徳島大学 / 教育研究者総覧 --- 和泉優奈

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徳島大学 ⟩ 大学院医歯薬学研究部 ⟩ 医学域 ⟩ 栄養科学部門 ⟩ 医科栄養学系 ⟩ 代謝栄養学 ⟩
徳島大学 ⟩ 大学院医歯薬学研究部 ⟩ 医学域 ⟩ 先端基礎栄養学教育研究プロジェクト ⟩
徳島大学 ⟩ 医科栄養学研究科 ⟩ 医科栄養学専攻 ⟩

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研究活動

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著書・論文

学術論文(審査論文):

1.	Takahiro Kato, Satoshi Kamiya, Soshi Narasaki, Ayako Sumii, M Yasuo Tsutsumi, Kyoka Machida, Kanako Hara, Yuna Izumi, Rie Tsutsumi and Hiroshi Sakaue : Partially Hydrolyzed Guar Gum Intake Supports the Gut Microbiota and Attenuates Inflammation during Influenza H1N1 Virus Infection in Mice., Nutrients, Vol.15, No.19, 4252, 2023. (要約) Partially hydrolyzed guar gum (PHGG) is a soluble dietary fiber that is effective for defecation control. It influences the gut microbiota, by which it is metabolized to yield short-chain fatty acids (SCFAs), and it was also recently shown to protect against influenza infection in humans. We here investigated the effects of PHGG in a mouse model of influenza H1N1 virus infection. Eight-week-old C57BL/6 mice were fed normal chow with or without PHGG (500 mg/kg per day) for 4 weeks, infected with H1N1 at 10 weeks of age, and analyzed at 12 weeks of age. Administration of PHGG attenuated the decline in body weight induced by H1N1 infection without affecting food intake. It also ameliorated intestinal atrophy and increased the production of SCFAs including acetic acid, propionic acid, and butyric acid in the cecum, thereby preventing the inhibitory effect of H1N1 infection on SCFA production. The H1N1-induced increases in the serum concentrations of inflammatory cytokines including interferon-γ and interleukin-6 and anti-inflammatory cytokine such as interleukin-10 were all inhibited by PHGG intake. In addition, PHGG administration attenuated inflammatory gene expression in the lung and promoted both natural killer cell activity and regulatory T-cell differentiation in the spleen. Our findings suggest that the consumption of PHGG may improve the gut environment and thereby limit the inflammatory response to H1N1 infection. They may thus provide the basis for novel dietary intervention strategies to suppress the excessive inflammation associated with virus infection. (キーワード) Humans / Mice / Animals / Influenza A Virus, H1N1 Subtype / Influenza, Human / Gastrointestinal Microbiome / Mice, Inbred C57BL / Inflammation / Galactans / Mannans / Plant Gums / Fatty Acids, Volatile / Orthomyxoviridae Infections / Communicable Diseases / Dietary Fiber (出版サイトへのリンク) ● Publication site (DOI): 10.3390/nu15194252 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37836536 ● Search Scopus @ Elsevier (PMID): 37836536 ● Search Scopus @ Elsevier (DOI): 10.3390/nu15194252 (DOI: 10.3390/nu15194252, PubMed: 37836536)

国内講演発表:

1.	山田苑子, 久保みゆ, 和泉優奈, 野村和弘, 神村盛一郎, 柏原秀也, 齋藤裕, 北村嘉章, 島田光生, 濵田康弘, 阪上浩 : 簡便に得られるデータから作成した四肢骨格筋量を予測する回帰式の妥当性検証, 第27回日本病態栄養学会年次学術集会, 2024年1月.
2.	和泉優奈, 藤本紗織, 谷口萌々花, 大村皐月, 山田苑子, 志内哲也, 岡松優子, 米代武司, 野村和弘, 堤理恵, 阪上浩 : 骨格筋-BAT間アミノ酸代謝連関に対する制御機構の解明, 第44回日本肥満学会学術集会, 2023年11月.
3.	大村皐月, 和泉優奈, 野村和弘, 山田苑子, 志内哲也, 岡松優子, 米代武司, 堤理恵, 阪上浩 : 臓器間アミノ酸代謝連関の調節因子としての骨格筋由来IL-6発現メカニズムの解明, 第56回栄養・食糧学会中国四国支部大会, 2023年10月.
4.	村上遥音, 和泉優奈, 鈴木由紀, 山田苑子, 野村和弘, 堤理恵, 阪上浩 : 廃用性筋萎縮の骨格筋代謝動態に対するMCT配合ケトン食の影響, 第56回栄養・食糧学会中国四国支部大会, 2023年10月.
5.	和泉優奈, 藤本紗織, 谷口萌々花, 大村皐月, 志内哲也, 岡松優子, 米代武司, 黒田雅士, 野村和弘, 堤理恵, 阪上浩 : 骨格筋による新たな体温維持機構の発見とその制御分子の同定, 第9回日本筋学会学術集会, 2023年8月.