徳島大学 / 教育研究者総覧 --- 大藤純

個人のホームページ

https://researchmap.jp/joto (researchmap)

専門分野

○	麻酔·集中治療

研究テーマ

○	急性血液浄化，脳卒中患者におけるサイトカイン，ATP感受性Kチャネル (急性血液浄化, サイトカイン (cytokine), K-ATPチャネル)

著書・論文

著書:

1.	秋本雄祐, 大藤純 : 血液浄化療法, 克誠堂出版株式会社, 2022年. (キーワード) ISBN 978-4-7719-0571-9
2.	大藤純 : アナフィラキシー:急性循環不全[各論]症状における病態と治療∼ショック∼, 2019年5月.
3.	大藤純 : 重症感染症の集中治療―成功に導く管理ポイント:人工呼吸管理のポイント．, 2017年10月.
4.	大藤純 : Recommended Article:''低用量デクスメデトミジンは，高齢者の非心臓手術後の睡眠の質を改善する:パイロット無作為化比較試験による検討'', 2017年.

学術論文(審査論文):

1.	Mai Azumi, Yoshifumi Mizobuchi, Nobuto Nakanishi, Kohhei Nakajima, Keijiro Hara, Toshitaka Fujihara, Manabu Ishihara, Jun Oto and Yasushi Takagi : Value of the Acute Physiology and Chronic Health Evaluation II (APACHE II) score in predicting hospital mortality for postoperative brain tumor patients in intensive care units in Japan: A retrospective case-control study, Clinical Neurology and Neurosurgery, Vol.244(2024), No.108435, 108435, 2024. (要約) Acute Physiology and Chronic Health Evaluation II (APACHE II) is based on the data of intensive care unit (ICU) patients and often correlates with disease severity and prognosis. However, no prognostic predictors exist based on ICU admission data for patients with brain tumors, and no studies have reported an association between APACHE II and prognosis in patients with brain tumors. The Japanese Intensive Care Patients Database (JIPAD) was established to improve the quality of care delivered in intensive care medicine in Japan. We used JIPAD to examine factors associated with in-hospital mortality based on available data of postoperative patients with brain tumors admitted to the ICU. Patients aged ≥16 years enrolled in JIPAD between April 2015 and March 2018 after surgical brain tumor resection or biopsy of brain tumors. We examined factors related to outcomes at discharge based on blood tests and medical procedures performed during ICU admission, tumor type, and APACHE II score. Among the 1454 patients (male:female ratio: 1:1.1, mean age: 62 years) in the study, 32 (2.2 %) died during hospital stay. In multivariate analysis, male sex (odds ratio [OR] 2.70, [95 % confidence interval, CI 1.22-6.00]), malignant tumor (OR 2.51 [95 % CI 1.13-5.55]), and APACHE II score ≥15 (OR 2.51 [95 % CI 3.08-14.3]) were significantly associated with in-hospital mortality. By picking up cases with a high risk of in-hospital death at an early stage, it is possible to improve methods of treatment and support for the patient's family. (キーワード) Humans / Male / Female / Middle Aged / Hospital Mortality / APACHE / Japan / Brain Neoplasms / Aged / Intensive Care Units / Retrospective Studies / Case-Control Studies / Adult / Prognosis / Aged, 80 and over / Predictive Value of Tests (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.clineuro.2024.108435 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38996799 ● Summary page in Scopus @ Elsevier: 2-s2.0-85198060266 (DOI: 10.1016/j.clineuro.2024.108435, PubMed: 38996799, Elsevier: Scopus)
2.	髙島拓也, 大藤純 : 横隔膜機能の評価方法と筋力維持の戦略「横隔膜機能評価と横隔膜保護換気」, LiSA, Vol.31, No.3, 284-289, 2024年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520018677356919168 (CiNii: 1520018677356919168)
3.	Satoshi Doi, Nobuto Nakanishi, Yoshimi Kawahara, Keiko Nomura, Mamiko Shima, Mie Shiraishi and Jun Oto : Effects of Vibration Therapy on the Physical Function of Critically Ill Adults Trial: A Randomized Controlled Trial., Critical Care Medicine, 2024. (要約) Among 180 patients, 86 and 90 patients remained in the vibration therapy and control groups, respectively. The mean age was 69 ± 13 vs. 67 ± 16 years in the vibration therapy and control groups, and the Acute Physiology and Chronic Health Evaluation (APACHE) II score was 19 (14-25) vs. 18 (13-23). The total FSS-ICU at ICU discharge was 24 (18-27) and 21 (17-26) in the intervention and control groups, respectively (p = 0.09), and the supine-to-sit ability significantly improved in the intervention group (p < 0.01). The secondary outcomes were not significantly different. Vital signs remained stable during vibration therapy. In the predefined subgroup analysis, FSS-ICU improved in the population with a higher body mass index (≥ 23 kg/m2), lower APACHE II scores (< 19), and higher IMS scores (≥ 6). (出版サイトへのリンク) ● Publication site (DOI): 10.1097/CCM.0000000000006210 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38277179 ● Search Scopus @ Elsevier (PMID): 38277179 ● Search Scopus @ Elsevier (DOI): 10.1097/CCM.0000000000006210 (DOI: 10.1097/CCM.0000000000006210, PubMed: 38277179)
4.	Miharu Arase, Nobuto Nakanishi, Rie Tsutsumi, Ayuka Kawakami, Yuta Arai, Hiroshi Sakaue and Jun Oto : The Utility of Urinary Titin to Diagnose and Predict the Prognosis of Acute Myocardial Infarction., International Journal of Molecular Sciences, Vol.25, No.1, 573, 2024. (要約) = 0.023). Urinary N-fragment titin can be used as non-invasive early diagnostic biomarker in AMI. Furthermore, it associates with hospital discharge disposition, providing prognostic utility. (キーワード) Humans / Biomarkers / Connectin / Creatine Kinase / Creatine Kinase, MB Form / 心臓 (heart) / Myocardial Infarction (出版サイトへのリンク) ● Publication site (DOI): 10.3390/ijms25010573 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38203744 ● Summary page in Scopus @ Elsevier: 2-s2.0-85182161094 (DOI: 10.3390/ijms25010573, PubMed: 38203744, Elsevier: Scopus)
5.	佐藤裕紀, 中瀧恵実子, 布村俊幸, 村上尚哉, 堀洋二, 大藤純, 板垣大雅 : 歯性感染症を契機に発症したPrevotella属によるレミエール症候群の一例．, 第51回日本救急医学会総会・学術集会, 2023年.
6.	Yusuke Akimoto, Taiga Itagaki, Keisuke Morinishi, Yusuke Chikata and Jun Oto : A bench evaluation of ineffective efforts related to the use of leak compensation algorithm during pressure support ventilation., American Association for Respiratory Care Congress 2023, 2023.
7.	Keisuke Morinishi, Taiga Itagaki, Yusuke Akimoto, Yusuke Chikata and Jun Oto : Effects of novel trigger algorithms on trigger performance and patient-ventilator synchrony: a lung model study. (Editors Choice Session), American Association for Respiratory Care Congress 2023, 2023.
8.	大藤純 : コロナ禍を振り返る, 徳島県医師会報, 20, 2023年.
9.	Hugues Courson de, Nicolas Massart, Karim Asehnoune, Raphaël Cinotti, Jun Oto and Yoshitoyo Ueno : Risk factors of extubation failure in neurocritical patients with the most impaired consciousness., Intensive Care Medicine, Vol.49, No.10, 1251-1253, 2023. (キーワード) Humans / Airway Extubation / Consciousness / Ventilator Weaning / Risk Factors / Respiration, Artificial / Treatment Failure (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00134-023-07189-3 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37610483 ● Search Scopus @ Elsevier (PMID): 37610483 ● Search Scopus @ Elsevier (DOI): 10.1007/s00134-023-07189-3 (DOI: 10.1007/s00134-023-07189-3, PubMed: 37610483)
10.	大藤純 : 「地域の病院紹介徳島大学病院 ∼救急医療∼」徳島の知りたい医療情報2023, 「地域の病院紹介徳島大学病院 ∼救急医療∼」徳島の知りたい医療情報2023, 27, 2023年.
11.	Nobuto Nakanishi, Shigeaki Inoue, Yuko Ono, Jun Sugiyama, Kazushi Takayama, Yuta Arai, Kensuke Nakamura, Jun Oto and Joji Kotani : Ultrasound-based upper limb muscle thickness is useful for screening low muscularity during intensive care unit admission: A retrospective study., Clinical Nutrition ESPEN, Vol.57, 569-574, 2023. (要約) ) had 76.9% sensitivity and 71.8% specificity. Upper limb muscle thickness was correlated with upper limb muscle cross-sectional area, quadriceps femoris muscle thickness, rectus femoris muscle cross-sectional area (r = 0.39-0.76, p < 0.01, n = 52). (キーワード) Female / Male / Humans / Middle Aged / Aged / Aged, 80 and over / Retrospective Studies / Upper Extremity / Muscle, Skeletal / Intensive Care Units / Malnutrition (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.clnesp.2023.07.089 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37739707 ● Search Scopus @ Elsevier (PMID): 37739707 ● Search Scopus @ Elsevier (DOI): 10.1016/j.clnesp.2023.07.089 (DOI: 10.1016/j.clnesp.2023.07.089, PubMed: 37739707)
12.	上野義豊, 大藤純 : 「人工呼吸中の加温加湿」いますぐ知りたい小児の気道・呼吸管理, いますぐ知りたい小児の気道・呼吸管理, 153-158, 2023年.
13.	大藤純 : 人工呼吸中の加温加湿, いますぐ知りたい小児の気道・呼吸管理, 142-148, 2023年.
14.	大藤純 : COVID-19診療の現状と今後の課題, 四国医学雑誌, Vol.2023;79, No.1,2, 13-24, 2023年. (キーワード) Coronavirus disease 2019 (COVID-19) / acute respiratory distress syndrome (ARDS) / mechanical ventilation (出版サイトへのリンク) ● Publication site (DOI): 10.57444/shikokuactamedica.79.1.2_13 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390015191534391040 ● Search Scopus @ Elsevier (DOI): 10.57444/shikokuactamedica.79.1.2_13 (DOI: 10.57444/shikokuactamedica.79.1.2_13, CiNii: 1390015191534391040)
15.	Sarah Wahlster, Monisha Sharma, Shaurya Taran, A James Town, D Robert Stevens, Raphaël Cinotti, Karim Asehoune, Paolo Pelosi, Chiara Robba, Jun Oto and Yoshitoyo Ueno : Utilization of mechanical power and associations with clinical outcomes in brain injured patients: a secondary analysis of the extubation strategies in neuro-intensive care unit patients and associations with outcome (ENIO) trial., Critical Care, Vol.27, No.1, 2023. (要約) We included 1217 patients (mean age 51.2 years [SD 18.1], 66% male, mean body mass index [BMI] 26.3 [SD 5.18]) hospitalized at 62 intensive care units in 18 countries. Hospital mortality was 11% (n = 139), 44% (n = 536) were extubated by HD7 of which 20% (107/536) required reintubation, 28% (n = 340) underwent tracheostomy placement, and 9% (n = 114) developed ARDS. The median MP on HD1, HD3, and HD7 was 11.9 J/min [IQR 9.2-15.1], 13 J/min [IQR 10-17], and 14 J/min [IQR 11-20], respectively. MP was overall higher in patients with ARDS, especially those with higher ARDS severity. After controlling for same-day pressure of arterial oxygen/fraction of inspired oxygen (P/F ratio), BMI, and neurological severity, MP at HD1, HD3, and HD7 was independently associated with hospital mortality, reintubation and tracheostomy placement. The adjusted relative risk (aRR) was greater at higher MP, and strongest for: mortality on HD1 (compared to the HD1 median MP 11.9 J/min, aRR at 17 J/min was 1.22, 95% CI 1.14-1.30) and HD3 (1.38, 95% CI 1.23-1.53), reintubation on HD1 (1.64; 95% CI 1.57-1.72), and tracheostomy on HD7 (1.53; 95%CI 1.18-1.99). MP was associated with the development of moderate-severe ARDS on HD1 (2.07; 95% CI 1.56-2.78) and HD3 (1.76; 95% CI 1.41-2.22). (キーワード) Adult / Humans / Male / Middle Aged / Female / Airway Extubation / Prospective Studies / Respiration, Artificial / Critical Care / Intensive Care Units / Brain Injuries / Brain / Respiratory Distress Syndrome / Oxygen (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s13054-023-04410-z (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37081474 ● Search Scopus @ Elsevier (PMID): 37081474 ● Search Scopus @ Elsevier (DOI): 10.1186/s13054-023-04410-z (DOI: 10.1186/s13054-023-04410-z, PubMed: 37081474)
16.	Manabu Ishihara, Yasuhisa Kanematsu, Nobuaki Yamamoto, Kenji Shimada, Takeshi Miyamoto, Izumi Yamaguchi, Shu Sogabe, Yuki Yamamoto, Jun Oto and Yasushi Takagi : Prognostic factors for acute large vessel occlusion with NIHSS 5 or lower., The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 22-27, 2023. (要約) MCA occlusion is associated with poor prognosis, even with NIHSS score ??5, and d-IAS may provide a predictor. J. Med. Invest. 70 : 22-27, February, 2023. (キーワード) Humans / Tissue Plasminogen Activator / Stroke / Prognosis / Retrospective Studies / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.70.22 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164724 ● Search Scopus @ Elsevier (PMID): 37164724 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.22 (DOI: 10.2152/jmi.70.22, PubMed: 37164724)
17.	Yuki Nakano, Yoshitoyo Ueno, Emi Ishitani, Koji Sato, Hiroki Sato, Kazuki Momota, Natsuki Bando, Yusuke Akimoto, Toshiyuki Nunomura, Manabu Ishihara, Natsuki Tane, Taiga Itagaki, Yoshiaki Kitamura and Jun Oto : Repetitive postoperative extubation failure due to dynamic inspiratory airway collapse concomitant with subglottic stenosis in a patient who previously underwent tracheostomy., The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 301-305, 2023. (要約) We should be aware of the history of tracheostomy, especially at high tracheostomy sites, even in the absence of respiratory symptoms as risk factors for dynamic inspiratory airway collapse concomitant with subglottic stenosis contributing to repeated respiratory failure after extubation. J. Med. Invest. 70 : 301-305, February, 2023. (キーワード) Humans / 女性 (female) / Adult / Tracheostomy / Airway Extubation / Constriction, Pathologic / Intubation, Intratracheal / Respiration, Artificial (徳島大学機関リポジトリ) ● Metadata: 118365 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.70.301 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164740 ● Summary page in Scopus @ Elsevier: 2-s2.0-85158867166 (徳島大学機関リポジトリ: 118365, DOI: 10.2152/jmi.70.301, PubMed: 37164740, Elsevier: Scopus)
18.	板垣大雅, 大藤純 : 急性呼吸不全における横隔膜保護的人工呼吸戦略, 日本集中治療医学会雑誌, Vol.2022;29, No.5, 510-517, 2022年. (キーワード) diaphragmatic injury / mechanical ventilation / inspiratory effort / atrophy (出版サイトへのリンク) ● Publication site (DOI): 10.3918/jsicm.29_510 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390574743625974912 ● Search Scopus @ Elsevier (DOI): 10.3918/jsicm.29_510 (DOI: 10.3918/jsicm.29_510, CiNii: 1390574743625974912)
19.	中野勇希, 佐藤功志, 佐藤裕紀, 百田和貴, 秋本雄祐, 布村俊幸, 新井悠太, 石原学, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : 経肺圧を指標としたPEEP設定により，致死的低酸素血症から改善した神経芽細胞種に伴う腹部コンパートメント症候群の一乳児症例, 四国医学雑誌, Vol.2022;78, No.3,4, 115-120, 2022年. (要約) Background : Neuroblastoma is the most common extracranial solid tumor of childhood. Although the prognosis of neuroblastoma is relatively good, newborns less than two months of age with stage 4S neuroblastoma may present with aggressive hypoxia and restrictive respiratory impairment due to abdominal compartment syndrome. Case presentation : Two-month-old girl, height of 63 cm and body weight of 10 kg. She was diagnosed as neuroblastoma with Stage 4S. Because she was suffered from refractory hypoxemia and restrictive respiratory impairment due to abdominal compartment syndrome induced by multiple liver metastasis and massive ascites, she was transferred to our ICU. Her trachea was intubated and ventilated with assist/controlled mode, driving pressure 22 cmH2O, positive end-expiratory pressure(PEEP)8 cmH2O, fraction of inspiratory oxygen(FIO2)1.0, but tidal volume was obtained only 3.2 mL/kg and PaO2/FIO2 ratio of 55 mmHg. Therefore, we insert esophageal sensor and monitored esophageal pressure to performed transpulmonary pressure guided PEEP titration. When we changed PEEP from 8 to 15 cmH2O so that the end-expiratory transpulmonary pressure achieving 0 to 5 cmH2O, her oxygenation(PaO2/FIO2 ratio : 55 to 178 mmHg)and respiratory compliance(1.4 to 3.0 mL/cmH2O)were dramatically improved. Her respiratory condition was further stabilized by ascites puncture and radiotherapy, and the patient was extubated successfully on the 25th ICU day. Conclusions : Although pediatric neuroblastoma with stage 4S may induce severe respiratory efficiency, the responsiveness of treatment for neuroblastoma is promising. Multimodal treatments including optimal ventilator management such as transpulmonary pressure -guided PEEP titration contributes to improved patient's prognosis. (キーワード) Neuroblastoma / Abdominal compartment syndrome / Transpulmonary pressure (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520012711615345664 (CiNii: 1520012711615345664)
20.	Taiga Itagaki, Yusuke Akimoto, Yuki Nakano, Yoshitoyo Ueno, Manabu Ishihara, Natsuki Tane, Yumiko Tsunano and Jun Oto : Relationships between double cycling and inspiratory effort with diaphragm thickness during the early phase of mechanical ventilation: A prospective observational study., PLoS ONE, Vol.17, No.8, 2022. (要約) Double cycling on the third day of mechanical ventilation was associated with strong inspiratory efforts and, possibly, changes in diaphragm thickness. (キーワード) 成人 (adult) / Aged / Diaphragm / Humans / Positive-Pressure Respiration / Respiration, Artificial / Retrospective Studies / Ventilators, Mechanical (徳島大学機関リポジトリ) ● Metadata: 118991 (出版サイトへのリンク) ● Publication site (DOI): 10.1371/journal.pone.0273173 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35976965 ● Search Scopus @ Elsevier (PMID): 35976965 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0273173 (徳島大学機関リポジトリ: 118991, DOI: 10.1371/journal.pone.0273173, PubMed: 35976965)
21.	Yoshitoyo Ueno, Saki Harada, Koji Sato, Kazuki Momota, Hiroki Sato, Yusuke Akimoto, Yuta Arai, Toshiyuki Nunomura, Manabu Ishihara, Natsuki Tane, Taiga Itagaki, Yasuhiko Nishioka and Jun Oto : Independent lung ventilation for the management of acute allograft rejection after single-lung transplantation for end-stage emphysema., The Journal of Medical Investigation : JMI, Vol.69, No.3.4, 323-327, 2022. (要約) Background : We herein report the use of independent lung ventilation (ILV) for managing acute allograft rejection after single-lung transplantation (SLT) for end-stage emphysema. Case presentation : A 54-year-old woman was transferred to our hospital with severe hypoxemia and respiratory distress due to unilateral lung disease with diffuse alveolar damage in the right donor lung associated with acute allograft rejection and with hyperinflation of the left native lung due to emphysema. She was unresponsive to immunosuppressive medications and conventional ventilation strategies, so different ventilator settings for each lung were required. A double-lumen endotracheal tube (DLT) was inserted, and ILV was initiated. The right lung was ventilated with high positive end-expiratory pressure (PEEP), intended for lung recruitment, and the left lung was ventilated with lung protective strategies using a low tidal volume and low levels of PEEP to avoid hyperinflation. Two days later, her lung function was dramatically improved, and the DLT was replaced with a single-lumen endotracheal tube. Gas exchange was maintained, and she was successfully weaned from mechanical ventilation on intensive-care unit day 15. Conclusions : ILV appears to be effective and safe for managing acute allograft rejection after SLT for emphysema. J. Med. Invest. 69 : 323-327, August, 2022. (キーワード) Allografts / Emphysema / Female / Humans / Lung / Lung Transplantation / Middle Aged / Pulmonary Emphysema / Respiration, Artificial (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.69.323 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36244790 ● Search Scopus @ Elsevier (PMID): 36244790 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.69.323 (DOI: 10.2152/jmi.69.323, PubMed: 36244790)
22.	Yusuke Akimoto, Natsuki Bando, Hiroki Sato, Koji Sato, Kazuki Momota, Toshiyuki Nunomura, Yoshitoyo Ueno, Manabu Ishihara, Natsuki Tane, Taiga Itagaki and Jun Oto : Acquired laryngomalacia as a cause of post-extubation respiratory failure in patient with postoperative seizure and central pontine myelinolysis after craniotomy., The Journal of Medical Investigation : JMI, Vol.69, No.3.4, 316-319, 2022. (要約) Background : Laryngomalacia is a congenital abnormality of the larynx that commonly occurs in children and rarely in adults. We report the first case of acquired laryngomalacia mainly due to postoperative seizure and central pontine myelinolysis after scheduled craniotomy. Case presentation : A 69-year-old man was admitted to the hospital for elective craniotomy for craniopharyngioma. After the surgery, he developed refractory seizure and required intubation and mechanical ventilation in the intensive-care unit (ICU). After treatment for the seizure, he was extubated. However, immediately after extubation, he developed stridor and respiratory retraction. We performed fiberoptic laryngoscopy and confirmed that the epiglottis had collapsed into the posterior wall of the pharynx during inspiration, which was suspected to be laryngomalacia. He received invasive mechanical ventilation for two days following re-extubation. After the second extubation, he developed stridor again due to acquired laryngomalacia. Six days later, his respiratory condition had worsened, and he received re-intubation and tracheostomy. After ICU discharge, central pontine myelinolysis was diagnosed by magnetic resonance imaging. Conclusions : Adult-onset laryngomalacia is a rare cause of upper airway obstruction but should be considered as a cause of postoperative extubation failure. We should not delay performing fiberoptic laryngoscopy to evaluate this pathology and provide optimal treatment. J. Med. Invest. 69 : 316-319, August, 2022. (キーワード) Aged / Airway Extubation / Child / Craniotomy / Humans / Laryngomalacia / Laryngoscopy / Male / Myelinolysis, Central Pontine / Respiratory Insufficiency / Respiratory Sounds / Seizures (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.69.316 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36244788 ● CiNii @ 国立情報学研究所 (CRID): 1390856738295204480 ● Search Scopus @ Elsevier (PMID): 36244788 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.69.316 (DOI: 10.2152/jmi.69.316, PubMed: 36244788, CiNii: 1390856738295204480)
23.	Yoshitoyo Ueno, Koji Sato, Kazuki Momota, Hiroki Sato, Yuki Nakano, Yusuke Akimoto, Toshiyuki Nunomura, Natsuki Tane, Taiga Itagaki and Jun Oto : The quality and quantity of sleep on dexmedetomidine during high-flow nasal cannula oxygen therapy in critically ill patients., The Journal of Medical Investigation : JMI, Vol.69, No.3.4, 266-272, 2022. (要約) Purpose : High-flow nasal cannula oxygen therapy (HFNC) is a new type of non-invasive respiratory support for acute respiratory failure patients. However, patients receiving HFNC often develop sleep disturbances. We therefore examined whether dexmedetomidine could preserve the sleep characteristics in patients who underwent HFNC. Patients and Methods : This was a pilot, randomized controlled study. We assigned critically ill patients treated with HFNC to receive dexmedetomidine (0.2 to 0.7 µg / kg / h, DEX group) or not (non-DEX group) at night (9:00 p.m. to 6:00 a.m.). Polysomnograms were monitored during the study period. The primary outcomes were total sleep time (TST), sleep efficiency and duration of stage 2 non-rapid eye movement (stage N2) sleep. Results : Of the 28 patients who underwent randomization, 24 were included in the final analysis (12 patients per group). Dexmedetomidine increased the TST (369 min vs. 119 min, p = 0.024) and sleep efficiency (68% vs. 22%, P = 0.024). The duration of stage N2 was increased in the DEX group compared with the non-DEX group, but this finding did not reach statistical significance. The incidences of respiratory depression and hemodynamic instability were similar between the two groups. Conclusions : In critically ill patients who underwent HFNC, dexmedetomidine may optimize the sleep quantity without any adverse events. J. Med. Invest. 69 : 266-272, August, 2022. (キーワード) Cannula / Critical Illness / Dexmedetomidine / Humans / Oxygen / Sleep (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.69.266 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36244779 ● CiNii @ 国立情報学研究所 (CRID): 1390293788341782528 ● Search Scopus @ Elsevier (PMID): 36244779 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.69.266 (DOI: 10.2152/jmi.69.266, PubMed: 36244779, CiNii: 1390293788341782528)
24.	上野義豊, 大藤純 : 人工呼吸器のウィーニングと抜管, 救急·集中治療, Vol.33, No.4, 1232-1242, 2021年. (キーワード) 上野//義豊 / ウエノ//ヨシトヨ (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1522543656133233152 (CiNii: 1522543656133233152)
25.	河原良美, 大藤純 : 集中治療室での早期離床の取り組みにおける基礎知識とアップデート, WOC Nursing, Vol.2021.9, No.10, 53-58, 2021年. (キーワード) 特集●褥瘡対策チームにおける多職種間の相互理解と連携強化のために知っておきたいコト
26.	大藤純 : 救急・集中治療(33巻3号) ショック管理2021-`22, 救急·集中治療, Vol.33, No.3, 757-764, 2021年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1130852778982150566 (CiNii: 1130852778982150566)
27.	Sachiyo Fukushima, Nobuto Nakanishi, Kazumichi Fujioka, Kenichi Suga, Taku Shirakawa, Kayo Osawa, Kanako Hara, Rie Tsutsumi, Maki Urushihara, Ryuji Nakagawa, Hiroyuki Awano, Jun Oto, Hiroshi Sakaue, Kazumoto Iijima and Masafumi Matsuo : Assessment of catabolic state in infants with the use of urinary titin N-fragment., Pediatric Research, 2021. (要約) Urinary titin N-fragment levels have been used to assess the catabolic state, and we used this biomarker to evaluate the catabolic state of infants. We retrospectively measured urinary titin N-fragment levels of urinary samples. The primary outcome was its changes according to postmenstrual age. The secondary outcomes included differences between gestational age, longitudinal change after birth, influence on growth, and relationship with blood tests. This study included 219 patients with 414 measurements. Urinary titin N-fragment exponentially declined with postmenstrual age. These values were 12.5 (7.1-19.6), 8.1 (5.1-13.0), 12.8 (6.0-21.3), 26.4 (16.4-52.0), and 81.9 (63.3-106.4) pmol/mg creatinine in full, late, moderate, very, and extremely preterm infants, respectively (p < 0.01). After birth, urinary levels of titin N-fragment exponentially declined, and the maximum level within a week was associated with the time to return to birth weight in preterm infants ( = 0.39, p < 0.01). This was correlated with creatine kinase in full-term infants ( = 0.58, p < 0.01) and with blood urea nitrogen in preterm infants ( = 0.50, p < 0.01). The catabolic state was increased during the early course of the postmenstrual age and early preterm infants. Catabolic state in infants, especially in preterm infants, was expected to be increased, but no study has clearly verified this. In this retrospective study of 219 patients with 414 urinary titin measurements, the catabolic state was exponentially elevated during the early postmenstrual age. The use of the urinary titin N-fragment clarified catabolic state was prominently increased in very and extremely preterm infants. (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41390-021-01658-5 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34274960 ● Search Scopus @ Elsevier (PMID): 34274960 ● Search Scopus @ Elsevier (DOI): 10.1038/s41390-021-01658-5 (DOI: 10.1038/s41390-021-01658-5, PubMed: 34274960)
28.	大藤純 : 歯科麻酔科医に役立つ周術期の呼吸管理, 日本歯科麻酔学会雑誌, Vol.49, No.3, 114-120, 2021年. (出版サイトへのリンク) ● Publication site (DOI): 10.24569/jjdsa.49.3_114 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390007226091078272 ● Search Scopus @ Elsevier (DOI): 10.24569/jjdsa.49.3_114 (DOI: 10.24569/jjdsa.49.3_114, CiNii: 1390007226091078272)
29.	Nobuto Nakanishi, Satoshi Doi, Yoshimi Kawahara, Mie Shiraishi and Jun Oto : Effect of vibration therapy on physical function in critically ill adults (VTICIA trial): protocol for a single-blinded randomised controlled trial., BMJ Open, Vol.11, No.3, 2021. (要約) This study will enrol 188 adult critically ill patients who require further ICU stay after they can achieve sitting at the edge of the bed or wheelchair. The sample size calculation is based on a 15% improvement of Functional Status Score for the ICU. They will be randomised to vibration therapy coupled with protocolised mobilisation or to protocolised mobilisation alone; outcomes will be compared between the two groups. Therapy will be administered using a low-frequency vibration device (5.6-13 Hz) for 15 min/day from when the patient first achieves a sitting position and onward until discharge from the ICU. Outcome assessments will be blinded to the intervention. Primary outcome will be measured using the Functional Status Score for the ICU during discharge. Secondary outcomes will be identified as follows: delirium, Medical Research Council Score, ICU-acquired weakness, the change of biceps brachii and rectus femoris muscle mass measured by ultrasound, ICU mobility scale and ventilator-free and ICU-free days (number of free days during 28 days after admission). For safety assessment, vital signs will be monitored during the intervention. (キーワード) Activities of Daily Living / Adult / Critical Illness / Humans / Intensive Care Units / Physical Therapy Modalities / Randomized Controlled Trials as Topic / Vibration (徳島大学機関リポジトリ) ● Metadata: 117420 (出版サイトへのリンク) ● Publication site (DOI): 10.1136/bmjopen-2020-043348 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33653754 ● Search Scopus @ Elsevier (PMID): 33653754 ● Search Scopus @ Elsevier (DOI): 10.1136/bmjopen-2020-043348 (徳島大学機関リポジトリ: 117420, DOI: 10.1136/bmjopen-2020-043348, PubMed: 33653754)
30.	Manabu Ishihara, Nobuto Nakanishi, Rie Tsutsumi, Kanako Hara, Kyoka Machida, Nobuaki Yamamoto, Yasuhisa Kanematsu, Hiroshi Sakaue, Jun Oto and Yasushi Takagi : Elevated Urinary Titin and its Associated Clinical Outcomes after Acute Stroke., Journal of Stroke & Cerebrovascular Diseases, Vol.30, No.3, 2021. (要約) Forty-one patients were included (29 male; age, 68 ± 15 years), 29 had ischemic stroke, 8 had intracerebral hemorrhage, and 4 had subarachnoid hemorrhage. The levels of urinary titin on days 1, 3, 5, and 7 were 9.9 (4.7-21.1), 16.2 (8.6-22.0), 8.9 (4.8-15.2), and 8.7 (3.6-16.2) pmol/mg Cr, respectively. The peak urinary titin level was associated with the mRS score (r = 0.55, p < 0.01), the NIHSS score (r = 0.72, p < 0.01), and the BI (r = -0.59, p < 0.01) upon hospital discharge. In multivariate analysis, the peak urinary titin was associated with poor outcome (p = 0.03). (キーワード) Aged / Aged, 80 and over / Biomarkers / Connectin / Disability Evaluation / Female / Functional Status / Humans / Male / Middle Aged / Patient Discharge / Predictive Value of Tests / Prospective Studies / Recovery of Function / Stroke / Time Factors / Treatment Outcome / Up-Regulation / Urinalysis (徳島大学機関リポジトリ) ● Metadata: 119486 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2020.105561 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33360523 ● Search Scopus @ Elsevier (PMID): 33360523 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jstrokecerebrovasdis.2020.105561 (徳島大学機関リポジトリ: 119486, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105561, PubMed: 33360523)
31.	Nobuto Nakanishi, Rie Tsutsumi, Kanako Hara, Masafumi Matsuo, Hiroshi Sakaue and Jun Oto : Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome., Journal of Clinical Medicine, Vol.10, No.4, 614, 2021. (要約) Titin is a giant protein that functions as a molecular spring in sarcomeres. Titin interconnects the contraction of actin-containing thin filaments and myosin-containing thick filaments. Titin breaks down to form urinary titin N-fragments, which are measurable in urine. Urinary titin N-fragment was originally reported to be a useful biomarker in the diagnosis of muscle dystrophy. Recently, the urinary titin N-fragment has been increasingly gaining attention as a novel biomarker of muscle atrophy and intensive care unit-acquired weakness in critically ill patients, in whom titin loss is a possible pathophysiology. Furthermore, several studies have reported that the urinary titin N-fragment also reflected muscle atrophy and weakness in patients with chronic illnesses. It may be used to predict the risk of post-intensive care syndrome or to monitor patients' condition after hospital discharge for better nutritional and rehabilitation management. We provide several tips on the use of this promising biomarker in post-intensive care syndrome. (徳島大学機関リポジトリ) ● Metadata: 117559 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/jcm10040614 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33561946 ● Search Scopus @ Elsevier (PMID): 33561946 ● Search Scopus @ Elsevier (DOI): 10.3390/jcm10040614 (徳島大学機関リポジトリ: 117559, DOI: 10.3390/jcm10040614, PubMed: 33561946)
32.	Takuya Takashima, Nobuto Nakanishi, Yuta Arai and Jun Oto : The effect of high-flow nasal cannula on diaphragm dysfunction including paradoxical diaphragmatic contraction in the intensive care unit., The Journal of Medical Investigation : JMI, Vol.68, No.1.2, 159-164, 2021. (要約) Background : Diaphragm dysfunction is a serious problem. However, a few management techniques exist for diaphragm dysfunction. Methods : Adult patients treated with high-flow nasal cannula (HFNC) in the intensive care unit were included in this study. The diaphragm function was evaluated using ultrasound measurement of thickening fraction before and after HFNC liberation. Normal diaphragm contraction was defined as thickening fraction ≥ 15% without HFNC, whereas decreased or paradoxical diaphragm contractions were 0%-15% or < 0%, respectively. Results : Forty patients were enrolled, and 16 (40%) had normal diaphragm contraction, whereas 19 (48%) or 5 (13%) had decreased or paradoxical diaphragm contractions, respectively. Thickening fraction increased after HFNC liberation (27.0% ± 25.7% vs. 38.8% ± 34.5%, p = 0.03 in HFNC vs. no HFNC) in patients without diaphragm dysfunction. In patients with decreased diaphragm contraction, thickening fraction did not change with or without HFNC (8.9% ± 11.7% vs. 6.7% ± 5.2%, p = 0.35), whereas paradoxical contraction decreased with HFNC (1.0% ± 10.2% vs. -10.3% ± 2.7%, p = 0.04) in patients with paradoxical diaphragm contraction. Conclusions : The work of breathing decreased with HFNC in patients without diaphragm dysfunction, but did not decrease in patients with decreased diaphragm contraction. Paradoxical diaphragm contraction decreased with HFNC. J. Med. Invest. 68 : 159-164, February, 2021. (キーワード) Adult / Cannula / Diaphragm / Humans / Intensive Care Units / Ultrasonography (徳島大学機関リポジトリ) ● Metadata: 116004 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.68.159 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33994463 ● Summary page in Scopus @ Elsevier: 2-s2.0-85106645331 (徳島大学機関リポジトリ: 116004, DOI: 10.2152/jmi.68.159, PubMed: 33994463, Elsevier: Scopus)
33.	大藤純 : 術後肺合併症を予防する呼吸管理, 外科と代謝·栄養, Vol.55, No.1, 29-33, 2021年. (出版サイトへのリンク) ● Publication site (DOI): 10.11638/jssmn.55.1_29 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.11638/jssmn.55.1_29 (DOI: 10.11638/jssmn.55.1_29)
34.	中西信人, 小出静代, 橋爪太, 大藤純 : 集中治療領域におけるクラウドファンディングの活用:筋萎縮ゼロプロジェクトとアンケート調査, 四国医学雑誌, Vol.76, No.5-6, 327-330, 2020年. (要約) In recent years, it is not easy to secure research funding, and this is a serious problem especially for young researchers. Therefore, we conducted a crowdfunding called Muscle Atrophy Zero Project and received research funding of 2 5 million yen in 2 months. Muscle Atrophy Zero Project aims to do a research about causes, diagnoses, and preventions of muscle atrophy in critically ill patients. In a questionnaire survey conducted by the crowdfunding organization(for all projects), 5% donated due to the attractive return gifts, and about half due to research or project content. We considered Muscle Atrophy Zero Project obtained the understanding for its contribution to the society. Through crowdfunding, we will deepen the understanding in the intensive care field as well as ensuring research funding. (キーワード) intensive care medicine / crowdfunding / questionnaire (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050302315064912000 (CiNii: 1050302315064912000)
35.	髙島拓也, 西川真理恵, 上野義豊, 中西信人, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : ARDS に対する長期人工呼吸管理中に不動に伴う高 Calcium 血症を呈した 1例, 四国医学雑誌, Vol.76, No.5-6, 307-310, 2020年. (要約) Immobilization hypercalcemia is a rare complication in critically ill patients and causes weakness and gastrointestinal symptoms, symptoms that may lead to delayed rehabilitation and mobilization. A45-year-old woman developed ARDS and received prolonged mechanical ventilation. She received deep sedation to control excessive inspiratory effort and agitation until the 10th day. She developed hypercalcemia, which induced nausea and vomiting, on the fifth day. It was difficult to implement early physical rehabilitation and mobilization due to hypercalcemic symptoms. She was diagnosed with immobilization hypercalcemia and received alendronate sodium and elcatonin. The serum corrected calcium rapidly normalized and nausea disappeared after these drugs administration. After that, she underwent rehabilitation and was liberated from mechanical ventilation on the 63rd day. For the diagnosis of immobilization hypercalcemia, it is important to recognize risk factors such as long-term immobility, obesity, and an internal history of antiestrogens preparation. We should consider pharmacological intervention if it is difficult to implement early rehabilitation and mobilization due to symptoms of hypercalcemia. (キーワード) Immobilization / Hypercalcemia / Intensive care (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050302315064922880 (CiNii: 1050302315064922880)
36.	大藤純 : 呼吸管理のデバイス-加温加湿デバイス-「呼吸管理管理中の加温加湿デバイス:その原理と使用法」, 人工呼吸, Vol.2020, No.37(2), 179-186, 2020年.
37.	Nobuto Nakanishi, Jun Oto, Rie Tsutsumi, Yusuke Akimoto, Yuki Nakano and Masaji Nishimura : Upper limb muscle atrophy associated with in-hospital mortality and physical function impairments in mechanically ventilated critically ill adults: a two-center prospective observational study., Journal of Intensive Care, Vol.8, No.1, 2020. (要約) In this two-center prospective observational study, we included adult patients who were expected to require mechanical ventilation for > 48 h and remain in the intensive care unit (ICU) for > 5 days. We used ultrasound to evaluate the cross-sectional area of the biceps brachii on days 1, 3, 5, and 7 and upon ICU discharge along with assessment of physical functions. The primary outcome was the relationship between muscle atrophy ratio and in-hospital mortality on each measurement day, which was assessed using multivariate analysis. The secondary outcomes were the relationships between upper limb muscle atrophy and Medical Research Council (MRC) score, handgrip strength, ICU Mobility Scale (IMS) score, and Functional Status Score for the ICU (FSS-ICU). (徳島大学機関リポジトリ) ● Metadata: 116553 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s40560-020-00507-7 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33292655 ● Search Scopus @ Elsevier (PMID): 33292655 ● Search Scopus @ Elsevier (DOI): 10.1186/s40560-020-00507-7 (徳島大学機関リポジトリ: 116553, DOI: 10.1186/s40560-020-00507-7, PubMed: 33292655)
38.	Nobuto Nakanishi, Jun Oto, Rie Tsutsumi, Tomoko Yamamoto, Yoshitoyo Ueno, Emiko Nakataki, Taiga Itagaki, Hiroshi Sakaue and Masaji Nishimura : Effect of Electrical Muscle Stimulation on Upper and Lower Limb Muscles in Critically Ill Patients: A Two-Center Randomized Controlled Trial., Critical Care Medicine, Vol.48, No.11, e997-e1003, 2020. (要約) In critically ill patients, electrical muscle stimulation prevented upper and lower limb muscle atrophy and attenuated proteolysis and decreased the length of hospitalization. (キーワード) Aged / Amino Acids / Critical Illness / Electric Stimulation Therapy / Extremities / Female / Humans / Male / Muscle, Skeletal / Muscular Atrophy / Quadriceps Muscle / Single-Blind Method (徳島大学機関リポジトリ) ● Metadata: 115045 (出版サイトへのリンク) ● Publication site (DOI): 10.1097/CCM.0000000000004522 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32897665 ● Search Scopus @ Elsevier (PMID): 32897665 ● Search Scopus @ Elsevier (DOI): 10.1097/CCM.0000000000004522 (徳島大学機関リポジトリ: 115045, DOI: 10.1097/CCM.0000000000004522, PubMed: 32897665)
39.	Yoshimi Kawahara, Nobuto Nakanishi, Keiko Nomura and Jun Oto : Upper limb movements and the risk of unplanned device removal in mechanically ventilated patients., Acute Medicine & Surgery, Vol.7, No.1, 2020. (出版サイトへのリンク) ● Publication site (DOI): 10.1002/ams2.572 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33072346 ● Search Scopus @ Elsevier (PMID): 33072346 ● Search Scopus @ Elsevier (DOI): 10.1002/ams2.572 (DOI: 10.1002/ams2.572, PubMed: 33072346)
40.	Nobuto Nakanishi, Yuri Okamoto, Tetsuya Okahisa and Jun Oto : Early Initiation of Awake Veno-Venous Extracorporeal Membrane Oxygenation Can Attenuate Muscle Atrophy and Weakness in Acute Respiratory Distress Syndrome., Curēus, Vol.12, No.8, 2020. (要約) Patients with acute respiratory distress syndrome (ARDS) exhibit prominent muscle atrophy and weakness. Although these patients often require deep sedation to perform lung-protective ventilation, extracorporeal membrane oxygenation (ECMO) can keep patients awake and make mobilization possible. A 60-year-old man was treated with ECMO due to ARDS. A multidisciplinary team conducted mobilization with standing on day 3. During intensive care unit (ICU) stay, catabolism was ongoing (urinary titin: 24.1-38.4 pmol/mg Cr), but the rectus femoris muscle, measured by ultrasound, moderately decreased by 5.3%, 10.8%, and 13.0% on days 3, 5, and 7, respectively, with maintained Medical Research Council score of 58-60. Diaphragm thickness remained unchanged. On day 5, he was separated from ECMO. After ambulation training, he was discharged from ICU on day 7. He returned home without prominent physical dysfunction. Our experience indicates early initiation of awake ECMO can accompany mobilization and attenuate muscle atrophy and weakness in ARDS. (出版サイトへのリンク) ● Publication site (DOI): 10.7759/cureus.9926 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32968587 ● Search Scopus @ Elsevier (PMID): 32968587 ● Search Scopus @ Elsevier (DOI): 10.7759/cureus.9926 (DOI: 10.7759/cureus.9926, PubMed: 32968587)
41.	Masayuki Chuma, Masateru Kondo, Yoshito Zamami, Kenshi Takechi, Mitsuhiro Goda, Naoto Okada, Akitomo Shibata, Mizuho Asada, Jun Oto, Hiroaki Yanagawa and Keisuke Ishizawa : Successful Vancomycin Dose Adjustment in a Sepsis patient with Bacterial Meningitis Using Cystatin C., Acta Medica Okayama, Vol.74, No.4, 365-370, 2020. (要約) Cystatin C-guided vancomycin (VCM) dosing is useful in critically ill patients. Its usefulness in septic patients with bacterial meningitis remains unknown, as there are no published reports. In this study, we sought to clarify its benefit. Cystatin C was used to guide VCM dosing in a septic bacterial meningitis patient with normal kidney function, according to therapeutic drug monitoring (TDM). Using cystatin C, the Bayesian method-based TDM made optimal VCM dosing possible, and decreased the predicted error (4.85 mg/L) compared to serum creatinine (16.83 mg/L). We concluded TDM of VCM using cystatin C can be considered in sepsis patients with bacterial meningitis with normal kidney function. (キーワード) Adult / Anti-Bacterial Agents / Biomarkers / Cystatin C / Drug Monitoring / Glomerular Filtration Rate / Humans / 男性 (male) / Meningitis, Bacterial / Sepsis / Vancomycin (出版サイトへのリンク) ● Publication site (DOI): 10.18926/AMO/60376 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32843769 ● Search Scopus @ Elsevier (PMID): 32843769 ● Search Scopus @ Elsevier (DOI): 10.18926/AMO/60376 (DOI: 10.18926/AMO/60376, PubMed: 32843769)
42.	Nobuto Nakanishi, Yasuhiro Suzuki, Manabu Ishihara, Yoshitoyo Ueno, Natsuki Tane, Yumiko Tsunano, Taiga Itagaki and Jun Oto : Effect of High-Flow Nasal Cannula on Sleep-disordered Breathing and Sleep Quality in Patients With Acute Stroke., Curēus, Vol.12, No.7, 2020. (要約) Introduction Sleep-disordered breathing (SDB) is common after stroke. Although the standard treatment of SDB is continuous positive airway pressure (CPAP) ventilation, the patient's intolerance and discomfort result in low adherence rates. Alternatively, high-flow nasal cannula (HFNC) may be useful as it reduces upper airway collapse with low level of positive pressure and well tolerability. The aim of this study was to investigate whether HFNC therapy reduces SDB and improves sleep quality with higher compliance rate. Methods We included acute stroke patients with SDB for the assessment of apnea-hypopnea index (AHI) >5/h using WatchPAT 200 (Itamar Medical Ltd, Caesarea, Israel). Patients who met inclusion criteria received HFNC therapy (40 L/min) with monitoring by WatchPAT. AHI, oxygen desaturation index (ODI), sleep efficiency, and rapid eye movement (REM) sleep were compared in patients with and without HFNC therapy. We also evaluated the patient's comfort of HFNC therapy (discomfort or not). Results Among 17 patients assessed for AHI, 12 received HFNC therapy. HFNC therapy was not adhered in two patients due to intolerance. Eight patients remained for final analysis. There were no differences in SDB and sleep quality with and without HFNC therapy as follows: HFNC therapy vs control; AHI 24.9 ± 20.1 vs 21.3 ± 15.0/h (p = 0.63), ODI 16.2 ± 16.5 vs 12.9 ± 12.3/h (p = 0.54), sleep efficiency 80.4 ± 12.9 vs 87.1 ± 6.2 (p = 0.28), percentage of REM sleep 19.4% ± 9.6% vs 27.6% ± 8.9% (p = 0.07). Two patients (17%) complained of discomfort among eight patients. Conclusion HFNC therapy did not improve SDB and sleep quality. Nonadherence and discomfort were observed in HFNC therapy. We need a large trial to confirm this result. (出版サイトへのリンク) ● Publication site (DOI): 10.7759/cureus.9303 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32832300 ● Search Scopus @ Elsevier (PMID): 32832300 ● Search Scopus @ Elsevier (DOI): 10.7759/cureus.9303 (DOI: 10.7759/cureus.9303, PubMed: 32832300)
43.	秋本雄祐, 上野義豊, 髙島拓也, 石原学, 中西信人, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : 側弯矯正固定術後の急性換気不全に対し気管支鏡による選択的気管支拡張術が奏功した1例, 日本集中治療医学会第4回中国・四国支部学術集会, 2020年.
44.	大藤純 : ICU運営を考える「徳島大学病院救急集中治療部の概要と取り組み」, 日本集中治療医学会第4回中国・四国支部学術集会, 2020年.
45.	Nobuto Nakanishi, Rie Tsutsumi, Kanako Hara, Takuya Takashima, Emiko Nakataki, Taiga Itagaki, Masafumi Matsuo, Jun Oto and Hiroshi Sakaue : Urinary Titin Is a Novel Biomarker for Muscle Atrophy in Nonsurgical Critically Ill Patients: A Two-Center, Prospective Observational Study., Critical Care Medicine, Vol.2020, No.48(9), 1327-1333, 2020. (要約) In nonsurgical critically ill patients, urinary titin level increased 10-30 times compared with the normal level. The increased urinary titin level was associated with lower limb muscle atrophy, occurrence of ICU-acquired weakness, and ICU mortality. (徳島大学機関リポジトリ) ● Metadata: 115044 (出版サイトへのリンク) ● Publication site (DOI): 10.1097/CCM.0000000000004486 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32706557 ● Summary page in Scopus @ Elsevier: 2-s2.0-85089802708 (徳島大学機関リポジトリ: 115044, DOI: 10.1097/CCM.0000000000004486, PubMed: 32706557, Elsevier: Scopus)
46.	近田優介, 大藤純 : ネーザルハイフロー用装置, 救急医学6月臨時増刊号, Vol.44, No.7, 788-794, 2020年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1523669554978297472 (CiNii: 1523669554978297472)
47.	髙島拓也, 板垣大雅, 上野義豊, 中西信人, 田根なつ紀, 綱野祐美子, 大藤純 : 急性呼吸不全を合併した免疫不全患者に対する呼吸療法がICU転帰に与える影響∼NPPVとHFNCの比較∼, 四国医学雑誌, Vol.76, No.1-2, 55-60, 2020年. (要約) Background : Non-invasive positive pressure ventilation (NPPV) is highly recommended for immunocompromised patients with acute respiratory failure. In this population it remains uncertain, however, whether high flow nasal canula(HFNC)is as beneficial as NPPV. Methods : We retrospectively studied immunocompromised patients with acute respiratory failure admitted to our ICU from 2011 to 2018. The background and clinical outcomes of patients initially treated with HFNC and NPPV were compared. Results : Upon admission, 12 patients were treated with HFNC and 10 with NPPV. While the length of ICU stay was significantly shorter in HFNC group (HFNC4．6days vs. NPPV13．8days, p=0．02), no intergroup difference was seen in ICU mortality (16．7% vs.30．0%, p=0．46)or intubation rate(33．3% vs.50．0%, p=0．43). Conclusions : For immunocompromised patients with acute respiratory failure, HFNC may be an alternative to NPPV. Further prospective investigation is warranted. (キーワード) Acute respiratory failure / Immunocompromised patients / Noninvasive positive pressure ventilation / High flow nasal cannula (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050865122805929984 (CiNii: 1050865122805929984)
48.	秋本雄祐, 上野義豊, 髙島拓也, 中西信人, 田根なつ紀, 綱野祐美子, 石原学, 板垣大雅, 大藤純 : 当院ICUにおけるカルバペネム系抗菌薬の使用状況とde-escalationに関する検討．, 第47回日本集中治療医学会学術集会, 2020年.
49.	髙島拓也, 上野義豊, 石原学, 中西信人, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : 目標換気量の表示が人工呼吸患者の低一回換気量/肺保護換気の順守率に与える影響．, 第47回日本集中治療医学会学術集会, 2020年.
50.	板垣大雅, 髙島拓也, 上野義豊, 中西信人, 田根なつ紀, 綱野祐美子, 大藤純 : 人工呼吸開始後早期の患者-人工呼吸器非同調が横隔膜厚の変化に与える影響．, 第47回日本集中治療医学会学術集会, 2020年.
51.	板垣大雅, 大藤純 : NPPVとハイフロー療法どっちがいいの?「急性呼吸不全におけるネーザルハイフローセラピーの現況」, 第47回日本集中治療医学会学術集会, 2020年.
52.	Nobuto Nakanishi, Takuya Takashima and Jun Oto : Muscle atrophy in critically ill patients: a review of its cause, evaluation, and prevention, The Journal of Medical Investigation : JMI, Vol.67, No.1, 1-10, 2020. (要約) Critically ill patients exhibit prominent muscle atrophy, which occurs rapidly after ICU admission and leads to poor clinical outcomes. The extent of atrophy differs among muscles as follows: upper limb: 0.7%-2.4% per day, lower limb: 1.2%-3.0% per day, and diaphragm 1.1%-10.9% per day. This atrophy is caused by numerous risk factors such as inflammation, immobilization, nutrition, hyperglycemia, medication, and mechanical ventilation. Muscle atrophy should be monitored noninvasively by ultrasound at the bedside. Ultrasound can assess muscle mass in most patients, although physical assessment is limited to almost half of all critically ill patients due to impaired consciousness. Important strategies to prevent muscle atrophy are physical therapy and electrical muscular stimulation. Electrical muscular stimulation is especially effective for patients with limited physical therapy. Regarding diaphragm atrophy, mechanical ventilation should be adjusted to maintain spontaneous breathing and titrate inspiratory pressure. However, the sufficient timing and amount of nutritional intervention remain unclear. Further investigation is necessary to prevent muscle atrophy and improve long-term outcomes. J. Med. Invest. 67 : 1-10, February, 2020. (徳島大学機関リポジトリ) ● Metadata: 114743 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.67.1 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32378591 ● Summary page in Scopus @ Elsevier: 2-s2.0-85084329335 (徳島大学機関リポジトリ: 114743, DOI: 10.2152/jmi.67.1, PubMed: 32378591, Elsevier: Scopus)
53.	Nobuto Nakanishi, Jun Oto, Yoshitoyo Ueno, Emiko Nakataki, Taiga Itagaki and Masaji Nishimura : Change in diaphragm and intercostal muscle thickness in mechanically ventilated patients: A prospective observational ultrasougraphy study, Journal of Intensive Care, Vol.7, 56, 2020. (徳島大学機関リポジトリ) ● Metadata: 114542 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s40560-019-0410-4 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1186/s40560-019-0410-4 (徳島大学機関リポジトリ: 114542, DOI: 10.1186/s40560-019-0410-4)
54.	Taiga Itagaki, Nobuto Nakanishi, Takuya Takashima, Yoshitoyo Ueno, Natsuki Tane, Yumiko Tsunano, Toshiyuki Nunomura and Jun Oto : Effect of controlled ventilation during assist-control ventilation on diaphragm thickness : a post hoc analysis of an observational study., The Journal of Medical Investigation : JMI, Vol.67, No.3.4, 332-337, 2020. (要約) Background : Since diaphragm passivity induces oxidative stress that leads to rapid atrophy of diaphragm, we investigated the effect of controlled ventilation on diaphragm thickness during assist-control ventilation (ACV). Methods : Previously, we measured end-expiratory diaphragm thickness (Tdiee) of patients mechanically ventilated for more than 48 hours on days 1, 3, 5 and 7 after the start of ventilation. We retrospectively investigated the proportion of controlled ventilation during the initial 48-hour ACV (CV48%). Patients were classified according to CV48% : Low group, less than 25% ; High group, higher than 25%. Results : Of 56 patients under pressure-control ACV, Tdiee increased more than 10% in 6 patients (11%), unchanged in 8 patients (14%) and decreased more than 10% in 42 patients (75%). During the first week of ventilation, Tdiee decreased in both groups : Low (difference, -7.4% ; 95% confidence interval [CI], -10.1% to -4.6% ; p < 0.001) and High group (difference, -5.2% ; 95% CI, -8.5% to -2.0% ; p = 0.049). Maximum Tdiee variation from baseline did not differ between Low (-15.8% ; interquartile range [IQR], -22.3 to -1.5) and High group (-16.7% ; IQR, -22.6 to -11.1, p = 0.676). Conclusions : During ACV, maximum variation in Tdiee was not associated with proportion of controlled ventilation higher than 25%. J. Med. Invest. 67 : 332-337, August, 2020. (徳島大学機関リポジトリ) ● Metadata: 115438 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.67.332 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33148911 ● Summary page in Scopus @ Elsevier: 2-s2.0-85095587008 (徳島大学機関リポジトリ: 115438, DOI: 10.2152/jmi.67.332, PubMed: 33148911, Elsevier: Scopus)
55.	髙島拓也, 上野義豊, 石原学, 田根なつ紀, 中西信人, 綱野祐美子, 板垣大雅, 大藤純 : 高度肥満患者でのElectrical Impedance Tomographyと経肺圧を用いた適正PEEPの検討．, 第47回日本救急医学会総会, 2019年.
56.	田根なつ紀, 石原学, 髙島拓也, 上野義豊, 中西信人, 綱野祐美子, 板垣大雅, 大藤純 : 当院脳卒中センターにおける急性脳主幹動脈閉塞症例での病院前皮質症状評価の検討．, 第47回日本救急医学会総会, 2019年.
57.	綱野祐美子, 髙島拓也, 上野義豊, 中西信人, 田根なつ紀, 板垣大雅, 大藤純 : ステロイドパルス療法により未診断の重症筋無力症の初期増悪から呼吸不全をきたした一症例, 日本救急医学会雑誌, 2019年.
58.	Takuya Takashima, Nobuto Nakanishi, Yoshitoyo Ueno, Natsuki Tane, Yumiko Tsunano, Taiga Itagaki and Jun Oto : Changes of diaphragm function before and after withdrawal of high flow nasal cannula in patients with acute respiratory failure., The 32nd Annual Congress of European Society of Intensive Care Medicine, Berlin, Germany, 2019.
59.	大藤純 : 教育講演「非ARDS患者の人工呼吸管理」, 第41回日本呼吸療法医学会学術集会, 2019年.
60.	中西信人, 髙島拓也, 西川真理恵, 岡久哲也, 土肥智史, 野村慶子, 福岡千佳, 河原良美, 吉田奈緒美, 中山志津, 中瀧恵実子, 板垣大雅, 大藤純 : 長期間の多職種連携による離床により人工呼吸器からの離脱に成功したacute respiratory distress syndrome (ARDS)の1症例, 四国医学雑誌, Vol.75, No.3, 4, 103-108, 2019年. (要約) Early mobilization is an effective way to improve the physical function of critically ill patients, but there are numerous barriers to mobilization. One such is an early ward transfer. Mobilization is often insufficient in a ward, and the patient cannot be liberated from mechanical ventilation. We experienced a case of a successfully liberated patient from prolonged mechanical ventilation in long-term mobilization as orchestrated by a multidisciplinary team in the ICU. A 45-year-old female was admitted to the ICU and placed on mechanical ventilation for acute respiratory distress syndrome(ARDS). We deployed a mobilization protocol, which was mostly restricted to passive exercise in the first 2 weeks after admission. On day 30, the patient recovered from unstable respiration, but could not be liberated from mechanical ventilation because of muscle weakness, diagnosed as ICU-acquired weakness. The patient was gradually mobilized and transferred to a chair on day 35, and she was able to stand on day 56. On day 65, she was completely liberated from mechanical ventilation and discharged from the ICU 70 days after her initial admission. Long-term mobilization is important for liberation of a patient from prolonged mechanical ventilation as well as early mobilization in the ICU. (キーワード) リハビリテーション / ICU退室 / multidisciplinary team / mechanical ventilation / acute respiratory distress syndrome (徳島大学機関リポジトリ) ● Metadata: 113811 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050865122806315136 (徳島大学機関リポジトリ: 113811, CiNii: 1050865122806315136)
61.	Taiga Itagaki, Nobuto Nakanishi, Yoshitoyo Ueno and Jun Oto : Effect of controlled ventilation on diaphragm atrophy during assist-control ventilation: a post hoc analysis., 6th SG-ANZICS Intensive Care Forum, Singapore, 2019.
62.	Yoshitoyo Ueno, Takuya Takashima, Nobuto Nakanishi, Natsuki Tane, Yumiko Tsunano, Taiga Itagaki and Jun Oto : Timing of tracheostomy in acute stroke patients., 6th SG-ANZICS Intensive Care Forum, Singapore, 2019.
63.	大藤純 : :座長「口演 86(O86) 呼吸症例 05」第46回日本集中治療医学会学術集会，2019年3月2日, P122, 2019年.
64.	Mutsuo Onodera, Emiko Nakataki, Nobuto Nakanishi, Taiga Itagaki, Masami Satou, Jun Oto and Masaji Nishimura : Bacterial Contamination of Circuit Inner Surfaces After High-Flow Oxygen Therapy., Respiratory Care, Vol.64, No.5, 545-549, 2019. (要約) Bacterial contamination of inner surfaces of the circuit after high-flow oxygen therapy was relatively high. (キーワード) contamination (出版サイトへのリンク) ● Publication site (DOI): 10.4187/respcare.06299 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30723170 ● Search Scopus @ Elsevier (PMID): 30723170 ● Search Scopus @ Elsevier (DOI): 10.4187/respcare.06299 (DOI: 10.4187/respcare.06299, PubMed: 30723170)
65.	Nobuto Nakanishi, Jun Oto, Taiga Itagaki, Emiko Nakataki, Mutsuo Onodera and Masaji Nishimura : Humidification Performance of Passive and Active Humidification Devices Within a Spontaneously Breathing Tracheostomized Cohort., Respiratory Care, Vol.64, No.2, 130-135, 2018. (要約) In spontaneously breathing subjects with tracheostomy, an heated-and-humidified high-flow system achieved higher absolute humidity than did an HME. (出版サイトへのリンク) ● Publication site (DOI): 10.4187/respcare.06294 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30254040 ● Search Scopus @ Elsevier (PMID): 30254040 ● Search Scopus @ Elsevier (DOI): 10.4187/respcare.06294 (DOI: 10.4187/respcare.06294, PubMed: 30254040)
66.	Taiga Itagaki, Nobuto Nakanishi, Nao Okuda, Emiko Nakataki, Mutsuo Onodera, Jun Oto and Masaji Nishimura : Effect of High-Flow Nasal Cannula on Thoraco-Abdominal Synchrony in Pediatric Subjects After Cardiac Surgery., Respiratory Care, Vol.64, No.1, 10-16, 2018. (要約) After cardiac surgery, HFNC oxygen therapy at 2 L/kg/min improved thoraco-abdominal synchrony and decreased breathing frequency in pediatric subjects. (Clinical trial registration: UMIN000023426.). (出版サイトへのリンク) ● Publication site (DOI): 10.4187/respcare.06193 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30206130 ● Search Scopus @ Elsevier (PMID): 30206130 ● Search Scopus @ Elsevier (DOI): 10.4187/respcare.06193 (DOI: 10.4187/respcare.06193, PubMed: 30206130)
67.	Taiga Itagaki, Yoshitoyo Ueno, Nobuto Nakanishi and Jun Oto : Reverse triggering induced by endotracheal tube leak in lightly sedated ARDS patient., Journal of Intensive Care, Vol.6, 2018. (要約) Reverse triggering is respiratory entrainment triggered by the ventilator especially seen among heavily sedated patients. We confirmed reverse triggering induced by auto-triggering in lightly sedated patient through an esophageal pressure monitoring. The reverse triggering frequently caused breath stacking with increased tidal volume. Physicians should be aware, even at an optimal level of sedation, that reverse triggering can develop, possibly caused by auto-triggering. (徳島大学機関リポジトリ) ● Metadata: 115520 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s40560-018-0314-8 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30065843 ● Summary page in Scopus @ Elsevier: 2-s2.0-85050655300 (徳島大学機関リポジトリ: 115520, DOI: 10.1186/s40560-018-0314-8, PubMed: 30065843, Elsevier: Scopus)
68.	Davide D'Antini, Robert Huhle, Jacob Herrmann, S Demet Sulemanji, Jun Oto, Pasquale Raimondo, Lucia Mirabella, T Sabrine N Hemmes, J Marcus Schultz, Paolo Pelosi, W David Kaczka, Francisco Melo Marcos Vidal, Marcelo de Abreu Gama and Gilda Cinnella : Respiratory System Mechanics During Low Versus High Positive End-Expiratory Pressure in Open Abdominal Surgery: A Substudy of PROVHILO Randomized Controlled Trial., Anesthesia & Analgesia, Vol.126, No.1, 143-149, 2018. (要約) E was increased in the lower compared to higher PEEP group (18.6 [16⋯22] vs 13.4 [11.0⋯17.0] cm H2O·L; P < .01). %E2 was reduced in the lower PEEP group compared to higher PEEP (-15.4 [-28.0⋯6.5] vs 6.2 [-0.8⋯14.0] %; P < .05). Intratidal R/D was increased in the lower PEEP group (61% vs 22%; P = .037). The incidence of intratidal overdistension did not differ significantly between groups (6%). (キーワード) Abdomen / Aged / Double-Blind Method / Female / Humans / Male / Middle Aged / Positive-Pressure Respiration / Postoperative Complications / Prospective Studies / Respiratory Mechanics (出版サイトへのリンク) ● Publication site (DOI): 10.1213/ANE.0000000000002192 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28632529 ● Search Scopus @ Elsevier (PMID): 28632529 ● Search Scopus @ Elsevier (DOI): 10.1213/ANE.0000000000002192 (DOI: 10.1213/ANE.0000000000002192, PubMed: 28632529)
69.	大藤純 : 特集:人工臓器の最近の進歩とケアリング:体外式膜型心肺(ECMO)の最近の進歩．, 四国医学雑誌, Vol.7, No.5,6, 207-220, 2017年. (要約) Extra Corporeal Membrane Oxygenation (ECMO) indications and usage has strikingly progressed over the last 20 years. It has become essential tool in the care of adults and children with severe cardiac and pulmonary dysfunction refractory to conventional management. Most commonly, it is instituted in an emergency or urgent situation after failure of other treatment modalities. It is used as temporary support, usually awaiting recovery of organs, or a bridging treatment to a ventricular assist device or cardiac transplantation. ECMO can be deployed in a veno-arterial configuration for the treatment of cardiogenic shock or as a tool for cardiopulmonary resuscitation. This is usually seen post cardiac surgery, septic shock, in severe cardiac failure due to almost any other cause ; cardiomyopathy, myocarditis, acute coronary syndrome with cardiogenic shock and cardiopulmonary arrest. Veno-venous ECMO is used for respiratory failure and usually involves peripheral cannulation using the femoral veins and/or internal jugular vein. The indications for veno-venous ECMO are respiratory failure, most commonly due to pneumonia, adult respiratory distress syndrome (ARDS), or primary graft failure following lung transplantation. In this article we will provide a review of ECMO development, clinical indications, complications, and patients' management while on ECMO. (キーワード) Veno-arterial ECMO / Veno-venous ECMO / Pulmonary or cardiac failure / extracorporeal life support / 心肺蘇生 (cardiopulmonary resuscitation) (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050302172853475584 (CiNii: 1050302172853475584)
70.	Shujie Liu, M Robert Kacmarek and Jun Oto : Are we fully utilizing the functionalities of modern operating room ventilators?, Current Opinion in Anaesthesiology, Vol.30, No.6, 698-704, 2017. (要約) The increase in number of new features of modern operating room ventilators clearly creates the opportunity for clinicians to optimize ventilatory care. However, improving the quality of ventilator care relies on a complete understanding and correct use of these new features. VIDEO ABSTRACT: http://links.lww.com/COAN/A47. (キーワード) Equipment Design / Humans / Noninvasive Ventilation / Operating Rooms / Respiration, Artificial / Ventilators, Mechanical (出版サイトへのリンク) ● Publication site (DOI): 10.1097/ACO.0000000000000527 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28938301 ● Search Scopus @ Elsevier (PMID): 28938301 ● Search Scopus @ Elsevier (DOI): 10.1097/ACO.0000000000000527 (DOI: 10.1097/ACO.0000000000000527, PubMed: 28938301)
71.	Nobuto Nakanishi, Jun Oto, Rie Tsutsumi, Marina Iuchi, Mutsuo Onodera and Masaji Nishimura : Upper and lower limb muscle atrophy in critically ill patients: an observational ultrasonography study., Intensive Care Medicine, Vol.44, No.2, 263-264, 2017. (徳島大学機関リポジトリ) ● Metadata: 113714 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00134-017-4975-x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29110031 ● Summary page in Scopus @ Elsevier: 2-s2.0-85033478769 (徳島大学機関リポジトリ: 113714, DOI: 10.1007/s00134-017-4975-x, PubMed: 29110031, Elsevier: Scopus)
72.	Taiga Itagaki, Jun Oto, M Sara Burns, Yandong Jiang, M Robert Kacmarek and R Jeremi Mountjoy : The effect of head rotation on efficiency of face mask ventilation in anaesthetised apnoeic adults: A randomised, crossover study., European Journal of Anaesthesiology, Vol.34, No.7, 432-440, 2017. (要約) Two patients were excluded due to protocol violation; thus, data from 38 patients were analysed. The mean expiratory tidal volume was significantly higher in the rotated head position than in the neutral position (612.6 vs. 544.0 ml: difference [95% confidence interval], 68.6 [46.8 to 90.4] ml, P < 0.0001). (出版サイトへのリンク) ● Publication site (DOI): 10.1097/EJA.0000000000000582 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28009638 ● Search Scopus @ Elsevier (PMID): 28009638 ● Search Scopus @ Elsevier (DOI): 10.1097/EJA.0000000000000582 (DOI: 10.1097/EJA.0000000000000582, PubMed: 28009638)
73.	大藤純 : ER・ICUにおける手技の基本と実際―ベテランに学ぶトラブル回避法―:末梢静脈カテーテル．, 救急·集中治療, Vol.29, e110-e117, 2017年.
74.	Yusuke Chikata, Mutsuo Onodera, Jun Oto and Masaji Nishimura : FIO2 in an Adult Model Simulating High-Flow Nasal Cannula Therapy., Respiratory Care, Vol.62, No.2, 193-198, 2016. (キーワード) Adult / Cannula / Humans / Inhalation / Models, Biological / Oxygen / Oxygen Inhalation Therapy / Partial Pressure / Tidal Volume / Ventilators, Mechanical (出版サイトへのリンク) ● Publication site (DOI): 10.4187/respcare.04963 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27879385 ● Search Scopus @ Elsevier (PMID): 27879385 ● Search Scopus @ Elsevier (DOI): 10.4187/respcare.04963 (DOI: 10.4187/respcare.04963, PubMed: 27879385)
75.	T Christopher Chenelle, Jun Oto, Demet Sulemanji, F Daniel Fisher and M Robert Kacmarek : Evaluation of an automated endotracheal tube cuff controller during simulated mechanical ventilation., Respiratory Care, Vol.60, No.2, 183-190, 2014. (要約) There was a clinically important drop in manually set cuff pressure during simulated mechanical ventilation in a stationary model and an even larger drop with movement, but this was significantly reduced by the IntelliCuff in both scenarios. Additionally, we observed that cuff pressure varied directly with inspiratory airway pressure for both techniques, leading to elevated average cuff pressures. (出版サイトへのリンク) ● Publication site (DOI): 10.4187/respcare.03387 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25425705 ● Summary page in Scopus @ Elsevier: 2-s2.0-84930939593 (DOI: 10.4187/respcare.03387, PubMed: 25425705, Elsevier: Scopus)
76.	Jun Oto, T Christopher Chenelle, Zhenbo Su, Q Mary Sun, Yandong Jiang and M Robert Kacmarek : Ventilation efficacy of video-laryngoscopes equipped with a ventilation feature., Respiratory Care, Vol.59, No.11, 1636-1642, 2014. (要約) Achieving effective ventilation is challenging for anesthesia care providers and emergency medical personnel, as difficult mask ventilation and difficult intubation frequently occur. The aim of this study was to determine whether video-laryngoscopes equipped with a ventilation feature can produce effective ventilation. An intubation mannequin with its trachea connected to a model lung with compliance 50 (normal compliance: C50) and 20 mL/cm H2O (low compliance: C20) was used. Ventilation was established via a ventilation catheter (inner diameter 3.5 mm, 50 cm length) extending to the tip of the video-laryngoscope blade. Three different views of the vocal cords (grade 1, vocal cords fully visualized; grade 2, partial vocal cord visualization; grade 3, only epiglottis visualized) were tested. Ventilation was provided by jet ventilator (Jet). The Jet was operated at 10, 15, and 20 psi (Jet10, Jet15, and Jet20). Effective tidal volume (V(T)) was defined as a V(T) greater than anatomical dead space (150 mL). In C50, Jet15 and Jet20 generated effective V(T) in all vocal cord views (for Jet15: grade 1, 663 ± 33 mL; grade 2, 363 ± 25 mL; and grade 3, 198 ± 9 mL; for Jet20: grade 1, 1,005 ± 114 mL; grade 2, 484 ± 38 mL; grade 3, 268 ± 8 mL, respectively). In C20, Jet15 and Jet20 generated effective V(T) in grades 1 and 2 (Jet15: grade 1, 288 ± 8 mL; grade 2, 160 ± 20 mL; grade 3, 81 ± 7 mL; Jet20: grade 1, 421 ± 20 mL; grade 2, 222 ± 16 mL; grade 3, 111 ± 8 mL, respectively). Jet10 achieved effective V(T) in grade 1 and 2 (grade 1, 354 ± 6 mL; grade 2, 223 ± 37 mL, respectively) in C50 and grade 1 (163 ± 12 mL) in C20. Video-laryngoscopes equipped with a ventilation feature provided effective V(T) in simulated clinical scenarios. Further clinical study is required to validate these findings. (出版サイトへのリンク) ● Publication site (DOI): 10.4187/respcare.03169 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25161299 ● Summary page in Scopus @ Elsevier: 2-s2.0-84941339344 (DOI: 10.4187/respcare.03169, PubMed: 25161299, Elsevier: Scopus)
77.	Alejandro Bustamante, Tomás Sobrino, Dolors Giralt, Teresa García-Berrocoso, Victor Llombart, Iratxe Ugarriza, Marc Espadaler, Noelia Rodríguez, Cathie Sudlow, Mar Castellanos, J Craig Smith, Manuel Rodríguez-Yánez, Ulrike Waje-Andreassen, David Tanne, Jun Oto, Mark Barber, Hans Worthmann, E Katja Wartenberg, J Kyra Becker, Baidarbhi Chakraborty, Seung-Hun Oh, N William Whiteley, José Castillo and Joan Montaner : Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: a systematic review and meta-analysis., Journal of Neuroimmunology, Vol.274, No.1-2, 215-224, 2014. (要約) We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592-5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR=2.346 (1.814-3.033), p<0.0001). However, the additional predictive value of IL-6 was moderate (IDI=1.5%, NRI=5.35%). Overall these results indicate an unlikely translation of IL-6 into clinical practice for this purpose. (キーワード) Biological Markers / Humans / Interleukin-6 / Predictive Value of Tests / Prognosis / Recovery of Function / Stroke (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jneuroim.2014.07.015 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25091431 ● Summary page in Scopus @ Elsevier: 2-s2.0-84906940671 (DOI: 10.1016/j.jneuroim.2014.07.015, PubMed: 25091431, Elsevier: Scopus)
78.	Jun Oto, Q M Sun, M R Kacmarek and Y Jiang : Efficacy of ventilation through a customized novel cuffed airway exchange catheter: a tracheal/lung model study., British Journal of Anaesthesia, Vol.112, No.5, 948-949, 2014. (キーワード) Catheters / Equipment Design / Humans / Lung / Models, Biological / 呼吸 (respiration) / Respiration, Artificial / Trachea (出版サイトへのリンク) ● Publication site (DOI): 10.1093/bja/aeu128 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24771795 ● Summary page in Scopus @ Elsevier: 2-s2.0-84899809619 (DOI: 10.1093/bja/aeu128, PubMed: 24771795, Elsevier: Scopus)
79.	Jun Oto, CT Chenelle, AD Marchese and RM Kacmarek : A comparison of leak compensation during pediatric noninvasive ventilation: a lung model study., Respiratory Care, Vol.59, No.2, 241-251, 2014. (要約) Ventilators used for noninvasive ventilation (NIV) must be able to synchronize in the presence of system leaks. We compared the ability of 7 ICU ventilators and 3 dedicated NIV ventilators to compensate for leaks during pediatric NIV. Using a lung simulator, we compared the Maquet Servo-i, Dräger V500, Dräger Carina, Covidien PB840, Respironics V60, Respironics Vision, GE Healthcare/Engström Carestation, CareFusion Avea, Hamilton C3, and Hamilton G5 during increasing (n = 6) and decreasing leaks (n = 6). With a lung simulator we tested 4 leak levels (baseline [BL] 2-3 L/min, L1 5-6 L/min, L2 9-10 L/min, and L3 19-20 L/min); 3 patient weights (10, 20, and 30 kg); and 3 lung mechanics scenarios (normal, obstructive, and restrictive). The ventilator settings were NIV mode, pressure support of 10 cm H2O, and PEEP of 5 cm H2O. The synchronization rate (synchronized cycles/total simulated respirations) was recorded for each ventilator and each leak scenario. Synchronization was defined as triggering without auto-triggering, miss-triggering, delayed cycling, or premature cycling. The mean synchronization rate across all ventilators was 68 ± 27% (range 23-96%) and marked differences existed between the ventilators (P < .001). Significant differences in synchronization rate were observed between the 10-kg model (mean 57 ± 30%, range 17-93%), the 20-kg model (69 ± 30%, 25-98%), and the 30-kg models (77 ± 22%, 28-97%) (P < .001). The synchronization rate for the obstructive model (60 ± 30%, 9-94%) was significantly different from the normal model (71 ± 29%, 18-98%) and the restrictive model (72 ± 28%, 23-98%) (P < .001). The PB840 and the C3 had synchronization rates over 90% overall across all body weights, all lung mechanic profiles, and all leak levels. Leak compensation in NIV for pediatric use can partially compensate for leaks, but varies widely among ventilators, patient weights, and lung mechanics. (キーワード) Computer Simulation / Equipment Design / Equipment Failure Analysis / Humans / Intensive Care / Manikins / Models, Biological / Noninvasive Ventilation / Pediatrics / Respiratory Mechanics (出版サイトへのリンク) ● Publication site (DOI): 10.4187/respcare.02616 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23821761 ● Summary page in Scopus @ Elsevier: 2-s2.0-84893320837 (DOI: 10.4187/respcare.02616, PubMed: 23821761, Elsevier: Scopus)
80.	Jun Oto, Emiko Nakataki, Mutsuo Onodera, Hideaki Imanaka and Masaji Nishimura : Hygrometric properties of inspired gas and oral dryness in patients with acute respiratory failure during noninvasive ventilation., Respiratory Care, Vol.59, No.1, 39-45, 2014. (要約) Because noninvasive ventilation (NIV) delivers medical gas at high flow, inadequate humidification may cause oral dryness and patient discomfort. Heated humidification can be used during NIV, but little has been reported about the effects on the hygrometric conditions inside an oronasal mask and oral dryness during 24 hours on NIV. We measured absolute humidity (AH) inside oronasal masks on subjects with acute respiratory failure during 24 hours on NIV. A single-limb turbine ventilator and oronasal mask with an exhalation port were used for NIV. Oral moistness was evaluated using an oral moisture-checking device, and 3 times during the 24 hours the subjects subjectively scored the feeling of dryness on a 0-10 scale in which 10 was the most severe dryness. Sixteen subjects were enrolled. The mean ± SD AH inside the mask was 30.0 ± 2.6 mg H2O/L (range 23.1-33.3 mg H2O/L). The median oral moistness was 19.2% (IQR 4.4-24.0%), and the median oral dryness score was 5.5 (IQR 4-7). AH and inspired gas leak correlated inversely, both within the subjects (r = -0.56, P < .001) and between the subjects (r = -0.58, P = .02). AH and oral moistness correlated within the subjects (r = 0.39, P = .04). Oral breathing was associated with reduced oral moistness (P = .001) and increased oral dryness score (P = .002). AH varied among the subjects, and some complained of oral dryness even with heated humidifier. Oral breathing decreased oral moistness and worsened the feeling of dryness. (キーワード) Acute Disease / Aged / Continuous Positive Airway Pressure / Female / Gases / Humans / Humidity / Male / Masks / Middle Aged / Noninvasive Ventilation / Respiratory Insufficiency / Steam / Xerostomia (出版サイトへのリンク) ● Publication site (DOI): 10.4187/respcare.02351 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23764857 ● Summary page in Scopus @ Elsevier: 2-s2.0-84891447713 (DOI: 10.4187/respcare.02351, PubMed: 23764857, Elsevier: Scopus)
81.	堤理恵, 平田容子, 中瀧恵実子, 大藤純, 堤保夫, 中屋豊, 今中秀光, 西村匡司 : ICU患者のエネルギー消費量と病勢との関連の検討．, 日本集中治療医学会雑誌, Vol.21, 173-174, 2014年. (キーワード) energy expenditure / respiratory quotient (RQ) / mechanical ventilation (出版サイトへのリンク) ● Publication site (DOI): 10.3918/jsicm.21.173 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001204445489664 ● Search Scopus @ Elsevier (DOI): 10.3918/jsicm.21.173 (DOI: 10.3918/jsicm.21.173, CiNii: 1390001204445489664)
82.	Emiko Nakataki, Jun Oto, Michiko Hata, Yumiko Tsunano, Nao Okuda, Hideaki Imanaka and Masaji Nishimura : Incidence of bacterial contamination in infusion set needles., AJIC - American Journal of Infection Control, Vol.41, No.3, 273-274, 2013. (要約) We examined the incidence and types of bacterial contamination in 265 infusion set needles in adult critically ill patients. Bacterial contamination was detected in 15 samples (5.7%), and a total of 17 organisms were isolated. Ten were coagulase-negative staphylococci (CNS) and Staphylococcus aureus, and the remainder were -Streptococcus, Corynebacterium, and gram-negative rods. Although the contamination was not directly related to catheter-related bloodstream infections exchanging infusion bottles can cause intraluminal contamination and is a possible route of these infections. (キーワード) Adult / Bacteria / Catheter-Related Infections / Humans / Incidence / Needles (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ajic.2012.02.028 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22884495 ● Search Scopus @ Elsevier (PMID): 22884495 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajic.2012.02.028 (DOI: 10.1016/j.ajic.2012.02.028, PubMed: 22884495)
83.	綱野祐美子, 中瀧恵実子, 大藤純, 今中秀光, 西村匡司 : Systemic lupus erythematosus治療中にサイトメガロウイルス腸炎による血小板減少と消化管出血が疑われた2症例, 日本集中治療医学会雑誌, Vol.20, 291-292, 2013年. (キーワード) cytomegalovirus colitis / thrombocytopenia / systemic lupus erythematosus (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001204443796224 (CiNii: 1390001204443796224)
84.	Nao Okuda, Mutsuo Onodera, Yumiko Tsunano, Emiko Nakataki, Jun Oto, Hideaki Imanaka and Masaji Nishimura : Acute cardiac failure in a pregnant woman due to thyrotoxic crisis., Case Reports in Cardiology, Vol.2012, 393580, 2012. (要約) Introduction. Cardiac failure during pregnancy is usually related to preeclampsia/eclampsia, rarely to hyperthyroidism. While hyperthyroidism can easily lead to hypertensive cardiac failure and may harm the fetus, it is sometimes difficult to distinguish hyperthyroidism from normal pregnancy. Case Presentation. We encountered a case of 41-year-old pregnant woman with hypertensive cardiac failure. Because we initially diagnosed as pre-eclampsia/eclampsia, Caesarian section was performed. However, her symptoms still persisted after delivery. After thyroid function test results taken on the day of admission were obtained on the fourth day, we could diagnose that her cardiac failure was caused by thyrotoxic crisis. Conclusions. Hypertensive cardiac failure due to hyperthyroidism during pregnancy is rare and difficult to diagnose because of similar presentation of normal pregnancy. However, physicians should be aware of the risks posed by hyperthyroidism during pregnancy. (出版サイトへのリンク) ● Publication site (DOI): 10.1155/2012/393580 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24804110 ● Search Scopus @ Elsevier (PMID): 24804110 ● Search Scopus @ Elsevier (DOI): 10.1155/2012/393580 (DOI: 10.1155/2012/393580, PubMed: 24804110)
85.	Yoshitoyo Ueno, Hideaki Imanaka, Jun Oto and Masaji Nishimura : Change in ratio of observed to expected deaths in pediatric patients after implementing a closed policy in an adult ICU that admits children., Critical Care Research and Practice, 674262, 2012. (要約) Backgrounds. We examined the effect on the prognosis of critically ill pediatric patients after a closed ICU policy was implemented into an adult ICU that admitted children. Materials and Methods. We assessed the Pediatric Index of Mortality 2 (PIM2) score of pediatric patients (≤15 y.o.) admitted to the ICU from 2001 to 2009. In our teaching hospital, the department for intensive care was established in January 2004. Since then, for critical care patients, we have followed a closed ICU policy with full-time intensivists. We subsequently compared PIM2 scores and the ratio of observed-to-expected deaths (O/E ratio) for three three-year periods: 2001-2003 (before closed policy), 2004-2006, and 2007-2009. Results. Data was collected from 532 pediatric patients. While the PIM2 score statistically significantly increased from 0.066 ± 0.130 for 2001-2003 to 0.114 ± 0.239 for 2004-2006 and 0.086 ± 0.147 for 2007-2009, the O/E ratio decreased from 1.49 for 2001-2003 to 0.82 for 2004-2006 and remained at 0.82 for 2007-2009. Conclusion. The O/E ratio for critically ill pediatric patients improved after the establishment of a closed policy in an adult ICU that admitted children. (出版サイトへのリンク) ● Publication site (DOI): 10.1155/2012/674262 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22645670 ● Summary page in Scopus @ Elsevier: 2-s2.0-84866236480 (DOI: 10.1155/2012/674262, PubMed: 22645670, Elsevier: Scopus)
86.	Shinji Kawahito, Takashi Kawano, Hiroshi Kitahata, Jun Oto, Akira Takahashi, Kazumi Takaishi, Nagakatsu Harada, Tadahiko Nakagawa, Hiroyuki Kinoshita, Toshiharu Azma, Yutaka Nakaya and Shuzo Oshita : Molecular mechanisms of the inhibitory effects of clonidine on vascular adenosine triphosphate-sensitive potassium channels., Anesthesia & Analgesia, Vol.113, No.6, 1374-1380, 2011. (要約) We investigated the effects of the imidazoline-derived α2-adrenoceptor agonist clonidine on vascular adenosine triphosphate-sensitive potassium (K(ATP)) channel activity in rat vascular smooth muscle cells and recombinant vascular K(ATP) channels transiently expressed in COS-7 cells. Using the patch-clamp method, we investigated the effects of clonidine on the following: (1) native vascular K(ATP) channels; (2) recombinant K(ATP) channels with different combinations of various types of inwardly rectifying potassium channel (Kir6.0 family: Kir6.1, 6.2) and sulfonylurea receptor (SUR1, 2A, 2B) subunits; (3) SUR-deficient channels derived from a truncated isoform of the Kir6.2 subunit (Kir6.2ΔC36 channels); and (4) mutant Kir6.2ΔC36 channels with diminished sensitivity to ATP (Kir6.2ΔC36-K185Q channels). Clonidine (≥3 × 10(-8) M) inhibited native K(ATP) channel activity in cell-attached configurations with a half-maximal inhibitory concentration value of 1.21 × 10(-6) M and in inside-out configurations with a half-maximal inhibitory concentration value of 0.89 × 10(-6) M. With similar potency, clonidine (10(-6) or 10(-3) M) also inhibited the activities of various recombinant SUR/Kir6.0 K(ATP) channels, the Kir6.2ΔC36 channel, and the Kir6.2ΔC36-K185Q channel. Clinically relevant concentrations of clonidine inhibit K(ATP) channel activity in vascular smooth muscle cells. This inhibition seems to be the result of its effect on the Kir6.0 subunit and not on the SUR subunit. (キーワード) Animals / COS Cells / Cell Line / Cercopithecus aethiops / Clonidine / Humans / KATP Channels / Muscle, Smooth, Vascular / Potassium Channel Blockers / Potassium Channels, Inwardly Rectifying / Rats (出版サイトへのリンク) ● Publication site (DOI): 10.1213/ANE.0b013e3182321142 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22003223 ● Search Scopus @ Elsevier (PMID): 22003223 ● Search Scopus @ Elsevier (DOI): 10.1213/ANE.0b013e3182321142 (DOI: 10.1213/ANE.0b013e3182321142, PubMed: 22003223)
87.	Yoshitoyo Ueno, Nobuto Nakanishi, Jun Oto, Hideaki Imanaka and Masaji Nishimura : A bench study of the effects of leak on ventilator performance during noninvasive ventilation., Respiratory Care, Vol.56, No.11, 1758-1764, 2011. (要約) Some of the ventilators compensated for leak better than others. With the larger leak none of the ventilators maintained the set PEEP or pressure support. (キーワード) Equipment Design / Humans / Manikins / Materials Testing / Positive-Pressure Respiration / Ventilators, Mechanical (出版サイトへのリンク) ● Publication site (DOI): 10.4187/respcare.01145 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21605483 ● Search Scopus @ Elsevier (PMID): 21605483 ● Search Scopus @ Elsevier (DOI): 10.4187/respcare.01145 (DOI: 10.4187/respcare.01145, PubMed: 21605483)
88.	Hideaki Imanaka, Bunji Takahara, Harutaka Yamaguchi, Emiko Nakataki, Akiko Mano, Daisuke Inui, Jun Oto and Masaji Nishimura : A Chest computed tomography of a patient revealing severe hypoxia due to amniotic fluid embolism: a case report., Journal of Medical Case Reports, Vol.4, 55, 2010. (要約) ABSTRACT: INTRODUCTION: Amniotic fluid embolism is one of the most severe complications in the peripartum period. Because its onset is abrupt and fulminant, it is unlikely that there will be time to examine the condition using thoracic computed tomography (CT). We report a case of life-threatening amniotic fluid embolism, where chest CT in the acute phase was obtained. CASE PRESENTATION: A 22-year-old Asian Japanese primiparous woman was suspected of having an amniotic fluid embolism. After a Cesarean section for cephalopelvic disproportion, her respiratory condition deteriorated. Her chest CT images were examined. CT findings revealed diffuse homogeneous ground-glass shadow in her bilateral peripheral lung fields. She was therefore transferred to our hospital. On admission to our hospital's intensive care unit, she was found to have severe hypoxemia, with SpO2 of 50% with a reservoir mask of 15 L/min oxygen. She was intubated with the support of noninvasive positive pressure ventilation. She was successfully extubated on the sixth day, and discharged from the hospital on the twentieth day. CONCLUSION: This is the first case report describing amniotic fluid embolism in which CT revealed an acute respiratory distress syndrome-like shadow. (出版サイトへのリンク) ● Publication site (DOI): 10.1186/1752-1947-4-55 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20167080 ● Search Scopus @ Elsevier (PMID): 20167080 ● Search Scopus @ Elsevier (DOI): 10.1186/1752-1947-4-55 (DOI: 10.1186/1752-1947-4-55, PubMed: 20167080)
89.	大藤純 : 脳神経疾患とバイタルサイン．, Brain Nursing, Vol.26, 63-76, 2010年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520010381102623616 (CiNii: 1520010381102623616)
90.	乾大資, 眞野暁子, 山口治隆, 大藤純, 今中秀光, 西村匡司 : 集中治療室closed化の心臓血管外科術後患者予後への影響, 日本集中治療医学会雑誌, Vol.17, No.4, 531-532, 2010年. (出版サイトへのリンク) ● Publication site (DOI): 10.3918/jsicm.17.531 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001204443517312 ● Search Scopus @ Elsevier (DOI): 10.3918/jsicm.17.531 (DOI: 10.3918/jsicm.17.531, CiNii: 1390001204443517312)
91.	原真也, 今中秀光, 中瀧恵実子, 眞野暁子, 山口治隆, 乾大資, 大藤純, 西村匡司 : 非侵襲的陽圧換気を用いて気管挿管を回避しえた重症急性膵炎による急性呼吸促迫症候群の1例, 日本集中治療医学会雑誌, Vol.17, No.2, 211-212, 2010年. (出版サイトへのリンク) ● Publication site (DOI): 10.3918/jsicm.17.211 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282679420877568 ● Search Scopus @ Elsevier (DOI): 10.3918/jsicm.17.211 (DOI: 10.3918/jsicm.17.211, CiNii: 1390282679420877568)
92.	Jun Oto, Kenichi Suga, Sato Matsuura, Shuji Kondo, Yoshiaki Ohnishi, Daisuke Inui, Hideaki Imanaka, Shoji Kagami and Masaji Nishimura : Low-density lipoprotein apheresis in a pediatric patient with refractory nephrotic syndrome due to focal segmental glomerulosclerosis, Journal of Anesthesia, Vol.23, No.2, 284-287, 2009. (要約) Focal segmental glomerulosclerosis (FSGS) often leads to refractory nephrotic syndrome (NS). A high level of low-density lipoprotein (LDL) is a risk factor for the progression of NS. An 8-year-old girl presented with severe proteinuria refractory to steroid therapy. She was diagnosed with non-IgA diffuse mesangial proliferative glomerulonephritis. Oral prednisolone, methylprednisolone (mPL) pulse therapy, and cyclosporine and cyclophosphamide therapy failed to achieve remission. Follow-up renal biopsy revealed FSGS. Her serum level of LDL was high, and LDL-apheresis (LDL-A) was performed five times, followed by mPL pulse therapy. Urinary protein decreased from 2-4 g x day(-) to 0.5-1.0 g x day(-). LDL-A may be beneficial in the treatment of multidrug-resistant FSGS. (キーワード) Anti-Inflammatory Agents / Blood Component Removal / 子ども (children) / Drug Resistance / Female / Glomerulosclerosis, Focal Segmental / Humans / Immunosuppressive Agents / Kidney / Lipoproteins, LDL / Nephrotic Syndrome / Proteinuria / Pulse Therapy, Drug (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00540-008-0726-z (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19444573 ● Summary page in Scopus @ Elsevier: 2-s2.0-65749107880 (DOI: 10.1007/s00540-008-0726-z, PubMed: 19444573, Elsevier: Scopus)
93.	森本雅美, 今中秀光, 中瀧恵実子, 山口治隆, 乾大資, 大藤純, 西村匡司 : 冠盗血現象のため抜管後に心不全に陥った Fallot 四徴症の一症例, 日本集中治療医学会雑誌, Vol.16, No.1, 97-98, 2009年. (キーワード) coronary steal phenomenon / tetralogy of Fallot / 心不全 (heart failure) (出版サイトへのリンク) ● Publication site (DOI): 10.3918/jsicm.16.97 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001204444638592 ● Search Scopus @ Elsevier (DOI): 10.3918/jsicm.16.97 (DOI: 10.3918/jsicm.16.97, CiNii: 1390001204444638592)
94.	Jun Oto, Atsuhiko Suzue, Daisuke Inui, Yasushi Fukuta, K Hosotsubo, M Torii, Shinji Nagahiro and Masaji Nishimura : Plasma proinflammatory and anti-inflammatory cytokine and catecholamine concentrations as predictors of neurological outcome in acute stroke patients, Journal of Anesthesia, Vol.22, No.3, 207-212, 2008. (要約) Proinflammatory and anti-inflammatory cytokines may play a pivotal role in cerebral inflammation, which is implicated in the development of brain injury. Systemic cytokine release is mediated by the sympathetic nervous system and catecholamines. The aim of this study was to investigate which parameters, among plasma levels of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor alpha (TNF-alpha) and the levels of the catecholamines, epinephrine and norepinephrine, contribute to the clinical outcome in acute stroke patients. Thirty-seven acute stroke patients (ischemic, n = 19; hemorrhagic, n = 18) were enrolled. All of them were admitted to our hospital within 8 h after stroke onset. Neurological status was evaluated by a modified National Institute of Health Stroke Scale (mNIHSS) on admission and by a modified Rankin Scale (mRS) at 1 month. An mRS score of 3 or more at 1 month was considered to indicate poor outcome. Serum samples for the cytokine and catecholamine measurements were collected on admission. Plasma levels of IL-1beta, IL-6, IL-10, and TNF-alpha were determined by an enzyme-linked immunosorbent assay (ELISA) method and epinephrine and norepinephrine concentrations were determined by high-performance liquid chromatography with electrochemical detection (HPLC-EC). In the ischemic stroke patients, poor outcome was noted in 9 (47%). There were no significant differences in cytokine or catecholamine concentrations between patients with poor and good outcomes, and there was no association between clinical outcome and cytokine and catecholamine concentrations. In the hemorrhagic stroke patients, poor outcome was noted in 10 (56%). IL-6 and IL-10 levels were higher in patients with poor outcome. On logistic regression analysis, higher values of IL-6 were significantly associated with clinical outcome at 1 month (odds ratio [OR], 1.25; 95% confidence interval [CI], 1.02-1.54). In ischemic stroke, plasma cytokines and catecholamines were not predictors of neurological outcome at 1 month. In hemorrhagic stroke, high levels of IL-6 in the early phase indicated a poor neurological outcome. (キーワード) Aged / Brain Ischemia / Catecholamines / Epinephrine / Female / Humans / Interleukin-10 / Interleukin-1beta / Interleukin-6 / Interleukins / Intracranial Hemorrhages / Male / Middle Aged / Norepinephrine / Outcome Assessment (Health Care) / Stroke / Tumor Necrosis Factor-alpha (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00540-008-0639-x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18685925 ● CiNii @ 国立情報学研究所 (CRID): 1572261550508135936 ● Search Scopus @ Elsevier (PMID): 18685925 ● Search Scopus @ Elsevier (DOI): 10.1007/s00540-008-0639-x (DOI: 10.1007/s00540-008-0639-x, PubMed: 18685925, CiNii: 1572261550508135936)
95.	Hiroshi Miyamoto, Toshiya Okahisa, Hiroshi Iwaki, Masahiro Murata, Susumu Ito, Yoshinori Nitta, Masatake Akutagawa, Yohsuke Kinouchi, Yoshiaki Ohnishi, Jun Oto and Masaji Nishimura : Influence of leukocytapheresis therapy for ulcerative colitis on anemia and hemodynamics., Therapeutic Apheresis and Dialysis, Vol.11, No.1, 16-21, 2007. (要約) In Japan, leukocytapheresis (LCAP) therapy has been carried out for ulcerative colitis as an effective therapy with a low incidence of side-effects. In the present study, we serially investigated the influence of LCAP therapy on anemia and hemodynamics in patients with ulcerative colitis using a non-invasive method with a Crit-Line monitor (CLM) (Hema Metrics Inc., Salt Lake City, UT and Boston, MA, USA). We carried out LCAP on 10 patients with ulcerative colitis using a CS-100 Cellsorba EX LCAP filter in 34 courses of LCAP. The mean hematocrit value, which was measured using the Crit-Line monitor, was 21.8 +/- 0.2% (21.0-22.4%), which showed no significant changes after each LCAP therapy. The actual erythrocyte count, hemoglobin and hematocrit values decreased by 244 000/mm3, 0.7 g/dL and 2.1%, respectively, however, the differences were insignificant. These values corresponded to 7.8, 8.0 and 7.6% of the values before LCAP, respectively. There were no significant changes in systolic blood pressure, diastolic blood pressure, or heart rate during LCAP. The results of this study suggest that one course of LCAP does not exacerbate anemia, and it does not influence hemodynamics. However, considering the exacerbation of anemia in patients with severe ulcerative colitis caused by massive melena, monitoring with a less invasive Crit-Line monitor and a vital information monitor might be useful. (キーワード) Adult / Aged / Anemia / Colitis, Ulcerative / Erythrocyte Count / Female / Hematocrit / Humans / Leukapheresis / Male / Melena / Middle Aged (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1744-9987.2007.00451.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17309570 ● Search Scopus @ Elsevier (PMID): 17309570 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1744-9987.2007.00451.x (DOI: 10.1111/j.1744-9987.2007.00451.x, PubMed: 17309570)

学術論文(紀要・その他):

1.	上野義豊, 大藤純 : 人工呼吸に付随する諸問題:鎮痛鎮静薬, --- 呼吸管理2020-21 ガイドライン，スタンダード，論点そして私見 ---, 救急·集中治療, Vol.2020, No.32(1,2), 271-278, 2020年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1523669554881304064 (CiNii: 1523669554881304064)
2.	綱野祐美子, 小野理恵, 今中秀光, 中瀧恵実子, 大藤純, 奥田菜緒, 西村匡司 : 熱傷治療中にabdominal compartment syndrome (ACS)の危険性から回避した症例, 日本集中治療医学会雑誌, Vol.19, 691-692, 2012年. (出版サイトへのリンク) ● Publication site (DOI): 10.3918/jsicm.19.691 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.3918/jsicm.19.691 (DOI: 10.3918/jsicm.19.691)
3.	奥田菜緒, 今中秀光, 綱野祐美子, 中瀧恵実子, 小野理恵, 大藤純, 西村匡司 : 心膜切開後症候群に対してアスピリンが有用であった小児症例, 日本集中治療医学会雑誌, Vol.19, 433-434, 2012年. (出版サイトへのリンク) ● Publication site (DOI): 10.3918/jsicm.19.433 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.3918/jsicm.19.433 (DOI: 10.3918/jsicm.19.433)
4.	宮本弘志, 岡久稔也, 居和城宏, 村田昌彦, 伊東進, 大西芳明, 大藤純, 大田宗幸, 安部正, 黒田泰弘 : 包括評価制度導入後の潰瘍性大腸炎に対する白血球除去療法, ICUとCCU, Vol.28, No.2, 215-217, 2004年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1523669555147628416 (CiNii: 1523669555147628416)
5.	岡久稔也, 宮本弘志, 居和城宏, 伊東進, 大西芳明, 大藤純, 黒田泰弘 : 包括評価制度導入後の急性血液浄化療法, ICUとCCU, Vol.28, No.2, 7-10, 2004年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1524232505373333376 (CiNii: 1524232505373333376)

総説・解説:

1.	原加奈子, 堤理恵, 中西信人, 三島優奈, 待田京香, 黒田雅士, 大藤純, 阪上浩 : 重症患者における筋萎縮と尿中タイチン濃度測定の意義, 四国医学雑誌, Vol.76, No.5-6, 267-272, 2020年12月. (要約) タイチンは，骨格筋において最初に分解される蛋白質として注目されている．尿中のタイチンN末端断片濃度を測定できるELISAが開発され，筋ジストロフィー患者では健常人の数百倍のタイチンN末端断片が検出されることが報告されている．これまでに行った，重症病態における筋萎縮，筋機能低下のバイオマーカーとしての尿中タイチン濃度測定の有用性についての研究を中心に概説した． (キーワード) バイオマーカー(尿) ICU 筋萎縮症(診断,X線診断) 筋節 X線CT 病勢悪化 Connectin(尿) ヒト (徳島大学機関リポジトリ) ● Metadata: 115785 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050020840088217216 (徳島大学機関リポジトリ: 115785, CiNii: 1050020840088217216)
2.	大黒由加里, 長谷川知早, 大藤純, 岡村昌彦, 野住雄策, 中瀧恵実子, 今中秀光, 西村匡司 : 急性呼吸促迫症候群および肺血症を合併した肺結核の一救命例, 日本集中治療医学会雑誌, Vol.17, 71-72, 2010年1月. (出版サイトへのリンク) ● Publication site (DOI): 10.3918/jsicm.17.71 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.3918/jsicm.17.71 (DOI: 10.3918/jsicm.17.71)
3.	眞野暁子, 中瀧恵実子, 山口治隆, 乾大資, 大藤純, 今中秀光, 西村匡司 : 重症患者における栄養管理, 四国医学雑誌, Vol.65, No.1,2, 2-6, 2009年4月.

国際会議:

1.	Masayuki Chuma, Masateru Kondo, Yoshito Zamami, Kenshi Takechi, Mitsuhiro Goda, Naoto Okada, Akitomo Shibata, Mizuho Asada, Jun Oto, Hiroaki Yanagawa and Keisuke Ishizawa : Successful dose adjustment of vancomycin utilizing cystatin C in septic patients with bacterial meningitis: A case report, FIP2019, Abu Dhabi, Sep. 2019.
2.	Nobuto Nakanishi, Jun Oto, Taiga Itagaki, Emiko Nakataki and Masaji Nishimura : Diaphragm and intercostal muscle atrophy in mechanically ventilated patients: an observational ultrasonography study, 48th Society of Critical Care Medicine (SCCM) Critical Care Congress, Feb. 2019.
3.	Nobuto Nakanishi, Jun Oto, Taiga Itagaki, Emiko Nakataki and Masaji Nishimura : Diaphragm and intercostal muscle atrophy in mechanically ventilated patients, Critical Care Medicine, Vol.47, No.1, 558, Jan. 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.1097/01.ccm.0000551908.03959.ae (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1097/01.ccm.0000551908.03959.ae (DOI: 10.1097/01.ccm.0000551908.03959.ae)
4.	Yoshitoyo Ueno and Jun Oto : Effects of nocturnal dexmedetomidine on sleep quality in critically ill patients equipped with high flow nasal cannula., The 30th Annual Congress of European Society of Intensive Care Medicine, Paris, France (October 20), Oct. 2018.
5.	Yoshitoyo Ueno, Emiko Nakataki, Taiga Itagaki, Jun Oto and Masaji Nishimura : Relationship between neurologic values and extubation failure in stroke patients., The 37th KSCCM Annual Congress and Asian Critical Care Conference 2018, Seoul, Korea (April 27-28), Apr. 2018.
6.	Nobuto Nakanishi, Emiko Nakataki, Taiga Itagaki, Jun Oto and Masaji Nishimura : Diaphragm atrophy in mechanically ventilated patients in the ICU., The 37th KSCCM Annual Congress and Asian Critical Care Conference 2018, Seoul, Korea (April 27-28), Apr. 2018.
7.	Yoshitoyo Ueno, Takuya Takashima, Nobuto Nakanishi, Natsuki Tane, Yumiko Tsunano, Taiga Itagaki and Jun Oto : Timing of tracheostomy in acute stroke patients., 6th SG-ANZICS Intensive Care Forum, Singapore(April 20-22), Singapore, Apr. 2018.
8.	Taiga Itagaki, Nobuto Nakanishi, Yoshitoyo Ueno and Jun Oto : Effect of controlled ventilation on diaphragm atrophy during assist-control ventilation: a post hoc analysis., 6th SG-ANZICS Intensive Care Forum, Singapore(April 20-22), Apr. 2018.
9.	中西信人, 大藤純, 板垣大雅, 中瀧恵実子, 小野寺睦雄, 西村匡司 : Heated and humidified high-flow system for tracheostomized patients with spontaneous breathing., 47th Society of Critical Care Medicine (SCCM) Critical Care Congress, サンアントニオ, 2018年2月. (出版サイトへのリンク) ● Publication site (DOI): 10.1097/01.ccm.0000529071.90892.7d (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1097/01.ccm.0000529071.90892.7d (DOI: 10.1097/01.ccm.0000529071.90892.7d)
10.	近田優介, 森西啓介, Jun Oto, Mutsuo Onodera and Masaji Nishimura : Very-high-flow nasal cannula therapy on humidification in adult lung models., The 63rd American Association of Respiratory Care Congress, Indianapolis, Oct. 2017.
11.	森西啓介, 近田優介, Jun Oto, Mutsuo Onodera and Masaji Nishimura : Evaluation of compensatory function for compression volume of transport ventilators: Bench study., The 63rd American Association of Respiratory Care Congress, Indianapolis, Oct. 2017.
12.	Yumiko Tsunano, Emiko Nakataki, Taiga Itagaki, Jun Oto and Masaji Nishimura : Effect of securement device for arterial catheter on catheter-related complications., 30th annual congress of European Society of Intensive Care Medicine, Wien, Sep. 2017.
13.	Taiga Itagaki, Emiko Nakataki, Mutsuo Onodera, Jun Oto and Masaji Nishimura : Effect of high-flow nasal cannula oxygen therapy on thoraco-abdominal synchrony in pediatric patients after cardiac surgery., 30th annual congress of European Society of Intensive Care Medicine, Wien, Sep. 2017.
14.	Emiko Nakataki, Taiga Itagaki, Mutsuo Onodera, Jun Oto and Masaji Nishimura : Gram stain at 24 hours after antibiotic administration predicts effectiveness of antibiotics in ICU patients with respiratory tract infection?, 30th annual congress of European Society of Intensive Care Medicine, Wien, Sep. 2017.
15.	Natsuki Tane, Taiga Itagaki, Yumiko Tsunano, Emiko Nakataki, Mutsuo Onodera, Jun Oto and Masaji Nishimura : A case of neonatal hepatic hemangioma., KSCCM - JSICM joint scientific congress, Seoul, Apr. 2017.
16.	Yumiko Tsunano, Natsuki Tane, Emiko Nakataki, Taiga Itagaki, Jun Oto, Mutsuo Onodera and Masaji Nishimura : Effect of securement device for arterial catheter on catheter-related complications., KSCCM - JSICM joint scientific congress, Seoul, Apr. 2017.
17.	Taiga Itagaki, Jun Oto, RM Kacmarek and JR Mountjoy : Effect of head rotation on efficiency of face mask ventilation in apneic adult patients., KSCCM - JSICM joint scientific congress, Seoul, Apr. 2017.
18.	上野義豊, Jun Oto, Mutsuo Onodera and Masaji Nishimura : Effect of alkalosis on outcome in patients with subarachinoid hemorrhage., EuroAsia, Hong Kong, Apr. 2017.
19.	Nobuto Nakanishi, Jun Oto, Taiga Itagaki, Emiko Nakataki, Mutsuo Onodera and Masaji Nishimura : Ultrasound measurement of the upper and lower limb muscle atrophy in intensive care patitens., EuroAsia, Hong Kong, Apr. 2017.
20.	Mutsuo Onodera, Emiko Nakataki, Jun Oto, Hideaki Imanaka and Masaji Nishimura : ICU-acquired weakness. Does it develop within a week?, European Society of Intensive Care Medicine 29th Annual Congress, Milan, Oct. 2016.
21.	Jun Oto, Emiko Nakataki, Yumiko Tsunano, Masayo Izawa, Natsuki Tane, Mutsuo Onodera and Masaji Nishimura : Bacterial colonization and complications with peripheral intravenous catheter in critically ill patients. Closed- vs. open-system., European Society of Intensive Care Medicine 29th Annual Congress, Milan, Oct. 2016.
22.	Taiga Itagaki, Jun Oto, M Sara Burns, Yandong Jiang, M Robert Kacmarek and R Jeremi Mountjoy : Effect of head rotation on efficiency of face mask ventilation in apneic adult patients under general anesthesia: a prospective randomized crossover study, 19th Asia Pacific Congress on Critical Care Medicine, San Francisco, May 2016.
23.	Yusuke Chikata, Mutsuo Onodera, Jun Oto and Masaji Nishimura : Inspiratory fraction of oxygen in hihg-flow nasal cannula therapy., The 61st Congress of American Association for Respiratory Care, Tampa, Nov. 2015.
24.	Jun Oto, Chenelle T Christopher, Marchese D. Andrew and Kacmarek M. Robert : VALIDATION OF FEASIBILITY AND FUNCTIONALITY OF A VIDEO-LARYNGOSCOPE EQUIPPED WITH VENTILATION FEATURE, The 59th International Respiratory Convention and Exhibition., California, Nov. 2013.
25.	Jun Oto, Chenelle T Christopher, Marchese D. Andrew and Kacmarek M. Robert : VALIDATION OF FEASIBILITY AND FUNCTIONALITY OF A VIDEO-LARYNGOSCOPE EQUIPPED WITH VENTILATION FEATURE, 11th MGH Clinical Research Day, Boston, Oct. 2013.
26.	Jun Oto, Chenelle T Christopher, Marchese D. Andrew and Kacmarek M. Robert : A COMPARISON OF LEAK COMPENSATION IN ACUTE CARE VENTILATORS DURING NON-INVASIVE VENTILATION; A LUNG MODEL STUDY, Scientific Advisory Council meeting 2013, Boston, Massachusetts., Boston, Mar. 2013.
27.	Y Chikata, Jun Oto, Mutsuo Onodera and Masaji Nishimura : Performance of heat and moisture exchangers and other humidifying devices for tracheostomized patients with spontaneous breathing: A bench study., The 58th American Association for Respiratory Care Congress, New Orleans, Nov. 2012.
28.	Jun Oto, Hideaki Imanaka, Mutsuo Onodera and Masaji Nishimura : Sleep quality sedated with dexmedetomidine during mechanical ventilation., 41th Critical Care Congress, Houston, Texas, USA, Feb. 2012.
29.	Jun Oto, Hideaki Imanaka, Mutsuo Onodera and Masaji Nishimura : Absolute humidity and oral dryness during non-invasive positive pressure ventilation., 41th Critical Care Congress, Houston, Texas, USA, Feb. 2012.
30.	Nao Okuda, Jun Oto, Hideaki Imanaka and Masaji Nishimura : Acute cardiac failure with thyrotoxic crisis in a pregnant woman., The 11th Joint Scientific Congress of the KSCCM and JSICM, Seoul, Apr. 2011.
31.	Nao Okuda, Yumiko Tsunano, Jun Oto, Hideaki Imanaka and Masaji Nishimura : Acute cardiac failure with thyrotoxic crisis in a pregnant woman., The 31st Annual Congress of the Korean Society of Critical Care Medicine, Seoul, Apr. 2011.
32.	Sumida Chihiro, Chikata Yusuke, Jun Oto, Hideaki Imanaka and Masaji Nishimura : Humidification performance of heat and moisture exchanger for tracheosomized patients., The 11th Joint Scientific Congress of the KSCCM and JSICM, Seoul, Apr. 2011.
33.	Jun Oto, Hideaki Imanaka and Masaji Nishimura : Effects of automatic tube compensation on respiratory workload in used endotracheal tubes., American Thoracic Society International Conference, Denver, Mar. 2011.
34.	Jun Oto : VAP予防と鎮静法―パネルディスカッション「VAP予防と診断・治療の最前線」, 第2回日米VAPセミナー, Tokyo, Jun. 2010.
35.	Jun Oto, Hideaki Imanaka and Masaji Nishimura : Sleep disturbance in mechanically ventilated patients., The 10th Joint Scientific Congress of KSCCM and JSICM, Hiroshima, Mar. 2010.
36.	Harutaka Yamaguchi, Emiko Nakataki, 眞野暁子, Daisuke Inui, Jun Oto, Hideaki Imanaka and Masaji Nishimura : A loading dose of teicoplanin in critically ill patients: effectiveness of dosing determined by data analysis software, The 21st Annual Congress of the European Society of Intensive Care Medicine, Lisbon, Sep. 2008.
37.	Yoshinori Nitta, Yohsuke Kinouchi, Masatake Akutagawa, Toshiya Okahisa, Hiroshi Miyamoto, Hiroshi Iwaki, Susumu Ito, Yoshiaki Ohnishi, Jun Oto, Yasuhiro Kuroda and Shuzo Oshita : Prediction of the hematocrit value using an artificial neural network during leukocytapheresis therapy, Proceedings of 4th World Congress of the International Society for Apheresis, A10, Nashville, TN, USA, Oct. 2003.
38.	Toshiya Okahisa, Hiroshi Iwaki, Hiroshi Miyamoto, Masahiro Sogabe, Susumu Ito, Yoshiaki Ohnishi, Jun Oto, Yasuhiro Kuroda, Shuzo Oshita, Yoshinori Nitta, Yohsuke Kinouchi and Masatake Akutagawa : Monitoring filter clogging by analyzing the conductive condition of the roller pump flow pressure wave, Proceedings of 4th World Congress of the International Society for Apheresis, A9, Nashville, TN, USA, Oct. 2003.
39.	Hiroshi Miyamoto, Toshiya Okahisa, Hiroshi Iwaki, Masaharu Suzuki, Susumu Ito, Yoshiaki Ohnishi, Jun Oto, Yasuhiro Kuroda, Shuzo Oshita, Yoshinori Nitta, Yohsuke Kinouchi and Masatake Akutagawa : Variation of the hematocrit value during leukocytapheresis therapy, Proceedings of 4th World Congress of the International Society for Apheresis, A5, Nashville, TN, USA, Oct. 2003.

国内講演発表:

1.	大藤純 : 大藤純．司会「シンポジウム:DIC診療における疑問点」, 第3回南四国・集中治療医学シンポジウム, 2023年11月.
2.	森西啓介, 林昌晃, 野田康裕, 玉上大暉, 平良竣也, 近田優介, 大藤純 : 小児用ECMOシステムの三方活栓の種類が回路内シャント流量に与える影響．, 第13回中四国臨床工学会, 2023年10月.
3.	秋本雄祐, 板東夏生, 佐藤功志, 佐藤裕紀, 百田和貴, 石原学, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : リーク補正機能が原因と考えられたミストリガの3例．(優秀演題), 第45回日本呼吸療法医学会学術集会, 2023年8月.
4.	板垣大雅, 秋本雄祐, 髙島拓也, 大藤純 : シンポジウム6:自発呼吸努力―どのように評価し，管理すべきか―「呼気筋動員の功罪∼オピオイドの影響など∼」, 第45回日本呼吸療法医学会学術集会, 2023年8月.
5.	新見秀美, 土肥智史, 福本和美, 吉田奈緒美, 白石美恵, 大藤純 : ICU入室患者におけるABCDEFGバンドル実施率の実態調査．, 日本集中治療医学会第7回中国・四国支部学術集会, 2023年7月.
6.	佐藤功志, 上野義豊, 板東夏生, 百田和貴, 髙島拓也, 佐藤裕紀, 布村俊幸, 石原学, 板垣大雅, 大藤純 : ステロイドパルス療法後にオルニチントランスカルバミラーゼ欠損症による高アンモニア脳症を発症した1例．, 日本集中治療医学会第7回中国・四国支部学術集会, 2023年7月.
7.	佐藤裕紀, 中瀧恵実子, 布村俊幸, 藤本稜, 川下陽一郎, 山村里恵, 板垣大雅, 大藤純 : カルバマゼピンによる薬剤性再生不良性貧血と薬疹から不良な転帰を辿った一症例．, 日本集中治療医学会第7回中国・四国支部学術集会, 2023年7月.
8.	新見秀美, 土肥智史, 福本和美, 白石美恵, 大藤純 : シンポジウム4:患者のADLとQOL向上に向けて私はここをみている「ICUから今後の生活を見据えた支援!多職種カンファレンスの活用」, 日本集中治療医学会第7回中国・四国支部学術集会, 2023年7月.
9.	大藤純 : 大藤純．司会「ランチョンセミナー1:人工呼吸器と患者間の非同調の認識と対策(則末泰博)」, 日本集中治療医学会第7回中国・四国支部学術集会, 2023年7月.
10.	大藤純 : 大藤純．記念講演:ICU患者の睡眠障害への対策と展望．, 日本集中治療医学会第7回中国・四国支部学術集会, 2023年7月.
11.	板東夏生, 百田和貴, 佐藤功志, 佐藤裕紀, 秋本雄祐, 布村俊幸, 石原学, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : セツキシマブ投与後のインフュージョンリアクションから心停止に至るも後遺症なく救命できた一症例．, 第39回日本救急医学会中国四国地方会, 2023年7月.
12.	佐藤功志, 上野義豊, 板東夏生, 百田和貴, 髙島拓也, 佐藤裕紀, 布村俊幸, 石原学, 田根なつ紀, 板垣大雅, 大藤純 : HELLP症候群に伴う急性肝不全，DICに対して血漿交換療法が効果的であった一症例．, 第39回日本救急医学会中国四国地方会, 2023年7月.
13.	大藤純 : 大藤純．司会「一般演題:集中治療1」, 第39回日本救急医学会中国四国地方会, 2023年7月.
14.	大藤純 : 大藤純．総合司会, 第2回敗血症診療 Up to Date, 2023年6月.
15.	大藤純 : 大藤純．司会「麻酔科領域講習(リフレッシャー)・アドバンスト:急性呼吸不全に対する治療戦略新たな肺保護の概念とまとめ(方山真朱)」, 日本麻酔科学会第70回学術集会, 2023年6月.
16.	佐藤功志, 上野義豊, 百田和貴, 板垣大雅, 大藤純 : COVID-19重症肺炎に対して電気インピーダンストモグラフィによるPEEP設定を行った一例．, 第34回日本臨床モニター学会総会, 2023年4月.
17.	大藤純 : 大藤純．臨床モニタリング講座2:臨床に役立つ血液ガス分析．, 第34回日本臨床モニター学会総会, 2023年4月.
18.	佐藤裕紀, 中瀧恵実子, 布村俊幸, 島谷佳光, 板垣大雅, 大藤純 : 原因不明の無菌性髄膜炎を契機に痙攣重積状態に進行し不良な転帰を辿った一症例, 第51回日本集中治療医学会学術集会, 2023年3月.
19.	板東夏生, 佐藤功志, 佐藤裕紀, 板東夏生, 佐藤功志, 布村俊幸, 中野勇希, 髙島拓也, 石原学, 上野義豊, 板垣大雅, 大藤純 : 動脈瘤性くも膜下出血へのクラゾセンタン投与により抜管後喉頭浮腫を来した2症例, 第51回日本集中治療医学会学術集会, 2023年3月.
20.	上野義豊, 西條早希, 河原良美, 板東夏生, 佐藤功志, 佐藤裕紀, 髙島拓也, 布村俊幸, 石原学, 板垣大雅, 大藤純 : 自発呼吸トライアル中のHFVIモニタリングに関する検討, 第51回日本集中治療医学会学術集会, 2023年3月.
21.	土肥智史, 中西信人, 河原良美, 島麻美子, 野村慶子, 白石美恵, 大藤純 : ICU入室患者における振動療法の効果:前向き無作為化比較試験, 第51回日本集中治療医学会学術集会, 2023年3月.
22.	森西啓介, 板垣大雅, 近田優介, 大藤純 : プレッシャーサポート換気におけるIntelliSync+の性能評価∼モデル肺を用いた研究∼．(優秀演題セッション2:臨床工学技士), 第51回日本集中治療医学会学術集会, 2023年3月.
23.	大藤純 : 大藤純．審査員「優秀セッション1:メディカルスタッフ」, 第51回日本集中治療医学会学術集会, 2023年3月.
24.	大藤純 : 大藤純．司会「シンポジウム14:多臓器不全の謎に迫る!臓器連関メカニズム解明の最新動向」, 第51回日本集中治療医学会学術集会, 2023年3月.
25.	土肥智史, 中西信人, 野村慶子, 島麻美子, 河原良美, 白石美恵, 大藤純 : ICU 長期入室患者に対する振動療法の有効性の検証．, 第50回日本集中治療医学会学術集会, 2023年3月.
26.	百田和貴, 板東夏生, 佐藤功志, 佐藤裕紀, 秋本雄祐, 布村俊幸, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : 非侵襲的陽圧換気中に縦隔気腫を来したCOVID-19肺炎の一症例．, 第50回日本集中治療医学会学術集会, 2023年3月.
27.	秋本雄祐, 板東夏生, 佐藤功志, 佐藤裕紀, 百田和貴, 石原学, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : 予定開頭手術後の橋中心髄鞘崩壊症が原因と考えられた成人喉頭軟化症の一症例．, 第50回日本集中治療医学会学術集会, 2023年3月.
28.	河原良美, 野村慶子, 土肥智史, 松本綾, 福本和美, 大藤純 : 心臓血管外科手術患者におけるpost-intensive care syndromeの実態調査, 第50回日本集中治療医学会学術集会, 2023年3月.
29.	板東夏生, 上野義豊, 百田和貴, 佐藤功志, 佐藤裕紀, 秋本雄祐, 石原学, 田根なつ紀, 板垣大雅, 大藤純 : 電気インピーダンス・トモグラフィにて閉塞性無気肺を疑い，早期介入に至った重症COVID-19症例．, 第50回日本集中治療医学会学術集会, 2023年3月.
30.	佐藤裕紀, 板東夏生, 百田和貴, 佐藤功志, 佐藤裕紀, 秋本雄祐, 石原学, 田根なつ紀, 板垣大雅, 大藤純 : 開心術周術期の出血量や輸血量が術後再開胸止血術の頻度に与える影響．, 第50回日本集中治療医学会学術集会, 2023年3月.
31.	中野勇希, 佐藤功志, 佐藤裕紀, 百田和貴, 秋本雄祐, 布村俊幸, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : 気管切開後25年間無症候性に経過した声門下狭窄が気管挿管を機に増悪し，術後抜管困難となった一症例, 第50回日本集中治療医学会学術集会, 2023年3月.
32.	森西啓介, 板垣大雅, 森督司, 近田優介, 大藤純 : 人工呼吸器の新しいトリガ様式IntelliSync+の性能評価∼モデル肺を用いた研究∼, 第50回日本集中治療医学会学術集会, 2023年3月.
33.	上野義豊, 百田和貴, 佐藤功志, 佐藤裕紀, 秋本雄祐, 布村俊幸, 石原学, 田根なつ紀, 板垣大雅, 大藤純 : 末期肺気腫に対する片肺移植後の急性拒絶反応に対し，分離肺換気が奏功した一症例, 第50回日本集中治療医学会学術集会, 2023年3月.
34.	上野義豊, 佐藤裕紀, 百田和貴, 佐藤功志, 秋本雄祐, 布村俊幸, 石原学, 田根なつ紀, 板垣大雅, 大藤純 : 開心術後患者における乳酸値ピークアウトまでの時間と術後経過との関連, 第50回日本集中治療医学会学術集会, 2023年3月.
35.	佐藤功志, 上野義豊, 佐藤裕紀, 百田和貴, 秋本雄祐, 布村俊幸, 石原学, 田根なつ紀, 板垣大雅, 大藤純 : VA-ECMO, 第50回日本集中治療医学会学術集会, 2023年3月.
36.	上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : パネルディスカッション9:シームレスICU∼診療の一貫性や質の担保をどうするか(1)「当院集中治療室で実践する週交代の診療責任者の配置:治療の一貫性・質の向上を目指した取り組み」, 第50回日本集中治療医学会学術集会, 2023年3月.
37.	大藤純 : 司会「ポスター113:多臓器不全②」, 第50回日本集中治療医学会学術集会, 2023年3月.
38.	大藤純 : 医師向け人工呼吸管理基礎教育プログラム第13回Basicコース, --- 6.鎮痛・鎮静・せん妄管理 ---, 医師向け人工呼吸管理基礎教育プログラム第13回Basicコース, 2023年3月.
39.	大藤純 : 合同シンポジウム:新型コロナウイルス感染症(COVID-19)の現状と対策「重症コロナ診療の現状」, 第266回徳島医学会学術集会, 2023年2月.
40.	中野勇希, 佐藤功志, 佐藤裕紀, 百田和貴, 秋本雄祐, 布村俊幸, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : 高位気管切開既往患者に生じた声門下狭窄および気管軟化症により術後抜管困難となった一症例, 第6回徳島外科学会, 2023年2月.
41.	板東夏生, 宮本憲哉, 百田和貴, 佐藤功志, 佐藤裕紀, 秋本雄祐, 布村俊幸, 石原学, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : セツキシマブ投与後のインフュージョンリアクションから心停止に至るも後遺症なく救命できた一症例, 第6回徳島外科学会, 2023年2月.
42.	大藤純 : 司会, 第6回ER ICU ASSISTセミナー, 2023年2月.
43.	大藤純 : 鎮痛・鎮静・せん妄管理, 医師向け人工呼吸管理基礎教育プログラム第12回Basicコース, 2023年2月.
44.	大藤純 : コメンテーター「シンポジウム．DIC の治療意義について」, 第2回南四国・集中治療医学シンポジウム, 2022年11月.
45.	大藤純 : 司会「特別講演．敗血症におけるあらたなトロンボモデュリンの作用-DAMPs 制御の可能性-(升田好樹)」, 第2回南四国・集中治療医学シンポジウム, 2022年11月.
46.	大藤純, 森西啓介, 坂東直紀 : 講師:人工呼吸器・体外式膜型人工肺(ECMO)の仕組みと管理上の注意事項，トラブル発生時の対応．, 新型コロナウイルス感染症対応看護職育成事業:重症患者対応研修, 2022年11月.
47.	秋本雄祐, 板東夏生, 佐藤功志, 佐藤裕紀, 百田和貴, 石原学, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : くも膜下出血後のたこつぼ心筋症および神経原性肺水腫に対してバゾプレシンを用いて循環管理を行った1例．, 第50回日本救急医学会総会・学術集会, 2022年10月.
48.	百田和貴, 板東夏生, 佐藤功志, 佐藤裕紀, 秋本雄祐, 布村俊幸, 石原学, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : 重篤な循環不全を呈した重症レジオネラ肺炎に対しVA-ECMO導入により救命した1例．, 第50回日本救急医学会総会・学術集会, 2022年10月.
49.	大藤純 : 講師:人工呼吸からの離脱．, 医師向け人工呼吸管理基礎教育プログラム第1回Refresherコース[オンライン]2022年度 – 呼吸療法専門医試験受験者レベル, 2022年10月.
50.	大藤純 : 司会「教授就任記念講演3」, 第265回徳島医学会学術集会, 2022年7月.
51.	大藤純 : 司会「一般演題(呼吸)」, 日本集中治療医学会第6回中国・四国支部学術集会, 2022年7月.
52.	大藤純 : 講師:鎮静・鎮痛・せん妄管理 ∼ICUからの早期離脱を目指して∼．, 第51回日本呼吸療法医学会セミナー, 2022年6月.
53.	近田優介, 佐藤翔平, 小林誠司, 緒方良輔, 森西啓介, 大西芳明, 大藤純, 田中克哉 : 医用テレメータの電界強度調査の必要性．, 第32回日本臨床工学会, 2022年5月.
54.	新井悠太, 中西信人, 原田雅史, 大藤純 : ICU入室時の筋エコーによるサルコペニアの評価．, 第49回日本集中治療医学会学術集会, 2022年3月.
55.	石原学, 黒田一駿, 山本雄貴, 上野義豊, 田根なつ紀, 綱野祐美子, 板垣大雅, 高木康志, 大藤純 : 重症COVID-19感染後に発症した，脳葉型出血の1例．, 第49回日本集中治療医学会学術集会, 2022年3月.
56.	荒瀬美晴, 中西信人, 堤理恵, 待田京香, 新井悠太, 阪上浩, 大藤純 : 急性心筋梗塞診断における尿中タイチンの有用性評価．, 第49回日本集中治療医学会学術集会, 2022年3月.
57.	田坂浩樹, 近田優介, 森西啓介, 林昌晃, 野田康裕, 大西芳明, 板垣大雅, 田中克哉, 大藤純 : Air Spiral® 熱線入り呼吸回路における経鼻高流量酸素療法中の回路結内露量の検討．, 第49回日本集中治療医学会学術集会, 2022年3月.
58.	大藤純 : シンポジウム16:包括的肺保護換気, 第49回日本集中治療医学会学術集会, 2022年3月.
59.	大藤純 : 人工呼吸中の加温加湿∼人工鼻と加温加湿器の使い分け∼, 加温加湿研究会 2022.Winter, 2022年2月.
60.	大藤純 : 人工呼吸中の加温加湿∼人工鼻と加温加湿器の使い分け∼．, 2022.Winter, 2022年2月.
61.	上野義豊, 秋本雄祐, 中野勇希, 石原学, 佐藤功志, 佐藤裕紀, 百田和貴, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : 重症COVID-19患者の転院および救急搬送における問題点の検討．, 第49回日本救急医学会総会・学術集会, 2021年11月.
62.	荒瀬美晴, 大村健史, 井川浩一, 新井悠太, 布村俊幸, 田根なつ紀, 中瀧恵実子, 三村誠二, 大藤純 : COVID-19患者におけるエアロゾルの発生を最小限に抑える経皮的気管切開術の工夫．, 第49回日本救急医学会総会・学術集会, 2021年11月.
63.	中野勇希, 佐藤功志, 佐藤裕紀, 百田和貴, 秋本雄祐, 上野義豊, 石原学, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : 腹部コンパートメント症候群による呼吸不全をきたした小児神経芽腫Stage 4Sの一症例．, 第49回日本救急医学会総会・学術集会, 2021年11月.
64.	布村俊幸, 板垣大雅, 新井悠太, 中瀧恵実子, 大藤純 : 集中治療室内での患者-人工呼吸器非同調に対する意識調査．, 第1回南四国・集中治療医学フォーラム, 2021年11月.
65.	上野義豊, 秋本雄祐, 中野勇希, 石原学, 荒瀬美晴, 百田和貴, 佐藤功志, 佐藤裕紀, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : 重症COVID-19患者の転院および救急搬送における問題点の検討．, 第1回南四国・集中治療医学フォーラム, 2021年11月.
66.	大藤純 : 徳島県における重症コロナ診療の現状, 第1回南四国・集中治療医学フォーラム, 2021年11月.
67.	福良翔子, 渡邊浩良, 七條光市, 近藤秀治, 横田典子, 森大樹, 石橋広樹, 大藤純, 生島仁史 : 緊急放射線照射を施行した神経芽腫stage4Sの乳児例, 第63回日本小児血液・がん学会学術集会, 2021年11月.
68.	石原学, 兼松康久, 中西信人, 森垣龍馬, 山本伸昭, 大藤純, 獅々堀正幹, 髙木康志 : 日本ICU患者データベース(JIPAD)による急性期脳卒中症例の検討機械学習(データマイニング)を用いた解析, 日本脳神経外科学会学術総会, 2021年10月.
69.	大藤純 : Special Lecture:敗血症性DICの新たな治療戦略-トロンボモジュリン製剤の可能性-, 敗血症診療 Up to Date, 2021年10月.
70.	板垣大雅, 秋本雄祐, 中野勇希, 上野義豊, 石原学, 田根なつ紀, 綱野祐美子, 大藤純 : 人工呼吸開始後早期のdouble cyclingが横隔膜厚の変化に与える影響．, 第43回日本呼吸療法医学会学術集会, 2021年7月.
71.	大藤純 : 「人工呼吸器からの離脱・抜管」, 第43回日本呼吸療法医学会学術集会, 2021年7月.
72.	大藤純 : 間質性肺炎とCOPD:良好な予後のための周術期管理を探る「COPD:予後に影響する周術期管理」, 日本麻酔科学会第68回学術集会, 2021年6月.
73.	大藤純 : 人工呼吸器からの離脱:∼抜管前の評価と抜管後呼吸不全の予防法．, 第50回日本呼吸療法医学会セミナー, 2021年6月.
74.	大藤純 : 包括的肺保護換気, 第49回日本集中治療医学会学術集会, 2021年3月.
75.	石原学, 中西信人, 兼松康久, 森垣龍馬, 山本伸昭, 髙木康志, 大藤純 : 日本ICU患者データベース(JIPAD)による急性期脳卒中症例の検討, 日本集中治療医学会雑誌, 2021年2月.
76.	髙島拓也, 上野義豊, 石原学, 中西信人, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : 目標換気量の表示が人工呼吸患者の低一回換気量/肺保護換気の順守率に与える影響, 日本集中治療医学会雑誌, 2021年2月.
77.	秋本雄祐, 中西信人, 中野勇気, 髙島拓也, 上野義豊, 田根なつ紀, 綱野祐美子, 石原学, 板垣大雅, 大藤純 : 本邦ICUにおける心臓血管外科術後患者の疫学調査 -JIPADデータ解析-(優秀演題), 日本集中治療医学会雑誌, 2021年2月.
78.	中西信人, 大藤純, 秋本雄祐, 中野勇気, 髙島拓也, 石原学, 中瀧恵実子, 西村匡司 : ワークショップ13「上下肢筋萎縮は院内死亡・身体機能障害と関連する」, 日本集中治療医学会雑誌, 2021年2月.
79.	大藤純 : 「新型コロナクラスターを経験して」, 第31回徳島救急医療研究会, 2021年1月.
80.	福良翔子, 渡邊浩良, 七條光市, 近藤秀治, 横田典子, 森大樹, 石橋広樹, 大藤純 : 緊急放射線照射を施行した神経芽腫stage4Sの乳児例, 第154回日本小児科学会徳島地方会学術集会, 2020年12月.
81.	原加奈子, 堤理恵, 三島優奈, 待田京香, 阪上浩, 中西信人, 大藤純 : 重症患者における筋萎縮と尿中タイチン濃度に関する検討, 四国医学雑誌, Vol.76, No.5-6, 341, 2020年12月. (キーワード) *筋萎縮症(診断) / 病勢悪化 / Connectin(尿) / ヒト
82.	石原学, 竹村星哉, 兼松康久, 森垣龍馬, 山本伸昭, 大藤純, 大野将樹, 獅々堀正幹, 髙木康志 : 機械的学習を用いた医療データの解析脳出血症例の検討, 第79回日本脳神経外科学会学術総会, 2020年10月.
83.	中西信人, 堤理恵, 原加奈子, 山本智子, 綱野祐美子, 中瀧恵実子, 板垣大雅, 松尾雅文, 阪上浩, 大藤純 : 侵襲時における臓器障害連関を科学する~基礎から臨床まで~ ICU入室患者における筋萎縮と尿中タイチン濃度に関する検討, 日本集中治療医学会雑誌, Vol.27, No.Suppl., 277, 2020年9月. (キーワード) ICU 筋萎縮症(超音波診断) *Connectin(尿) ヒト中年(45~64) 高齢者(65~79) 高齢者(80~)
84.	秋本雄祐, 上野義豊, 髙島拓也, 石原学, 中西信人, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : 側弯矯正固定術後の急性換気不全に対し気管支鏡による選択的気管支拡張術が奏功した1例, 日本集中治療医学会第4回中国・四国支部学術集会, 2020年7月.
85.	大藤純 : ICU運営を考える「徳島大学病院救急集中治療部の概要と取り組み」, 日本集中治療医学会第4回中国・四国支部学術集会, 2020年7月.
86.	板垣大雅, 大藤純 : パネルディスカッション6/NPPVとハイフロー療法どっちがいいの?「急性呼吸不全におけるネーザルハイフローセラピーの現況」, 日本集中治療医学会雑誌, 2020年4月.
87.	石原学, 兼松康久, 山本伸昭, 曽我部周, 宮本健志, 島田健司, 山本雄貴, 大藤純, 髙木康志 : NIHSS5点以下軽症脳主幹動脈閉塞症例における転帰, 第25回日本脳神経外科救急学会, 2020年2月.
88.	石原学, 兼松康久, 山本伸昭, 宮本健志, 高麗雅章, 島田健司, 山本雄貴, 大藤純, 髙木康志 : NIHSS 5点以下の軽症脳主幹動脈閉塞症例における予後因子, 日本脳神経外科学会第78回学術集会, 2019年10月.
89.	石原学, 髙島拓也, 上野義豊, 中西信人, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : NIHSS5点以下の軽症脳主幹動脈閉塞症例の予後因子, 第47回日本救急医学会総会, 2019年10月.
90.	綱野祐美子, 髙島拓也, 上野義豊, 中西信人, 田根なつ紀, 板垣大雅, 大藤純 : ステロイドパルス療法により未診断の重症筋無力症の初期増悪から呼吸不全をきたした一症例, 第47回日本救急医学会総会, 2019年10月.
91.	上野義豊, 大藤純 : High Flow Nasal Cannula 装着中の患者におけるデクスメデトミジンの効果．, 日本集中治療医学会雑誌, 2019年3月.
92.	板垣大雅, 上野義豊, 中西信人, 奥田菜緒, 中瀧恵実子, 大藤純 : チューブリークに起因したリバーストリガを認めたARDS症例．, 日本集中治療医学会雑誌, 2019年3月.
93.	中西信人, 大藤純, 川下陽一郎, 板垣大雅, 中瀧恵実子, 西村匡司 : ICUにおけるサルコペニア対策私たちの取り組み「ICU入室患者の上下肢電気刺激療法」, 日本集中治療医学会雑誌, 2019年3月.
94.	中西信人, 大藤純, 岡久哲也, 土肥智史, 野村慶子, 福岡千佳, 河原良美, 中山志津, 板垣大雅, 中瀧恵実子, 西村匡司 : ICUでの多職種連携による長期間の離床により人工呼吸器からの離脱に成功したacute respiratory distress syndrome (ARDS) の1症例．, 日本集中治療医学会第3回中国四国支部学術集会, 2019年2月.
95.	中西信人, 大藤純, 川下陽一郎, 板垣大雅, 中瀧恵実子, 西村匡司 : ICUにおけるサルコペニア対策私たちの取り組み ICU入室患者の上下肢電気刺激療法 2施設前向き無作為化比較試験, 日本集中治療医学会雑誌, Vol.26, No.Suppl., [SY2-3], 2019年2月.
96.	板垣大雅, 上野義豊, 中西信人, 奥田菜緒, 中瀧恵実子, 大藤純 : チューブリークに起因したリバーストリガを認めたARDS症例, 日本集中治療医学会雑誌, Vol.26, No.Suppl., [O7-2], 2019年2月.
97.	大藤純, 上野義豊, 中西信人, 髙島拓也, 板垣大雅 : 重症患者における血漿中オレキシン濃度と急性脳機能障害との関連, 日本集中治療医学会雑誌, Vol.26, No.Suppl., [O16-4], 2019年2月.
98.	西川真理恵, 髙島拓也, 鈴木康大, 上野義豊, 中西信人, 田根なつ紀, 奥田菜緒, 中瀧恵実子, 板垣大雅, 大藤純 : ウイルス性気管支肺炎によりair leak syndromeを呈し2度のVenovenous ECMOを要した小児の一例, 日本集中治療医学会雑誌, Vol.26, No.Suppl., [O53-4], 2019年2月.
99.	髙島拓也, 板垣大雅, 鈴木康大, 上野義豊, 中西信人, 西川真理恵, 田根なつ紀, 奥田菜緒, 中瀧恵実子, 大藤純 : 免疫不全患者の急性呼吸不全における呼吸療法 HFNCとNPPVの比較, 日本集中治療医学会雑誌, Vol.26, No.Suppl., [O83-2], 2019年2月.
100.	髙島拓也, 中西信人, 鈴木康大, 上野義豊, 西川真理恵, 田根なつ紀, 奥田菜緒, 中瀧恵実子, 板垣大雅, 大藤純 : High Flow Nasal Cannulaの横隔膜機能に対する効果, 日本集中治療医学会雑誌, Vol.26, No.Suppl., [O83-3], 2019年2月.
101.	大井貴裕, 板垣大雅, 中西信人, 大藤純 : 補助-調節換気における調節呼吸が横隔膜厚の変化に与える影響, 日本集中治療医学会雑誌, Vol.26, No.Suppl., [O84-3], 2019年2月.
102.	白神壮洋, 中西信人, 野寺裕之, 上野義豊, 板垣大雅, 中瀧恵実子, 大藤純 : ICU患者における上下肢筋萎縮の定性的評価超音波画像のテクスチャ解析, 日本集中治療医学会雑誌, Vol.26, No.Suppl., [O129-2], 2019年2月.
103.	田根なつ紀, 髙島拓也, 鈴木康大, 上野義豊, 中西信人, 西川真理恵, 奥田菜緒, 中瀧恵実子, 板垣大雅, 大藤純 : 小児人工呼吸患者の鎮痛・鎮静レベルの評価 COMFORT-Bスケールの使用経験, 日本集中治療医学会雑誌, Vol.26, No.Suppl., [P53-4], 2019年2月.
104.	髙島拓也, 西川真理恵, 鈴木康大, 上野義豊, 中西信人, 田根なつ紀, 奥田奈緒, 中瀧恵実子, 板垣大雅, 大藤純 : 重症ARDSによる長期人工呼吸中に廃用性高Ca血症を呈した一症例, 日本救急医学会雑誌, Vol.29, No.10, 570, 2018年10月.
105.	田根なつ紀, 髙島拓也, 鈴木康大, 上野義豊, 中西信人, 西川真理恵, 綱野祐美子, 奥田菜緒, 中瀧恵実子, 板垣大雅, 大藤純 : 気管チューブの固定により屈曲し内腔の狭窄を起こした一症例, 日本救急医学会雑誌, Vol.29, No.10, 572, 2018年10月.
106.	板垣大雅, 上野義豊, 中西信人, 西川真理恵, 田根なつ紀, 奥田菜緒, 中瀧恵実子, 大藤純 : RAM cannulaTMを用いた新生児非侵襲的人工換気の経験, , 2018年8月.
107.	上野義豊, 板垣大雅, 大藤純, 西村匡司 : ヨード含有の軟膏使用によりアナフィラキシーショックに至った一例, 第34回日本救急医学会中国四国地方会学術集会(5月11∼12日,広島市), 2018年5月.
108.	上野義豊, 大藤純 : High Flow Nasal Cannula 装着中の患者におけるデクスメデトミジンの効果, 日本集中治療医学会雑誌, 2018年3月.
109.	上野義豊, 大藤純, 西村匡司 : High flow nasal cannula装着中の患者における睡眠動態の検討．, 第45回日本集中治療医学会学術集会, 2018年2月.
110.	鈴木康大, 大藤純, 中西信人, 田根なつ紀, 奥田菜緒, 綱野祐美子, 中瀧恵実子, 板垣大雅, 小野寺睦雄, 西村匡司 : 脳卒中患者における睡眠時呼吸障害に対するHigh Flow Nasal Cannulaの効果について．, 第45回日本集中治療医学会学術集会, 2018年2月.
111.	黒崎里菜, 大野恵, 大藤純, 中瀧恵実子, 小野寺睦雄, 西村匡司 : 当院集中治療室におけるアンチバイオグラムと多剤耐性菌検出状況, 第45回日本集中治療医学会学術集会, 2018年2月.
112.	井内茉莉奈, 堤理恵, 中西信人, 山本智子, 田中志歩, 大藤純, 中瀧恵実子, 小野寺睦雄, 阪上浩, 西村匡司 : 重症患者におけるエネルギー代謝動態の解析．, 第45回日本集中治療医学会学術集会, 2018年2月.
113.	中西信人, 大藤純, 西村匡司, 板垣大雅, 中瀧恵実子, 小野寺睦雄, 西村匡司 : シンポジウム:ICU-AWの病態生理とその対策 up to date「人工呼吸管理を要するICU患者の横隔膜萎縮」, 第45回日本集中治療医学会学術集会, 2018年2月.
114.	中西信人, 大藤純, 板垣大雅, 中瀧恵実子, 小野寺睦雄, 西村匡司 : ICU-AWの病態生理とその対策 up to date「人工呼吸管理を要するICU患者の横隔膜萎縮」, 日本集中治療医学会雑誌, 2018年2月.
115.	西川真理恵, 鈴木康大, 上野義豊, 中西信人, 田根なつ紀, 綱野祐美子, 奥田菜緒, 板垣大雅, 小野寺睦雄, 大藤純, 西村匡司 : 当院ICUにおける低血小板血症に対する抗凝固療法の実施状況と出血性合併症．, 日本集中治療医学会第2回中国・四国支部学術集会, 2018年1月.
116.	上野義豊, 小野寺睦雄, 大藤純, 西村匡司 : 気管挿管中の脳血管障害患者における神経学的重症度および人工呼吸期間と抜管の成否との関係．, 日本集中治療医学会第2回中国・四国支部学術集会, 2018年1月.
117.	大藤純, Kacmarek M Robert : ICU患者の睡眠障害と譫妄への対策:デクスメデトミジンによる薬物的介入の可能性．, 第39回日本呼吸療法医学会学術集会, 2017年7月.
118.	板垣大雅, 大藤純, Kacmarek M Robert, Mountjoy R Jeremi : 頭部回旋が全身麻酔導入中のマスク換気に与える影響:前向きクロスオーバー試験, 日本麻酔科学会第64回学術集会, 2017年6月.
119.	中瀧恵実子, 上野義豊, 中西信人, 西川真理恵, 田根なつ紀, 綱野祐美子, 板垣大雅, 小野寺睦雄, 大藤純, 西村匡司 : RSV感染による縦隔気腫を発症しvenovenous ECMOを導入した小児例．, 第33回日本救急医学会中国四国地方会学術集会, 2017年5月.
120.	田根なつ紀, 上野義豊, 中西信人, 綱野祐美子, 井澤眞代, 中瀧恵実子, 板垣大雅, 小野寺睦雄, 大藤純, 西村匡司 : 肝血管腫のコイル塞栓後に敗血症で死亡した1症例．, 第33回日本救急医学会中国四国地方会学術集会, 2017年5月.
121.	小野寺睦雄, 上野義豊, 中西信人, 西川真理恵, 田根なつ紀, 綱野祐美子, 中瀧恵実子, 板垣大雅, 大藤純, 西村匡司 : 片側痙攣片側てんかん症候群(HHE症候群)の1例．, 第33回日本救急医学会中国四国地方会学術集会, 2017年5月.
122.	森西啓介, 林昌晃, 近田優介, 大藤純, 小野寺睦雄, 西村匡司 : ECMO導入患者に対しCARDIOHELPの使用経験, 第44回日本集中治療医学会学術集会, 2017年3月.
123.	綱野祐美子, 上野義豊, 大藤純, 中西信人, 西川真理恵, 井澤眞代, 中瀧恵実子, 板垣大雅, 大藤純, 小野寺睦雄, 西村匡司 : 当院ICUにおける心原性肺水腫患者へのHigh flow nasal cannulaの使用状況．, 第44回日本集中治療医学会学術集会, 2017年3月.
124.	井内茉莉奈, 堤理恵, 中西信人, 大藤純, 中瀧恵実子, 小野寺睦雄, 阪上浩, 西村匡司 : 重症患者における栄養投与開始時期と体組成変化の関連性の検討．, 第44回日本集中治療医学会学術集会, 2017年3月.
125.	中瀧恵実子, 上野義豊, 中西信人, 西川真理恵, 綱野祐美子, 井澤眞代, 板垣大雅, 大藤純, 小野寺睦雄, 西村匡司 : 人工呼吸中の気道感染患者における抗菌薬投与前後の吸引痰のグラム染色像の変化と抗菌薬有効性との関係．, 第44回日本集中治療医学会学術集会, 2017年3月.
126.	中西信人, 堤理恵, 大藤純, 井内茉莉奈, 上野義豊, 西川真理恵, 綱野祐美子, 中瀧恵実子, 小野寺睦雄, 西村匡司 : 超音波によるICU患者の上肢・下肢筋委縮評価．, 第44回日本集中治療医学会学術集会, 2017年3月.
127.	高橋叡, 大藤純, 綱野祐美子, 井澤眞代, 中瀧恵実子, 小野寺睦雄, 西村匡司 : 当院ICUにおける低一回換気量による肺保護換気の遵守率に関する検討．, 第44回日本集中治療医学会学術集会, 2017年3月.
128.	上野義豊, 大藤純, 西村匡司 : 保護キャップ付き閉鎖式輸液システムの細菌汚染頻度の検討．, 第44回日本集中治療医学会学術集会, 2017年3月.
129.	田根なつ紀, 綱野祐美子, 井澤眞代, 中瀧恵実子, 小野寺睦雄, 大藤純, 西村匡司 : 中部食道癌への内視鏡的粘膜下層剥離術(ESD)により緊張性気胸を呈し心肺停止となった一症例．, 第44回日本集中治療医学会学術集会, 2017年3月.
130.	板垣大雅, 大藤純, 西村匡司, Kacmarek M. Robert : 新生児におけるリーク補正機能を併用した圧補正従量式換気の検討．, 第44回日本集中治療医学会学術集会, 2017年3月.
131.	井澤眞代, 綱野祐美子, 板垣大雅, 中瀧恵実子, 小野寺睦雄, 大藤純, 西村匡司 : 来院時左室壁運動異常を伴っていなかった左室内可動性血栓の一症例．, 第44回日本集中治療医学会学術集会, 2017年3月.
132.	大藤純 : シンポジウム:術後患者の予後を集中治療で改善する「術後呼吸器合併症への対策:非侵襲的陽圧換気と高流量酸素療法を中心に．」, 第44回日本集中治療医学会学術集会, 2017年3月.
133.	中西信人, 中瀧恵実子, 小野寺睦雄, 大藤純, 西村匡司 : 赤血球輸血を必要とした乳児重症肺炎の1例．, 日本集中治療医学会第1回中国四国支部学術集会, 2017年2月.
134.	上野義豊, 大藤純, 綱野祐美子, 井澤眞代, 中瀧恵実子, 板垣大雅, 小野寺睦雄, 西村匡司 : 小児重症呼吸不全患者に対して静脈-静脈体外式膜型人工肺を導入し予後良好であった一症例．, 日本集中治療医学会第1回中国四国支部学術集会, 2017年2月.
135.	上野義豊, 板垣大雅, 綱野祐美子, 井澤眞代, 中瀧恵実子, 小野寺睦雄, 大藤純, 西村匡司 : Reverse triggeringに起因した二段呼吸を横隔膜活動電位のモニタリングによって観察した一例．, 日本集中治療医学会第1回中国四国支部学術集会, 2017年2月.
136.	大藤純 : 司会「臨床研究・基礎研究」, 日本集中治療医学会第1回中国四国支部学術集会, 2017年2月.
137.	小野寺睦雄, 大藤純, 田根なつ紀, 西村匡司 : ICU-acquired weakness:比較的短期の人工呼吸患者での発症の可能性．, 第44回日本救急医学会総会・学術集会, 2016年11月.
138.	大藤純, 西村匡司 : カフ付気管留置カテーテルの換気能．, 第44回日本救急医学会総会・学術集会, 2016年11月.
139.	綱野祐美子, 井澤眞代, 中瀧恵実子, 小野寺睦雄, 大藤純, 今中秀光, 西村匡司 : 動脈圧ライン固定具による刺入部合併症の軽減効果の検討．, 第43回日本集中治療医学会学術集会, 2016年2月.
140.	井澤眞代, 綱野祐美子, 小野寺睦雄, 大藤純, 西村匡司 : 徳島大学病院集中治療室における長期滞在例の検討．, 第43回日本集中治療医学会学術集会, 2016年2月.
141.	大藤純, 綱野祐美子, 中瀧恵実子, 安田裕一郎, 井澤眞代, 田根なつ紀, 小野寺睦雄, 今中秀光, 西村匡司 : 閉鎖式システムによる末梢静脈カテーテルの細菌汚染・合併症軽減効果の検討．, 第43回日本集中治療医学会学術集会, 2016年2月.
142.	井内茉莉奈, 大藤純, 堤理恵, 小野寺睦雄, 阪上浩, 今中秀光, 西村匡司 : 重症患者における栄養予後指標としての位相角の有用性．, 第43回日本集中治療医学会学術集会, 2016年2月.
143.	大西沙紀, 近田優介, 小野寺睦雄, 大藤純, 西村匡司 : 新生児/乳児用high flow nasal cannula中の吸入酸素濃度．, 第43回日本集中治療医学会学術集会, 2016年2月.
144.	近田優介, 大西沙紀, 小野寺睦雄, 大藤純, 西村匡司 : 新生児/乳児用high flow nasal cannula中の加温加湿．, 第43回日本集中治療医学会学術集会, 2016年2月.
145.	堤理恵, 大藤純, 井内茉莉奈, 小野寺睦雄, 堤保夫, 今中秀光, 原田永勝, 西村匡司 : ICU入室中の筋肉量減少と予後の関連性, 第43回日本集中治療医学会学術集会, 2016年2月.
146.	高磯甫隆, 安見武哲, 大西沙紀, 大藤純, 近田優介, 今中秀光, 西村匡司 : 酸素マスクの形状による吸入酸素濃度および二酸化炭素濃度に関する研究．, 第43回日本集中治療医学会学術集会, 2016年2月.
147.	奥田菜緒, 綱野祐美子, 井澤眞代, 小野寺睦雄, 大藤純, 今中秀光, 西村匡司 : 小児開心術後縦隔炎の検討．, 第43回日本救急医学会, 2015年10月.
148.	近田優介, 井澤眞代, 奥田菜緒, 大藤純, 西村匡司 : High flow nasal cannula療法中の吸入気酸素濃度．, 第42回日本集中治療医学会学術集会, 2015年2月.
149.	堤理恵, 大藤純, 小野寺睦雄, 今中秀光, 西村匡司 : 重症患者におけるインピーダンス測定の有効性の検討．, 第42回日本集中治療医学会学術集会, 2015年2月.
150.	大藤純, RM Kacmarek, Y Jiang : カフ付チューブエクスチェンジャーの換気能に関する動物実験による検討．, 第42回日本集中治療医学会学術集会, 2015年2月.
151.	大藤純, RM Kacmarek, Y Jiang : カフ付チューブエクスチェンジャーの換気能に関するモデル肺を用いた検討．, 第42回日本集中治療医学会学術集会, 2015年2月.
152.	宇内和明, 近田優介, 井澤眞代, 奥田菜緒, 大藤純, 西村匡司 : ハイフローネーザルカニューラ(HFNC)療法中の回路内結露の検討．, 第42回日本集中治療医学会学術集会, 2015年2月.
153.	近田優介, 大西芳明, 小畠久和, 板垣大雅, 中瀧恵実子, 大藤純, 小野寺睦雄, 今中秀光, 西村匡司 : 在宅・移動用人工呼吸器の吸気ガス温度, 第40回日本集中治療医学会, 2013年3月.
154.	綱野祐美子, 小野理恵, 中瀧恵実子, 大藤純, 今中秀光, 西村匡司 : サイトメガロウイルス腸炎による血小板減少と消化管出血をきたした2症例, 第28回日本集中治療医学会中国四国地方会, 2011年6月.
155.	近田優介, 隅田ちひろ, 大藤純, 今中秀光, 西村匡司 : 気管切開用人工鼻の加湿能力, 第28回日本集中治療医学会中国四国地方会, 2011年6月.
156.	小野理恵, 西村匡司, 大藤純, 今中秀光, 千田淳司, 木戸博 : 重症患者の末梢血ATP乳酸値比, 日本麻酔科学会第58回学術集会，神戸, 2011年5月.
157.	尾﨑啓介, 綱野祐美子, 奥田菜緒, 中瀧恵実子, 小野理恵, 大藤純, 今中秀光, 西村匡司 : ペースメーカー埋込患者に発症した低体温の一症例, 第27回日本救急医学会中国四国地方会, 2011年5月.
158.	綱野祐美子, 中瀧恵実子, 奥田菜緒, 小野理恵, 大藤純, 今中秀光, 西村匡司 : 摂食障害患者に発症した敗血症ショックの2症例, 第38回日本集中治療医学会学術集会, 2011年2月.
159.	奥田菜緒, 綱野祐美子, 中瀧恵実子, 小野理恵, 大藤純, 今中秀光, 西村匡司 : 甲状腺クリ―ゼによる急性心不全を発症した妊婦症例, 第38回日本集中治療医学会学術集会, 2011年2月.
160.	中瀧恵実子, 大藤純 : 閉鎖式動脈圧測定回路による動脈ライン汚染軽減効果の検討, 第26回日本環境感染学会総会, 2011年2月.
161.	中瀧恵実子, 大藤純 : 輸液容器と輸液ラインの連結針の細菌汚染について, 第26回日本環境感染学会総会, 2011年2月.
162.	中瀧恵実子, 山口治隆, 小野理恵, 眞野暁子, 乾大資, 大藤純, 今中秀光, 西村匡司 : 解析支援ソフトウェアを用いたテイコプラニン初期投与, 第37回日本集中治療医学会学術集会, 2010年3月.
163.	中西信人, 上野義豊, 小野理恵, 乾大資, 中瀧恵実子, 眞野暁子, 乾大資, 大藤純, 今中秀光, 西村匡司 : 非侵襲的陽圧換気中のリークが患者-人工呼吸器間の同調性に及ぼす影響, 第37回日本集中治療医学会学術集会, 2010年3月.
164.	大藤純, 小野理恵, 乾大資, 眞野暁子, 中瀧恵実子, 今中秀光, 西村匡司 : 非侵襲的陽圧換気中の加温加湿器の温度設定が口腔内乾燥に与える影響, 第37回日本集中治療医学会学術集会, 2010年3月.
165.	上野義豊, 中西信人, 小野理恵, 中瀧恵実子, 眞野暁子, 乾大資, 大藤純, 今中秀光, 西村匡司 : 非侵襲的陽圧換気中のリークが換気設定に及ぼす影響, 第37回日本集中治療医学会学術集会, 2010年3月.
166.	中西信人, 上野義豊, 小野理恵, 乾大資, 中瀧恵実子, 眞野暁子, 乾大資, 大藤純, 今中秀光, 西村匡司 : 非侵襲的陽圧換気中のリークが患者-人工呼吸器間の同調性に及ぼす影響, 第37回日本集中治療医学会学術集会, 2010年3月.
167.	大藤純, 小野理恵, 乾大資, 中瀧恵実子, 今中秀光, 西村匡司 : 非侵襲的陽圧換気中の加温加湿器の温度設定が口腔内乾燥に与える影響, 第37回日本集中治療医学会学術集会, 2010年3月.
168.	坂東美佳, 森本雅美, 小野理恵, 中瀧恵実子, 眞野暁子, 大藤純, 乾大資, 今中秀光, 西村匡司 : 膿胸に対する胸腔内洗浄中に空気脳塞栓症を来たした1例, 第27回日本集中治療医学会中国四国地方会, 2010年1月.
169.	綱野祐美子, 坂東美佳, 小野理恵, 中瀧恵実子, 眞野暁子, 乾大資, 大藤純, 今中秀光, 西村匡司 : 分離肺換気下のリクルートメント手技が有効であった大動脈解離・破裂術後の低酸素血症の一例, 第27回日本集中治療医学会中国四国地方会, 2010年1月.
170.	小笠原梢, 久山寿子, 中瀧恵実子, 小野理恵, 眞野暁子, 乾大資, 大藤純, 今中秀光, 西村匡司 : 中心静脈カテーテルが腹壁静脈に迷入し腹壁発赤，麻痺性イレウスをきたした一例, 第27回日本集中治療医学会中国四国地方会, 2010年1月.
171.	中西信人, 上野義豊, 小野理恵, 中瀧恵実子, 眞野暁子, 乾大資, 大藤純, 西村匡司 : 非侵襲的陽圧換気中のリークが患者-人工呼吸器間の同調性に及ぼす影響, 日本集中治療医学会雑誌, Vol.17, No.Suppl., 331, 2010年1月. (キーワード) ICU 人工呼吸器 *非侵襲的陽圧呼吸
172.	山口治隆, 眞野暁子, 乾大資, 大藤純, 今中秀光, 西村匡司 : 徳島大学病院ICUにおけるNPPV使用目的の変遷, 第36回日本集中治療医学会学術集会, 2009年2月.
173.	今中秀光, 大藤純, 眞野暁子, 中瀧恵実子, 山口治隆, 乾大資, 西村匡司 : 胸腹部大動脈切除術後に急性膵炎を併発した一例, 日本集中治療医学会雑誌, Vol.16, No.3, 315-316, 2009年. (出版サイトへのリンク) ● Publication site (DOI): 10.3918/jsicm.16.315 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.3918/jsicm.16.315 (DOI: 10.3918/jsicm.16.315)
174.	金川俊哉, 今中秀光, 森本篤志, 眞野暁子, 中瀧恵実子, 乾大資, 大藤純, 西村匡司 : 免疫抑制療法中に壊死性皮膚筋膜感染症による敗血症ショック，多臓器不全から救命できた1症例, 日本集中治療医学雑誌, Vol.16, No.3, 305-306, 2009年. (出版サイトへのリンク) ● Publication site (DOI): 10.3918/jsicm.16.305 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.3918/jsicm.16.305 (DOI: 10.3918/jsicm.16.305)
175.	山口治隆, 中瀧恵実子, 乾大資, 大藤純, 今中秀光, 西村匡司 : 解析支援ソフトウェアを用いたテイコプラニンのローディング, 日本麻酔科学会第55回学術集会, 2008年6月.
176.	山口治隆, 乾大資, 大藤純, 福田靖, 今中秀光, 西村匡司 : TDM解析支援ソフトウェアを用いたテイコプラニン(TEIC)連日投与の有効性, 第35回日本集中治療医学会学術集会, 2008年2月.
177.	新田佳伯, 芥川正武, 宮本弘志, 岡久稔也, 大西芳明, 大藤純, 伊東進, 西村匡司, 木内陽介 : 人工ニューラルネットワークを用いたCHF施行時におけるHt値の予測, 日本集中治療医学会雑誌, Vol.13, 306, 2006年3月.
178.	村上昭継, 岡久稔也, 宮本弘志, 伊東進, 大西芳明, 大藤純, 西村匡司, 新田佳伯, 芥川正武, 木内陽介 : 高速フーリエ変換を用いた血液浄化フィルタの目詰まり評価システムの開発, 第32回日本集中治療医学会学術集会プログラム・抄録集, Vol.12, 312, 2005年2月.
179.	新田佳伯, 木内陽介, 芥川正武, 岡久稔也, 宮本弘志, 居和城宏, 大西芳明, 大藤純, 西村匡司 : 白血球除去療法施行中のヘマトクリット値の予測, --- 人工ニューラルネットワークの最適化と予測時点の延長 ---, 第32回日本集中治療医学会学術集会プログラム・抄録集, Vol.12, 309, 2005年2月.

その他・研究会:

1.	綱野祐美子, 奥田菜緒, 井澤眞代, 小野寺睦雄, 大藤純, 西村匡司, 田根なつ紀, 今中秀光 : 気道熱傷を疑う要因についての検討, 第31回日本救急医学会中国四国地方会, 2015年5月.
2.	近田優介, 井澤眞代, 奥田菜緒, 大藤純, 小野寺睦雄, 今中秀光, 西村匡司 : High-flow nasal cannula療法のガス流量が加温・加湿に与える影響, 第31回日本救急医学会中国四国地方会, 2015年5月.
3.	林昌晃, 近田優介, 奥田菜緒, 井澤眞代, 大藤純, 小野寺睦雄, 今中秀光, 西村匡司 : 徳島大学病院救急集中治療部における補助循環．, 第32回日本集中治療医学会中国四国地方会, 2015年1月.
4.	井澤眞代, 田根なつ紀, 綱野祐美子, 奥田菜緒, 小野寺睦雄, 大藤純, 今中秀光, 西村匡司 : 当院集中治療室13年間における長期滞在症例の検討．, 第32回日本集中治療医学会中国四国地方会, 2015年1月.
5.	近田優介, 林昌晃, 宇内和明, 大藤純, 小野寺睦雄, 大藤純, 西村匡司 : High flow nasal cannula療法中の回路内結露量の比較．, 第32回日本集中治療医学会中国四国地方会, 2015年1月.
6.	奥田菜緒, 田根なつ紀, 綱野祐美子, 井澤眞代, 小野寺睦雄, 大藤純, 今中秀光, 西村匡司 : EMR施行後敗血症から腸腰筋膿瘍を発症した一例．, 第32回日本集中治療医学会中国四国地方会, 2015年1月.
7.	小野寺睦雄, 田根なつ紀, 綱野祐美子, 奥田菜緒, 井澤眞代, 大藤純, 今中秀光, 西村匡司 : 重症熱性血小板減少症候群の2症例．, 第32回日本集中治療医学会中国四国地方会, 2015年1月.
8.	大藤純 : 鎮静と譫妄の評価, 第4回徳島人工呼吸ワークショップ, 2014年11月.
9.	近田優介, 大西芳明, 大藤純, 小野寺睦雄, 今中秀光, 西村匡司 : 血漿交換が効果的であった血栓性血小板減少紫斑病の一例, 第27回徳島急性血液浄化研究会, 2011年6月.
10.	大藤純 : 小児難治性ネフローゼ症候群に対する血液浄化療法, 第26回徳島急性血液浄化研究会, 2010年6月.
11.	綱野祐美子, 小野理恵, 今中秀光, 中瀧恵実子, 大藤純, 奥田菜緒, 西村匡司 : 重症熱傷治療中Abdominal Compartment Syndrome (ACS)をきたした症例, 第21回徳島救急医療研究会, 2010年5月.
12.	Hiroshi Miyamoto, Toshiya Okahisa, Hiroshi Iwaki, Masaharu Suzuki, Susumu Ito, Yoshiaki Ohnishi, Jun Oto, Yasuhiro Kuroda, Shuzo Oshita, Yoshinori Nitta, Yohsuke Kinouchi and Masatake Akutagawa : Variation of the hematocrit value during leukocytapheresis therapy., Ther Apher&Dial(Therapeutic Apheresis and Dialysis), Vol.7, No.5, A5, Oct. 2003.
13.	Toshiya Okahisa, Hiroshi Iwaki, Hiroshi Miyamoto, Masahiro Sogabe, Susumu Ito, Yoshiaki Ohnishi, Jun Oto, Yasuhiro Kuroda, Shuzo Oshita, Yoshinori Nitta, Yohsuke Kinouchi and Masatake Akutagawa : Monitoring filter clogging by analyzing the conductive condition of the roller pump flow pressure wave., Ther Apher&Dial(Therapeutic Apheresis and Dialysis), Vol.7, No.5, A9, Oct. 2003.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

敗血症における代謝産物を介した生命維持機構の解明 (研究課題/領域番号: 21K11724 )
抜管時の陽圧換気が呼吸機能に与える影響：経肺圧と電気インピーダンス法による評価 (研究課題/領域番号: 21K09049 )
重症患者における血中オレキシン活性がICU譫妄発症の病態機序に与える影響 (研究課題/領域番号: 16K11406 )
非侵襲的陽圧換気療法中の加湿と口腔内乾燥度の検討 (研究課題/領域番号: 21791768 )
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教授 : 大藤 純

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教授 : 大藤純