, Tohru Sakai and Mitsuo Shimada : Polymethoxylated flavone sudachitin is a safe anticancer adjuvant that targets glycolysis in cancer-associated fibroblasts., Oncology Letters, Vol.24, No.1, 236, 2022. (要約) Sudachitin is a polymethoxylated flavone found in the peel of , a unique specialty citrus fruit in Tokushima Prefecture, Japan. Previous reports have demonstrated that sudachitin has anti-inflammatory and metabolic regulatory activities. However, to the best of our knowledge, no studies have explored whether sudachitin can act as an antitumor therapeutic agent by regulating metabolic functions in the tumor microenvironment. In the present study, cell proliferation and cytotoxicity assays were used to determine whether sudachitin inhibited the growth of liver cancer and pancreatic carcinoma, cholangiocarcinoma and colorectal cancer cells and to compare its toxicity against normal fibroblasts and induced cancer-associated fibroblasts (CAFs). Using lactate assays and reverse transcription-quantitative PCR, the effects of sudachitin on glycolysis in CAFs were investigated. The effects of CAFs on malignant tumor cells were evaluated using cell proliferation, wound healing and invasion assays. As result, sudachitin inhibited various types of tumor cells with different half-maximal inhibitory concentrations. Treatment with 50 µM sudachitin for 48 h suppressed tumor and CAFs proliferation but was not cytotoxic against normal fibroblasts. This dose also inhibited glycolysis in CAFs and, thus, diminished their pro-tumorigenic activities. Overall, the present study revealed that sudachitin has promise as a safe and widely available natural antitumor adjuvant. (徳島大学機関リポジトリ) ● Metadata: 118072 (出版サイトへのリンク) ● Publication site (DOI): 10.3892/ol.2022.13356 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35720469 ● Search Scopus @ Elsevier (PMID): 35720469 ● Search Scopus @ Elsevier (DOI): 10.3892/ol.2022.13356 (徳島大学機関リポジトリ: 118072, DOI: 10.3892/ol.2022.13356, PubMed: 35720469)

総説・解説:

1.	酒井徹, 中本晶子, 新居佳孝 : 徳島県特産のスダチ -果皮成分の機能性についてー, New Food Industry, Vol.60, No.9, 19-24, 2018年.

国内講演発表:

1.	虎見昂輝, 中本真理子, THUY THI BUI, 中本晶子, 酒井徹 : 若年者の空腹状態による食選択行動に及ぼす潜在的要因の影響, 第8回日本栄養改善学会四国支部学術総会, 2023年5月.
2.	東條歩実, 中本真理子, 山田佳奈, 虎見昂輝, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 : 徳島県勤労者における食事摂取の多様性と炎症性マーカーとの横断的検討, 第8回日本栄養改善学会四国支部学術総会, 2023年5月.
3.	中本晶子, 服部蒔季, 中本真理子, 酒井徹 : 抗炎症機構に対するポリメトキシフラボノイドの作用, 第77回日本栄養・食糧学会大会, 295, 2023年5月.
4.	中本真理子, 東條歩実, 山田佳奈, 虎見昂輝, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 : 徳島県勤労者における食事摂取の多様性と炎症マーカーとの関連, 日本栄養・食糧学会誌, 74, 2023年5月.
5.	中本真理子, 清水佑衣, 中本晶子, 酒井徹 : 管理栄養士養成課程の学生立案献立における食事多様性の高い献立の特徴, 第17回日本給食経営管理学会学術総会, 2022年11月.
6.	山本真子, 中本晶子, 中本真理子, 八木田秀雄, 酒井徹 : 大豆イソフラボンのガン免疫チェックポイント療法への応用, 栄養学雑誌, Vol.80, No.5, 200, 2022年9月.
7.	中本晶子, 守田栞捺, 中本真理子, 酒井徹 : ノビレチンのサイトカイン産生調節作用を介した抗肥満効果, 栄養学雑誌, Vol.80, No.5, 195, 2022年9月.
8.	中本真理子, 中本晶子, 酒井徹 : 管理栄養士養成課程の学生に対する給食経営管理実習が管理栄養士のコンピテンシーへ及ぼす影響, 栄養学雑誌, Vol.80, No.5, 186, 2022年9月. (キーワード) 給食経営管理 / 給食 / 教育効果 / コンピテンシー / 管理栄養士
9.	山田佳奈, 中本真理子, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 : 徳島県勤労者のイソフラボン摂取量とメタボリックシンドローム構成因子との関連, 栄養学雑誌, Vol.80, No.5, 207, 2022年9月. (キーワード) 疫学 (epidemiology) / 公衆栄養 / 栄養疫学
10.	中本晶子, 平林悠和, 中本真理子, 酒井徹 : 17型ヘルパーT細胞に対するポリメトキシフラボノイドの作用-In vitroおよびin vivo系での検討-, 第20回四国免疫フォーラム, 2022年6月.
11.	山田佳奈, 中本真理子, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 : 徳島県勤労者の大豆イソフラボン摂取量とメタボリックシンドロームとの関連, 第264回徳島医学会学術集会, 32, 2022年2月.
12.	山田佳奈, 中本真理子, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 : 徳島県勤労者のイソフラボン摂取量とメタボリックシンドロームとの関連, 第6回日本糖尿病・生活習慣病ヒューマンデータ学会年次学術集会, 2021年12月.
13.	竹井理恵, 首藤恵泉, 中本晶子, 中本真理子, 酒井徹 : 大豆イソフラボンの癌間細胞に及ぼす影響, 第54回日本栄養・食糧学会中国四国支部大会・第7回日本栄養改善学会四国支部学術総会合同大会, 2021年10月.
14.	山田佳奈, 中本真理子, 上村美玖, 吉田舞, 上ノ薗理乃, 中本晶子, 酒井徹 : 新型コロナウイルス感染拡⼤による高齢者の食選択動機及び食生活への影響, 第54回日本栄養・食糧学会中四国支部大会・第7回日本栄養改善学会四国支部学術合同総会, 2021年10月.
15.	中本晶子, 中本真理子, 酒井徹 : スダチ果皮由来精油成分が免疫細胞に及ぼす作用と抗原特異的免疫応答への影響, 第68回日本栄養改善学会学術総会, Vol.79, No.5, 107, 2021年10月.
16.	中本真理子, 上村美玖, 吉田舞, 上ノ薗理乃, 山田佳奈, 中本晶子, 酒井徹 : 新型コロナウイルス感染拡大に伴う初回緊急事態宣言前後での高齢者の食選択動機及び食品摂取多様性の変化, 第68回日本栄養改善学会学術総会, Vol.79, No.5, 187, 2021年10月. (キーワード) 疫学 (epidemiology) / 食選択動機 / 食生活 / 高齢者
17.	平林悠和, 中本晶子, 安崎千咲里, 中本真理子, 首藤恵泉, 酒井徹 : T細胞分化に与えるポリメトキシフラボノイドの影響, 第75回日本栄養・食糧学会大会, 27, 2021年7月.
18.	平林悠和, 中本晶子, 安崎千咲里, 中本真理子, 首藤恵泉, 酒井徹 : 実験的自己免疫性脳脊髄炎(EAE)マウスに対するノビレチンの作用, 第53回日本栄養・食糧学会中国・四国支部大会, 13, 2020年10月.
19.	中本真理子, 小野聖実, 田中由貴子, 中本晶子, 首藤恵泉, 酒井徹 : 徳島県の子育て世代におけるワークライフバランスと食行動の関係, 第67回日本栄養改善学会学術総会, Vol.78, No.5, 2020年9月.
20.	中本晶子, 安崎千咲里, 平林悠和, 中本真理子, 首藤恵泉, 酒井徹 : マクロファージに対するポリメトキシフラボンの作用-敗血症モデルマウスを用いた検討-, 第67回日本栄養改善学会学術総会, Vol.78, No.5, 67, 2020年9月.
21.	中本晶子, 平林悠和, 安崎千咲里, 中本真理子, 首藤恵泉, 酒井徹 : ノビレチンによる実験的自己免疫性脳脊髄炎(EAE)におけるT細胞機能への影響, 第74回日本栄養・食糧学会大会, 205, 2020年4月.
22.	中本真理子, 大嶺茉利子, 尹優奈, 首藤恵泉, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 : 徳島県勤労者における食事摂取の多様性とアレルギー性疾患との関連, 四国公衆衛生学会雑誌, Vol.65, No.1, 32, 2020年2月. (キーワード) 疫学 (epidemiology) / 栄養 (nutrition) / アレルギー (allergy) / 日本 (Japan)
23.	中本晶子, 浦山佳菜, 安崎千咲里, 平林悠和, 中本真理子, 首藤恵泉, 酒井徹 : ポリメトキシフラボンの免疫細胞に対する機能評価 -マクロファージおよび肥満細胞での解析-, 第66回日本栄養改善学会学術総会, 2019年9月.
24.	浦山佳菜, 中本晶子, 安崎千咲里, 平林悠和, 中本真理子, 首藤恵泉, 酒井徹 : 免疫細胞に対するスダチ果皮フラボノイドの作用に関する研究-肥満細胞およびマクロファージにおける検討-, 第259回徳島医学会学術集会, 2019年8月.
25.	中本晶子, 首藤恵泉, 中本真理子, 酒井徹 : スダチ果皮に含まれるスダチチンのin vitroにおける機能評価 -マクロファージおよび肥満細胞での解析-, 第73回日本栄養・食糧学会大会, 2019年5月.
26.	首藤恵泉, 中本真理子, 中本晶子, 酒井徹 : エクオールの前駆脂肪細胞3T3-L1に対する作用, 第73回日本栄養・食糧学会大会, 2019年5月.
27.	浦山佳菜, 中本晶子, 安崎千咲里, 平林悠和, 中本真理子, 首藤恵泉, 酒井徹 : スダチ果皮フラボノイドの免疫細胞に対する作用に関する研究―肥満細胞およびマクロファージに対する作用―, 第6回日本栄養改善学会四国支部学術総会, 2019年4月.
28.	畑山翔, 下畑隆明, 木戸純子, 神田結奈, 天宅あや, 福島志帆, 中橋睦美, 中本晶子, 首藤恵泉, 上番増喬, 馬渡一諭, 髙橋章 : Campylobacter jejuni汚染調理器具に対するUVA-LED照射殺菌の有効性について, 第39回日本食品微生物学会学術総会, 2018年9月.
29.	首藤恵泉, 中本真理子, 中本晶子, 酒井徹 : 食餌誘導性肥満マウスにおけるエクオールの作用, 第65回日本栄養改善学会学術総会, 2018年9月.
30.	中本晶子, 中本真理子, 首藤恵泉, 酒井徹 : スダチチンおよびデメトキシスダチチンによる免疫調節作用, 第65回日本栄養改善学会学術総会, 2018年9月.
31.	中本晶子, 中本真理子, 首藤恵泉, 酒井徹 : デメトキシスダチチンの免疫調節作用, 第5回日本栄養改善学会四国支部学術総会, 2018年6月.
32.	首藤恵泉, 國松真由香, 中本晶子, 中本真理子, 酒井徹 : 食餌誘導性肥満マウスにおけるエクオールの作用, 第72回日本栄養・食糧学会大会, 2018年5月.
33.	中本晶子, 中本真理子, 首藤恵泉, 酒井徹 : デメトキシスダチチンによる免疫調節作用, 第72回日本栄養・食糧学会大会, 2018年5月.

その他・研究会:

1.	畑山翔, 下畑隆明, 木戸純子, 神田結奈, 天宅あや, 福島志帆, 中橋睦美, 中本晶子, 首藤恵泉, 上番増喬, 馬渡一諭, 髙橋章 : UVA-LED照射による調理器具汚染Campylobacter jejuniの殺菌効果について, 第11回日本カンピロバクター研究会総会, 2018年12月.

報告書:

1.	Mariko Nakamoto, Mori Sarasa, Emi Shuto, Akiko Nakamoto, Akiko Hata, Aki Nanako, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : Soy and Isoflavone Intake and Lifestyle and Health Awareness in Japanese Workers, SOY PROTEIN RESEARCH, Japan, Vol.24, 154-161, Jul. 2022.
2.	中本真理子, 森更紗, 大河内章充, 首藤恵泉, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 : 大豆製品・大豆含有成分摂取と推定腎機能との関係を探る臨床疫学研究, 大豆たん白質研究, Vol.23, 182-191, 2020年.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

フラボノイドのM2マクロファージ誘導機構を基盤とした慢性炎症疾患克服戦略 (研究課題/領域番号: 22K17778 )
フラボノイドメトキシ基の構造機能学解析-代謝ダイナミックスと癌免疫療法への新展開 (研究課題/領域番号: 19K11768 )
大豆イソフラボンの免疫調節作用によるメタボリックシンドローム予防とその機構解明 (研究課題/領域番号: 18K17967 )
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