徳島大学 / 教育研究者総覧 --- 酒井徹

個人のホームページ

https://researchmap.jp/read0184057 (researchmap)

専門分野

○	公衆栄養学 (Public Health Nutrition), 栄養免疫学 (Nutritional Immunology)

研究テーマ

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著書・論文

著書:

1.	酒井徹, 郡俊之, 中本真理子, 中本晶子 : 公衆栄養学第7版, 株式会社講談社, 東京, 2023年1月.
2.	酒井徹 : 改訂感染と生体防御, 東京, 2018年9月.
3.	酒井徹 : 公衆栄養学2018年版, 医歯薬出版株式会社, 東京, 2018年2月.
4.	酒井徹 : 公衆栄養学第5版, 株式会社講談社サイエンティフィク, 東京, 2015年2月.
5.	酒井徹 : 公衆栄養学第5版, 株式会社中外医学社, 東京, 2015年2月.
6.	酒井徹 : 免疫疾患(食物アレルギーなど), 株式会社中外医学社, 東京, 2014年8月.
7.	酒井徹 : 公衆栄養学概論，がんを防ぐ食生活, 東京, 2014年2月.
8.	酒井徹, 郡俊之, 山本茂 : 公衆栄養学第4版栄養科学シリーズNEXT, 講談社サイエンティフィック, 東京, 2013年3月.
9.	酒井徹 : 改訂給食経営管理論, 建ぱく社, 2011年3月.

学術論文(審査論文):

1.	Jing Wang, Yuki Hashimoto, Miki Hiemori-Kondo, Akiko Nakamoto, Tohru Sakai, Wenxiu Ye and Naomi Abe-Kanoh : Resveratrol and piceid enhance efferocytosis by increasing the secretion of MFG-E8 in human THP-1 macrophages., Bioscience, Biotechnology, and Biochemistry, 1-12, 2024. (要約) The process of apoptotic cell clearance by phagocytes, known as efferocytosis, plays an essential role in maintaining homeostasis. Defects in efferocytosis can lead to inflammatory diseases such as atherosclerosis and autoimmune disorders. Therefore, the maintenance and promotion of efferocytosis are considered crucial for preventing these diseases. In this study, we observed that resveratrol, a representative functional food ingredient, and its glycoside, piceid, promoted efferocytosis in both human THP-1 macrophages differentiated with phorbol 12-myristate 13-acetate and peritoneal macrophages from thioglycolate-elicited mice. Resveratrol and piceid significantly increased mRNA expression and protein secretion of MFG-E8 in THP-1 macrophages. Furthermore, the activation of efferocytosis and the increment in MFG-E8 protein secretion caused by resveratrol or piceid treatment were canceled by MFG-E8 knockdown in THP-1 macrophages. In conclusion, we have demonstrated for the first time that resveratrol and piceid promote efferocytosis through the upregulation of MFG-E8 excretion in human THP-1 macrophages. (出版サイトへのリンク) ● Publication site (DOI): 10.1093/bbb/zbae079 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38830798 ● Search Scopus @ Elsevier (PMID): 38830798 ● Search Scopus @ Elsevier (DOI): 10.1093/bbb/zbae079 (DOI: 10.1093/bbb/zbae079, PubMed: 38830798)
2.	Mariko Nakamoto, Koki Torami, Thuy Thi Bui, Ayumi Tojyo, Kana Yamada, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : Associations between dietary diversity and high sensitive C-reactive protein among Japanese workers: findings of a cross-sectional and longitudinal study., European Journal of Nutrition, 2024. (要約) In the cross-sectional analysis, the hs-CRP concentration in male participants was significantly lower in those who had a high QUANTIDD score (adjusted mean [95% CI]: 0.074 [0.009-0.140] mg/dL in the lower group vs. 0.038 [-0.029-0.105] mg/dL in the higher group, p-value = 0.034). In the longitudinal analysis, the hs-CRP concentration of male participants also tended to be lower in those with higher QUANTIDD scores (p-value = 0.103). In both the cross-sectional and longitudinal analyses in women, there was no significant difference between the lower and higher QUANTIDD score groups. (徳島大学機関リポジトリ) ● Metadata: 119532 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00394-024-03389-9 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38780630 ● Search Scopus @ Elsevier (PMID): 38780630 ● Search Scopus @ Elsevier (DOI): 10.1007/s00394-024-03389-9 (徳島大学機関リポジトリ: 119532, DOI: 10.1007/s00394-024-03389-9, PubMed: 38780630)
3.	Yuko Tanaka, Akiko Nakamoto, Haruka Ohhashi, Mariko Nakamoto and Tohru Sakai : Flavonoids, nobiletin, heptamethoxyflavone, and genistein enhance antigen-presenting cell function in vitro, Exploration of Immunology, Vol.4, 333-340, 2024. (出版サイトへのリンク) ● Publication site (DOI): 10.37349/ei.2024.00144 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85196819738 (DOI: 10.37349/ei.2024.00144, Elsevier: Scopus)
4.	Thuy Thi Bui, Mariko Nakamoto, Kana Yamada, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : Associations between dietary diversity and dyslipidemia among Japanese workers: cross-sectional study and longitudinal study findings., European Journal of Nutrition, 2024. (要約) Cross-sectional analysis showed that the highest DDS reduced the odds of dyslipidemia in men (OR [95% CI] in Tertile 3: 0.67 [0.48-0.95], p value = 0.023). In longitudinal analysis, a moderate DDS reduced the risk of dyslipidemia (OR [95% CI] in Tertile 2: 0.21 [0.07-0.60], p value = 0.003) in women. (徳島大学機関リポジトリ) ● Metadata: 119533 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00394-024-03403-0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38703224 ● Search Scopus @ Elsevier (PMID): 38703224 ● Search Scopus @ Elsevier (DOI): 10.1007/s00394-024-03403-0 (徳島大学機関リポジトリ: 119533, DOI: 10.1007/s00394-024-03403-0, PubMed: 38703224)
5.	Mariko Nakamoto, Koki Torami, Miku Kanmura, Mai Yoshida, Akiko Nakamoto and Tohru Sakai : Changes in higher-level functional capacity during the COVID-19 pandemic among older adults living in Japan., The Journal of Medical Investigation : JMI, Vol.71, No.1.2, 66-74, 2024. (要約) The findings suggest an association of the COVID-19 pandemic with a decrease in higher-level functional capacity, especially in Social Role, among older adults living in Japan. J. Med. Invest. 71 : 66-74, February, 2024. (キーワード) Humans / COVID-19 / Female / Male / Aged / 日本 (Japan) / Aged, 80 and over / Retrospective Studies / Pandemics / Surveys and Questionnaires / ライフスタイル (lifestyle) / Geriatric Assessment (徳島大学機関リポジトリ) ● Metadata: 119430 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.71.66 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38735727 ● CiNii @ 国立情報学研究所 (CRID): 1390018672472901376 ● Summary page in Scopus @ Elsevier: 2-s2.0-85192885272 (徳島大学機関リポジトリ: 119430, DOI: 10.2152/jmi.71.66, PubMed: 38735727, CiNii: 1390018672472901376, Elsevier: Scopus)
6.	Yuko Tanaka, Mako Yamamoto, Haruka Ohhashi, Akiko Nakamoto, Mariko Nakamoto and Tohru Sakai : The Soy Isoflavone Genistein Enhances IFN-γ-Induced PD-L1 Expression in B16F1 Melanoma Cells in Vitro, BPB Reports, Vol.7, No.1, 21-25, 2024. (キーワード) soy isoflavone / genistein / flavonoids / PD-L1 / B16F1 melanoma (出版サイトへのリンク) ● Publication site (DOI): 10.1248/bpbreports.7.1_21 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390862112961703552 ● Search Scopus @ Elsevier (DOI): 10.1248/bpbreports.7.1_21 (DOI: 10.1248/bpbreports.7.1_21, CiNii: 1390862112961703552)
7.	Mako Yamamoto, Yuko Tanaka, Risako Takeda, Akiko Nakamoto, Mariko Nakamoto, Hideo Yagita and Tohru Sakai : Soy isoflavone genistein attenuates the efficacy of immune checkpoint therapy in C57BL/6 mice inoculated with B16F1 melanoma and a high PD-L1 expression level reflects tumor resistance., Journal of Clinical Biochemistry and Nutrition, Vol.74, No.1, 57-62, 2023. (要約) cells and the concentrations of interferon-γ and tumor necrosis factor-α in tumor tissue were not different among the experimental groups. A significant difference was also not found in microbe composition. Interestingly, a high expression level of PD-ligand (L)1 closely reflected the outcome of therapy by genistein or anti-PD-1 antibody. The study showed that a combination of genistein treatment does not improve the effect of immune blockade therapy. It also showed that a high PD-L1 expression level in tumors is a good prediction maker for the outcome of tumor therapy. (出版サイトへのリンク) ● Publication site (DOI): 10.3164/jcbn.23-76 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38292119 ● CiNii @ 国立情報学研究所 (CRID): 1390298668091681152 ● Search Scopus @ Elsevier (PMID): 38292119 ● Search Scopus @ Elsevier (DOI): 10.3164/jcbn.23-76 (DOI: 10.3164/jcbn.23-76, PubMed: 38292119, CiNii: 1390298668091681152)
8.	Akiko Nakamoto, Yuwa Hirabayashi, Chieri Anzaki, Mariko Nakamoto, Emi Shuto, Yoshitaka Nii and Tohru Sakai : Effects of polymethoxyflavonoids on T helper 17 cell differentiation in vitro and in vivo., The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 166-170, 2023. (徳島大学機関リポジトリ) ● Metadata: 118348 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.70.166 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164715 ● Search Scopus @ Elsevier (PMID): 37164715 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.166 (徳島大学機関リポジトリ: 118348, DOI: 10.2152/jmi.70.166, PubMed: 37164715)
9.	Mariko Nakamoto, Tsuzuri Nagashima, Yukiko Tanaka, Satomi Ono, Yuki Iwasaki, Akiko Nakamoto, Shu Zhang, Kaori Kinoshita, Kanae Furuya, Tomoko Imai, Rei Otsuka and Tohru Sakai : Validation of a dietary balance score in middle-aged and older community-dwelling Japanese, The Journal of Medical Investigation : JMI, Vol.70, No.3.4, 377-387, 2023. (キーワード) dietary balance / middle-aged and older community-dwelling Japanese / nutritional balance (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.70.377 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.377 (DOI: 10.2152/jmi.70.377)
10.	Akiko Nakamoto, Miho Goto, Hina Hasegawa, Chieri Anzaki, Mariko Nakamoto, Emi Shuto and Tohru Sakai : Essential Oil of Citrus sudachi Suppresses T Cell Activation Both In Vitro and In Vivo., Journal of Nutritional Science and Vitaminology, Vol.68, No.6, 513-520, 2022. (出版サイトへのリンク) ● Publication site (DOI): 10.3177/jnsv.68.513 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36596549 ● Search Scopus @ Elsevier (PMID): 36596549 ● Search Scopus @ Elsevier (DOI): 10.3177/jnsv.68.513 (DOI: 10.3177/jnsv.68.513, PubMed: 36596549)
11.	Mariko Nakamoto, Miku Kanmura, Mai Yoshida, Yukiko Tanaka, Satomi Ono, Yuki Iwasaki, Akiko Nakamoto and Tohru Sakai : Validity of dietary diversity assessed using short-form questionnaire among older Japanese community dwellers., The Journal of Medical Investigation : JMI, Vol.69, No.1.2, 31-37, 2022. (要約) The validity of dietary variety score (DVS) using a short-form questionnaire has not been investigated using dietary diversity based on a quantitative distribution of consumed foods in older Japanese. We examined the association between DVS and objective dietary diversity using a Quantitative Index for Dietary Diversity (QUANTIDD) based on the quantitative distribution of foods consumed by older Japanese community dwellers. The subjects were 65 older Japanese community dwellers aged 60?79 years. We used two kinds of scores for assessment of dietary diversity. At first, dietary diversity was determined using DVS calculated from answers to a questionnaire about frequencies of intake of 10 food groups. Second, dietary intake was assessed using a 3-day dietary record with photographs, and dietary diversity was determined using QUANTIDD. The relationships between DVS and QUANTIDD were assessed using partial correlation coefficients controlling for confounders. The correlation coefficient between DVS and QUANTIDD was moderate (r=0.212-0.458). After controlling for confounders, those correlation coefficient between DVS and QUANTIDD remained moderate. The findings suggest that there was a moderate relationship between DVS and QUANTIDD, and DVS using a short-form questionnaire may be useful for assessing dietary diversity in older Japanese community dwellers. J. Med. Invest. 69 : 31-37, February, 2022. (キーワード) Aged / Diet / Eating / Food / Humans / Japan / Surveys and Questionnaires (徳島大学機関リポジトリ) ● Metadata: 117008 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.69.31 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35466143 ● CiNii @ 国立情報学研究所 (CRID): 1390010457686573824 ● Search Scopus @ Elsevier (PMID): 35466143 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.69.31 (徳島大学機関リポジトリ: 117008, DOI: 10.2152/jmi.69.31, PubMed: 35466143, CiNii: 1390010457686573824)
12.	Mariko Nakamoto, Miku Kanmura, Mai Yoshida, Kana Yamada, Akiko Nakamoto and Tohru Sakai : Dietary diversity and food choice motives during the COVID-19 pandemic among older Japanese: An Internet Panel Survey., Asia Pacific Journal of Clinical Nutrition, Vol.31, No.3, 433-440, 2022. (要約) The findings suggest that the COVID-19 pandemic was associated with an increase in some food choice motives and a decrease in the frequency of eating out among elderly female Japanese. (キーワード) Aged / COVID-19 / Diet / Feeding Behavior / Female / Humans / Internet / Japan / Male / Pandemics / Retrospective Studies / Surveys and Questionnaires (徳島大学機関リポジトリ) ● Metadata: 118468 (出版サイトへのリンク) ● Publication site (DOI): 10.6133/apjcn.202209_31(3).0011 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36173215 ● CiNii @ 国立情報学研究所 (CRID): 1010017193307986432 ● Search Scopus @ Elsevier (PMID): 36173215 ● Search Scopus @ Elsevier (DOI): 10.6133/apjcn.202209_31(3).0011 (徳島大学機関リポジトリ: 118468, DOI: 10.6133/apjcn.202209_31(3).0011, PubMed: 36173215, CiNii: 1010017193307986432)
13.	Akiko Nakamoto, Hirabayashi Yuwa, Anzaki Chieri, Mariko Nakamoto, Emi Shuto and Tohru Sakai : Nobiletin suppresses the development of experimental autoimmune encephalomyelitis mediated by modulation of T helper 17 cell differentiation, Journal of Clinical Biochemistry and Nutrition, Vol.69, No.2, 145-150, 2021. (要約) Multiple sclerosis is an organ-specific autoimmune disease that targets the myelin antigen in the central nervous system. Nobiletin is a dietary polymethoxylated flavonoid found in citrus fruits. In this study, we investigated how nobiletin affects the disease state and immune responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis mice. Nobiletin was administered orally from 14 days before immunization until the end of the experiment, and clinical scores were determined. The production levels of interleukin-17A and interferon-γ were measured in a culture supernatant of splenocytes stimulated with myelin oligodendrocyte glycoprotein. In addition, flow cytometric analysis was performed to examine the effect of nobiletin on T cell differentiation . Admin-istration of nobiletin significantly decreased the clinical score and interleukin-17A production in splenocytes. Furthermore, analysis showed that nobiletin significantly suppressed Th17 cell differentiation and interleukin-17A production in a dose-dependent manner. The results suggest that nobiletin attenuates experimental autoimmune encephalomyelitis severity through modulation of Th17 cell differentiation. (徳島大学機関リポジトリ) ● Metadata: 116141 (出版サイトへのリンク) ● Publication site (DOI): 10.3164/JCBN.20-178 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34616106 ● Summary page in Scopus @ Elsevier: 2-s2.0-85114706108 (徳島大学機関リポジトリ: 116141, DOI: 10.3164/JCBN.20-178, PubMed: 34616106, Elsevier: Scopus)
14.	Mariko Nakamoto, Rei Otsuka, Chikako Tange, Yukiko Nishita, Makiko Tomida, Tomoko Imai, Tohru Sakai, Fujiko Ando and Hiroshi Shimokata : Intake of isoflavones reduces the risk of all-cause mortality in middle-aged Japanese., European Journal of Clinical Nutrition, 2021. (要約) There were 491 deaths during the follow-up period. We found inverse associations of the intake of total soy products and intake of each of the isoflavones with all-cause mortality (p for trend < 0.05) in subjects aged < 60 years: the multivariate-adjusted hazard ratios (95% confidence intervals) for all-cause mortality in the highest intake group (third tertile) of total soy products and total isoflavones were 0.32 (0.13-0.78) and 0.35 (0.17-0.73), respectively, compared with the reference group (first tertile). In contrast, there were no significant associations of intake amounts of legumes, soybeans, and isoflavones with all-cause mortality in subjects aged 60 years or older. (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41430-021-00890-w (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33712722 ● Search Scopus @ Elsevier (PMID): 33712722 ● Search Scopus @ Elsevier (DOI): 10.1038/s41430-021-00890-w (DOI: 10.1038/s41430-021-00890-w, PubMed: 33712722)
15.	Akiko Nakamoto, Risako Takeda, Yuwa Hirabayashi, Mariko Nakamoto, Emi Shuto and Tohru Sakai : Citrus Polymethoxyflavonoids, Nobiletin, Heptamethoxyflavone and Natsudaidain, Suppress T Cell Activation In Vitro and In Vivo, BPB Reports, Vol.3, No.4, 138-141, 2020. (出版サイトへのリンク) ● Publication site (DOI): 10.1248/bpbreports.3.4_138 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1248/bpbreports.3.4_138 (DOI: 10.1248/bpbreports.3.4_138)
16.	Hitomi Sakai, Tohru Sakai, Badr Ali Hoida, Kaori Kanemaru and Kumio Yokoigawa : Analysis of cereal extracts as conditioning solutes to suppress the initial attachment of Escherichia coli to abiotic surfaces, European Food Research and Technology, 2020. (キーワード) Cereals / Escherichia coli / Attachment / Abiotic materials (徳島大学機関リポジトリ) ● Metadata: 114680 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00217-020-03444-9 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85081030075 (徳島大学機関リポジトリ: 114680, DOI: 10.1007/s00217-020-03444-9, Elsevier: Scopus)
17.	Mariko Nakamoto, Yuna Yun, Mariko Omine, Sarasa Mori, Emi Shuto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : Dietary diversity and characteristics of lifestyle and awareness of health in Japanese workers:a cross-sectional study., The Journal of Medical Investigation : JMI, Vol.67, No.3.4, 255-264, 2020. (要約) The aim of this study was to clarify the characteristics of lifestyle and health awareness according to dietary diversity in a Japanese worksite population. The participants were 1,312 men and women aged 20 to 63 years who were living in Tokushima Prefecture, Japan during the period 2012-2013. We obtained anthropometric data and information on lifestyle characteristics using a self-administered questionnaire. Dietary intake was assessed using a food frequency questionnaire, and dietary diversity was determined using the Quantitative Index for Dietary Diversity (QUANTIDD). The characteristics of lifestyle and health awareness according to quartiles of the QUANTIDD score were assessed using the chi-square test and a general linear model. The higher the QUANTIDD score was, the larger were the proportions of participants who knew the appropriate amount of dietary intake and participants who referred to nutritional component information when choosing and / or buying food. Among participants with higher QUANTIDD scores, the proportion of participants who considered their current diet was good was high in women, whereas the proportion of participants who wanted to improve their diet in the future was high in men. Those results indicate that higher dietary diversity was related to better characteristics of lifestyle and awareness of health. J. Med. Invest. 67 : 255-264, August, 2020. (徳島大学機関リポジトリ) ● Metadata: 115420 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.67.255 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33148898 ● Search Scopus @ Elsevier (PMID): 33148898 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.255 (徳島大学機関リポジトリ: 115420, DOI: 10.2152/jmi.67.255, PubMed: 33148898)
18.	Mami Mitani, Yuki Minatogawa, Akiko Nakamoto, Mariko Nakamoto, Emi Shuto, Yoshitaka Nii and Tohru Sakai : Sudachitin, polymethoxyflavone from Citrus sudachi, enhances antigen-specific cellular and humoral immune responses in BALB/c mice., Journal of Clinical Biochemistry and Nutrition, Vol.64, No.2, 158-163, 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.3164/jcbn.18-70 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30936628 ● Summary page in Scopus @ Elsevier: 2-s2.0-85064387091 (DOI: 10.3164/jcbn.18-70, PubMed: 30936628, Elsevier: Scopus)
19.	Mariko Nakamoto, Mariko Omine, Yuna Yun, Emi Shuto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : Associations of dietary diversity with allergic diseases in Japanese workers: a cross-sectional study., Asia Pacific Journal of Clinical Nutrition, Vol.28, No.4, 857-869, 2019. (要約) The aim of this study was to determine the associations of dietary diversity with prevalences of allergic diseases. The participants were 1,317 men and women aged 20 to 63 years who were living in Tokushima Prefecture, Japan during the period 2012-2013. We obtained anthropometric data and information on lifestyle characteristics and current medical histories of allergic diseases using a self-administered questionnaire. Dietary intake was assessed using a food frequency questionnaire, and dietary diversity was determined using the Quantitative Index for Dietary Diversity (QUANTIDD). The ORs and 95% CIs for each of the allergic diseases with a 1 standard deviation (SD) increase in the QUANTIDD score were estimated, controlling for age, family history of allergic diseases, education, smoking, drinking, physical activity, energy intake and BMI. Higher dietary diversity showed significant inverse dose-response relationships with allergic diseases and allergic rhinitis in women. Multivariate-adjusted ORs (95% CI) for allergic diseases and allergic rhinitis with 1 SD increase in the QUANTIDD score were 0.77 (95% CI: 0.60-0.98, p=0.037) and 0.69 (95% CI: 0.53-0.90, p=0.007), respectively, in women. There were no significant associations between dietary diversity and allergic diseases in men. The results indicate that there is an inverse association between higher dietary diversity and allergic rhinitis in Japanese female workers. (キーワード) Adult / Asthma / Cross-Sectional Studies / Dermatitis, Atopic / Diet / Female / Food / Humans / Japan / Male / Middle Aged / Rhinitis, Allergic / Risk Factors / Young Adult (出版サイトへのリンク) ● Publication site (DOI): 10.6133/apjcn.201912_28(4).0023 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31826384 ● Summary page in Scopus @ Elsevier: 2-s2.0-85076486533 (DOI: 10.6133/apjcn.201912_28(4).0023, PubMed: 31826384, Elsevier: Scopus)
20.	Mariko Nakamoto, Yukiko Tanaka, Satomi Ono, Akiko Nakamoto, Emi Shuto and Tohru Sakai : Associations of marital and parental status and family members living together with health-related behaviors in Japanese young workers : a cross-sectional study., The Journal of Medical Investigation : JMI, Vol.66, No.1-2, 141-147, 2019. (要約) The aim of this study was to clarify the associations of family members living together with healthrelated behaviors in Japanese young workers. The participants were 300 men and women aged 20-39 years in 2015 who had a job. A web-based self-administered questionnaire on status of partnering and parenting, number of family members living together, dietary habits, drinking habit, smoking habit, self-rated health, employment status, working time and commuting time was conducted through Internet. Multiple logistic regression analysis and general linear models were used to assess the association of family members living together with healthrelated behaviors. The multivariate-adjusted odds ratio (95% confidence interval, p-value) for current drinking in unmarried participants living with their parents compared to unmarried participants living alone was 0.35 (0.13-0.93, p=0.036). The adjusted means of frequency of breakfast skipping and frequency of eating out showed a trend for inverse associations with the presence of a partner and children. However, those associations disappeared after adjustment for age of youngest child. The findings suggest that the presence of parents might affect drinking behavior and that age of youngest child living together might affect the frequency of breakfast skipping in young Japanese workers. J. Med. Invest. 66 : 141-147, February, 2019. (キーワード) 疫学 (epidemiology) / 栄養 (nutrition) (徳島大学機関リポジトリ) ● Metadata: 113409 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.66.141 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31064927 ● Search Scopus @ Elsevier (PMID): 31064927 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.141 (徳島大学機関リポジトリ: 113409, DOI: 10.2152/jmi.66.141, PubMed: 31064927)
21.	Akiko Nakamoto, Mami Mitani, Kana Urayama, Akari Maki, Mariko Nakamoto, Emi Shuto, Yoshitaka Nii and Tohru Sakai : Nobiletin Enhances Induction of Antigen-Specific Immune Responses in BALB/c Mice Immunized with Ovalbumin., Journal of Nutritional Science and Vitaminology, Vol.65, No.3, 278-282, 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.3177/jnsv.65.278 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31257269 ● Search Scopus @ Elsevier (PMID): 31257269 ● Search Scopus @ Elsevier (DOI): 10.3177/jnsv.65.278 (DOI: 10.3177/jnsv.65.278, PubMed: 31257269)
22.	Mariko Nakamoto, Rei Otsuka, Yukiko Nishita, Chikako Tange, Makiko Tomida, Yuki Kato, Tomoko Imai, Tohru Sakai, Fujiko Ando and Hiroshi Shimokata : Soy food and isoflavone intake reduces the risk of cognitive impairment in elderly Japanese women., European Journal of Clinical Nutrition, Vol.27, No.6, 1458-1462, 2018. (要約) Data were derived from the National Institute for Longevity Sciences-Longitudinal Study of Aging. Subjects comprised 403 men and 373 women aged 60-81 years at baseline who participated in the follow-up study at least once. Bean, soy product and soy isoflavone intake was assessed using a 3-day dietary record at baseline. Cognitive function was assessed by the Mini-Mental State Examination (MMSE). MMSE scores of 23 were used to define cognitive impairment. The relationship between bean, soy product and soy isoflavone intake and cognitive impairment was assessed using a generalized estimating equation. Multivariate-adjusted odds ratios (95% confidence intervals) for cognitive impairment with a 1 s.d. increase in total bean, total soybean and total soy isoflavone intakes were 0.48 (0.28-0.81; p = 0.006), 0.51 (0.32-0.83; p = 0.007), and 0.55 (0.32-0.93; p = 0.026), respectively, in women. Total soybean and soy isoflavone intake might decrease the risk of cognitive impairment in elderly Japanese women. (キーワード) 栄養 (nutrition) / 疫学 (epidemiology) / 認知症 (dementia) (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41430-017-0061-2 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29348624 ● Summary page in Scopus @ Elsevier: 2-s2.0-85040678215 (DOI: 10.1038/s41430-017-0061-2, PubMed: 29348624, Elsevier: Scopus)
23.	Mariko Nakamoto, Emi Shuto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : Soy product and isoflavone intake associations with allergic diseases in Japanese workers: rhinitis, dermatitis and asthma., Asia Pacific Journal of Clinical Nutrition, Vol.27, No.6, 1277-1285, 2018. (要約) The aim of this study was to determine the associations of intake of soy products and isoflavones with allergic diseases. We conducted a cross-sectional study in 1437 participants (aged 20-64 years) who were living in Tokushima Prefecture, Japan during the period 2010- 2011. We obtained anthropometric data and information on life style characteristics including dietary intake and current medical histories of allergic diseases using a structural self-administered questionnaire. Multiple logistic regression models were used to assess the associations of soy products and isoflavones with allergic diseases after controlling for age, family history of allergic diseases, smoking, drinking, physical activity, energy intake, BMI and dietary factors. Intake of soy products showed significant inverse dose-response relationships with allergic rhinitis. The third quartile for soy products had an adjusted OR of 0.56 (95% CI: 0.35-0.91) compared to the reference group (first quartile), though intake of soy products showed no dose-response relationship with atopic dermatitis. Intake of soy isoflavones showed a significant inverse dose-response relationship with atopic dermatitis, though the association between intake of soy isoflavones and atopic dermatitis was U-shaped after adjustments for potential confounders. On the other hand, the associations between intake of soy isoflavones and other allergic diseases were not significant. The results indicate that higher intake of soy products is associated with reduced risk of allergic rhinitis in Japanese workers. Furthermore, moderate intake amounts of soy products and soy isoflavones are associated with inverse risk of atopic dermatitis. (キーワード) 疫学 (epidemiology) / 栄養 (nutrition) (出版サイトへのリンク) ● Publication site (DOI): 10.6133/apjcn.201811_27(6).0015 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30485927 ● Search Scopus @ Elsevier (PMID): 30485927 ● Search Scopus @ Elsevier (DOI): 10.6133/apjcn.201811_27(6).0015 (DOI: 10.6133/apjcn.201811_27(6).0015, PubMed: 30485927)
24.	Xiaolin Yang, Mariko Nakamoto, Emi Shuto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Ayako Tamura, Hirokazu Uemura, Kokichi Arisawa, Makoto Funaki and Tohru Sakai : Associations between intake of dietary fermented soy food and concentrations of inflammatory markers: a cross-sectional study in Japanese workers, The Journal of Medical Investigation : JMI, Vol.65, No.1-2, 74-80, 2018. (要約) Epidemiological investigations have shown that consumption of soybeans or soy foods reduces the risk of the development of cardiovascular disease, cancer and osteoporosis. The aim of this study was to determine the associations between different soy foods and inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, and IL-18, in Japanese workers. The cross-sectional study included 1,426 Japanese workers (1,053 men and 373 women) aged 20 to 64 years. Intake of 12 soy foods was estimated by a validated food frequency questionnaire. Associations of total soy foods, fermented soy food, non-fermented soy food, soy isoflavone with hs-CRP, IL-6, and IL-18 levels were examined by general linear model regression analysis. We found that total fermented soy food intake was inversely associated with multivariable-adjusted geometric concentration of IL-6 in men (Q1:1.03 pg/mL, Q5:0.94 pg /mL;P for trend = 0.031). Furthermore, it was shown that IL-6 concentrations were inversely associated with miso intake (β = -0.068;p = 0.034) and soy sauce intake in men (β = -0.074;p = 0.018). This study suggests that intake of total fermented soy food, miso and soy sauce be associated with IL-6 concentrations in Japanese men. J. Med. Invest. 65:74-80, February, 2018. (徳島大学機関リポジトリ) ● Metadata: 111414 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.65.74 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29593198 ● CiNii @ 国立情報学研究所 (CRID): 1390282679224674560 ● Summary page in Scopus @ Elsevier: 2-s2.0-85044467994 (徳島大学機関リポジトリ: 111414, DOI: 10.2152/jmi.65.74, PubMed: 29593198, CiNii: 1390282679224674560, Elsevier: Scopus)
25.	Tohru Sakai, Miyuki Ohhata, Misaki Fujii, Sayaka Oda, Yasuna Kusaka, Miki Matsumoto, Akiko Nakamoto, Tomoyo Taki, Mariko Nakamoto and Emi Shuto : Brazilian Green Propolis Promotes Weight Loss and Reduces Fat Accumulation in C57BL/6 Mice Fed A High-Fat Diet, Biological & Pharmaceutical Bulletin, Vol.40, No.4, 391-395, 2017. (要約) Propolis is a bee product with various biological properties. C57BL/6 mice were fed a high-fat diet and treated with propolis for 14 weeks. Body weight in mice treated with 2% propolis was less than that in control mice from 3 weeks after the start of treatment until 14 weeks except for the 7th week. Mice treated with propolis showed significantly lower epididymal fat weight and subcutaneous fat weight. Infiltration of epididymal fat by macrophages and T cells was reduced in the propolis group. Supplementation of propolis increased feces weight and fat content in feces, suggesting that mechanisms of weight reduction by propolis partly include a laxative effect and inhibition of fat absorption. (キーワード) propolis / weight / fat absorption (出版サイトへのリンク) ● Publication site (DOI): 10.1248/bpb.b16-00577 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28381793 ● Summary page in Scopus @ Elsevier: 2-s2.0-85016978833 (DOI: 10.1248/bpb.b16-00577, PubMed: 28381793, Elsevier: Scopus)
26.	Hitomi Kobayashi, Mami Mitani, Yuka Minatogawa, Satoko Hayashi, Mariko Nakamoto, Emi Shuto, Yoshitaka Nii and Tohru Sakai : Extracts of citrus Sudachi peel attenuate body weight gain in C57BL/6 mice fed a high-fat diet, The Journal of Medical Investigation : JMI, Vol.64, No.1.2, 20-23, 2017. (要約) Citrus Sudachi is the special local product of Tokushima Prefecture, and over 98% of Sudachi consumed in Japan every year is produced in Tokushima Prefecture. In this study, we evaluated the function of sudachi peel extract (SPE) using an animal model of obesity. C57BL/6 mice were fed a high-fat diet containing 1% SPE powder. Treatment with SPE significantly decreased body weight compared to that of mice fed a high-fat diet. A significant difference in body weight was observed between the control and SPE groups from 7 weeks after the start of the experiment, the significant difference continued until the end of the 14-week experiment. Reduction of blood glucose levels following insulin administration in SPE-treated mice was grater than that in control mice. Determination of mRNA expression in adipose tissue showed that the expression level of TNF-α in the SPE group was significantly decreased compared to that on the control group. These results suggest that SPE potentially has the ability to attenuate body weight gain. J. Med. Invest. 64: 20-23, February, 2017. (キーワード) Citrus sudachi / high-fat diet / inflammation / weight (徳島大学機関リポジトリ) ● Metadata: 111075 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.64.20 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28373623 ● Search Scopus @ Elsevier (PMID): 28373623 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.64.20 (徳島大学機関リポジトリ: 111075, DOI: 10.2152/jmi.64.20, PubMed: 28373623)
27.	Rie Tsutsumi, Masakazu Goda, Chisa Fujimoto, Kyoko Kanno, Misaki Nobe, Yoshiaki Kitamura, Koji Abe, Misako Kawai, Hideki Matsumoto, Tohru Sakai and Noriaki Takeda : Effects of chemotherapy on gene expression of lingual taste receptors in patients with head and neck cancer., The Laryngoscope, Vol.126, No.3, E103-E109, 2015. (要約) We aimed to test the hypothesis that chemotherapy changes the gene expression of taste receptors in the tongue to induce dysgeusia in patients with head and neck cancer. Prospective observation study. We enrolled 21 patients who received chemoradiotherapy and five patients who underwent radiotherapy for head and neck cancer. The messenger RNA (mRNA) levels of the taste receptor subunits T1R1, T1R2, T1R3, and T2R5 were measured in lingual mucosa scrapings obtained with a small spatula. The perception thresholds of umami, sweet, and bitter tastes were assessed by the whole mouth gustatory test. In four patients with severe stomatitis induced by chemoradiotherapy, the mRNA levels of T1R1, T1R2, T1R3, and T2R5 in the lingual mucosa were significantly decreased. However, in 17 patients with mild/moderate stomatitis, the mRNA levels of T1R3 were significantly and transiently decreased, whereas those of T1R1 and T1R2 remained unchanged and those of T2R5 mRNA were significantly and transiently increased after chemotherapy. There was a significant negative correlation between the perception thresholds of umami or sweet tastes and lingual mRNA levels of T1R3 in patients with mild/moderate stomatitis after chemotherapy. Although the perception threshold of bitter taste remained unchanged, lingual mRNA levels of T2R5 were significantly increased in patients who complained of phantogeusia after chemotherapy. Chemotherapy specifically changed the gene expression of T1R3 and T2R5 in head and neck cancer patients with mild/moderate stomatitis, resulting in both dysgeusia of umami and sweet tastes as well as phantogeusia. 4. Laryngoscope, 126:E103-E109, 2016. (キーワード) Adult / Aged / Aged, 80 and over / 分散分析 (analysis of variance) / Antineoplastic Agents / Chemoradiotherapy / Cohort Studies / Dysgeusia / Female / 遺伝子発現 (gene expression) / Head and Neck Neoplasms / Humans / 日本 (Japan) / Male / Middle Aged / Prognosis / Prospective Studies / RNA, Messenger / Receptors, G-Protein-Coupled / Risk Assessment / Severity of Illness Index / Taste Buds / Tongue (出版サイトへのリンク) ● Publication site (DOI): 10.1002/lary.25679 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26422579 ● Search Scopus @ Elsevier (PMID): 26422579 ● Search Scopus @ Elsevier (DOI): 10.1002/lary.25679 (DOI: 10.1002/lary.25679, PubMed: 26422579)
28.	Tohru Sakai, Tomoyo Taki, Akiko Nakamoto, Shiho Tazaki, Mai Arakawa, Mariko Nakamoto, Rie Tsutsumi and Emi Shuto : Dietary ribonucleic Acid suppresses inflammation of adipose tissue and improves glucose intolerance that is mediated by immune cells in C57BL/6 mice fed a high-fat diet., Journal of Nutritional Science and Vitaminology, Vol.61, No.1, 73-78, 2015. (要約) Recent evidence suggests that immune cells play an important role in differentiation of inflammatory macrophages in adipose tissue, which contributes to systemic chronic inflammation. Dietary ribonucleic acid (RNA) has been shown to modulate immune function. We hypothesized that RNA affects immune cell function in adipose tissue and then improves inflammatory response in adipose tissue. C57/BL6 mice and recombination activating gene-1 (RAG-1) knockout mice on a C57BL/6 mice background were fed a high-fat diet containing 1% RNA for 12 wk. An oral glucose tolerance test was performed. Supplementation of dietary RNA in C57BL/6 mice fed a high-fat diet resulted in a smaller area under the curve (AUC) after oral glucose administration than that for control mice. The mRNA expression levels of inflammation-related cytokines in adipose tissue and serum interleukin-6 levels were reduced by dietary RNA supplementation. Interestingly, reduction of the AUC value by RNA supplementation was abolished in T and B cell-deficient RAG-1 knockout mice. These results indicate that RNA improves inflammation in adipose tissue and reduces the AUC value following oral glucose administration in a T and B cell-dependent manner. (出版サイトへのリンク) ● Publication site (DOI): 10.3177/jnsv.61.73 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25994141 ● Summary page in Scopus @ Elsevier: 2-s2.0-84929733065 (DOI: 10.3177/jnsv.61.73, PubMed: 25994141, Elsevier: Scopus)
29.	Akiko Nakamoto, Emi Shuto, Rie Tsutsumi, Mariko Nakamoto, Yoshitaka Nii and Tohru Sakai : Vitamin A Deficiency Impairs Induction of Oral Tolerance in Mice., Journal of Nutritional Science and Vitaminology, Vol.61, No.2, 147-153, 2015. (要約) Oral tolerance is a phenomenon of induction of systemic unresponsiveness to antigens ingested by the oral route and loss of immune response. Studies have shown the importance of vitamin A in oral tolerance in vitro but not in an in vivo experimental model. Therefore, we carried out experiments to determine how vitamin A deficiency affects tolerance induction and the ability of mesenteric lymph node (MLN) CD11c(+) cells to induce regulatory T cells (Tregs). Immunological tolerance was induced by oral ovalbumin (OVA) administration in vitamin A-sufficient mice. OVA-specific antibody and cytokine production were significantly reduced. On the other hand, in vitamin A-deficient mice, both OVA-specific antibody and cytokine production were not suppressed by oral OVA administration. Regarding induction of Tregs, the conversion rate of Foxp3(+) cells from naïve CD4(+) cell by CD11c(+) cells was decreased in vitamin A-deficient mice. Our study indicates that vitamin A deficiency causes the breakdown of oral tolerance in vivo. (出版サイトへのリンク) ● Publication site (DOI): 10.3177/jnsv.61.147 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26052145 ● Summary page in Scopus @ Elsevier: 2-s2.0-84930703907 (DOI: 10.3177/jnsv.61.147, PubMed: 26052145, Elsevier: Scopus)
30.	Rie Tsutsumi, Tomomi Yoshida, Yoshitaka Nii, Naoki Okahisa, Shinya Iwata, Masao Tsukayama, Rei Hashimoto, Yasuko Taniguchi, Hiroshi Sakaue, Toshio Hosaka, Emi Shuto and Tohru Sakai : Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle., Nutrition & Metabolism, Vol.11, 32, 2014. (要約) Obesity is a major risk factor for insulin resistance, type 2 diabetes, and stroke. Flavonoids are effective antioxidants that protect against these chronic diseases. In this study, we evaluated the effects of sudachitin, a polymethoxylated flavonoid found in the skin of the Citrus sudachi fruit, on glucose, lipid, and energy metabolism in mice with high-fat diet-induced obesity and db/db diabetic mice. In our current study, we show that sudachitin improves metabolism and stimulates mitochondrial biogenesis, thereby increasing energy expenditure and reducing weight gain. C57BL/6 J mice fed a high-fat diet (40% fat) and db/db mice fed a normal diet were treated orally with 5 mg/kg sudachitin or vehicle for 12 weeks. Following treatment, oxygen expenditure was assessed using indirect calorimetry, while glucose tolerance, insulin sensitivity, and indices of dyslipidemia were assessed by serum biochemistry. Quantitative polymerase chain reaction was used to determine the effect of sudachitin on the transcription of key metabolism-regulating genes in the skeletal muscle, liver, and white and brown adipose tissues. Primary myocytes were also prepared to examine the signaling mechanisms targeted by sudachitin in vitro. Sudachitin improved dyslipidemia, as evidenced by reduction in triglyceride and free fatty acid levels, and improved glucose tolerance and insulin resistance. It also enhanced energy expenditure and fatty acid β-oxidation by increasing mitochondrial biogenesis and function. The in vitro assay results suggest that sudachitin increased Sirt1 and PGC-1α expression in the skeletal muscle. Sudachitin may improve dyslipidemia and metabolic syndrome by improving energy metabolism. Furthermore, it also induces mitochondrial biogenesis to protect against metabolic disorders. (出版サイトへのリンク) ● Publication site (DOI): 10.1186/1743-7075-11-32 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25114710 ● Search Scopus @ Elsevier (PMID): 25114710 ● Search Scopus @ Elsevier (DOI): 10.1186/1743-7075-11-32 (DOI: 10.1186/1743-7075-11-32, PubMed: 25114710)
31.	酒井徹, 中本真理子, 中本晶子, 首藤恵泉, 小林ゆき子, 土居幸雄, 木戸康弘 : 管理栄養士・栄養士養成施設における教員の学位取得状況および教員に求められる知識や技能等に関する調査, 栄養学雑誌, Vol.72, No.5, 262-271, 2014年. (要約) 【目的】管理栄養士および栄養士養成施設において管理栄養士・栄養士免許を有する教員の数，教員の学位取得状況，各養成施設において教員に求められる知識や技能等を明らかにする．【方法】教員の学位取得状況，教員に求められる知識や技能および担当科目等の基礎情報に関する質問用紙を作成し，2013年2∼3月に全国の管理栄養士および栄養士養成施設に郵送した．【結果】回答が得られた施設は，管理栄養士養成施設78校(回答率66.1%)，栄養士養成施設102校であった(回答率68.5%)．教員の年齢区分では管理栄養士および栄養士養成施設共に30∼49歳が最も高かった．管理栄養士養成施設で管理栄養士免許を有する教員で博士の学位を有する者の割合は年齢層が上昇するごとに増え30歳以上では約4割程度であった．管理栄養士養成施設において管理栄養士免許保有教員のうち修士または博士の学位を有するものは，20∼29歳42.5%，30∼49歳75.7%，50∼65歳66.5%であった．栄養士養成施設において管理栄養士免許を有する教員で博士の学位を有するものの割合は30歳以上で約2割程度であった．栄養士養成校において管理栄養士免許保有教員のうち修士および博士の学位を有するものは，20∼29歳28.4%，30∼49歳47.4%，50∼65歳42.0%であった．養成施設が教員に求める知識や技能に関しては，「教育」が最も高く，エフォートに対する割合としては50∼59%と回答する施設が最も多かった．【結論】管理栄養士および栄養士養成施設における管理栄養士または栄養士免許を有する教員の年齢構成，学位取得状況等の基本情報が得られた．また養成施設が教員に対して求める知識や技能として最も高いのは「教育」であった． (キーワード) 管理栄養士・栄養士養成施設 / 教員 / 学位 / 知識・技能 (出版サイトへのリンク) ● Publication site (DOI): 10.5264/eiyogakuzashi.72.262 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001206547275776 ● Search Scopus @ Elsevier (DOI): 10.5264/eiyogakuzashi.72.262 (DOI: 10.5264/eiyogakuzashi.72.262, CiNii: 1390001206547275776)
32.	Toshio Hosaka, Sayaka Sasaga, Yukiko Yamasaka, Yoshitaka Nii, Kazuhiro Edazawa, Rie Tsutsumi, Emi Shuto, Naoki Okahisa, Shinya Iwata, Hiroyuki Tomotake and Tohru Sakai : Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fatty liver in KK-A(y) mice., The Journal of Medical Investigation : JMI, Vol.61, No.3-4, 345-352, 2014. (要約) Buckwheat powder or protein has been shown to decrease the total serum cholesterol level in non-diabetic mice or rats. However, the lipid-lowering effect of buckwheat bran extract (BBE) in diabetic mice has not been fully elucidated. KK-A(y) mice that received six-week treatment with BBE showed decreased body weight and liver weight compared to those of control (vehicle) mice. However, there was no significant difference in food intake. BBE treatments prevented liver triglyceride accumulation and decreased the serum level of triglycerides. In addition, mRNA expression levels lipogenic enzyme genes, fatty acid synthase, acetyl-coenzyme a oxidase and stearyl-coenzyme a desaturase 1, but not those of -oxidized enzyme genes, were decreased in BBE-treated mice. Level of transcription factors ChREBP and SREBP1c, transcripts of lipogenic genes, were also decreased in BBE-treated mice. These results suggest that chronic treatment with BBE derivatives could have beneficial effects on hypertriglycemia in patients with type 2 diabetes mellitus. (徳島大学機関リポジトリ) ● Metadata: 109583 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.61.345 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25264053 ● Summary page in Scopus @ Elsevier: 2-s2.0-84907513565 (徳島大学機関リポジトリ: 109583, DOI: 10.2152/jmi.61.345, PubMed: 25264053, Elsevier: Scopus)
33.	Mariko Nakamoto, Kokichi Arisawa, Hirokazu Uemura, Sakurako Katsuura-Kamano, Hidenobu Takami, Fusakazu Sawachika, Miwa Yamaguchi, Tomoya Juta, Tohru Sakai, Eisaku Toda, Kei Mori, Manabu Hasegawa, Masaharu Tanto, Masayuki Shima, Yoshio Sumiyoshi, Kenji Morinaga, Kazunori Kodama, Takaichiro Suzuki, Masaki Nagai and Hiroshi Satoh : Association between blood levels of PCDDs/PCDFs/dioxin-like PCBs and history of allergic and other diseases in the Japanese population., International Archives of Occupational and Environmental Health, Vol.86, No.8, 849-859, 2013. (要約) Previous studies reported that exposure to dioxins was associated with an increased risk of various diseases in general populations. The aim of this study was to examine the association between levels of dioxins in blood and allergic and other diseases. We conducted a cross-sectional study on 1,063 men and 1,201 women (aged 15-76 years), who were living throughout Japan and not occupationally exposed to dioxins, during 2002-2010. In fasting blood samples, polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) were analyzed by isotope dilution high-resolution gas chromatography/mass spectrometry. We obtained information on life style and self-reported history of diseases using a questionnaire. Blood pressure, blood levels of hemoglobin A1c, and serum lipids were also measured. Multiple logistic regression models were used to analyze the association between dioxin levels in blood and various diseases. Toxic equivalents of PCDDs/PCDFs and total dioxins showed significant inverse dose-response relationships with atopic dermatitis, after adjustments for potential confounders. The highest quartile for total dioxins had an adjusted odds ratio of 0.26 (95 % confidence interval 0.08-0.70) compared to the reference group (first quartile). The odds ratios for hypertension, diabetes mellitus, hyperlipidemia, gout in men, and gynecologic diseases in women significantly increased with increasing toxic equivalents of PCDDs/PCDFs, DL-PCBs, and total dioxins in blood. The present findings suggest that background exposure to dioxins was associated with reduced risk of atopic dermatitis. The results also support the idea that low-level exposure to dioxins is associated with an increased risk of diabetes, hypertension, and hyperlipidemia. (キーワード) Adolescent / Adult / Aged / Benzofurans / Cross-Sectional Studies / Dermatitis, Atopic / Diabetes Mellitus / Environmental Exposure / Female / Humans / Hyperlipidemias / Hypertension / Japan / Life Style / Male / Middle Aged / Polychlorinated Biphenyls / Questionnaires / Tetrachlorodibenzodioxin / Young Adult (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00420-012-0819-8 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23014754 ● Search Scopus @ Elsevier (PMID): 23014754 ● Search Scopus @ Elsevier (DOI): 10.1007/s00420-012-0819-8 (DOI: 10.1007/s00420-012-0819-8, PubMed: 23014754)
34.	市原多香子, 田村綾子, 南川貴子, 桑村由美, 小杉知里, 安藝菜奈子, 保坂利男, 首藤恵泉, 酒井徹, 船木真理 : 勤労男性の生活における身体活動とメタボリックシンドロームとの関連, 糖尿病, Vol.56, No.9, 637-645, 2013年. (キーワード) メタボリックシンドローム / 身体活動 / 勤労男性 / 横断調査 (出版サイトへのリンク) ● Publication site (DOI): 10.11213/tonyobyo.56.637 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282679885162752 ● Summary page in Scopus @ Elsevier: 2-s2.0-84886613919 (DOI: 10.11213/tonyobyo.56.637, CiNii: 1390282679885162752, Elsevier: Scopus)
35.	中本真理子, 酒井徹, 首藤恵泉, 安藝菜奈子, 小杉知里, 秦明子, 篠田香織, 桑村由美, 南川貴子, 市原多香子, 田村綾子, 船木真理 : 勤労者の夕食終了から就寝時間までの間隔と健康状態との関係, 日本栄養・食糧学会誌, Vol.66, No.4, 185-193, 2013年. (要約) 近年, 生活習慣病や精神疾患などを抱える勤労者が増加している．一方, 朝食欠食, 過食, 身体活動の不足, 短時間睡眠など, 生活習慣の乱れが疾病の発症に関連することが報告されている．我々は, 徳島県勤労者において, 夕食終了から就寝までの間隔と生活習慣病の有病状況との関係について横断研究を行った．20歳以上の勤労者735名を対象に, 食物摂取頻度調査, 生活に関する質問票調査, 採血, 身体計測を実施した．夕食終了から就寝までの間隔が2時間未満の対象者を対照群とし, ロジスティック回帰分析を用いて解析を行った．高血圧に関して, 対照群に比し3-4時間, 4時間以上の群で, 有意に調整オッズ比が低下した．さらに21時以降の食事摂取者で, 高血圧の調整オッズ比は3-4時間空ける群で有意に低下し, 量反応性の関係が認められた．これらのことより, 夕食終了から就寝までの間隔を空けることが, 高血圧の予防につながる可能性が示唆された． (キーワード) 高血圧 / 生活スタイル / 横断研究 / 労働者 (出版サイトへのリンク) ● Publication site (DOI): 10.4327/jsnfs.66.185 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282681268995200 ● Search Scopus @ Elsevier (DOI): 10.4327/jsnfs.66.185 (DOI: 10.4327/jsnfs.66.185, CiNii: 1390282681268995200)
36.	Tohru Sakai, Tomoyo Taki, Akiko Nakamoto, Emi Shuto, Rie Tsutsumi, Takayuki Toshimitsu, Seiya Makino and Shuuji Ikegami : Lactobacillus plantarum OLL2712 regulates glucose metabolism in C57BL/6 mice fed a high-fat diet., Journal of Nutritional Science and Vitaminology, Vol.59, No.2, 144-147, 2013. (要約) The aim of the present study was to determine the effect of oral administration of Lactobacillus plantarum OLL2712 (L. plantarum OLL2712) on glucose and lipid metabolism in mice with high-fat diet-induced obesity. Mice that had been administered 10(9) cfu heat-killed L. plantarum OLL2712 for 12 wk showed significant reduction of blood glucose levels in response to insulin. Furthermore, mRNA expression of interleukin-1β in adipose tissue and serum levels of nonesterified fatty acids in mice administered L. plantarum OLL2712 were significantly lower than those in control mice. These results indicate that L. plantarum OLL2712 regulates glucose metabolism. (キーワード) Adipose Tissue / Animals / Blood Glucose / コレステロール (cholesterol) / Diet, High-Fat / Fatty Acids, Nonesterified / インスリン (insulin) / Interleukin-1beta / Lactobacillus plantarum / Lipid Metabolism / Male / Mice / Mice, Inbred C57BL / 肥満症 (obesity) / Probiotics / RNA, Messenger / Triglycerides (出版サイトへのリンク) ● Publication site (DOI): 10.3177/jnsv.59.144 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23727645 ● CiNii @ 国立情報学研究所 (CRID): 1390282681301114368 ● Summary page in Scopus @ Elsevier: 2-s2.0-84878434562 (DOI: 10.3177/jnsv.59.144, PubMed: 23727645, CiNii: 1390282681301114368, Elsevier: Scopus)
37.	Mariko Nakamoto, Emi Shuto, Toshio Hosaka and Tohru Sakai : Dietary deoxynucleic acid induces type 2 T-helper immune response through toll-like receptor 9 in mice., European Journal of Nutrition, Vol.50, No.6, 421-426, 2011. (要約) It has been shown that dietary nucleotides modulate immune response. Due to their unique properties in immune responses, nucleotides are used as immunonutrition in the field of clinical nutrition. In this study, we examined the effect of dietary deoxynucleic acid (DNA) on antigen (Ag)-specific immune response in ovalbumin (OVA)-immunized BALB/c mice and determined the mechanism using toll-like receptor 9 (TLR9) knock-out (KO) mice. BALB/c or TLR9 KO mice were fed control and 1% DNA diets and immunized with OVA. Spleen cells from OVA-immunized mice were stimulated with OVA in vitro, and the contents of IFN-γ and IL-4 in supernatants were measured by an ex vivo system. CD11c(+) dendritic cells were purified, and ability of cytokine induction to CD4(+) cells was examined. The level of OVA-specific IL-4 production in the DNA group was significantly higher than that in the control group. In contrast, the level of OVA-specific IFN-γ production in the DNA group was lower than that in the control group. The DNA diet decreased Ag-specific IL-4 production and enhanced Ag-specific IFN-γ production in TLR9 KO mice. CD11c(+) DCs from mice fed the DNA diet had a greater ability than CD11c(+) DCs from mice fed the control diet to induce the production of IL-4 from DO11.10 CD4(+) T cells. Dietary DNA increases Ag-specific IL-4 production and decreases IFN-γ production through a TLR9-dependent pathway. CD11c(+) dendritic cells are target cells in dietary DNA-induced immune regulation. (キーワード) Animals / Antigens, CD11c / Antigens, CD4 / Cell Differentiation / Cells, Cultured / DNA / Dendritic Cells / Diet / Female / Immunomodulation / Interferon-gamma / Interleukin-4 / Mice / Mice, Inbred BALB C / Mice, Knockout / Ovalbumin / Specific Pathogen-Free Organisms / Spleen / Th2 Cells / Toll-Like Receptor 9 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00394-010-0153-4 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21132311 ● Search Scopus @ Elsevier (PMID): 21132311 ● Search Scopus @ Elsevier (DOI): 10.1007/s00394-010-0153-4 (DOI: 10.1007/s00394-010-0153-4, PubMed: 21132311)
38.	Asuka Shiota, Yutaka Taketani, Yoichi Maekawa, Koji Yasutomo, Masataka Sata, Tohru Sakai, R. Mizuno, M. Isshiki, Hironori Yamamoto and Eiji Takeda : High phosphate diet reduces atherosclerosis formation in apolipoprotein E-deficient mice., Journal of Clinical Biochemistry and Nutrition, Vol.49, No.2, 109-114, 2011. (要約) Although higher serum phosphate level is a risk factor for cardiovascular diseases in general population as well as chronic kidney disease patients, it has not been clarified whether higher phosphate can affect atherosclerotic plaque formation. In this study, we investigated the effect of prolonged-intake of different concentrations of phosphate on atherosclerosis formation using apolipoprotein E-deficient mice. Apolipoprotein E-deficient mice were fed with high fat diet including 0.6%, 1.2% or 1.8% phosphate. After 20-week treatment, atherosclerotic plaque formation in aorta in 1.8% phosphate diet group was unexpectedly less than that in the other groups. To elucidate mechanisms of suppression of plaque formation by high phosphate diet, we hypothesized that high phosphate diet may modify a profile of monocytes/macrophages suppressing plaque formation. We confirmed that elevated peripheral monocytes (CD11b+, F4/80+ cell numbers) in apolipoprotein E-deficient mice were decreased by feeding with 1.8% P diet. In addition, ex vivo study indicated that high dose of phosphate induced macrophage apoptosis. These observations suggest that excess phosphate intake decreased atherosclerosis formation, at least in part, by changing the profile of peripheral monocytes or inducing apoptosis of macrophages in apolipoprotein E-deficient mice. (出版サイトへのリンク) ● Publication site (DOI): 10.3164/jcbn.10-150 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21980226 ● Search Scopus @ Elsevier (PMID): 21980226 ● Search Scopus @ Elsevier (DOI): 10.3164/jcbn.10-150 (DOI: 10.3164/jcbn.10-150, PubMed: 21980226)
39.	Tohru Sakai, Yuko Hirota, Mariko Nakamoto, Emi Shuto, Toshio Hosaka, Seiya Makino and Shuji Ikegami : Suppression of oral tolerance by Lactococcus lactis in mice., Bioscience, Biotechnology, and Biochemistry, Vol.75, No.3, 599-601, 2011. (要約) Although oral ovabumin (OVA) administration suppressed the antibody (Ab) response in OVA-immunized mice, Lactococcus lactis increased OVA-specific IgG2a in these mice. L. lactis increased the casein-specific IgG level in NC/Nga mice fed on a casein diet. The percentage of CD4(+)CD25(+) cells was increased in DO11.10 mice orally given OVA, but this increase of CD4(+)CD25(+) cells were suppressed in L. lactis-fed DO11.10 mice. (キーワード) Administration, Oral / Animals / CD4-Positive T-Lymphocytes / Caseins / Cytokines / Enzyme-Linked Immunosorbent Assay / Female / Immune Tolerance / Immunity, Mucosal / Immunization / Immunoglobulins / Lactococcus lactis / Mice / Mice, Transgenic / Ovalbumin / Probiotics (出版サイトへのリンク) ● Publication site (DOI): 10.1271/bbb.100714 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21389605 ● CiNii @ 国立情報学研究所 (CRID): 1390001206480013312 ● Search Scopus @ Elsevier (PMID): 21389605 ● Search Scopus @ Elsevier (DOI): 10.1271/bbb.100714 (DOI: 10.1271/bbb.100714, PubMed: 21389605, CiNii: 1390001206480013312)
40.	Tohru Sakai, Sakina Furoku, Mariko Nakamoto, Emi Shuto, Toshio Hosaka, Yasuhiko Nishioka and Saburo Sone : Soy isoflavone equol perpetuates dextran sulfate sodium-induced acute colitis in mice., Bioscience, Biotechnology, and Biochemistry, Vol.75, No.3, 593-595, 2011. (要約) The effects of the soy isoflavones, genistein, daidzein and equol, on experimental colitis were examined. Equol severely perpetrated dextran sulfate sodium (DSS)-induced colitis as evaluated by the weight loss. Production of the anti-inflammatory cytokine, IL-10, from T cells was decreased in the equol-treated mice. The results show that the soy isoflavone, equol, played an important role in the inflammatory response in the gastrointestinal tract. (キーワード) Animals / Body Weight / Colitis / Dextran Sulfate / Disease Models, Animal / Equol / Female / Genistein / Interleukin-10 / Isoflavones / Mice / Mice, Inbred BALB C / Tリンパ球 (T lymphocytes) (出版サイトへのリンク) ● Publication site (DOI): 10.1271/bbb.100710 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21389602 ● Search Scopus @ Elsevier (PMID): 21389602 ● Search Scopus @ Elsevier (DOI): 10.1271/bbb.100710 (DOI: 10.1271/bbb.100710, PubMed: 21389602)
41.	Yohko Hirata, Toshio Hosaka, Takeo Iwata, Le Thi Kim Chung, Bayasgalan Jambaldorj, Kiyoshi Teshigawara, Nagakatsu Harada, Hiroshi Sakaue, Tohru Sakai, Katsuhiko Yoshimoto and Yutaka Nakaya : Vimentin binds IRAP and is involved in GLUT4 vesicle trafficking., Biochemical and Biophysical Research Communications, Vol.405, No.1, 96-101, 2011. (要約) Insulin-responsive aminopeptidase (IRAP) and GLUT4 are two major cargo proteins of GLUT4 storage vesicles (GSVs) that are translocated from a postendosomal storage compartment to the plasma membrane (PM) in response to insulin. The cytoplasmic region of IRAP is reportedly involved in retention of GSVs. In this study, vimentin was identified using the cytoplasmic domain of IRAP as bait. The validity of this interaction was confirmed by pull-down assays and immunoprecipitation in 3T3-L1 adipocytes. In addition, it was shown that GLUT4 translocation to the PM by insulin was decreased in vimentin-depleted adipocytes, presumably due to dispersing GSVs away from the cytoskeleton. These findings suggest that the IRAP binding protein, vimentin, plays an important role in retention of GSVs. (キーワード) 3T3-L1 Cells / Animals / Cystinyl Aminopeptidase / Cytoplasmic Vesicles / Gene Knockdown Techniques / Glucose Transporter Type 4 / Mice / Protein Transport / Vimentin (徳島大学機関リポジトリ) ● Metadata: 113298 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.bbrc.2010.12.134 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21216232 ● Search Scopus @ Elsevier (PMID): 21216232 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2010.12.134 (徳島大学機関リポジトリ: 113298, DOI: 10.1016/j.bbrc.2010.12.134, PubMed: 21216232)
42.	Toshio Hosaka, Yoshitaka Nii, Hiroyuki Tomotake, Takahiro Ito, Aya Tamanaha, Yukiko Yamasaka, Sayaka Sasaga, Kazuhiro Edazawa, Rie Tsutsumi, Emi Shuto, Naoki Okahisa, Shinya Iwata and Tohru Sakai : Extracts of common buckwheat bran prevent sucrose digestion., Journal of Nutritional Science and Vitaminology, Vol.57, No.6, 441-445, 2011. (要約) Buckwheat has been shown to have various health benefits such as reduction of hypertension and improvement of hypercholesterolemia; however, its effect on diabetes has not been fully elucidated. In this study, buckwheat bran extracts (BBE) inhibited sucrase activity in vitro more effectively than buckwheat. Balb/c mice pretreated with BBE showed dose-dependent reductions of blood glucose, greater than those observed with control mice, within 60 min following oral sucrose administration. Blood glucose levels in mice pretreated with buckwheat extracts were also significantly lower compared to those in control mice within 30 min following oral administration of sucrose. However, rutin, one of the abundant polyphenols of BBE, did not lower blood glucose level. Our data indicate that components of BBE other than rutin have inhibitory activity against sucrase in vivo. These results suggest that BBE could have beneficial effects on diabetes. (キーワード) Administration, Oral / Animals / Blood Glucose / 糖尿病 (diabetes mellitus) / Dietary Sucrose / 消化 (digestion) / Dose-Response Relationship, Drug / Fagopyrum / Male / Mice / Mice, Inbred BALB C / Phytotherapy / Plant Extracts / Rutin / Seeds / Sucrose (出版サイトへのリンク) ● Publication site (DOI): 10.3177/jnsv.57.441 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22472288 ● Search Scopus @ Elsevier (PMID): 22472288 ● Search Scopus @ Elsevier (DOI): 10.3177/jnsv.57.441 (DOI: 10.3177/jnsv.57.441, PubMed: 22472288)
43.	中本真理子, 酒井徹, 首藤恵泉, 保坂利男, 片岡菜奈子, 小杉知里, 秦明子, 篠田香織, 桑村由美, 南川貴子, 市原多香子, 田村綾子, 船木真理 : 食物摂取および生活習慣とアレルギー疾患との関連について, Journal of rehabilitation and health science, Vol.8, 15-21, 2010年. (キーワード) アレルギー (allergy) / 栄養調査 / 豆類 / ビタミンA (vitamin A) / 生活習慣病 (lifestyle-related disease) (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390573242531347328 (CiNii: 1390573242531347328)
44.	Kiyoshi Teshigawara, Toshio Hosaka, Miwa Yamaguchi, Eri Terada, Yuka Kisyuku, Keiko Fukunaga, Yohko Hirata, Bayasgalan Jambaldorj, Nagakatsu Harada, Tohru Sakai and Yutaka Nakaya : Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice., The Journal of Medical Investigation : JMI, Vol.57, No.3-4, 224-231, 2010. (要約) Hyperbaric air (HBA) is used to improve healing of wounds including diabetic ulcer. The aim of this study was to clarify the effects of HBA exposure on lipid and glucose metabolism in db/db mice. HBA did not influence the weight of db/db mice. Serum levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly decreased after 6 weeks of treatment with HBA. The mRNA expressions of CPT-1, PPAR and PGC-1 genes, which are related to lipid metabolism, were significantly up-regulated in the muscle and liver. Increases in TNF and MCP1 mRNA, which impaired lipid metabolism, were also attenuated by HBA treatment. These results suggest that exposure of HBA could have beneficial effects on lipid metabolism in patients with type 2 diabetes mellitus. (キーワード) Animals / Base Sequence / Blood Glucose / Carnitine O-Palmitoyltransferase / Chemokine CCL2 / DNA Primers / Diabetes Mellitus, Type 2 / Fatty Acids, Nonesterified / Humans / Hyperbaric Oxygenation / Hyperlipidemias / インスリン (insulin) / Lipid Metabolism / Male / Mice / Mice, Mutant Strains / PPAR alpha / RNA, Messenger / Trans-Activators / Triglycerides / Tumor Necrosis Factor-alpha (徳島大学機関リポジトリ) ● Metadata: 79137 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.57.224 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20847521 ● Search Scopus @ Elsevier (PMID): 20847521 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.57.224 (徳島大学機関リポジトリ: 79137, DOI: 10.2152/jmi.57.224, PubMed: 20847521)
45.	酒井徹, 中本真理子, 首藤恵泉, 保坂利男 : 栄養と免疫機能—非必須栄養素，低栄養状態，過栄養状態と免疫—, 四国医学雑誌, Vol.66, No.1, 19-26, 2010年. (要約) It is known that nutritional state crucially affects immune function. In recent years, the contributionof the diet to the optimal working of the immune system has become wildly appreciatedand the influence of different dietary components on specific aspects of immune function has beenextensively studied. Soy isoflavone genistein suppresses antigen-specific immune response inBALB/c mice and suppresses development of atopic-like dermatitis in NC/Nga mice. In other soyisoflavone equol enhances antigen-specific IgE production via IL-13-mediated pathway. Further,equol exacerbates colitis of dextran sulfate sodium-treated mice. Therefore, immune stimulatoryeffects are strikingly different among soy isoflavones. In this reviews, in addition of the isoflavone,we overview the effects of dietary nucleic acid and protein-deficiency on antigen-specific immuneresponses. Furthermore, we present hot topics researches in the field of obesity and T cellfunction. (キーワード) soy isoflavone / genistein / equol / 肥満症 (obesity) / T細胞 (T cell) (徳島大学機関リポジトリ) ● Metadata: 110309 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050583647830845568 (徳島大学機関リポジトリ: 110309, CiNii: 1050583647830845568)
46.	Tohru Sakai, Sakina Furoku, Mariko Nakamoto, Emi Shuto, Toshio Hosaka, Yasuhiko Nishioka and Saburo Sone : The Soy isoflavone equol enhances antigen-specific IgE production in ovalbumin-immunized BALB/c mice., Journal of Nutritional Science and Vitaminology, Vol.56, No.1, 72-76, 2010. (要約) Although an immunomodulatory role of the soy isoflavone genistein has been demonstrated, the effects of other soy isoflavones on induction of antigen (Ag)-specific immune responses are not known. In this study, we therefore investigated the effects of daidzein and equol on ovalbumin (OVA)-specific T cell and B cell responses in BALB/c mice. Mice that had been treated with 20 mg/kg equol showed a significantly higher level of OVA-specific IgE than control mice. Levels of interferon (IFN)-gamma and interleukin (IL)-4 production were not different between the control and equol groups. However, IL-13 production level in mice administered 20 mg/kg equol was significantly higher than that in control mice. Strong induction of OVA-specific IgE production by equol was also observed in ovariectomized BALB/c mice, suggesting that the immunomodulatory effect of equol is not affected by endogenous estrogen. (出版サイトへのリンク) ● Publication site (DOI): 10.3177/jnsv.56.72 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20354350 ● Search Scopus @ Elsevier (PMID): 20354350 ● Search Scopus @ Elsevier (DOI): 10.3177/jnsv.56.72 (DOI: 10.3177/jnsv.56.72, PubMed: 20354350)
47.	Le Thi Kim Chung, Toshio Hosaka, Nagakatsu Harada, Bayasgalan Jambaldorj, Keiko Fukunaga, Yuka Nishiwaki, Kiyoshi Teshigawara, Tohru Sakai, Yutaka Nakaya and Makoto Funaki : Myosin IIA participates in docking of Glut4 storage vesicles with the plasma membrane in 3T3-L1 adipocytes., Biochemical and Biophysical Research Communications, Vol.391, No.1, 995-999, 2009. (要約) In adipocytes and myocytes, insulin stimulation translocates glucose transporter 4 (Glut4) storage vesicles (GSVs) from their intracellular storage sites to the plasma membrane (PM) where they dock with the PM. Then, Glut4 is inserted into the PM and initiates glucose uptake into these cells. Previous studies using chemical inhibitors demonstrated that myosin II participates in fusion of GSVs and the PM and increase in the intrinsic activity of Glut4. In this study, the effect of myosin IIA on GSV trafficking was examined by knocking down myosin IIA expression. Myosin IIA knockdown decreased both glucose uptake and exposures of myc-tagged Glut4 to the cell surface in insulin-stimulated cells, but did not affect insulin signal transduction. Interestingly, myosin IIA knockdown failed to decrease insulin-dependent trafficking of Glut4 to the PM. Moreover, in myosin IIA knockdown cells, insulin-stimulated binding of GSV SNARE protein, vesicle-associated membrane protein 2 (VAMP2) to PM SNARE protein, syntaxin 4 was inhibited. These data suggest that myosin IIA plays a role in insulin-stimulated docking of GSVs to the PM in 3T3-L1 adipocytes through SNARE complex formation. (キーワード) 3T3-L1 Cells / Adipocytes / Animals / Cell Membrane / Cytoplasmic Vesicles / Gene Knockdown Techniques / Glucose / Glucose Transporter Type 4 / Insulin / Mice / Nonmuscle Myosin Type IIA / Protein Transport / SNARE Proteins / 情報伝達 (signal transduction) / Vesicle-Associated Membrane Protein 2 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.bbrc.2009.12.004 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19968963 ● Search Scopus @ Elsevier (PMID): 19968963 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2009.12.004 (DOI: 10.1016/j.bbrc.2009.12.004, PubMed: 19968963)
48.	Chung Thi Kim Le, Toshio Hosaka, Yoshida Masaki, Nagakatsu Harada, Hiroshi Sakaue, Tohru Sakai and Yutaka Nakaya : Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression., Biochemical and Biophysical Research Communications, Vol.390, No.3, 613-618, 2009. (要約) Exendin-4 (Ex-4) is a glucagon-like peptide-1 receptor (GLP-1R) agonist that has been used as a drug injected subcutaneously for treatment of type 2 diabetes. Many studies have revealed molecular targets of Ex-4, but its influence on adipokines has not been determined. Our study showed that Ex-4 induced secretion of adiponectin into the culture medium of 3T3-L1 adipocytes. This effect of Ex-4 is due to increased adiponectin mRNA level through the GLP-1R. Both forskolin and 3-isobutyl-1-methylxanthine (IBMX), which may finally elevate cyclic adenosine monophosphate (cAMP) concentration, prevented the induction of adiponectin expression by Ex-4. Moreover, H89, a protein kinase A inhibitor, blocked the effect of Ex-4 on adiponectin. On the other hand, Ex-4 decreased the mRNA levels of inflammatory adipokines. The results indicate that Ex-4 directly promotes adiponectin secretion via the protein kinase A pathway in 3T3-L1 adipocytes and may ameliorate insulin resistance. (キーワード) 1-Methyl-3-isobutylxanthine / 3T3-L1 Cells / Adipocytes / Adipokines / Adiponectin / Animals / Cyclic AMP-Dependent Protein Kinases / Forskolin / Glucagon-Like Peptide 1 / Inflammation / インスリン抵抗性 (insulin resistance) / Isoquinolines / Mice / Peptides / Phosphodiesterase Inhibitors / Protein Kinase Inhibitors / RNA, Messenger / Receptors, Glucagon / Sulfonamides / Venoms (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.bbrc.2009.10.015 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19850014 ● Search Scopus @ Elsevier (PMID): 19850014 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2009.10.015 (DOI: 10.1016/j.bbrc.2009.10.015, PubMed: 19850014)
49.	首藤恵泉, 竹谷豊, 酒井徹, 武田英二 : 高リン血症と心血管疾患, 四国医学雑誌, Vol.64, No.3,4, 114-116, 2008年. (要約) Hyperphosphatemia has been known as a risk factor for cardiovascular disease particularly inchronic kidney disease patients. Hyperphosphatemia can be involved in the calcification of vascularsmooth muscle cells, resulting in M¨onkeberg medial calcific sclerosis which is a type of arteriosclerosis.However, it has not been clarified whether hyperphosphatemia can deteriorate endothelialfunction and can be a risk factor of atherosclerosis. Our recent study demonstrated that hyperphosphatemiaincreased oxidative stress and decreased nitric oxide production in endothelial cells.In addition, hyperphosphatemia attenuated endothelium-dependent vasodilation reaction. Theseobservations suggest that hyperphosphatemia may cause endothelial dysfunction, and be an importantfactor for progression of atherosclerosis as well as vascular calcification. Positive associationbetween hyperphosphatemia and cardiovascular disease may be explained by the dual harmfuleffects of phosphorus on the vessels. (キーワード) 高リン血症 (hyperphosphatemia) / 心血管疾患 (cardiovascular disease) / endothelial cell / 酸化ストレス (oxidative stress) / vascular calcification (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050583647830869504 (CiNii: 1050583647830869504)
50.	Tohru Sakai and Mari Kogiso : Soy isoflavones and immunity., The Journal of Medical Investigation : JMI, Vol.55, No.3-4, 167-173, 2008. (要約) The amount of soy products consumed in Japan is much greater than that in Western countries. Recent evidence indicates that soy isoflavones play a beneficial role in obesity, cancer, osteoporosis, and cardiovascular disease. The soybean isoflavone genistein is present at high levels in soy products. Genistein is structurally similar to 17beta-estradiol (E2), and genistein has been suggested to be act as E2 or an antagonist against E2. Genistein suppresses antigen-specific immune response in vivo and lymphocyte proliferation response in vitro. However, genistein enhances the cytotoxic response mediated by NK and cytotoxic T cells and the cytokine production from T cells. Thus, the effect of genistein on immunity is immune cell-dependent. Due to its unique effect on immune function, genistein has been used for the treatment of the diseases in animal models and it has been found that genistein inhibits allergic inflammatory responses. In this review, we summarize current studies related to the effect of isoflavone genistein on the immune system. (キーワード) Animals / Antibody Formation / Cell Differentiation / Genistein / Humans / Immunity / Immunity, Cellular / Isoflavones / Neoplasms, Experimental / Phytoestrogens / Soybeans / T-Lymphocytes (徳島大学機関リポジトリ) ● Metadata: 110856 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.55.167 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18797128 ● Search Scopus @ Elsevier (PMID): 18797128 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.55.167 (徳島大学機関リポジトリ: 110856, DOI: 10.2152/jmi.55.167, PubMed: 18797128)
51.	Ono Kaori, Kazuaki Mawatari, Nagakatsu Harada, Akira Takahashi, Tohru Sakai, Ogoshi Shohei and Yutaka Nakaya : Nucleoside and nucleotide mixture OG-VI rescues cytotoxicity induced by chemotherapeutic agents in intestinal-like epithelial cell., The Journal of Medical Investigation : JMI, Vol.54, No.3,4, 235-242, 2007. (要約) Immune cells and cells undergoing rapid turn-over can obtain exogenous nucleotides via salvage synthesis. We evaluated whether or not the balanced nucleoside and nucleotide mixture OG-VI, could rescue intestinal epithelial-like Caco-2 cells from the cytotoxic effects of several chemotherapeutic agents, in the presence and absence of glutamine (Gln). Cells were exposed to 5-fluorouracil (5FU), methotrexate (MTX) or 6-mercaptopurine (6MP), after which proliferation and cell cycle analyses were performed. Following exposure to the chemotherapeutic agents, we observed that cells treated with OG-VI proliferated well, whereas those without the supplement did not proliferate. Furthermore, following treatment with either 5FU or MTX, we observed that the number of cells in the G0/G1 phase decreased and those in the S phases increased. However, these cell cycle alterations were prevented by the addition of OG-VI. With the exception of 6MP-treated cells, we did not observe any effects on proliferation or cell cycle regulation that could be ascribed to the presence of Gln. Thus, we have demonstrated that OG-VI rescues cells from the cytotoxic effects of several chemotherapeutic agents. (キーワード) 6-Mercaptopurine / Antineoplastic Agents / Caco-2 Cells / Cell Cycle / Cell Proliferation / Cell Survival / Epithelial Cells / Fluorouracil / Humans / Intestines / Methotrexate / Nucleosides / Nucleotides (徳島大学機関リポジトリ) ● Metadata: 111518 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.54.235 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17878671 ● Search Scopus @ Elsevier (PMID): 17878671 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.54.235 (徳島大学機関リポジトリ: 111518, DOI: 10.2152/jmi.54.235, PubMed: 17878671)
52.	Hiroyuki Kose, Tohru Sakai, Shin-ichi Tsukumo, Kaichun Wei, Takahisa Yamada, Koji Yasutomo and Kozo Matsumoto : Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase κ gene in LEC rats, Genomics, Vol.89, No.6, 673-677, 2007. (要約) The Long-Evans Cinnamon (LEC) rat has a spontaneous mutation, T helper immunodeficiency (thid), which causes a markedly reduced CD4(+) thymocyte population. Here we positionally clone the locus and identify a deletion in the gene encoding a receptor-like protein tyrosine phosphatase kappa (Ptprk) that led to complete loss of the transcript. The rat Ptprk gene exhibits 98% identity with the human and mouse counterparts and is expressed most abundantly in the CD4(-)CD8(-) double-negative stage. The downregulation of Ptprk in mouse immature thymocytes by RNA interference mimicked the thid phenotype. These results indicate that thid maps to the Ptprk locus and that functional Ptprk is crucial for lineage commitment or progression of CD4(+) T cells. We also found that Ptprk appears to function in parallel with or downstream of Th-POK/cKrox (also known as ZBTB7B), a master regulator of T cell lineage decision. (キーワード) T cell differentiation / Protein phosphatase / LEC rat / Thymus / Th-POK/cKrox (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ygeno.2007.03.001 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17434290 ● Search Scopus @ Elsevier (PMID): 17434290 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ygeno.2007.03.001 (DOI: 10.1016/j.ygeno.2007.03.001, PubMed: 17434290)

学術論文(紀要・その他):

1.	山田佳奈, 中本真理子, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 : 日本人勤労者の大豆製品摂取行動がメタボリック症候群発症に与える影響の検証, 大豆たん白質研究, Vol.26, No.44, 200-209, 2023年. (キーワード) soy products / metabolic syndrome / Japanese male workers / a longitudinal study (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520301231228971136 (CiNii: 1520301231228971136)
2.	Shuhai Chen, Masaaki Nishi, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto, Akiko Nakamoto, Tohru Sakai and Mitsuo Shimada : Polymethoxylated flavone sudachitin is a safe anticancer adjuvant that targets glycolysis in cancer-associated fibroblasts., Oncology Letters, Vol.24, No.1, 236, 2022. (要約) Sudachitin is a polymethoxylated flavone found in the peel of , a unique specialty citrus fruit in Tokushima Prefecture, Japan. Previous reports have demonstrated that sudachitin has anti-inflammatory and metabolic regulatory activities. However, to the best of our knowledge, no studies have explored whether sudachitin can act as an antitumor therapeutic agent by regulating metabolic functions in the tumor microenvironment. In the present study, cell proliferation and cytotoxicity assays were used to determine whether sudachitin inhibited the growth of liver cancer and pancreatic carcinoma, cholangiocarcinoma and colorectal cancer cells and to compare its toxicity against normal fibroblasts and induced cancer-associated fibroblasts (CAFs). Using lactate assays and reverse transcription-quantitative PCR, the effects of sudachitin on glycolysis in CAFs were investigated. The effects of CAFs on malignant tumor cells were evaluated using cell proliferation, wound healing and invasion assays. As result, sudachitin inhibited various types of tumor cells with different half-maximal inhibitory concentrations. Treatment with 50 µM sudachitin for 48 h suppressed tumor and CAFs proliferation but was not cytotoxic against normal fibroblasts. This dose also inhibited glycolysis in CAFs and, thus, diminished their pro-tumorigenic activities. Overall, the present study revealed that sudachitin has promise as a safe and widely available natural antitumor adjuvant. (徳島大学機関リポジトリ) ● Metadata: 118072 (出版サイトへのリンク) ● Publication site (DOI): 10.3892/ol.2022.13356 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35720469 ● Search Scopus @ Elsevier (PMID): 35720469 ● Search Scopus @ Elsevier (DOI): 10.3892/ol.2022.13356 (徳島大学機関リポジトリ: 118072, DOI: 10.3892/ol.2022.13356, PubMed: 35720469)

総説・解説:

1.	高岡司, 遠藤亜紀, 松田和徳, 上田千鶴, 猿倉薫子, 堤理恵, 阪上浩, 酒井徹, 山本茂, 武田憲昭 : 新しい亜鉛栄養状態の評価法の開発と亜鉛欠乏性味覚障害の解明 (武田憲昭教授退任記念総説集), 耳鼻咽喉科臨床補冊, No.158, 133-137, 2022年2月. (出版サイトへのリンク) ● Publication site (DOI): 10.5631/jibirinsuppl.158.133 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390573560394202496 ● Search Scopus @ Elsevier (DOI): 10.5631/jibirinsuppl.158.133 (DOI: 10.5631/jibirinsuppl.158.133, CiNii: 1390573560394202496)
2.	酒井徹, 中本晶子, 新居佳孝 : 徳島県特産のスダチ -果皮成分の機能性についてー, New Food Industry, Vol.60, No.9, 19-24, 2018年.
3.	Tohru Sakai, Emi Shuto and Rie Tsutsumi : Soy-Derived Compounds and Immune Response, Soy: Nutrition, consumption and Health, 147-159, 2013. (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-84892079014 (Elsevier: Scopus)

国際会議:

1.	Akiko Hata, Koji Yonemoto, Nanako Aki, Tohru Sakai, Emi Shuto, Takayuki Nakao, Masashi Miyoshi and Makoto Funaki : Identifying a Dietary Pattern Associated with Metabolic Syndrome by Reduced Rank Regression in Japanese Male Workers, Diabetes, Vol.65, No.Suppl.1, A604-A605, Jun. 2016.
2.	Takako Ichihara, Ayako Tamura, Yumi Kuwamura, Takako Minagawa, Nanako Kataoka, Chisato Kosugi, Hata Akiko, Emi Shuto, Tohru Sakai and Makoto Funaki : The Effects of physical Activity on Metabolic Symdrome, --- From the 2009 Cross-Sectional Syudy on Working Men in Tokushima ---, 9th International Diabetes Federation Westeran Pacific Region Congress,4th Scientific Meeting of the Asian Association Study of Diabetes, Vol.3, No.Supplement 1, 269, Kyoto, Nov. 2012.
3.	Emi Shuto, Yutaka Taketani, W Kusunise, T Tanaka, D Horie, Kikuko Amou, Hironori Yamamoto, Tohru Sakai and Eiji Takeda : Excessive dietary phosphorus acutely impairs endothelial function in healthy men, The American Society of Nephrology 42nd ANNUAL MEETING & Scientific Exposition, San Diego, Oct. 2009.

国内講演発表:

1.	國富遥葵, 中本真理子, Bui Thi Thuy, 虎見昂輝, 中本晶子, 酒井徹 : 若年女性の食品重量推定に食品に対する視覚的注意は影響するか:食行動試験データの2次分析, 第71回日本栄養改善学会学術総会, 2024年9月.
2.	虎見昂輝, 中本真理子, Bui Thi thuy, 古谷結, 國富遥葵, 中本晶子, 酒井徹 : 若年女性における空腹状態に起因する食選択行動の違いに食品注視時間が及ぼす影響, 第267回徳島医学会学術集会, 2024年8月.
3.	東條歩実, 中本真理子, Bui Thi Thuy, 虎見昂輝, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 桑村由美, 船木真理, 酒井徹 : 徳島県勤労者における植物性食事と脂質代謝マーカーとの縦断的検討, 第269回徳島医学会学術集会(令和6年度夏期), 2024年7月.
4.	國富遥葵, 中本真理子, Bui Thi Thuy, 虎見昂輝, 中本晶子, 酒井徹 : 栄養学専攻学生における食品重量推定精度に及ぼす影響の検討, 第9回日本栄養改善学会四国支部学術総会, 2024年6月.
5.	大橋悠加, 田中結子, 中本晶子, 中本真理子, 酒井徹 : ノビレチンによるT細胞活性化に伴うサイトカイン産生の制御機構, 第78回日本栄養・食糧学会大会, 276, 2024年5月.
6.	中本晶子, 石橋芽依, 中本真理子, 酒井徹 : 肥満誘導初期におけるノビレチンのマクロファージ分極制御作用, 第78回日本栄養・食糧学会大会, 274, 2024年5月.
7.	中本真理子, 西田裕紀子, 下方浩史, 酒井徹, 大塚礼 : 地域在住中高年者におけるイソフラボン摂取が10年間の海馬容積変化に及ぼす影響, 第78回日本栄養・食糧学会大会, 2024年5月.
8.	中本真理子, 長島蓮梨, 田中由貴子, 小野里実, 岩崎夕貴, 中本晶子, 張姝, 木下かほり, 古屋かな恵, 今井具子, 大塚礼, 酒井徹 : 地域在住高齢者における日本食品成分表に基づく主要な13食品群の摂取頻度を用いた食事バランススコアの検討, 第34回日本疫学会学術総会, 2024年1月. (キーワード) 地域在住高齢者 / 日本食品成分表 / 食事バランススコア
9.	中本晶子, 竹内萌優, 中本真理子, 酒井徹 : 給食施設における使用済み布巾の殺菌方法とその効果に関する検討, 第18回日本給食経営管理学会学術総会, 2023年11月.
10.	中本真理子, 中本晶子, 長谷川優花, 酒井徹 : 環境負荷に基づく食事の寄与食品群特性に関する検証, 第18回日本給食経営管理学会学術総会, 2023年11月. (キーワード) 環境負荷 / 食事
11.	虎見昂輝, 中本真理子, BUI THI THUY, 古谷結, 國富遥葵, 中本晶子, 酒井徹 : 若年者における空腹状態に起因する食選択行動に及ぼす食品注視時間の影響, 第70回日本栄養改善学会学術総会, 2023年9月.
12.	虎見昂輝, 中本真理子, THUY THI BUI, 中本晶子, 酒井徹 : 若年者の空腹状態による食選択行動に及ぼす潜在的要因の影響, 第8回日本栄養改善学会四国支部学術総会, 2023年5月.
13.	東條歩実, 中本真理子, 山田佳奈, 虎見昂輝, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 : 徳島県勤労者における食事摂取の多様性と炎症性マーカーとの横断的検討, 第8回日本栄養改善学会四国支部学術総会, 2023年5月.
14.	酒井徹, 山本真子, 中本晶子, 中本真理子 : ガン免疫チェックポイント療法に対する大豆イソフラボンの併用投与に関する研究, 第77回日本栄養・食糧学会大会, 295, 2023年5月.
15.	中本晶子, 服部蒔季, 中本真理子, 酒井徹 : 抗炎症機構に対するポリメトキシフラボノイドの作用, 第77回日本栄養・食糧学会大会, 295, 2023年5月.
16.	中本真理子, 東條歩実, 山田佳奈, 虎見昂輝, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 : 徳島県勤労者における食事摂取の多様性と炎症マーカーとの関連, 日本栄養・食糧学会誌, 74, 2023年5月.
17.	中本真理子, 清水佑衣, 中本晶子, 酒井徹 : 管理栄養士養成課程の学生立案献立における食事多様性の高い献立の特徴, 第17回日本給食経営管理学会学術総会, 2022年11月.
18.	酒井仁美, 酒井徹, 横井川久己男 : 身の回りの素材に対する小麦粉由来アラビノキシランの大腸菌付着抑制効果について, 第43回日本食品微生物学会, 2022年9月.
19.	山本真子, 中本晶子, 中本真理子, 八木田秀雄, 酒井徹 : 大豆イソフラボンのガン免疫チェックポイント療法への応用, 栄養学雑誌, Vol.80, No.5, 200, 2022年9月.
20.	中本晶子, 守田栞捺, 中本真理子, 酒井徹 : ノビレチンのサイトカイン産生調節作用を介した抗肥満効果, 栄養学雑誌, Vol.80, No.5, 195, 2022年9月.
21.	中本真理子, 中本晶子, 酒井徹 : 管理栄養士養成課程の学生に対する給食経営管理実習が管理栄養士のコンピテンシーへ及ぼす影響, 栄養学雑誌, Vol.80, No.5, 186, 2022年9月. (キーワード) 給食経営管理 / 給食 / 教育効果 / コンピテンシー / 管理栄養士
22.	山田佳奈, 中本真理子, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 : 徳島県勤労者のイソフラボン摂取量とメタボリックシンドローム構成因子との関連, 栄養学雑誌, Vol.80, No.5, 207, 2022年9月. (キーワード) 疫学 (epidemiology) / 公衆栄養 / 栄養疫学
23.	中本晶子, 平林悠和, 中本真理子, 酒井徹 : 17型ヘルパーT細胞に対するポリメトキシフラボノイドの作用-In vitroおよびin vivo系での検討-, 第20回四国免疫フォーラム, 2022年6月.
24.	山田佳奈, 中本真理子, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 : 徳島県勤労者の大豆イソフラボン摂取量とメタボリックシンドロームとの関連, 第264回徳島医学会学術集会, 32, 2022年2月.
25.	山田佳奈, 中本真理子, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 : 徳島県勤労者のイソフラボン摂取量とメタボリックシンドロームとの関連, 第6回日本糖尿病・生活習慣病ヒューマンデータ学会年次学術集会, 2021年12月.
26.	竹井理恵, 首藤恵泉, 中本晶子, 中本真理子, 酒井徹 : 大豆イソフラボンの癌間細胞に及ぼす影響, 第54回日本栄養・食糧学会中国四国支部大会・第7回日本栄養改善学会四国支部学術総会合同大会, 2021年10月.
27.	山田佳奈, 中本真理子, 上村美玖, 吉田舞, 上ノ薗理乃, 中本晶子, 酒井徹 : 新型コロナウイルス感染拡⼤による高齢者の食選択動機及び食生活への影響, 第54回日本栄養・食糧学会中四国支部大会・第7回日本栄養改善学会四国支部学術合同総会, 2021年10月.
28.	近藤あかり, 酒井徹, 寺尾純二, 向井理恵 : 血管内皮細胞における過酸化水素誘導性カベオリン-1リン酸化に対するケルセチンの抑制効果, 第54回日本栄養・食糧学会中国・四国支部大会第7回日本栄養改善学会四国支部学術総会合同大会(オンライン開催), 2021年10月.
29.	中本晶子, 中本真理子, 酒井徹 : スダチ果皮由来精油成分が免疫細胞に及ぼす作用と抗原特異的免疫応答への影響, 第68回日本栄養改善学会学術総会, Vol.79, No.5, 107, 2021年10月.
30.	中本真理子, 上村美玖, 吉田舞, 上ノ薗理乃, 山田佳奈, 中本晶子, 酒井徹 : 新型コロナウイルス感染拡大に伴う初回緊急事態宣言前後での高齢者の食選択動機及び食品摂取多様性の変化, 第68回日本栄養改善学会学術総会, Vol.79, No.5, 187, 2021年10月. (キーワード) 疫学 (epidemiology) / 食選択動機 / 食生活 / 高齢者
31.	平林悠和, 中本晶子, 安崎千咲里, 中本真理子, 首藤恵泉, 酒井徹 : T細胞分化に与えるポリメトキシフラボノイドの影響, 第75回日本栄養・食糧学会大会, 27, 2021年7月.
32.	平林悠和, 中本晶子, 安崎千咲里, 中本真理子, 首藤恵泉, 酒井徹 : 実験的自己免疫性脳脊髄炎(EAE)マウスに対するノビレチンの作用, 第53回日本栄養・食糧学会中国・四国支部大会, 13, 2020年10月.
33.	中本真理子, 小野聖実, 田中由貴子, 中本晶子, 首藤恵泉, 酒井徹 : 徳島県の子育て世代におけるワークライフバランスと食行動の関係, 第67回日本栄養改善学会学術総会, Vol.78, No.5, 2020年9月.
34.	中本晶子, 安崎千咲里, 平林悠和, 中本真理子, 首藤恵泉, 酒井徹 : マクロファージに対するポリメトキシフラボンの作用-敗血症モデルマウスを用いた検討-, 第67回日本栄養改善学会学術総会, Vol.78, No.5, 67, 2020年9月.
35.	中本晶子, 平林悠和, 安崎千咲里, 中本真理子, 首藤恵泉, 酒井徹 : ノビレチンによる実験的自己免疫性脳脊髄炎(EAE)におけるT細胞機能への影響, 第74回日本栄養・食糧学会大会, 205, 2020年4月.
36.	中本真理子, 大嶺茉利子, 尹優奈, 首藤恵泉, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 : 徳島県勤労者における食事摂取の多様性とアレルギー性疾患との関連, 四国公衆衛生学会雑誌, Vol.65, No.1, 32, 2020年2月. (キーワード) 疫学 (epidemiology) / 栄養 (nutrition) / アレルギー (allergy) / 日本 (Japan)
37.	中本晶子, 浦山佳菜, 安崎千咲里, 平林悠和, 中本真理子, 首藤恵泉, 酒井徹 : ポリメトキシフラボンの免疫細胞に対する機能評価 -マクロファージおよび肥満細胞での解析-, 第66回日本栄養改善学会学術総会, 2019年9月.
38.	浦山佳菜, 中本晶子, 安崎千咲里, 平林悠和, 中本真理子, 首藤恵泉, 酒井徹 : 免疫細胞に対するスダチ果皮フラボノイドの作用に関する研究-肥満細胞およびマクロファージにおける検討-, 第259回徳島医学会学術集会, 2019年8月.
39.	中本晶子, 首藤恵泉, 中本真理子, 酒井徹 : スダチ果皮に含まれるスダチチンのin vitroにおける機能評価 -マクロファージおよび肥満細胞での解析-, 第73回日本栄養・食糧学会大会, 2019年5月.
40.	首藤恵泉, 中本真理子, 中本晶子, 酒井徹 : エクオールの前駆脂肪細胞3T3-L1に対する作用, 第73回日本栄養・食糧学会大会, 2019年5月.
41.	浦山佳菜, 中本晶子, 安崎千咲里, 平林悠和, 中本真理子, 首藤恵泉, 酒井徹 : スダチ果皮フラボノイドの免疫細胞に対する作用に関する研究―肥満細胞およびマクロファージに対する作用―, 第6回日本栄養改善学会四国支部学術総会, 2019年4月.
42.	酒井仁美, 金丸芳, 酒井徹, 横井川久己男 : 調理器具素材への大腸菌の付着を抑制する小麦粉の成分の同定, 第39回日本食品微生物学会総会, 2018年9月.
43.	首藤恵泉, 中本真理子, 中本晶子, 酒井徹 : 食餌誘導性肥満マウスにおけるエクオールの作用, 第65回日本栄養改善学会学術総会, 2018年9月.
44.	中本晶子, 中本真理子, 首藤恵泉, 酒井徹 : スダチチンおよびデメトキシスダチチンによる免疫調節作用, 第65回日本栄養改善学会学術総会, 2018年9月.
45.	中本晶子, 中本真理子, 首藤恵泉, 酒井徹 : デメトキシスダチチンの免疫調節作用, 第5回日本栄養改善学会四国支部学術総会, 2018年6月.
46.	首藤恵泉, 國松真由香, 中本晶子, 中本真理子, 酒井徹 : 食餌誘導性肥満マウスにおけるエクオールの作用, 第72回日本栄養・食糧学会大会, 2018年5月.
47.	中本晶子, 中本真理子, 首藤恵泉, 酒井徹 : デメトキシスダチチンによる免疫調節作用, 第72回日本栄養・食糧学会大会, 2018年5月.
48.	酒井仁美, 酒井徹, 横井川久己男 : 調理器具素材への大腸菌の付着を抑制する小麦粉の成分について, 第38回日本食品微生物学会学術総会, 2017年10月.
49.	庄野仁志, 合田正和, 阿部晃治, 堤理恵, 酒井徹, 武田憲昭 : 頭頸部癌患者に対する化学療法が舌の味覚受容体遺伝子発現に与える影響, 第42回日本外科系連合学会学術集会, 2017年6月.
50.	酒井仁美, 酒井徹, 横井川久己男 : 調理器具素材への大腸菌の付着に及ぼす穀類の影響, 第37回日本食品微生物学会学術総会講演要旨集, 111, 2016年9月.
51.	楊暁琳, 中本真理子, 酒井徹, 首藤恵泉, 篠原尚子, 秦明子, 南川貴子, 市原多香子, 田村綾子, 桑村由美, 船木真理 : 徳島県男性勤労者の大豆発酵食品摂取は血清IL-6濃度を低下させる, 第63回日本栄養改善学会学術総会, 2016年9月.
52.	篠原尚子, 中本真理子, 酒井徹, 首藤恵泉, 楊暁琳, 秦明子, 南川貴子, 市原多香子, 田村綾子, 桑村由美, 船木真理 : 徳島県男性勤労者における珈琲，緑茶およびその他のお茶摂取と高尿酸血症との関連, 第63回日本栄養改善学会学術総会, 2016年9月.
53.	中本真理子, 楊暁琳, 篠原尚子, 酒井徹 : 徳島県勤労者の婚姻・子供の有無と欠食行動との関係, 第63回日本栄養改善学会学術総会, 2016年9月.
54.	Takako Ichihara, Akiko Hata, Toshimi Onishi, Mariko Nakamoto, Emi Shuto, Tohru Sakai, Ayako Tamura, Takako Minagawa, Yukari Hisaka and Makoto Funaki : Association between daily life activities and blood pressure increaseThree-year longitudinal study in Japanese male employees living in suburban cities, The 6th Joint Symposium between Kagawa University and Chiang Mai University, Aug. 2016.
55.	篠原尚子, 中本真理子, 酒井徹, 首藤恵泉, 楊暁琳, 秦明子, 安藝菜奈子, 四釜洋介, 板東由記子, 日坂ゆかり, 南川貴子, 田村綾子, 桑村由美, 市原多香子, 船木真理 : 徳島県男性勤労者におけるリスク保有状況別の嗜好飲料摂取と高尿酸血症の関連の検討, 第253回徳島医学会, 2016年7月.
56.	酒井仁美, 酒井徹, 横井川久己男 : 大腸菌の非生物素材への付着に対する穀類の影響, 日本農芸化学会中四国支部第45回講演会要旨集, 23, 2016年6月.
57.	三谷麻美, 中本真理子, 首藤恵泉, 酒井徹 : スダチチンの免疫調節作用-卵白アルブミン免疫マウスモデルでの検討-, 第70回日本栄養・食糧学会大会, 2016年5月.
58.	楊曉琳, 中本真理子, 酒井徹, 首藤恵泉, 篠原尚子, 秦明子, 安藝菜奈子, 小杉知里, 四釜洋介, 坂東由記子, 南川貴子, 市原多香子, 田村綾子, 桑村由美, 船木真理 : 徳島県勤労者を対象とした大豆摂取と炎症マーカーとの関連について, 第70回日本栄養食糧学会, 2016年5月.
59.	篠原尚子, 中本真理子, 酒井徹, 首藤恵泉, 楊暁琳, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 南川貴子, 市原多香子, 田村綾子, 桑村由美, 船木真理 : 徳島県勤労者における珈琲摂取と高尿酸血症との関連, 第70回日本栄養・食糧学会, 2016年5月.
60.	中本真理子, 酒井徹, 首藤恵泉, 安藝菜奈子, 秦明子, 桑村由美, 南川貴子, 市原多香子, 田村綾子, 船木真理 : 徳島県勤労者のイソフラボン摂取量とアレルギー疾患との関係, 第70回日本栄養・食糧学会, 2016年5月.
61.	國松真由香, 首藤恵泉, 三谷麻美, 中本真理子, 酒井徹 : 食餌誘導性肥満マウスにおけるエクオールの効果, 第70回日本栄養・食糧学会大会, 2016年5月.
62.	秦明子, 米本孝二, 安藝菜奈子, 酒井徹, 首藤恵泉, 中尾隆之, 三好雅士, 船木真理 : 徳島県におけるメタボリックシンドロームと関連する食事パターンの検討, 糖尿病, Vol.59, No.Suppl.1, 2016年5月.
63.	篠原尚子, 中本真理子, 酒井徹, 首藤恵泉, 楊暁琳, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 南川貴子, 市原多香子, 田村綾子, 桑村由美, 船木真理 : 第3回日本栄養改善学会(四国支部会), 第3回日本栄養改善学会(四国支部会), 2016年4月.
64.	楊曉琳, 中本真理子, 酒井徹, 鈴木公 : 中国雲南省昆明市における幼児体型の違いに基づく生活習慣・食習慣に関する実態調査, 第14回日本栄養改善学会近畿支部学術総会, 2015年12月. (キーワード) 幼児 / 肥満 / 食習慣
65.	酒井徹, 中本真理子, 首藤恵泉 : スダチ果皮による血糖上昇抑制作用の検討, 第62回日本栄養改善学会学術総会, 2015年9月.
66.	首藤恵泉, 三谷麻実, 中本真理子, 酒井徹 : 食餌誘導性肥満マウスにおけるエクオールの効果, 第62回日本栄養改善学会学術総会, 2015年9月.
67.	三谷麻実, 中本真理子, 首藤恵泉, 酒井徹 : In vivo におけるスダチチンの免疫調節作用 -ALZET pumpを用いた検討-, 第62回日本栄養改善学会学術総会, 2015年9月.
68.	中本真理子, 首藤恵泉, 三谷麻実, 酒井徹 : 豆乳摂取は若年者の心身ストレスを改善するか, 第62回日本栄養改善学会学術総会, 2015年9月.
69.	坂口真由香, 秦明子, 四釜洋介, 安藝菜奈子, 酒井徹, 首藤恵泉, 堤理恵, 中尾隆之, 三好雅士, 船木真理, 米本孝二 : Reduced Rank Regressionにより抽出された食事パターンの一般化可能性に関する検討∼メタボリックシンドローム発症追跡データを用いて∼, 糖尿病, Vol.58, No.Suppl.1, 2015年5月.
70.	合田正和, 北村嘉章, 高橋美香, 島谷美映, 堤理恵, 酒井徹, 武田憲昭 : 頭頸部癌化学療法が舌の味覚受容体遺伝子発現に及ぼす影響, 日本耳鼻咽喉科学会第39回四国四県地方部会連合学会, 2013年12月.
71.	中本晶子, 首藤恵泉, 酒井徹 : ビタミンA欠乏は経口免疫寛容を破綻させる, 第60回日本栄養改善学会学術総会, 2013年9月.
72.	喜岡美久, 首藤恵泉, 酒井徹 : 実験的自己免疫性脳脊髄炎マウスにおける大豆イソフラボンの効果, 第60回日本栄養改善学会学術総会, 2013年9月.
73.	酒井徹, 中本真理子, 中本晶子, 小林ゆき子, 土居幸雄, 木戸康博 : 管理栄養士・栄養士養成施設における栄養士・管理栄養士の就業状態等の調査研究, 第60回日本栄養改善学会学術総会, 2013年9月.
74.	合田正和, 堤理恵, 藤本知佐, 酒井徹, 武田憲昭 : 頭頸部癌化学療法が舌の味覚受容体遺伝子発現に及ぼす影響, 第26回日本口腔・咽頭科学会, 2013年9月.
75.	中本真理子, 酒井徹, 首藤恵泉, 安藝菜奈子, 小杉知里, 秦明子, 篠田香織, 桑村由美, 南川貴子, 市原多香子, 田村綾子, 船木真理 : 徳島県勤労者の血清脂肪酸濃度とインスリン抵抗性との関係に関する疫学研究, 第67回日本栄養・食糧学会大会, 2013年5月.
76.	秦明子, 坂東由記子, 四釜洋介, 安藝菜奈子, 小杉知里, 西村美穂, 阿部房代, 佐藤美子, 中奥真理子, 片山りか, 赤松康代, 酒井徹, 首藤恵泉, 堤理恵, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 中尾隆之, 三好雅士, 森口博基, 玉木悠, 松本俊夫, 船木真理 : 徳島県におけるadiponectinや高感度CRPとメタボリックシンドロームとの関連, 糖尿病, Vol.Vol.56, No.Suppl.1, S.208, 2013年5月.
77.	秦明子, 坂東由記子, 四釜洋介, 安藝菜奈子, 小杉知里, 西村美穂, 阿部房代, 佐藤美子, 中奥真理子, 片山りか, 赤松康代, 丹下幸子, 酒井徹, 首藤恵泉, 堤理恵, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 桑村由美, 中尾隆之, 三好雅士, 森口博基, 玉木悠, 松本俊夫, 船木真理 : 徳島県におけるadiponectinや高感度CRPとメタボリックシンドロームとの関連, 糖尿病, Vol.56, 2013年4月.
78.	堤理恵, 酒井徹, 合田正和, 北村嘉章, 阿部晃治, 武田憲昭, 藤本知佐, 河合美佐, 松本英希 : 頭頸部癌の放射線・化学療法中における味覚異常と味覚受容体について, 日本耳鼻咽喉科学会徳島県地方部会第70回学術講演会, 2013年3月.
79.	酒井徹 : 核酸は免疫調節機能により糖脂質代謝を制御するか?, 第8回日本食品免疫学会, 2012年10月.
80.	中本真理子, 首藤恵泉, 酒井徹 : 徳島県勤労者の食事パターンとアレルギー既往との関連, 第59回日本栄養改善学会, 2012年9月.
81.	中本真理子, 酒井徹, 首藤恵泉, 片岡菜奈子, 小杉知里, 秦明子, 篠田香織, 桑村由美, 南川貴子, 市原多香子, 田村綾子, 船木真理 : 徳島県勤労者の夕食終了から就寝時間までの間隔と生活習慣病有病状況との関係に関する疫学研究, 第66回日本栄養食糧学会大会, 2012年5月.
82.	吉田知美, 笹賀早也香, 三好まどか, 堤理恵, 首藤恵泉, 保坂利男, 新居佳孝, 津嘉山正夫, 岡久修己, 岩田深也, 酒井徹 : スダチ抽出物であるスダチチンの肥満および糖尿病予防作用, 第66回日本栄養食糧学会大会, 2012年5月.
83.	中本真理子, 酒井徹, 首藤恵泉, 片岡菜奈子, 小杉知里, 秦明子, 篠田香織, 桑村由美, 南川貴子, 市原多香子, 田村綾子, 船木真理 : 徳島県勤労者の夕食終了から就寝時間までの間隔と生活習慣病有病状況との関係に関する疫学研究, 第66回日本栄養・食糧学会大会, 2012年5月.
84.	坂東由記子, 四釜洋介, 西村美穂, 小杉知里, 安芸菜奈子, 秦明子, 赤松康代, 片山りか, 阿部房代, 酒井徹, 首藤恵泉, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 森口博基, 森川富昭, 玉木悠, 船木真理 : 徳島県におけるadiponectinの糖代謝異常予測因子としての検討, 糖尿病, Vol.Vol.55, No.Suppl.1, S.359, 2012年5月.
85.	小杉知里, 安藝菜奈子, 坂東由記子, 四釜洋介, 西村美穂, 片山りか, 丹下幸子, 阿部房代, 赤松康代, 秦明子, 木宿由佳, 篠田香織, 酒井徹, 首藤恵泉, 堤理恵, 保坂利男, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 森川富昭, 玉木悠, 船木真理 : 初期糖代謝異常を発見する指標としてのIL-18測定有用性の検討, 糖尿病, Vol.Vol.55, No.Suppl.1, S.290, 2012年5月.
86.	酒井徹, 首藤恵泉 : 食餌性核酸による糖および脂質代謝調節機構, 第58回日本栄養改善学会学術総会, 2011年9月.
87.	中本真理子, 首藤恵泉, 酒井徹 : 徳島県勤労者のイソフラボン摂取とアレルギー既往との関係に関する疫学研究, 第58回日本栄養改善学会学術総会, 2011年9月.
88.	首藤恵泉, 酒井徹 : 食餌誘導性肥満マウスにおける大豆イソフラボンの効果, 第58回日本栄養改善学会学術総会, 2011年9月.
89.	中本真理子, 酒井徹, 首藤恵泉, 保坂利男, 片岡菜奈子, 小杉知里, 秦明子, 篠田香織, 桑村由美, 南川貴子, 市原多香子, 田村綾子, 船木真理 : 徳島県勤労者の豆類摂取量とアレルギー既往との関係に関する疫学研究, 第65回日本栄養食糧学会大会, 2011年5月.
90.	酒井徹, 荒川真衣, 田崎志保, 首藤恵泉, 中本真理子, 保坂利男 : 核酸およびリボ核酸はインスリン抵抗性および脂質代謝を改善する, 第65回日本栄養食糧学会大会, 2011年5月.
91.	首藤恵泉, 荒川真衣, 田崎志保, 中本真理子, 堤理恵, 保坂利男, 酒井徹 : 食餌誘導性肥満マウスにおける大豆イソフラボンの炎症反応への影響, 第65回日本栄養食糧学会大会, 2011年5月.
92.	中本真理子, 酒井徹, 首藤恵泉, 保坂利男, 片岡菜奈子, 小杉知里, 秦明子, 篠田香織, 桑村由美, 南川貴子, 市原多香子, 田村綾子, 船木真理 : 徳島県勤労者の豆類摂取量とアレルギー既往との関係に関する疫学研究, 第65回日本栄養・食糧学会大会, 2011年5月.
93.	四釜洋介, 小杉知里, 片岡菜奈子, 坂東由記子, 秦明子, 篠田香織, 木村純子, 赤松康代, 片山りか, 庄野真代, 簾馨, 藤森洋子, 酒井徹, 首藤恵泉, 保坂利男, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 森口博基, 森川富昭, 玉木悠, 船木真理 : 非肥満者に見られる糖・脂質代謝異常，高血圧に脂肪組織の機能異常が関与する可能性の検討, 糖尿病, Vol.Vol.54, No.Suppl.1, 2011年5月.
94.	坂東由記子, 小杉知里, 片岡菜奈子, 四釜洋介, 秦明子, 赤松康代, 片山りか, 庄野真代, 簾馨, 篠田香織, 酒井徹, 首藤恵泉, 保坂利男, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 森口博基, 森川富昭, 玉木悠, 船木真理 : 徳島県におけるadiponectinおよびHOMA-IRと糖・脂質早期代謝異常との相関性についての考察, 糖尿病, Vol.Vol.54, No.Suppl.1, 2011年5月.
95.	坂東由記子, 小杉知里, 片岡菜奈子, 四釜洋介, 秦明子, 木村純子, 赤松康代, 片山りか, 庄野真代, 簾馨, 篠田香織, 酒井徹, 首藤恵泉, 保坂利男, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 森口博基, 森川富昭, 玉木悠, 船木真理 : 徳島県におけるadiponectinおよびHOMA-IRと糖・脂質早期代謝異常との相関性についての考察, 糖尿病, Vol.54, No.Suppl.1, S-248, 2011年.
96.	四釜洋介, 小杉知里, 片岡菜奈子, 坂東由記子, 秦明子, 篠田香織, 木村純子, 赤松康代, 片山りか, 庄野真代, 簾馨, 藤森洋子, 酒井徹, 首藤恵泉, 保坂利男, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 森口博基, 森川富昭, 玉木悠, 船木真理 : 非肥満者に見られる糖・脂質代謝異常，高血圧に脂肪組織の機能異常が関与する可能性の検討, 糖尿病, Vol.54, No.Suppl.1, S-355, 2011年.
97.	酒井徹, 中本真理子, 首藤恵泉 : 徳島県勤労者における練り製品摂取量と食品群別摂取量・生活習慣との関連について, 第57回日本栄養改善学会集会, 2010年9月.
98.	酒井徹, 中本真理子, 首藤恵泉 : 徳島県勤労者における練り製品摂取量と食品群別摂取量・生活習慣との関連について, 第57回日本栄養改善学会集会, 2010年9月.
99.	酒井徹, 中本真理子, 首藤恵泉, 保坂利男 : 核酸による2型ヘルパーT細胞分化制御のメカニズム, 核酸・核タンパク質機能性研究会, 2010年8月.
100.	酒井徹 : 大豆イソフラボンの免疫制御機構, 第6回食品免疫学会学術総会, 2010年6月.
101.	首藤恵泉, 竹谷豊, 大屋美穂, 小河真理子, 中西美咲, 阿望幾久子, 保坂利男, 山本浩範, 酒井徹, 武田英二 : ヒトにおける食事性高リン負荷による血管内皮機能への影響, 第64回日本栄養・食糧学会大会,徳島,平成22年5月21日~23日, 2010年5月.
102.	酒井徹, 府録咲奈, 中本真理子, 首藤恵泉, 保坂利男 : 大豆イソフラボンの大腸炎病態制御に関する研究, 第64回日本栄養食糧学会大会, 2010年5月.
103.	小杉知里, 片岡菜奈子, 篠田香織, 秦明子, 木村純子, 赤松康代, 片山りか, 藤森洋子, 酒井徹, 首藤恵泉, 保坂利男, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 中屋豊, Bayasgalan Jambaldorj, 森口博基, 森川富昭, 玉木悠, 福原俊一, 竹上美沙, 船木真理 : 初期糖代謝異常状態の慢性炎症管理におけるIL-18の有用性についての検討, 糖尿病, Vol.Vol.53, No.Suppl.1, S.299, 2010年5月.
104.	片岡菜奈子, 篠田香織, 小杉知里, 秦明子, 木村純子, 赤松康代, 片山りか, 藤森洋子, 酒井徹, 首藤恵泉, 保坂利男, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 中屋豊, Bayasgalan Jambaldorj, 森口博基, 森川富昭, 玉木悠, 福原俊一, 竹上美沙, 船木真理 : 徳島県における糖代謝異常発生過程でのインスリン抵抗性の関与, 糖尿病, Vol.Vol.53, No.Suppl.1, S.298, 2010年5月.
105.	秦明子, 小杉知里, 片岡菜奈子, 篠田香織, 木村純子, 赤松康代, 片山りか, 藤森洋子, 酒井徹, 首藤恵泉, 保坂利男, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 中屋豊, Bayasgalan Jambaldorj, 森口博基, 森川富昭, 玉木悠, 福原俊一, 竹上美沙, 船木真理 : インスリン抵抗性を伴う高リスク糖尿病発症者となる危険因子の探索, 糖尿病, Vol.Vol.53, No.Suppl 1, S207, 2010年5月.
106.	秦明子, 小杉知里, 片岡菜奈子, 篠田香織, 木村純子, 赤松康代, 片山りか, 藤森洋子, 酒井徹, 首藤恵泉, 保坂利男, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 中屋豊, Jambaldorj Baysaglan, 森口博基, 森川富昭, 玉木悠, 福原俊一, 船木真理 : インスリン抵抗性を伴う高リスク糖尿病発症者となる危険因子の探索, 糖尿病, Vol.53, No.Suppl.1, S-207, 2010年5月.
107.	片岡菜奈子, 篠田香織, 小杉知里, 秦明子, 木村純子, 赤松康代, 片山りか, 藤森洋子, 酒井徹, 首藤恵泉, 保坂利男, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 中屋豊, Jambaldorj Baysaglan, 森口博基, 森川富昭, 玉木悠, 福原俊一, 竹上美沙, 船木真理 : 徳島県における糖代謝異常発生過程でのインスリン抵抗性の関与, 糖尿病, Vol.53, No.Suppl.1, S-298, 2010年5月.
108.	小杉知里, 片岡菜奈子, 篠田香織, 秦明子, 木村純子, 赤松康代, 片山りか, 藤森洋子, 酒井徹, 首藤恵泉, 保坂利男, 田村綾子, 市原多香子, 南川貴子, 桑村由美, 中屋豊, Jambaldorj Baysaglan, 森口博基, 森川富昭, 玉木悠, 福原俊一, 竹上美沙, 船木真理 : 初期糖代謝異常状態の慢性炎症管理におけるIL-18の有用性についての検討, 糖尿病, Vol.53, No.Suppl.1, S-299, 2010年5月.
109.	首藤恵泉, 竹谷豊, 阿望幾久子, 保坂利男, 山本浩範, 酒井徹, 武田英二 : 食事性のリン過剰摂取は血管内皮機能を障害する, 第13回日本病態栄養学会年次学術集会, 2010年1月.
110.	首藤恵泉, 竹谷豊, 山本浩範, 酒井徹, 武田英二 : ヒトにおける食事性高リン負荷による血管内皮機能障害, 第63回日本栄養・食糧学会大会, 2009年5月.
111.	首藤恵泉, 竹谷豊, 山本浩範, 奥村仙示, 酒井徹, 武田英二 : 食後高リン血症は血管内皮機能障害を惹起し心血管疾患のリスクとなる, 第55回栄養改善学会学術総会, 2008年9月.

報告書:

1.	Mariko Nakamoto, Sarasa Mori, Emi Shuto, Akiko Nakamoto, Akiko Hata, Nanako Aki, Yosuke Shikama, Yukiko Bandou, Takako Ichihara, Takako Minagawa, Ayako Tamura, Yumi Kuwamura, Makoto Funaki and Tohru Sakai : Soy and Isoflavone Intake and Lifestyle and Health Awareness in Japanese Workers, SOY PROTEIN RESEARCH, Japan, Vol.24, 154-161, Jul. 2022.
2.	中本真理子, 森更紗, 大河内章充, 首藤恵泉, 中本晶子, 秦明子, 安藝菜奈子, 四釜洋介, 坂東由記子, 市原多香子, 南川貴子, 田村綾子, 桑村由美, 船木真理, 酒井徹 : 大豆製品・大豆含有成分摂取と推定腎機能との関係を探る臨床疫学研究, 大豆たん白質研究, Vol.23, 182-191, 2020年.
3.	酒井徹, 中本真理子 : 味噌・大豆製品摂取とインスリン抵抗性およびメタボリックシンドローム構成因子との関係に関する縦断研究, 中央味噌研究所研究報告, No.38, 68-76, 2017年3月.
4.	中本真理子, 酒井徹 : 地域在住高齢者のエクオール産生能に基づく大豆製品摂取と認知機能との関係を探る調査研究, 大豆たん白質研究, Vol.20, 165-172, 2017年. (キーワード) 認知症 (dementia) / 疫学 (epidemiology) / 栄養 (nutrition)
5.	中本真理子, 酒井徹 : 豆乳摂取は大学生のストレス状態を改善する, 大豆たん白質研究, Vol.36, No.18, 182-187, 2016年6月. (キーワード) 豆乳 / ストレス (stress) / 大学生 / cross-over trial

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

ポリメトキシフラボノイドの免疫制御に関する新学術研究を構築する基盤研究 (研究課題/領域番号: 22K11701 )
フラボノイドメトキシ基の構造機能学解析-代謝ダイナミックスと癌免疫療法への新展開 (研究課題/領域番号: 19K11768 )
大豆イソフラボンの癌幹細胞抑制作用の解明とがん治療に向けた新しいアプローチ (研究課題/領域番号: 17K00857 )
大豆製品によるメタボリックシンドローム制御機構ー基礎および疫学研究による検証ー (研究課題/領域番号: 25350126 )
大豆イソフラボンのアレルギー予防に関する基盤的研究および臨床疫学研究への展開 (研究課題/領域番号: 22500760 )
抗アレルギー作用を有する大豆イソフラボンの免疫疾患病態制御に関する基盤的研究 (研究課題/領域番号: 19500685 )
ベトナム乳幼児への亜鉛投与がワクチンの抗体獲得および感染症罹患に及ぼす影響 (研究課題/領域番号: 18406027 )
調節性T細胞を標的とした細胞内寄生性原虫のエスケープ機構の解明 (研究課題/領域番号: 15790214 )
個別栄養指導を効果的に行うための双方向型集団栄養教育法の確立と評価に関する研究 (研究課題/領域番号: 15590548 )
食品抗原に対する免疫寛容誘導の環境ホルモンによる修飾機構に関する研究 (研究課題/領域番号: 14657017 )
メラノーマに対するフュージョン及びコンビネーションDNAワクチン療法の新規開発 (研究課題/領域番号: 13218090 )
メラノーマに対するフュージョン及びコンビネーションDNAワクチン療法の新規開発 (研究課題/領域番号: 12217101 )
マラリアの病原性に関与する熱ショック蛋白質90の遺伝子解析 (研究課題/領域番号: 11877046 )
遺伝子銃を用いたマラリアMSP-1遺伝子によるDNAワクチン及びワクチン抗原同定 (研究課題/領域番号: 11770131 )
マラリア原虫の病原性(エスケープ)に係わる分子シャペロンHSP90の機能 (研究課題/領域番号: 11153219 )
マラリア原虫の病原性に係わる熱ショック蛋白質の機能 (研究課題/領域番号: 11147219 )
熱ショック蛋白質を戦略基盤においた原虫エスケープ機構の解明 (研究課題/領域番号: 10470067 )
分子シャペロンHSP90のマラリア原虫の病原性における機能の解析 (研究課題/領域番号: 10172222 )
Th分化を調節する抗原提示細胞内酵素・カテプシンB (研究課題/領域番号: 10167214 )
マラリア原虫の病原性に係わる熱ショック蛋白質の機能 (研究課題/領域番号: 10166216 )
遺伝子鏡を用いたマラリア感染に対するDNAワクチネーションの基礎的研究 (研究課題/領域番号: 09877055 )
分子シャペロンHSP65による原虫感染宿主細胞のアポトーシスの抑制と感染防御 (研究課題/領域番号: 09276221 )
マラリア原虫感染における原虫および宿主の熱ショック蛋白質の機能 (研究課題/領域番号: 09270218 )
システインプロテアーゼによるリーシュマニア感染T細胞機能的分化の新しい制御理論 (研究課題/領域番号: 08877052 )
マラリア原虫の病原性に係わる分子としての熱ショック蛋白質の機能 (研究課題/領域番号: 08281210 )
原虫のエスケープ・感染防御に係わる熱ショック蛋白質の機能とT細胞による発現機序 (研究課題/領域番号: 06454200 )
研究者番号（40274196）による検索

教授 : 酒井徹

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

教授 : 酒井 徹

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専門分野

研究テーマ

著書・論文

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

教授 : 酒井徹