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徳島大学生物資源産業学部生物資源産業学科食料科学講座
徳島大学先端技術科学教育部物質生命システム工学専攻生命テクノサイエンスコース生物反応工学講座
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研究活動

個人のホームページ

専門分野

生物有機化学 (Bioorganic Chemistry), 食品機能学 (Functional Food Science), 天然物化学 (Natural Products Chemistry)

研究テーマ

アスコルビン酸誘導体の開発とその応用研究, 健康増進や治療促進に寄与する食品の機能性成分に関する研究, 生物活性物質の構造活性相関研究

著書・論文

著書:

1. 田井 章博 :
ビタミン・バイオファクター総合事典(日本ビタミン学会 編)2.9 ビタミンC, 2.9.6 薬理学(誘導体と生理・薬理作用),
朝倉書店, 東京, 2021年7月.
2. 田井 章博, 山本 格 :
ビタミン総合事典 (日本ビタミン学会 編) 9. ビタミンC, 9.5 薬理作用,
朝倉書店, 東京, 2010年11月.
3. Jun Takebayashi, Jianbin Chen and Akihiro Tai :
Advanced Protocols in Oxidative Stress II (Donald Armstrong ed.) 20. A method for evaluation of antioxidant activity based on inhibition of free radical-induced erythrocyte hemolysis,
The Humana Press, Totowa, New Jersey, Dec. 2009.
(DOI: 10.1007/978-1-60761-411-1_20,   PubMed: 20072925)

学術論文(審査論文):

1. Koga Takeru, Ito Hideyuki, Iwaoka Yuji, Noshita Toshiro and Akihiro Tai :
Neurite outgrowth-promoting compounds from the petals of Paeonia lactiflora in PC12 cells,
Molecules, Vol.27, No.22, 7670, 2022.
(DOI: 10.3390/molecules27227670)
2. Koga Takeru, Shiki Nanako, Ito Hideyuki, Iwaoka Yuji and Akihiro Tai :
Degranulation inhibitors from petals of Coreopsis grandiflora,
Records of Natural Products, Vol.16, No.6, 645-650, 2022.
(DOI: 10.25135/rnp.319.2202.2351,   Elsevier: Scopus)
3. Yuji Iwaoka, Misaki Fukushima, Hideyuki Ito, Takeru Koga, Naoaki Kawahara and Akihiro Tai :
Synthesis of ascorbic acid derivatives with different types of C8 straight acyl chain and their neurite outgrowth-enhancing activities,
Journal of Nutritional Science and Vitaminology, Vol.68, No.3, 236-239, 2022.
(DOI: 10.3177/jnsv.68.236,   PubMed: 35768255)
4. Takeru Koga and Akihiro Tai :
Neurite outgrowth-promoting compounds from cockscomb hydrolysate,
Nutrients, Vol.14, No.7, 1422, 2022.
(徳島大学機関リポジトリ: 117247,   DOI: 10.3390/nu14071422,   PubMed: 35406035)
5. Iwaoka Yuji, Fukushima Misaki, Ito Hideyuki and Akihiro Tai :
Highly efficient and low-cost process for synthesis of 2-O-α-D-glucopyranosyl-6-O-(2-propylpentanoyl)-L-ascorbic acid,
Process Biochemistry, Vol.111, No.Part1, 71-77, 2021.
(DOI: 10.1016/j.procbio.2021.09.004,   Elsevier: Scopus)
6. Kaori Miura, Hiroaki Matsuno, Yuji Iwaoka, Hideyuki Ito and Akihiro Tai :
Antiallergic activity of 6-deoxy-2-O-methyl-6-(N-hexadecanoyl)amino-L-ascorbic acid,
Molecules, Vol.26, No.15, 4684, 2021.
(徳島大学機関リポジトリ: 116602,   DOI: 10.3390/molecules26154684,   PubMed: 34361837)
7. Doi Natsumi, Togari Hiro, Minagi Kenji, Iwaoka Yuji, Akihiro Tai, Nakaoji Koichi, Hamada Kazuhiko and Tatsuka Masaaki :
2-O-Octadecylascorbic acid represses RhoGDIβ expression and ameliorates DNA damage-induced abnormal spindle orientations,
Journal of Cellular Biochemistry, Vol.122, No.7, 739-751, 2021.
(DOI: 10.1002/jcb.29908,   PubMed: 33586155,   Elsevier: Scopus)
8. Toshiro Noshita, Kentaro Fujita, Takeru Koga, Hidekazu Ouchi and Akihiro Tai :
Synthesis and biological activity of (±)-7,3',4'-trihydroxyhomoisoflavan and its analogs,
Bioorganic & Medicinal Chemistry Letters, Vol.31, 127674, 2021.
(DOI: 10.1016/j.bmcl.2020.127674,   PubMed: 33161123)
9. Noshita Toshiro, Kakizoe Yusuke, Tanabe Satoshi, Ouchi Hidekazu and Akihiro Tai :
Isolation and identification of a potent PTP1B inhibitor, ursolic acid, from Carolina Jasmine (Gelsemium sempervirens (L.) J.St.-Hil.),
Letters in Organic Chemistry, Vol.17, No.12, 939-943, 2020.
(DOI: 10.2174/1570178617666200409101248)
10. Takeru Koga, Takaiku Sakamoto, Eiji Sakuradani and Akihiro Tai :
Neurite Outgrowth-Promoting Activity of Compounds in PC12 Cells from Sunflower Seeds,
Molecules, Vol.25, No.20, 4748, 2020.
(徳島大学機関リポジトリ: 116242,   DOI: 10.3390/molecules25204748)
11. Yuji Iwaoka, Nao Ikeda, Asako Ohno, Hideyuki Ito and Akihiro Tai :
Antioxidant activity and Neurite outgrowth-enhancing activity of scorbamic acid and a red pigment derived from ascorbic acid.,
Natural Product Research, Vol.34, No.6, 838-842, 2020.
(DOI: 10.1080/14786419.2018.1499641,   PubMed: 30422002)
12. Yuta Morishita, Kaoru Ikeda, Hiroaki Matsuno, Hideyuki Ito and Akihiro Tai :
Identification of degranulation inhibitors from rooibos (Aspalathus linearis) tea in rat basophilic leukaemia cells,
Natural Product Research, Vol.33, No.10, 1472-1476, 2019.
(DOI: 10.1080/14786419.2017.1416377,   PubMed: 29262735)
13. Toshiro Noshita, Ryoya Onishi, Kaori Miura, Yoshitomo Hamada, Yuki Nishino, Hidekazu Ouchi and Akihiro Tai :
Synthetic and in vitro studies to indicate that the structure of the PTP1B inhibitor isolated from Acanthopanax senticosus requires reinvestigation,
Phytochemistry Letters, Vol.27, 214-218, 2018.
(DOI: 10.1016/j.phytol.2018.07.028)
14. Toshiro Noshita, Kaori Miura, Kaoru Ikeda, Hidekazu Ouchi, Takuya Matsumoto and Akihiro Tai :
Structure-activity relationships of flavanones, flavanone glycosides, and flavones in anti-degranulation activity in rat basophilic leukemia RBL-2H3 cells,
Journal of Natural Medicines, Vol.72, No.2, 551-556, 2018.
(DOI: 10.1007/s11418-017-1169-3,   PubMed: 29349649)
15. Yuji Iwaoka, Kohei Nishino, Takahiro Ishikawa, Hideyuki Ito, Yoshihiro Sawa and Akihiro Tai :
Affinity resins as new tools for identifying target proteins of ascorbic acid,
Analyst, Vol.143, No.4, 874-882, 2018.
(DOI: 10.1039/c7an01592e,   PubMed: 29327754)
16. Kaori Miura, Misaki Haraguchi, Hideyuki Ito and Akihiro Tai :
Potential Antitumor Activity of 2-O-α-d-Glucopyranosyl-6-O-(2-Pentylheptanoyl)-l-Ascorbic Acid,
International Journal of Molecular Sciences, Vol.19, No.2, E535, 2018.
(徳島大学機関リポジトリ: 114573,   DOI: 10.3390/ijms19020535,   PubMed: 29439410)
17. Kaori Miura, Yuta Morishita, Hiroaki Matsuno, Yusuke Aota, Hideyuki Ito and Akihiro Tai :
Anti-Allergic Activity of Monoacylated Ascorbic Acid 2-Glucosides,
Molecules, Vol.22, No.12, E2202, 2017.
(DOI: 10.3390/molecules22122202,   PubMed: 29231858)
18. Akihiro Tai, Atsuko Iomori and Hideyuki Ito :
Structural evidence for the DPPH radical-scavenging mechanism of 2-O-α-d-glucopyranosyl-l-ascorbic acid,
Bioorganic & Medicinal Chemistry, Vol.25, No.20, 5303-5310, 2017.
(DOI: 10.1016/j.bmc.2017.07.044,   PubMed: 28789909)
19. Toshiro Noshita, Akihiro Tai, Takuya Matsumoto, Kaori Miura, Kaoru Ikeda and Yoshitomo Hamada :
Structure-activity relationship of flavanone. Anti-degranulation activity of 7-O-substituted hesperetin,
Natural Product Research, Vol.31, No.18, 2137-2142, 2017.
(DOI: 10.1080/14786419.2017.1280486,   PubMed: 28105859)
20. Kaori Miura and Akihiro Tai :
2-O-α-D-Glucopyranosyl-l-ascorbic acid as an antitumor agent for infusion therapy,
Biochemistry and Biophysics Reports, Vol.10, 232-236, 2017.
(DOI: 10.1016/j.bbrep.2017.04.014,   PubMed: 28955751)
21. Akihiro Tai, Asako Ohno and Hideyuki Ito :
Isolation and Characterization of the 2,2'-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) Radical Cation-Scavenging Reaction Products of Arbutin,
Journal of Agricultural and Food Chemistry, Vol.64, No.38, 7285-7290, 2016.
(DOI: 10.1021/acs.jafc.6b02847,   PubMed: 27607833)
22. Nao Ishimata, Hideyuki Ito and Akihiro Tai :
Structure-activity relationships of vanillic acid ester analogs in inhibitory effect of antigen-mediated degranulation in rat basophilic leukemia RBL-2H3 cells,
Bioorganic & Medicinal Chemistry Letters, Vol.26, No.15, 3533-3536, 2016.
(DOI: 10.1016/j.bmcl.2016.06.028,   PubMed: 27324979)
23. Ai Morita, Akihiro Tai, Hideyuki Ito, Natsuki Ganeko and Shin-Ichi Aizawa :
Proanthocyanidins in an astringent persimmon inhibit Salmonella pathogenicity island 1 (SPI1) secretion,
Journal of the Science of Food and Agriculture, Vol.96, No.5, 1798-1802, 2016.
(DOI: 10.1002/jsfa.7289,   PubMed: 26041125)
24. Toshiro Noshita, Akihiro Tai, Hikaru Nishikawa, Kaoru Ikeda, Hidekazu Ouchi, Yoshitomo Hamada, Akiko Saito and Teiko Yamada :
Synthesis and degranulation-inhibiting activities of the proposed apteniols B, C, and G,
Bioscience, Biotechnology, and Biochemistry, Vol.79, No.11, 1743-1749, 2015.
(DOI: 10.1080/09168451.2015.1061421,   PubMed: 26176735)
25. Kaori Miura, Futoshi Yazama and Akihiro Tai :
Oxidative stress-mediated antitumor activity of erythorbic acid in high doses,
Biochemistry and Biophysics Reports, Vol.3, 117-122, 2015.
(DOI: 10.1016/j.bbrep.2015.07.018,   PubMed: 29124174)
26. Tairo Ogura, Takeshi Bamba, Akihiro Tai and Eiichiro Fukusaki :
Method for the Compound Annotation of Conjugates in Nontargeted Metabolomics Using Accurate Mass Spectrometry, Multistage Product Ion Spectra and Compound Database Searching,
Mass Spectrometry, Vol.4, No.1, A0036, 2015.
(DOI: 10.5702/massspectrometry.A0036,   PubMed: 26819907)
27. Kohei Kawata, Ken-ichi Morishita, Mariko Nakayama, Shoya Yamada, Toshiki Kobayashi, Yuki Furusawa, Sakae Arimoto-Kobayashi, Toshitaka Oohashi, Makoto Makishima, Hirotaka Naitou, Erika Ishitsubo, Hiroaki Tokiwa, Akihiro Tai and Hiroki Kakuta :
RXR partial agonist produced by side chain repositioning of alkoxy RXR full agonist retains antitype 2 diabetes activity without the adverse effects,
Journal of Medicinal Chemistry, Vol.58, No.2, 912-926, 2015.
(DOI: 10.1021/jm501863r,   PubMed: 25486327)
28. Toshiki Kobayashi, Yuki Furusawa, Shoya Yamada, Masaru Akehi, Fumiaki Takenaka, Takanori Sasaki, Akiya Akahoshi, Takahisa Hanada, Eiji Matsuura, Hiroyuki Hirano, Akihiro Tai and Hiroki Kakuta :
Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid X receptor agonists,
ACS Medicinal Chemistry Letters, Vol.6, No.3, 334-338, 2015.
(DOI: 10.1021/ml500511m,   PubMed: 25815156)
29. Akihiro Tai, Mei Aburada and Hideyuki Ito :
A simple efficient synthesis and biological evaluation of 3-O-ethylascorbic acid,
Bioscience, Biotechnology, and Biochemistry, Vol.78, No.12, 1984-1987, 2014.
(DOI: 10.1080/09168451.2014.946396,   PubMed: 25127395)
30. Ryuji Asano, Amon Nagami, Yuki Fukumoto, Kaori Miura, Futoshi Yazama, Hideyuki Ito, Isao Sakata and Akihiro Tai :
Synthesis and biological evaluation of new BSH-conjugated chlorin derivatives as agents for both photodynamic therapy and boron neutron capture therapy of cancer,
Journal of Photochemistry and Photobiology B: Biology, Vol.140, 140-149, 2014.
(DOI: 10.1016/j.jphotobiol.2014.07.008,   PubMed: 25123528)
31. Akihiro Tai, Kanako Fukunaga, Asako Ohno and Hideyuki Ito :
Antioxidative properties of ascorbigen in using multiple antioxidant assays,
Bioscience, Biotechnology, and Biochemistry, Vol.78, No.10, 1723-1730, 2014.
(DOI: 10.1080/09168451.2014.932668,   PubMed: 25273138)
32. Hikaru Nishikawa, Toshiro Noshita, Akihiro Tai, Hidekazu Ouchi, Taisuke Okamoto, Akiko Saito, Teiko Yamada, Atsuko Iomori and Nao Ishimata :
Syntheses and biological activities of the proposed structure of apteniol A and its derivatives,
Bioscience, Biotechnology, and Biochemistry, Vol.78, No.9, 1485-1489, 2014.
(DOI: 10.1080/09168451.2014.930322,   PubMed: 25209495)
33. Ryuji Asano, Amon Nagami, Yuki Fukumoto, Kaori Miura, Futoshi Yazama, Hideyuki Ito, Isao Sakata and Akihiro Tai :
Synthesis and biological evaluation of new boron-containing chlorin derivatives as agents for both photodynamic therapy and boron neutron capture therapy of cancer,
Bioorganic & Medicinal Chemistry Letters, Vol.24, No.5, 1339-1343, 2014.
(DOI: 10.1016/j.bmcl.2014.01.054,   PubMed: 24508130)
34. Yukako Hanada, Atsuko Iomori, Rie Ishii, Eiichi Gohda and Akihiro Tai :
Protection of free radical-induced cytotoxicity by 2-O-α-D-glucopyranosyl-L-ascorbic acid in human dermal fibroblasts,
Bioscience, Biotechnology, and Biochemistry, Vol.78, No.2, 301-306, 2014.
(DOI: 10.1080/09168451.2014.882756,   PubMed: 25036685)
35. Akihiro Tai, Yuji Iwaoka and Hideyuki Ito :
Highly efficient and regioselective production of an erythorbic acid glucoside using cyclodextrin glucanotransferase from Thermoanaerobacter sp. and amyloglucosidase,
Journal of Molecular Catalysis B: Enzymatic, Vol.92, 19-23, 2013.
(DOI: 10.1016/j.molcatb.2013.03.011)
36. Yoshimi Watanabe, Kazuyasu Murakami, Koji Sakamoto, Tomoko Fujiwara, Akihiro Tai and Norio Muto :
Production of γ-Aminobutyric Acid in Pumpkin Tissue Treated with Freeze-thaw Infusion of L-Glutamic Acid Monosodium Salt,
Food Science and Technology Research, Vol.19, No.4, 641-646, 2013.
(DOI: 10.3136/fstr.19.641,   CiNii: 1390282679436468096)
37. Ryuji Asano, Amon Nagami, Yuki Fukumoto, Futoshi Yazama, Hideyuki Ito, Isao Sakata and Akihiro Tai :
Synthesis and biological evaluation of new chlorin derivatives as potential photosensitizers for photodynamic therapy,
Bioorganic & Medicinal Chemistry, Vol.21, No.8, 2298-2304, 2013.
(DOI: 10.1016/j.bmc.2013.02.005,   PubMed: 23477944)
38. Fuminori Ohsawa, Shoya Yamada, Nobumasa Yakushiji, Ryosuke Shinozaki, Mariko Nakayama, Kohei Kawata, Manabu Hagaya, Toshiki Kobayashi, Kazutaka Kohara, Yuuki Furusawa, Chisa Fujiwara, Yui Ohta, Makoto Makishima, Hirotaka Naitou, Akihiro Tai, Yutaka Yoshikawa, Hiroyuki Yasui and Hiroki Kakuta :
Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency,
Journal of Medicinal Chemistry, Vol.56, No.5, 1865-1877, 2013.
(DOI: 10.1021/jm400033f,   PubMed: 23391145)
39. Jun Takebayashi, Noriko Iwahashi, Yoshiko Ishimi and Akihiro Tai :
Development of a simple 96-well plate method for evaluation of antioxidant activity based on the oxidative hemolysis inhibition assay (OxHLIA),
Food Chemistry, Vol.134, No.1, 606-610, 2012.
(DOI: 10.1016/j.foodchem.2012.02.086)
40. Hiroki Kakuta, Nobumasa Yakushiji, Ryosuke Shinozaki, Fuminori Ohsawa, Shoya Yamada, Yui Ohta, Kohei Kawata, Mariko Nakayama, Manabu Hagaya, Chisa Fujiwara, Makoto Makishima, Shigeyuki Uno, Akihiro Tai, Ami Maehara, Masaru Nakayama, Toshitaka Oohashi, Hiroyuki Yasui and Yutaka Yoshikawa :
RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists,
ACS Medicinal Chemistry Letters, Vol.3, No.5, 427-432, 2012.
(DOI: 10.1021/ml300055n,   PubMed: 24900488)
41. Akihiro Tai, Sayoko Ikeda, Futoshi Yazama and Hideyuki Ito :
Intramolecular acyl migration and enzymatic hydrolysis of 2-O-α-D-glucopyranosyl-6-O-(2-pentylheptanoyl)-L-ascorbic acid,
Journal of Bioscience and Bioengineering, Vol.113, No.4, 545-548, 2012.
(DOI: 10.1016/j.jbiosc.2011.11.023,   PubMed: 22197500)
42. Hiroki Kakuta, Fuminori Ohsawa, Shoya Yamada, Makoto Makishima, Akihiro Tai, Hiroyuki Yasui and Yutaka Yoshikawa :
Feasibility of structural modification of retinoid X receptor agonists to separate blood glucose-lowering action from adverse effects: studies in KKA(y) type 2 diabetes model mice,
Biological & Pharmaceutical Bulletin, Vol.35, No.4, 629-633, 2012.
(DOI: 10.1248/bpb.35.629,   PubMed: 22466572)
43. Akihiro Tai, Takeshi Sawano and Hideyuki Ito :
Antioxidative properties of vanillic acid esters in multiple antioxidant assays,
Bioscience, Biotechnology, and Biochemistry, Vol.76, No.2, 314-318, 2012.
(DOI: 10.1271/bbb.110700,   PubMed: 22313772)
44. Hidekazu Ishimoto, Akihiro Tai, Morio Yoshimura, Yoshiaki Amakura, Takashi Yoshida, Tsutomu Hatano and Hideyuki Ito :
Antioxidative properties of functional polyphenols and their metabolites assessed by an ORAC assay,
Bioscience, Biotechnology, and Biochemistry, Vol.76, No.2, 395-399, 2012.
(DOI: 10.1271/bbb.110717,   PubMed: 22313776)
45. Akihiro Tai, Takeshi Sawano and Futoshi Yazama :
Antioxidant properties of ethyl vanillin in vitro and in vivo,
Bioscience, Biotechnology, and Biochemistry, Vol.75, No.12, 2346-2350, 2011.
(DOI: 10.1271/bbb.110524,   PubMed: 22146718)
46. Akihiro Tai, Yuji Iwaoka and Hideyuki Ito :
Regioselective monoacylation of 2-O-α-D-glucopyranosyl-L-ascorbic acid by a polymer catalyst in N,N-dimethylformamide,
Carbohydrate Research, Vol.346, No.15, 2511-2514, 2011.
(DOI: 10.1016/j.carres.2011.08.010,   PubMed: 21903204)
47. Hidekazu Ishimoto, Mari Shibata, Yuki Myojin, Hideyuki Ito, Yukio Sugimoto, Akihiro Tai and Tsutomu Hatano :
In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A,
Bioorganic & Medicinal Chemistry Letters, Vol.21, No.19, 5901-5904, 2011.
(DOI: 10.1016/j.bmcl.2011.07.086,   PubMed: 21843938)
48. Futoshi Yazama and Akihiro Tai :
Unexpected role of α-fetoprotein in spermatogenesis,
PLoS ONE, Vol.6, No.5, e19387, 2011.
(DOI: 10.1371/journal.pone.0019387,   PubMed: 21573244)
49. Ryosuke Fukai, Xiaoxia Zheng, Kazunori Motoshima, Akihiro Tai, Futoshi Yazama and Hiroki Kakuta :
Design and synthesis of novel cyclooxygenase-1 inhibitors as analgesics: 5-amino-2-ethoxy-N-(substituted-phenyl)benzamides,
ChemMedChem, Vol.6, No.3, 550-560, 2011.
(DOI: 10.1002/cmdc.201000462,   PubMed: 21360824)
50. Akihiro Tai, Takeshi Sawano, Futoshi Yazama and Hideyuki Ito :
Evaluation of antioxidant activity of vanillin by using multiple antioxidant assays,
Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1810, No.2, 170-177, 2011.
(DOI: 10.1016/j.bbagen.2010.11.004,   PubMed: 21095222)
51. Tuty Anggraini, Akihiro Tai, Tomoyuki Yoshino and Tomio Itani :
Antioxidative activity and catechin content of four kinds of Uncaria gambir extracts from West Sumatra, Indonesia,
African Journal of Biochemistry Research, Vol.5, No.1, 33-38, 2011.
52. Akihiro Tai, Yuji Iwaoka, Tasuku Mori and Hideyuki Ito :
Protease-catalyzed monoacylation of 2-O-α-D-glucopyranosyl-L-ascorbic acid in three solvent systems,
Bioscience, Biotechnology, and Biochemistry, Vol.74, No.9, 1969-1971, 2010.
(DOI: 10.1271/bbb.100362,   PubMed: 20834147)
53. Shuji Fujii, Fuminori Ohsawa, Shoya Yamada, Ryosuke Shinozaki, Ryosuke Fukai, Makoto Makishima, Shuichi Enomoto, Akihiro Tai and Hiroki Kakuta :
Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation,
Bioorganic & Medicinal Chemistry Letters, Vol.20, No.17, 5139-5142, 2010.
(DOI: 10.1016/j.bmcl.2010.07.012,   PubMed: 20656484)
54. Shoya Yamada, Fuminori Ohsawa, Shuji Fujii, Ryosuke Shinozaki, Makoto Makishima, Hirotaka Naitou, Shuichi Enomoto, Akihiro Tai and Hiroki Kakuta :
Fluorescent retinoid X receptor ligands for fluorescence polarization assay,
Bioorganic & Medicinal Chemistry Letters, Vol.20, No.17, 5143-5146, 2010.
(DOI: 10.1016/j.bmcl.2010.07.011,   PubMed: 20667726)
55. Akihiro Tai, Tasuku Mori, Yuka Kimura and Hideyuki Ito :
Monoacylation of 2-O-alpha-D-glucopyranosyl-L-ascorbic acid by protease in N,N-dimethylformamide with low water content,
Carbohydrate Research, Vol.345, No.12, 1658-1662, 2010.
(DOI: 10.1016/j.carres.2010.04.028,   PubMed: 20566192)
56. Akihiro Tai, Tasuku Mori, Masaya Urushihara, Hideyuki Ito, Daisuke Kawasaki and Itaru Yamamoto :
Intramolecular acyl migration and enzymatic hydrolysis of a novel monoacylated ascorbic acid derivative, 6-O-dodecanoyl-2-O-alpha-d-glucopyranosyl-L-ascorbic acid,
Bioorganic & Medicinal Chemistry, Vol.18, No.16, 6179-6183, 2010.
(DOI: 10.1016/j.bmc.2010.06.027,   PubMed: 20638286)
57. Jun Takebayashi, Rie Ishii, Jianbin Chen, Teruki Matsumoto, Yoshiko Ishimi and Akihiro Tai :
Reassessment of antioxidant activity of arbutin: multifaceted evaluation using five antioxidant assay systems,
Free Radical Research, Vol.44, No.4, 473-478, 2010.
(DOI: 10.3109/10715761003610760,   PubMed: 20166881)
58. Hiroki Kakuta, Ryosuke Fukai, Zheng Xiaoxia, Fuminori Ohsawa, Takeshi Bamba, Kazumasa Hirata and Akihiro Tai :
Identification of urine metabolites of TFAP, a cyclooxygenase-1 inhibitor,
Bioorganic & Medicinal Chemistry Letters, Vol.20, No.6, 1840-1843, 2010.
(DOI: 10.1016/j.bmcl.2010.01.161,   PubMed: 20185310)
59. Kenji Ichiyama, Hitoshi Mitsuzumi, Ming Zhong, Akihiro Tai, Akihiro Tsuchioka, Saeko Kawai, Itaru Yamamoto and Eiichi Gohda :
Promotion of IL-4- and IL-5-dependent differentiation of anti-mu-primed B cells by ascorbic acid 2-glucoside,
Immunology Letters, Vol.122, No.2, 219-226, 2009.
(DOI: 10.1016/j.imlet.2009.01.007,   PubMed: 19201381)
60. Ken-ichi Morishita, Nobumasa Yakushiji, Fuminori Ohsawa, Kayo Takamatsu, Nobuyasu Matsuura, Makoto Makishima, Masatoshi Kawahata, Kentaro Yamaguchi, Akihiro Tai, Kenji Sasaki and Hiroki Kakuta :
Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity,
Bioorganic & Medicinal Chemistry Letters, Vol.19, No.3, 1001-1003, 2009.
(DOI: 10.1016/j.bmcl.2008.11.086,   PubMed: 19095448)
61. Xiaoxia Zheng, Hiroyuki Oda, Shun Harada, Yukio Sugimoto, Akihiro Tai, Kenji Sasaki and Hiroki Kakuta :
Effect of the oral absorption of benzenesulfonanilide-type cyclooxygenase-1 inhibitors on analgesic action and gastric ulcer formation,
Journal of Pharmaceutical Sciences, Vol.97, No.12, 5446-5452, 2008.
(DOI: 10.1002/jps.21388,   PubMed: 18452178)
62. Jun Takebayashi, Yasuyuki Yagi, Rie Ishii, Shigeki Abe, Kazuhiko Yamada and Akihiro Tai :
Antioxidant properties of 2-O-beta-D-glucopyranosyl-L-ascorbic acid,
Bioscience, Biotechnology, and Biochemistry, Vol.72, No.6, 1558-1563, 2008.
(DOI: 10.1271/bbb.80063,   PubMed: 18540110)
63. Kensuke Namba, Xiaoxia Zheng, Kazunori Motoshima, Hidetomo Kobayashi, Akihiro Tai, Eizo Takahashi, Kenji Sasaki, Keinosuke Okamoto and Hiroki Kakuta :
Design and synthesis of benzenesulfonanilides active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus,
Bioorganic & Medicinal Chemistry, Vol.16, No.11, 6131-6144, 2008.
(DOI: 10.1016/j.bmc.2008.04.040,   PubMed: 18468909)
64. Mai Yoshikawa, Kazunori Motoshima, Kanji Fujimoto, Akihiro Tai, Hiroki Kakuta and Kenji Sasaki :
Pyridinium cationic-dimer antimalarials, unlike chloroquine, act selectively between the schizont stage and the ring stage of Plasmodium falciparum,
Bioorganic & Medicinal Chemistry, Vol.16, No.11, 6027-6033, 2008.
(DOI: 10.1016/j.bmc.2008.04.051,   PubMed: 18479926)
65. Kayo Takamatsu, Atsushi Takano, Nobumasa Yakushiji, Kazunori Morohashi, Ken-ichi Morishita, Nobuyasu Matsuura, Makoto Makishima, Akihiro Tai, Kenji Sasaki and Hiroki Kakuta :
The first potent subtype-selective retinoid X receptor (RXR) agonist possessing a 3-isopropoxy-4-isopropylphenylamino moiety, NEt-3IP (RXRalpha/beta-dual agonist),
ChemMedChem, Vol.3, No.5, 780-787, 2008.
(DOI: 10.1002/cmdc.200700313,   PubMed: 18297677)
66. Hiroki Kakuta, Xiaoxia Zheng, Hiroyuki Oda, Shun Harada, Yukio Sugimoto, Kenji Sasaki and Akihiro Tai :
Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor,
Journal of Medicinal Chemistry, Vol.51, No.8, 2400-2411, 2008.
(DOI: 10.1021/jm701191z,   PubMed: 18363350)
67. Kayo Takamatsu, Atsushi Takano, Nobumasa Yakushiji, Ken-ichi Morishita, Nobuyasu Matsuura, Makoto Makishima, Ismail Hamed Ali, Eiichi Akaho, Akihiro Tai, Kenji Sasaki and Hiroki Kakuta :
Reduction of lipophilicity at the lipophilic domain of RXR agonists enables production of subtype preference: RXRalpha-preferential agonist possessing a sulfonamide moiety,
ChemMedChem, Vol.3, No.3, 454-460, 2008.
(DOI: 10.1002/cmdc.200700265,   PubMed: 18157857)
68. Jun Takebayashi, Hiroaki Kaji, Kenji Ichiyama, Kazutaka Makino, Eiichi Gohda, Itaru Yamamoto and Akihiro Tai :
Inhibition of free radical-induced erythrocyte hemolysis by 2-O-substituted ascorbic acid derivatives,
Free Radical Biology and Medicine, Vol.43, No.8, 1156-1164, 2007.
(DOI: 10.1016/j.freeradbiomed.2007.07.002,   PubMed: 17854711)
69. Kazunori Motoshima, Yoshiko Hiwasa, Mai Yoshikawa, Kanji Fujimoto, Akihiro Tai, Hiroki Kakuta and Kenji Sasaki :
Antimalarial cation-dimers synthesized in two steps from an inexpensive starting material, isonicotinic acid,
ChemMedChem, Vol.2, No.10, 1527-1532, 2007.
(DOI: 10.1002/cmdc.200700107,   PubMed: 17607684)
70. Akihiro Tai and Eiichi Gohda :
Determination of ascorbic acid and its related compounds in foods and beverages by hydrophilic interaction liquid chromatography,
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, Vol.853, No.1-2, 214-220, 2007.
(DOI: 10.1016/j.jchromb.2007.03.024,   PubMed: 17418650)
71. Yuka Kamata, Hiromi Shiraga, Akihiro Tai, Yuko Kawamoto and Eiichi Gohda :
Induction of neurite outgrowth in PC12 cells by the medium-chain fatty acid octanoic acid,
Neuroscience, Vol.146, No.3, 1073-1081, 2007.
(DOI: 10.1016/j.neuroscience.2007.03.001,   PubMed: 17434686)
72. Jun Takebayashi, Ryuji Asano, Yoshinori Nakae, Morio Saito, Eiichi Gohda, Itaru Yamamoto and Akihiro Tai :
2-O-alpha-D-glucopyranosyl-L-ascorbic acid scavenges 1,1-diphenyl-2-picrylhydrazyl radicals via a covalent adduct formation,
Bioscience, Biotechnology, and Biochemistry, Vol.71, No.3, 754-760, 2007.
(PubMed: 17341834)
73. Kenji Ichiyama, Akihiro Tai and Itaru Yamamoto :
Augmentation of antigen-specific antibody production and IL-10 generation with a fraction from Rooibos (Aspalathus linearis) tea,
Bioscience, Biotechnology, and Biochemistry, Vol.71, No.2, 598-602, 2007.
(PubMed: 17284834)
74. Xiaoxia Zheng, Hiroyuki Oda, Kayo Takamatsu, Yukio Sugimoto, Akihiro Tai, Eiichi Akaho, Ismail Hamed Ali, Toshiyuki Oshiki, Hiroki Kakuta and Kenji Sasaki :
Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors,
Bioorganic & Medicinal Chemistry, Vol.15, No.2, 1014-1021, 2007.
(DOI: 10.1016/j.bmc.2006.10.029,   PubMed: 17079150)
75. Akihiro Tai, Jun Takebayashi, Ayako Ueno, Eiichi Gohda and Itaru Yamamoto :
An isocratic HPLC method for the simultaneous determination of novel stable lipophilic ascorbic acid derivatives and their metabolites,
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, Vol.840, No.1, 38-43, 2006.
(DOI: 10.1016/j.jchromb.2006.04.051,   PubMed: 16822727)
76. Jun Takebayashi, Akihiro Tai, Eiichi Gohda and Itaru Yamamoto :
Characterization of the radical-scavenging reaction of 2-O-substituted ascorbic acid derivatives, AA-2G, AA-2P, and AA-2S: a kinetic and stoichiometric study.,
Biological & Pharmaceutical Bulletin, Vol.29, No.4, 766-771, 2006.
(DOI: 10.1248/bpb.29.766,   PubMed: 16595915)
77. Hiroaki Kaji, Akihiro Tai, Kazufumi Matsushita, Hiroshi Kanzaki and Itaru Yamamoto :
Activation of murine peritoneal macrophages by water-soluble extracts of Bursaphelenchus xylophilus, a pine wood nematode,
Bioscience, Biotechnology, and Biochemistry, Vol.70, No.1, 203-210, 2006.
(PubMed: 16428838)
78. Ming Zhong, Akihiro Tai and Itaru Yamamoto :
In vitro augmentation of natural killer activity and interferon-gamma production in murine spleen cells with Agaricus blazei fruiting body fractions,
Bioscience, Biotechnology, and Biochemistry, Vol.69, No.12, 2466-2469, 2005.
(PubMed: 16377912)
79. Eriko Aoyama, Ritsuko Yoshihara, Akihiro Tai, Itaru Yamamoto and Eiichi Gohda :
PKC- and PI3K-dependent but ERK-independent proliferation of murine splenic B cells stimulated by chondroitin sulfate B,
Immunology Letters, Vol.99, No.1, 80-84, 2005.
(DOI: 10.1016/j.imlet.2005.01.005,   PubMed: 15894115)
80. Takahiro Motoki, Yoichiro Takami, Yasuyuki Yagi, Akihiro Tai, Itaru Yamamoto and Eiichi Gohda :
Inhibition of hepatocyte growth factor induction in human dermal fibroblasts by tryptanthrin,
Biological & Pharmaceutical Bulletin, Vol.28, No.2, 260-266, 2005.
(DOI: 10.1248/bpb.28.260,   PubMed: 15684480)
81. Akihiro Tai, Satomi Goto, Yutaka Ishiguro, Kazuko Suzuki, Teruhiko Nitoda and Itaru Yamamoto :
Permeation and metabolism of a series of novel lipophilic ascorbic acid derivatives, 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic acids with a branched-acyl chain, in a human living skin equivalent model,
Bioorganic & Medicinal Chemistry Letters, Vol.14, No.3, 623-627, 2004.
(DOI: 10.1016/j.bmcl.2003.11.059,   PubMed: 14741256)
82. Jun Takebayashi, Akihiro Tai and Itaru Yamamoto :
pH-dependent long-term radical scavenging activity of AA-2G and 6-Octa-AA-2G against 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation,
Biological & Pharmaceutical Bulletin, Vol.26, No.9, 1368-1370, 2003.
(DOI: 10.1248/bpb.26.1368,   PubMed: 12951491)
83. Akihiro Tai, Daisuke Kawasaki, Satomi Goto, Eiichi Gohda and Itaru Yamamoto :
Vitamin C activity in guinea pigs of 6-O-acyl-2-O-alpha-D-glucopyranosyl-L- ascorbic acids with a branched-acyl chain,
Bioscience, Biotechnology, and Biochemistry, Vol.67, No.8, 1675-1682, 2003.
(DOI: 10.1271/bbb.67.1675,   PubMed: 12951499)
84. Xiaohua Zhou, Akihiro Tai and Itaru Yamamoto :
Enhancement of neurite outgrowth in PC12 cells stimulated with cyclic AMP and NGF by 6-acylated ascorbic acid 2-O-alpha-glucosides (6-Acyl-AA-2G), novel lipophilic ascorbate derivatives,
Biological & Pharmaceutical Bulletin, Vol.26, No.3, 341-346, 2003.
(DOI: 10.1248/bpb.26.341,   PubMed: 12612444)
85. Hiroaki Kaji, Masahiko Kawada, Akihiro Tai, Hiroshi Kanzaki and Itaru Yamamoto :
Augmentation by Bursaphelenchus xylophilus, a pine wood nematode, of polyclonal IgE production induced by lipopolysaccharide plus interleukin-4 in murine splenocytes,
Journal of Pharmacological Sciences, Vol.91, No.2, 158-162, 2003.
(PubMed: 12686761)
86. Akihiro Tai, Daisuke Kawasaki, Kenji Sasaki, Eiichi Gohda and Itaru Yamamoto :
Synthesis and characterization of 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic acids with a branched-acyl chain,
Chemical & Pharmaceutical Bulletin, Vol.51, No.2, 175-180, 2003.
(DOI: 10.1248/cpb.51.175,   PubMed: 12576651)
87. Jun Takebayashi, Akihiro Tai and Itaru Yamamoto :
Long-term radical scavenging activity of AA-2G and 6-acyl-AA-2G against 1,1-diphenyl-2-picrylhydrazyl,
Biological & Pharmaceutical Bulletin, Vol.25, No.11, 1503-1505, 2002.
(DOI: 10.1248/bpb.25.1503,   PubMed: 12419971)
88. Akihiro Tai, Yoshihito Fujinami, Kyoko Matsumoto, Daisuke Kawasaki and Itaru Yamamoto :
Bioavailability of a series of novel acylated ascorbic acid derivatives, 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic acids, as an ascorbic acid supplement in rats and guinea pigs,
Bioscience, Biotechnology, and Biochemistry, Vol.66, No.8, 1628-1634, 2002.
(DOI: 10.1271/bbb.66.1628,   PubMed: 12353620)
89. Itaru Yamamoto, Akihiro Tai, Yoshihito Fujinami, Kenji Sasaki and Shino Okazaki :
Synthesis and characterization of a series of novel monoacylated ascorbic acid derivatives, 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic acids, as skin antioxidants,
Journal of Medicinal Chemistry, Vol.45, No.2, 462-468, 2002.
(DOI: 10.1021/jm010379f,   PubMed: 11784150)
90. Kazuyoshi Kunishiro, Akihiro Tai and Itaru Yamamoto :
Effects of rooibos tea extract on antigen-specific antibody production and cytokine generation in vitro and in vivo,
Bioscience, Biotechnology, and Biochemistry, Vol.65, No.10, 2137-2145, 2001.
(PubMed: 11758901)
91. Akihiro Tai, Shino Okazaki, Noriko Tsubosaka and Itaru Yamamoto :
Protease-catalyzed monoacylation of 2-O-alpha-D-Glucopyranosyl-L-ascorbic acid in pyridine,
Chemical & Pharmaceutical Bulletin, Vol.49, No.8, 1047-1049, 2001.
(DOI: 10.1248/cpb.49.1047,   PubMed: 11515578)
92. Ming Zhong, Akihiro Tai and Itaru Yamamoto :
IgE production is involved in butyrate-enhanced NK cell activity in vivo,
Chinese Medical Sciences Journal, Vol.16, No.2, 76-81, 2001.
(PubMed: 12901494)
93. Yoshihito Fujinami, Akihiro Tai and Itaru Yamamoto :
Radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl of ascorbic acid 2-glucoside (AA-2G) and 6-acyl-AA-2G,
Chemical & Pharmaceutical Bulletin, Vol.49, No.5, 642-644, 2001.
(DOI: 10.1248/cpb.49.642,   PubMed: 11383624)
94. Akihiro Tai, Kazuyoshi Kawazu and Akio Kobayashi :
Species-specificity of an elicitor-active oligosaccharide, LN-3, to leguminous plants,
Zeitschrift für Naturforschung. C, A Journal of Biosciences, Vol.51, No.5-6, 371-378, 1996.
(DOI: 10.1515/znc-1996-5-614)
95. Akihiro Tai, Eri Ohsawa, Kazuyoshi Kawazu and Akio Kobayashi :
A minimum essential structure of LN-3 elicitor activity in bean cotyledons,
Zeitschrift für Naturforschung. C, A Journal of Biosciences, Vol.51, No.1-2, 15-19, 1996.
(DOI: 10.1515/znc-1996-1-205)
96. Akio Kobayashi, Akihiro Tai and Kazuyoshi Kawazu :
Structural elucidation of an elicitor-active oligosaccharide, LN-3, prepared from algal laminaran,
Journal of Carbohydrate Chemistry, Vol.14, No.6, 819-832, 1995.
(DOI: 10.1080/07328309508005378)
97. Goro Okamoto, Yuichiro Fujii, Ken Hirano, Akihiro Tai and Akio Kobayashi :
Pollen tube growth inhibitors from 'Pione' grape pistils,
American Journal of Enology and Viticulture, Vol.46, No.1, 17-21, 1995.
98. Akio Kobayashi, Akihiro Tai, Hiroshi Kanzaki and Kazuyoshi Kawazu :
Elicitor-active oligosaccharides from algal laminaran stimulate the production of antifungal compounds in alfalfa,
Zeitschrift für Naturforschung. C, A Journal of Biosciences, Vol.48, No.7-8, 575-579, 1993.
(DOI: 10.1515/znc-1993-7-808)

総説・解説:

1. 田井 章博 :
アスコルビン酸誘導体を用いた医薬品開発への可能性,
ビタミン, Vol.96, No.7, 311-321, 2022年7月.
(CiNii: 1520574490473734016)
2. 岩岡 裕二, 福嶋 美咲, 伊東 秀之, 田井 章博 :
2-O-α-D-Glucopyranosyl-6-O-(2-propylpentanoyl)-L-ascorbic acidの高効率的かつ低コストな合成プロセス,
ビタミン, Vol.96, No.5/6, 230-233, 2022年6月.
(CiNii: 1520292715730584704)
3. 三浦 香織, 松野 弘明, 岩岡 裕二, 伊東 秀之, 田井 章博 :
6-Deoxy-2-O-methyl-6-(N-hexadecanoyl)amino-L-ascorbic acidの抗アレルギー作用,
ビタミン, Vol.95, No.11, 483-486, 2021年11月.
(CiNii: 1572543029276256128)
4. 田井 章博 :
アスコルビン酸誘導体を用いた基礎研究から応用研究まで,
ビタミン, Vol.93, No.9, 383-393, 2019年9月.
(DOI: 10.20632/vso.93.9_383,   CiNii: 1390567172582498304)
5. 田井 章博, 五百森 敦子, 伊東 秀之 :
2-O-α-D-Glucopyranosyl-L-ascorbic acidの DPPHラジカル捕捉機構の構造的証拠,
ビタミン, Vol.92, No.7, 313-315, 2018年7月.
(DOI: 10.20632/vso.92.7_313,   CiNii: 1390845713085915904)
6. 三浦 香織, 森下 雄太, 松野 弘明, 青田 湧介, 伊東 秀之, 田井 章博 :
モノアシル化アスコルビン酸グルコシドの抗アレルギー作用,
ビタミン, Vol.92, No.5/6, 263-266, 2018年6月.
(DOI: 10.20632/vso.92.5.6_263,   CiNii: 1390845713080590592)
7. 三浦 香織, 田井 章博 :
高濃度アスコルビン酸点滴療法における抗がん薬としてのアスコルビン酸2-グルコシド,
ビタミン, Vol.91, No.11, 646-648, 2017年11月.
(DOI: 10.20632/vso.91.11_646,   CiNii: 1390845713026521984)
8. 田井 章博 :
アスコルビン酸誘導体の創製とその医薬品開発応用への可能性(日本薬学会第136回シンポジウム「ビタミンのケミカルバイオロジー研究」),
ビタミン, Vol.91, No.5/6, 338-347, 2017年6月.
(DOI: 10.20632/vso.91.5.6_338,   CiNii: 1390845712971104000)
9. 三浦 香織, 矢間 太, 田井 章博 :
高濃度エリソルビン酸による酸化ストレス誘導性の抗がん作用,
ビタミン, Vol.90, No.9, 433-434, 2016年9月.
(DOI: 10.20632/vso.90.9_433,   CiNii: 1390001205762305792)
10. 森下 雄太, 田井 章博 :
ビタミンC 再生経路と酸化ストレス,
ビタミン, Vol.90, No.8, 398-401, 2016年8月.
(DOI: 10.20632/vso.90.8_398,   CiNii: 1390282680739024896)
11. 田井 章博, 岩岡 裕二, 伊東 秀之 :
シクロデキストリングルカノトランスフェラーゼとアミログルコシダーゼを用いた高効率的かつ位置選択的なエリソルビン酸グルコシドの合成,
ビタミン, Vol.87, No.7, 364-366, 2013年7月.
(DOI: 10.20632/vso.87.7_364,   CiNii: 1390001205669471488)
12. 田井 章博, 岩岡 裕二, 伊東 秀之 :
高分子触媒によるDMF中アスコルビン酸2-グルコシドの部位選択的モノアシル化,
ビタミン, Vol.87, No.3, 154-155, 2013年3月.
(DOI: 10.20632/vso.87.3_154,   CiNii: 1390001205669575040)
13. 田井 章博 :
2-O-置換型アスコルビン酸誘導体の抗酸化特性,
ビタミン, Vol.87, No.2, 70-80, 2013年2月.
(DOI: 10.20632/vso.87.2_70,   CiNii: 1390001205669564544)
14. 田井 章博, 森 佑, 木村 友香, 伊東 秀之 :
少量の水を含むDMF中におけるアスコルビン酸2-グルコシドのプロテアーゼによるモノアシル化,
ビタミン, Vol.84, No.11, 548-549, 2010年11月.
(DOI: 10.20632/vso.84.11_548,   CiNii: 1390282680677571584)
15. 田井 章博, 森 佑, 漆原 将也, 伊東 秀之, 川崎 大輔, 山本 格 :
新規モノアシル化アスコルビン酸誘導体6-O-dodecanoyl-2-O-α-D-glucopyranosyl-L-ascorbic acidの分子内アシル基転位と酵素的加水分解,
ビタミン, Vol.84, No.11, 550-551, 2010年11月.
(DOI: 10.20632/vso.84.11_550,   CiNii: 1390001205700858624)
16. 田井 章博 :
親油性安定型アスコルビン酸誘導体の創製とその特性に関する研究,
ビタミン, Vol.82, No.3, 151-160, 2008年3月.
(DOI: 10.20632/vso.82.3_151,   CiNii: 1390282680678690944)
17. 竹林 純, 加地 弘明, 市山 健司, 牧野 和隆, 合田 榮一, 山本 格, 田井 章博 :
2-O-置換型アスコルビン酸誘導体によるフリーラジカル誘導性赤血球溶血反応の抑制,
ビタミン, Vol.82, No.3, 187-189, 2008年3月.
(DOI: 10.20632/vso.82.3_187,   CiNii: 1390282680678704256)
18. 田井 章博 :
プロビタミンC剤の新しい利用法,
生物工学会誌, Vol.85, No.6, 281, 2007年6月.
(CiNii: 1571417127247204480)
19. 田井 章博 :
親油性安定型アスコルビン酸誘導体の開発と応用,
バイオサイエンスとインダストリー, Vol.65, No.3, 132-133, 2007年3月.
(CiNii: 1573387450151515520)
20. 山本 格, 田井 章博 :
アスコルビン酸(ビタミンC)誘導体の開発動向,
ビタミン, Vol.78, No.1, 36-42, 2004年1月.
(DOI: 10.20632/vso.78.1_36,   CiNii: 1390001205702158336)
21. 田井 章博 :
ビタミンCとがんとの関係,
化学, Vol.57, No.2, 64-65, 2002年2月.
22. 山本 格, 田井 章博 :
新しいビタミン製剤の研究開発動向,
日本臨牀, Vol.57, No.10, 2332-2338, 1999年10月.

国内講演発表:

1. 吉田 愛菜, 中村 光裕, 田井 章博 :
高感度かつハイスループットなアスコルビン酸定量法,
日本農芸化学会2022年度中四国支部大会(第63回講演会), 2022年9月.
2. 川原 直晃, 千振 正登, 伊東 秀之, 古賀 武尊, 田井 章博 :
アルキルエリソルビン酸の抗アレルギー作用,
日本ビタミン学会第74回大会, 2022年6月.
3. 古賀 武尊, 志岐 菜々子, 伊東 秀之, 岩岡 裕二, 田井 章博 :
Coreopsis grandifloraの花由来の脱顆粒抑制作用物質,
日本農芸化学会西日本・中四国・関西支部合同大会(第60回講演会), 2021年9月.
4. 吉田 真生, 田井 章博, 向井 理恵 :
ケルセチンのプレニル化による抗酸化特性の変化,
日本農芸化学会2021年度大会, 2021年3月.
5. 古賀 武尊, 阪本 鷹行, 櫻谷 英治, 田井 章博 :
ヒマワリ種子由来のPC12細胞における神経突起形成促進作用物質,
日本農芸化学会中四国支部第57回講演会(例会), 2020年9月.
6. 西原 好美, 西野 耕平, 岩岡 裕二, 丸田 隆典, 小川 貴央, 重岡 成, 田井 章博, 澤 嘉弘, 石川 孝博 :
アフィニティー樹脂によるシロイヌナズナアスコルビン酸結合タンパク質の探索,
日本農芸化学会2020年度大会, 2020年3月.
7. 垣添 佑介, 野下 俊朗, 田邊 聖, 大内 秀一, 田井 章博 :
カロライナジャスミンの花弁に含まれるPTP1B阻害活性物質の探索,
日本農芸化学会中四国支部第56回講演会(例会), 2020年1月.
8. 三浦 香織, 松野 弘明, 岩岡 裕二, 伊東 秀之, 田井 章博 :
モノパルミトイルアスコルビン酸誘導体の抗アレルギー作用,
日本農芸化学会西日本・中四国支部合同大会(第55回講演会), 2019年11月.
9. 前 史織, 千振 正登, 伊東 秀之, 田井 章博 :
3-O-ドデシルアスコルビン酸の抗アレルギー作用,
日本農芸化学会西日本・中四国支部合同大会(第55回講演会), 2019年11月.
10. 竹元 聡, 伊東 秀之, 田井 章博 :
アスコルビン酸固定化アフィニティーゲルの消化酵素に対する結合性評価,
日本農芸化学会西日本・中四国支部合同大会(第55回講演会), 2019年11月.
11. 古賀 武尊, 池田 奈央, 伊東 秀之, 若山 祥夫, 田井 章博 :
神経突起形成促進作用を示す鶏冠加水分解物由来水溶性物質,
日本農芸化学会西日本・中四国支部合同大会(第55回講演会), 2019年11月.
12. 古賀 武尊, 伊東 秀之, 油田 芽衣, 田井 章博 :
アルキルアスコルビン酸の合成と神経突起形成促進作用,
日本ビタミン学会第71回大会, 2019年6月.
13. 竹元 聡, 伊東 秀之, 田井 章博 :
3-ドデシルアスコルビン酸の脱顆粒抑制作用発現に関与する標的タンパク質の探索,
日本農芸化学会中四国支部第53回講演会(例会), 2019年1月.
14. 青田 湧介, 加来田 博貴, 田井 章博 :
蛍光誘導体を用いたアスコルビン酸のライブセルイメージング,
日本農芸化学会中四国支部第53回講演会(例会), 2019年1月.

その他・研究会:

1. 田井 章博 :
ビタミンCと同じ働きを持つものにはどんなものがあるの?,
第2回ビタミンC研究委員会シンポジウム, 2022年8月.
2. 田井 章博 :
アスコルビン酸誘導体を用いた医薬品開発への可能性,
日本ビタミン学会第73回大会part2シンポジウム, 2021年11月.
3. 田井 章博 :
健康と美容を支えるビタミンC,
日本農芸化学会中四国支部 支部創立20周年記念 第39回 市民フォーラム, 2021年10月.
4. 田井 章博, 三浦 香織, 松野 弘明, 岩岡 裕二, 伊東 秀之 :
6-パルミトイルアスコルビン酸誘導体の抗アレルギー作用,
第163回ビタミンC研究委員会, 2021年6月.
5. 田井 章博 :
アスコルビン酸誘導体の生理・薬理作用,
第1回ビタミンC研究委員会シンポジウム, 2019年8月.
6. 田井 章博, 青田 湧介, 髙村 祐太, 加来田 博貴 :
アスコルビン酸蛍光誘導体を用いたライブセルイメージング,
第158回ビタミンC研究委員会, 2019年3月.

特許:

1. 田井 章博, 古賀 武尊, 若山 祥夫 : 神経伸長促進剤, 特願2018-102184 (2018年5月), 特開2018-203722 (2018年12月), 特許第7142284号 (2022年9月).
2. 田井 章博, 古賀 武尊, 若山 祥夫 : 神経形成促進剤,内服剤,培地用添加剤,細胞希釈液用添加剤,培地および細胞希釈液, 特願2018-098569 (2018年5月), 特開2019-202954 (2019年11月), .
3. 田井 章博, 三浦 香織, 若山 祥夫 : 化合物,抗アレルギー剤およびメディエーター遊離阻害剤, 特願2018-098570 (2018年5月), 特開2019-202955 (2019年11月), 特許第7140325号 (2022年9月).
4. 髙寺 恒慈, 田井 章博 : 中性脂肪及びコレステロール低減用組成物, 特願2017-191634 (2017年9月), 特開2019-064958 (2019年4月), 特許第7016074号 (2022年1月).
5. 田井 章博, 森下 雄太, 若山 祥夫 : アンジオテンシン変換酵素阻害活性剤とその製造方法,内服剤, 特願2017-123518 (2017年6月), 特開2019-006708 (2019年1月), .
6. 田井 章博 : 抗アレルギー剤,メディエーター遊離阻害剤及び内服薬, 特願2017-122090 (2017年6月), 特開2019-006692 (2019年1月), 特許第6986375号 (2021年12月).
7. 若山 祥夫, 田井 章博 : 抗酸化剤, 特願2016-024655 (2016年2月), 特開2017-141392 (2017年8月), 特許第6622613号 (2019年11月).
8. 若山 祥夫, 田井 章博 : 神経伸長促進剤,内服剤,培地用添加剤,細胞希釈液用添加剤,培地および細胞希釈液, 特願2016-024657 (2016年2月), 特開2017-141207 (2017年8月), 特許第6230638号 (2017年10月).
9. 若山 祥夫, 田井 章博 : 創傷治療剤, 特願2016-024656 (2016年2月), 特開2017-141206 (2017年8月), 特許第6198867号 (2017年9月).
10. 田井 章博, 三浦 香織, 和田 晃 : 抗腫瘍剤, 特願2015-152439 (2015年7月), 特開2016-138087 (2016年8月), 特許第6588764号 (2019年9月).
11. 田井 章博, 三浦 香織 : 抗アレルギー剤及びメディエーター遊離阻害剤, 特願2015-151157 (2015年7月), 特開2017-031083 (2017年2月), 特許第6606370号 (2019年10月).
12. 合田 榮一, 田井 章博, 鎌田 祐佳 : 神経細胞分化誘導剤, 特願2006-037294 (2006年2月), 特開2007-217311 (2007年8月), 特許第5050195号 (2012年8月).
13. 藤浪 良仁, 岡崎 志野, 田井 章博, 佐々木 健二, 山本 格 : グリコシル-L-アスコルビン酸のアシル化誘導体, 特願10-101855 (1998年3月), 特開11-286497 (1999年10月), 特許第4981198号 (2012年4月).
14. 小林 昭雄, 秋山 康紀, 田井 章博, 河津 一儀 : 部分N-アセチルキトサンオリゴ糖の合成方法, 特願07-060862 (1995年3月), 特開08-259603 (1996年10月), .
15. 小林 昭雄, 田井 章博, 神崎 浩, 河津 一儀 : 糖のエリシター活性を高める方法, 特願05-220260 (1993年9月), 特開07-067681 (1995年3月), 特許第3498979号 (2003年12月).
16. 小林 昭雄, 河津 一儀, 神崎 浩, 仲江 良則, 秋山 康紀, 田井 章博, 中本 泰子 : 脱分化初期細胞系による物質の生産方法, 特願02-402423 (1990年12月), 特開06-022754 (1994年2月), 特許第2823702号 (1998年9月).

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

  • 脳機能障害治療薬を志向した新規なAChE阻害活性-神経突起伸張促進作用物質の作出 (研究課題/領域番号: 22K05458 )
  • 新規安定型アスコルビン酸プローブによる植物アスコルビン酸結合タンパク質の探索 (研究課題/領域番号: 17K19239 )
  • ジアリールエーテル型PTP 1B阻害剤の作出および構造活性相関の解明 (研究課題/領域番号: 16K07720 )
  • 真菌類由来アスコルビン酸類似体の動物における機能解明並びに生物学的利用 (研究課題/領域番号: 17780103 )
  • 神経・免疫クロストークを制御する因子に関する研究 (研究課題/領域番号: 11470485 )
  • 常在性および炎症性マクロファージの活性化機構に関する研究 (研究課題/領域番号: 10771290 )
  • 研究者番号(70284081)による検索